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Volumn 137, Issue 3, 2016, Pages 460-471

Acylated but not des-acyl ghrelin is neuroprotective in an MPTP mouse model of Parkinson's disease

Author keywords

acylated ghrelin; corticosterone; des acylated ghrelin; dopamine; GOAT; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ACYLATED GHRELIN; ACYLTRANSFERASE; CELL PROTEIN; DES ACYL GHRELIN; GHRELIN; GHRELIN O ACYLTRANSFERASE; GLIAL FIBRILLARY ACIDIC PROTEIN; IONIZED CALCIUM BINDING ADAPTOR MOLECULE 1; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; CALCIUM BINDING PROTEIN; GHRELIN O-ACYLTRANSFERASE, MOUSE; GLIAL FIBRILLARY ASTROCYTIC PROTEIN, MOUSE; NEUROPROTECTIVE AGENT;

EID: 84963776678     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13576     Document Type: Article
Times cited : (45)

References (53)
  • 1
    • 77953439761 scopus 로고    scopus 로고
    • Alterations in monoamine levels and oxidative systems in frontal cortex, striatum, and hippocampus of the rat brain during chronic unpredictable stress
    • Ahmad A., Rasheed N., Banu N., and, Palit G., (2010) Alterations in monoamine levels and oxidative systems in frontal cortex, striatum, and hippocampus of the rat brain during chronic unpredictable stress. Stress 13, 355-364.
    • (2010) Stress , vol.13 , pp. 355-364
    • Ahmad, A.1    Rasheed, N.2    Banu, N.3    Palit, G.4
  • 2
    • 12244299859 scopus 로고    scopus 로고
    • Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay
    • Akamizu T., Shinomiya T., Irako T., Fukunaga M., Nakai Y., Nakai Y., and, Kangawa K., (2005) Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay. J. Clin. Endocrinol. Metab. 90, 6-9.
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 6-9
    • Akamizu, T.1    Shinomiya, T.2    Irako, T.3    Fukunaga, M.4    Nakai, Y.5    Nakai, Y.6    Kangawa, K.7
  • 3
    • 70449673061 scopus 로고    scopus 로고
    • Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism
    • Andrews Z. B., Erion D., Beiler R., et al,. (2009) Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. J. Neurosci. 29, 14057-14065.
    • (2009) J. Neurosci. , vol.29 , pp. 14057-14065
    • Andrews, Z.B.1    Erion, D.2    Beiler, R.3
  • 4
    • 17944380559 scopus 로고    scopus 로고
    • A role of ghrelin in neuroendocrine and behavioral responses to stress in mice
    • Asakawa A., Inui A., Kaga T., et al,. (2001) A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinology 74, 143-147.
    • (2001) Neuroendocrinology , vol.74 , pp. 143-147
    • Asakawa, A.1    Inui, A.2    Kaga, T.3
  • 5
    • 84878542289 scopus 로고    scopus 로고
    • Exenatide and the treatment of patients with Parkinson's disease
    • Aviles-Olmos I., Dickson J., Kefalopoulou Z., et al,. (2013) Exenatide and the treatment of patients with Parkinson's disease. J. Clin. Investig. 123, 2730-2736.
    • (2013) J. Clin. Investig. , vol.123 , pp. 2730-2736
    • Aviles-Olmos, I.1    Dickson, J.2    Kefalopoulou, Z.3
  • 6
    • 38849196303 scopus 로고    scopus 로고
    • Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease
    • Bertilsson G., Patrone C., Zachrisson O., et al,. (2008) Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease. J. Neurosci. Res. 86, 326-338.
    • (2008) J. Neurosci. Res. , vol.86 , pp. 326-338
    • Bertilsson, G.1    Patrone, C.2    Zachrisson, O.3
  • 8
    • 84872737871 scopus 로고    scopus 로고
    • Calorie-restricted weight loss reverses high-fat diet-induced ghrelin resistance, which contributes to rebound weight gain in a ghrelin-dependent manner
    • Briggs D. I., Lockie S. H., Wu Q., Lemus M. B., Stark R., and, Andrews Z. B., (2013) Calorie-restricted weight loss reverses high-fat diet-induced ghrelin resistance, which contributes to rebound weight gain in a ghrelin-dependent manner. Endocrinology 154, 709-717.
    • (2013) Endocrinology , vol.154 , pp. 709-717
    • Briggs, D.I.1    Lockie, S.H.2    Wu, Q.3    Lemus, M.B.4    Stark, R.5    Andrews, Z.B.6
  • 9
    • 70449460896 scopus 로고    scopus 로고
    • Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils
    • Bulgarelli I., Tamiazzo L., Bresciani E., Rapetti D., Caporali S., Lattuada D., Locatelli V., and, Torsello A., (2009) Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils. J. Neurosci. Res. 87, 2718-2727.
    • (2009) J. Neurosci. Res. , vol.87 , pp. 2718-2727
    • Bulgarelli, I.1    Tamiazzo, L.2    Bresciani, E.3    Rapetti, D.4    Caporali, S.5    Lattuada, D.6    Locatelli, V.7    Torsello, A.8
  • 11
    • 53349175016 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells
    • Chung H., Seo S., Moon M., and, Park S., (2008) Phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3 beta and ERK1/2 pathways mediate protective effects of acylated and unacylated ghrelin against oxygen-glucose deprivation-induced apoptosis in primary rat cortical neuronal cells. J. Endocrinol. 198, 511-521.
    • (2008) J. Endocrinol. , vol.198 , pp. 511-521
    • Chung, H.1    Seo, S.2    Moon, M.3    Park, S.4
  • 12
    • 0035433977 scopus 로고    scopus 로고
    • A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    • Cummings D. E., Purnell J. Q., Frayo R. S., Schmidova K., Wisse B. E., and, Weigle D. S., (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50, 1714-1719.
    • (2001) Diabetes , vol.50 , pp. 1714-1719
    • Cummings, D.E.1    Purnell, J.Q.2    Frayo, R.S.3    Schmidova, K.4    Wisse, B.E.5    Weigle, D.S.6
  • 13
    • 0032466716 scopus 로고    scopus 로고
    • Effects of major depression, aging and gender upon calculated diurnal free plasma cortisol concentrations: A re-evaluation study
    • Deuschle M., Weber B., Colla M., Depner M., and, Heuser I., (1998) Effects of major depression, aging and gender upon calculated diurnal free plasma cortisol concentrations: a re-evaluation study. Stress 2, 281-287.
    • (1998) Stress , vol.2 , pp. 281-287
    • Deuschle, M.1    Weber, B.2    Colla, M.3    Depner, M.4    Heuser, I.5
  • 14
    • 84875656786 scopus 로고    scopus 로고
    • Hunger in the absence of caloric restriction improves cognition and attenuates Alzheimer's disease pathology in a mouse model
    • Dhurandhar E. J., Allison D. B., van Groen T., and, Kadish I., (2013) Hunger in the absence of caloric restriction improves cognition and attenuates Alzheimer's disease pathology in a mouse model. PLoS ONE 8, e60437.
    • (2013) PLoS ONE , vol.8 , pp. e60437
    • Dhurandhar, E.J.1    Allison, D.B.2    Van Groen, T.3    Kadish, I.4
  • 15
    • 33344479006 scopus 로고    scopus 로고
    • Ghrelin controls hippocampal spine synapse density and memory performance
    • Diano S., Farr S. A., Benoit S. C., et al,. (2006) Ghrelin controls hippocampal spine synapse density and memory performance. Nat. Neurosci. 9, 381-388.
    • (2006) Nat. Neurosci. , vol.9 , pp. 381-388
    • Diano, S.1    Farr, S.A.2    Benoit, S.C.3
  • 17
    • 71849117236 scopus 로고    scopus 로고
    • Role of the ghrelin/obestatin balance in the regulation of neuroendocrine circuits controlling body composition and energy homeostasis
    • Epelbaum J., Bedjaoui N., Dardennes R., et al,. (2010) Role of the ghrelin/obestatin balance in the regulation of neuroendocrine circuits controlling body composition and energy homeostasis. Mol. Cell. Endocrinol. 314, 244-247.
    • (2010) Mol. Cell. Endocrinol. , vol.314 , pp. 244-247
    • Epelbaum, J.1    Bedjaoui, N.2    Dardennes, R.3
  • 18
    • 33645069631 scopus 로고    scopus 로고
    • Therapeutic action of ghrelin in a mouse model of colitis
    • Gonzalez-Rey E., Chorny A., and, Delgado M., (2006) Therapeutic action of ghrelin in a mouse model of colitis. Gastroenterology 130, 1707-1720.
    • (2006) Gastroenterology , vol.130 , pp. 1707-1720
    • Gonzalez-Rey, E.1    Chorny, A.2    Delgado, M.3
  • 19
    • 0030739052 scopus 로고    scopus 로고
    • Twenty-four hour cortisol release profiles in patients with Alzheimer's and Parkinson's disease compared to normal controls: Ultradian secretory pulsatility and diurnal variation
    • Hartmann A., Veldhuis J. D., Deuschle M., Standhardt H., and, Heuser I., (1997) Twenty-four hour cortisol release profiles in patients with Alzheimer's and Parkinson's disease compared to normal controls: ultradian secretory pulsatility and diurnal variation. Neurobiol. Aging 18, 285-289.
    • (1997) Neurobiol. Aging , vol.18 , pp. 285-289
    • Hartmann, A.1    Veldhuis, J.D.2    Deuschle, M.3    Standhardt, H.4    Heuser, I.5
  • 20
    • 68449105015 scopus 로고    scopus 로고
    • Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4
    • Hwang S., Moon M., Kim S., Hwang L., Ahn K. J., and, Park S., (2009) Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4. Endocr. J. 56, 609-617.
    • (2009) Endocr. J. , vol.56 , pp. 609-617
    • Hwang, S.1    Moon, M.2    Kim, S.3    Hwang, L.4    Ahn, K.J.5    Park, S.6
  • 21
    • 80053605315 scopus 로고    scopus 로고
    • Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET
    • Ikawa M., Okazawa H., Kudo T., Kuriyama M., Fujibayashi Y., and, Yoneda M., (2011) Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET. Nucl. Med. Biol. 38, 945-951.
    • (2011) Nucl. Med. Biol. , vol.38 , pp. 945-951
    • Ikawa, M.1    Okazawa, H.2    Kudo, T.3    Kuriyama, M.4    Fujibayashi, Y.5    Yoneda, M.6
  • 22
    • 47349087292 scopus 로고    scopus 로고
    • Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra
    • Jiang H., Li L. J., Wang J., and, Xie J. X., (2008) Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra. Exp. Neurol. 212, 532-537.
    • (2008) Exp. Neurol. , vol.212 , pp. 532-537
    • Jiang, H.1    Li, L.J.2    Wang, J.3    Xie, J.X.4
  • 23
    • 25644439977 scopus 로고    scopus 로고
    • Immobilization stress causes increases in tetrahydrobiopterin, dopamine, and neuromelanin and oxidative damage in the nigrostriatal system
    • Kim S. T., Choi J. H., Chang J. W., Kim S. W., and, Hwang O., (2005) Immobilization stress causes increases in tetrahydrobiopterin, dopamine, and neuromelanin and oxidative damage in the nigrostriatal system. J. Neurochem. 95, 89-98.
    • (2005) J. Neurochem. , vol.95 , pp. 89-98
    • Kim, S.T.1    Choi, J.H.2    Chang, J.W.3    Kim, S.W.4    Hwang, O.5
  • 24
    • 0032100191 scopus 로고    scopus 로고
    • Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • Kohutnicka M., Lewandowska E., Kurkowska-Jastrzebska I., Czlonkowski A., and, Czlonkowska A., (1998) Microglial and astrocytic involvement in a murine model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Immunopharmacology 39, 167-180.
    • (1998) Immunopharmacology , vol.39 , pp. 167-180
    • Kohutnicka, M.1    Lewandowska, E.2    Kurkowska-Jastrzebska, I.3    Czlonkowski, A.4    Czlonkowska, A.5
  • 25
    • 84919742940 scopus 로고    scopus 로고
    • Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor(s)
    • Ku J. M., Andrews Z. B., Barsby T., et al,. (2015) Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor(s). Endocrinology 156, 280-290.
    • (2015) Endocrinology , vol.156 , pp. 280-290
    • Ku, J.M.1    Andrews, Z.B.2    Barsby, T.3
  • 26
    • 2442419837 scopus 로고    scopus 로고
    • Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells
    • Li W. G., Gavrila D., Liu X., et al,. (2004) Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation 109, 2221-2226.
    • (2004) Circulation , vol.109 , pp. 2221-2226
    • Li, W.G.1    Gavrila, D.2    Liu, X.3
  • 27
    • 33646231528 scopus 로고    scopus 로고
    • Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats
    • Li L., Zhang L. K., Pang Y. Z., Pan C. S., Qi Y. F., Chen L., Wang X., Tang C. S., and, Zhang J., (2006) Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats. Acta Pharmacol. Sin. 27, 527-535.
    • (2006) Acta Pharmacol. Sin. , vol.27 , pp. 527-535
    • Li, L.1    Zhang, L.K.2    Pang, Y.Z.3    Pan, C.S.4    Qi, Y.F.5    Chen, L.6    Wang, X.7    Tang, C.S.8    Zhang, J.9
  • 28
    • 59049087723 scopus 로고    scopus 로고
    • GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism
    • Li Y., Perry T., Kindy M. S., et al,. (2009) GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc. Natl Acad. Sci. USA 106, 1285-1290.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 1285-1290
    • Li, Y.1    Perry, T.2    Kindy, M.S.3
  • 29
    • 70350625508 scopus 로고    scopus 로고
    • Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2
    • Liu Y., Chen L., Xu X., Vicaut E., and, Sercombe R., (2009) Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2. BMC Physiol. 9, 17.
    • (2009) BMC Physiol. , vol.9 , pp. 17
    • Liu, Y.1    Chen, L.2    Xu, X.3    Vicaut, E.4    Sercombe, R.5
  • 30
    • 84883442249 scopus 로고    scopus 로고
    • Protective but not anticonvulsant effects of ghrelin and JMV-1843 in the pilocarpine model of Status epilepticus
    • Lucchi C., Curia G., Vinet J., Gualtieri F., Bresciani E., Locatelli V., Torsello A., and, Biagini G., (2013) Protective but not anticonvulsant effects of ghrelin and JMV-1843 in the pilocarpine model of Status epilepticus. PLoS ONE 8, e72716.
    • (2013) PLoS ONE , vol.8 , pp. e72716
    • Lucchi, C.1    Curia, G.2    Vinet, J.3    Gualtieri, F.4    Bresciani, E.5    Locatelli, V.6    Torsello, A.7    Biagini, G.8
  • 31
    • 0032057656 scopus 로고    scopus 로고
    • Cortisol levels during human aging predict hippocampal atrophy and memory deficits
    • Lupien S. J., de Leon M., de Santi S., et al,. (1998) Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nat. Neurosci. 1, 69-73.
    • (1998) Nat. Neurosci. , vol.1 , pp. 69-73
    • Lupien, S.J.1    De Leon, M.2    De Santi, S.3
  • 32
    • 40849123723 scopus 로고    scopus 로고
    • Circadian pattern of total and free corticosterone concentrations, corticosteroid-binding globulin, and physical activity in mice selectively bred for high voluntary wheel-running behavior
    • Malisch J. L., Breuner C. W., Gomes F. R., Chappell M. A., and, Garland T., Jr, (2008) Circadian pattern of total and free corticosterone concentrations, corticosteroid-binding globulin, and physical activity in mice selectively bred for high voluntary wheel-running behavior. Gen. Comp. Endocrinol. 156, 210-217.
    • (2008) Gen. Comp. Endocrinol. , vol.156 , pp. 210-217
    • Malisch, J.L.1    Breuner, C.W.2    Gomes, F.R.3    Chappell, M.A.4    Garland, T.5
  • 33
    • 84906790036 scopus 로고    scopus 로고
    • Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse
    • Mani B. K., Walker A. K., Lopez Soto E. J., Raingo J., Lee C. E., Perello M., Andrews Z. B., and, Zigman J. M., (2014) Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse. J. Comp. Neurol. 522, 3644-3666.
    • (2014) J. Comp. Neurol. , vol.522 , pp. 3644-3666
    • Mani, B.K.1    Walker, A.K.2    Lopez Soto, E.J.3    Raingo, J.4    Lee, C.E.5    Perello, M.6    Andrews, Z.B.7    Zigman, J.M.8
  • 34
    • 25844444170 scopus 로고    scopus 로고
    • Modulation of motor function by stress: A novel concept of the effects of stress and corticosterone on behavior
    • Metz G. A., Jadavji N. M., and, Smith L. K., (2005) Modulation of motor function by stress: a novel concept of the effects of stress and corticosterone on behavior. Eur. J. Neurosci. 22, 1190-1200.
    • (2005) Eur. J. Neurosci. , vol.22 , pp. 1190-1200
    • Metz, G.A.1    Jadavji, N.M.2    Smith, L.K.3
  • 35
    • 84927178171 scopus 로고    scopus 로고
    • A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear
    • Meyer R. M., Burgos-Robles A., Liu E., Correia S. S., and, Goosens K. A., (2014) A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear. Mol. Psychiatry 19, 1284-1294.
    • (2014) Mol. Psychiatry , vol.19 , pp. 1284-1294
    • Meyer, R.M.1    Burgos-Robles, A.2    Liu, E.3    Correia, S.S.4    Goosens, K.A.5
  • 36
    • 70449527787 scopus 로고    scopus 로고
    • Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation
    • Moon M., Kim H. G., Hwang L., et al,. (2009) Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation. Neurotox. Res. 15, 332-347.
    • (2009) Neurotox. Res. , vol.15 , pp. 332-347
    • Moon, M.1    Kim, H.G.2    Hwang, L.3
  • 39
    • 84930479945 scopus 로고    scopus 로고
    • Des-acyl ghrelin attenuates pilocarpine-induced limbic seizures via the ghrelin receptor and not the orexin pathway
    • Portelli J., Coppens J., Demuyser T., and, Smolders I., (2015) Des-acyl ghrelin attenuates pilocarpine-induced limbic seizures via the ghrelin receptor and not the orexin pathway. Neuropeptides 51, 1-7.
    • (2015) Neuropeptides , vol.51 , pp. 1-7
    • Portelli, J.1    Coppens, J.2    Demuyser, T.3    Smolders, I.4
  • 41
    • 77957266562 scopus 로고    scopus 로고
    • Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium
    • Satou M., Nishi Y., Yoh J., Hattori Y., and, Sugimoto H., (2010) Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium. Endocrinology 151, 4765-4775.
    • (2010) Endocrinology , vol.151 , pp. 4765-4775
    • Satou, M.1    Nishi, Y.2    Yoh, J.3    Hattori, Y.4    Sugimoto, H.5
  • 43
    • 84892668996 scopus 로고    scopus 로고
    • Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans
    • Takagi K., Legrand R., Asakawa A., et al,. (2013) Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans. Nat. Commun. 4, 2685.
    • (2013) Nat. Commun. , vol.4 , pp. 2685
    • Takagi, K.1    Legrand, R.2    Asakawa, A.3
  • 44
    • 70149084413 scopus 로고    scopus 로고
    • Suppression of experimental autoimmune encephalomyelitis by ghrelin
    • Theil M. M., Miyake S., Mizuno M., et al,. (2009) Suppression of experimental autoimmune encephalomyelitis by ghrelin. J. Immunol. 183, 2859-2866.
    • (2009) J. Immunol. , vol.183 , pp. 2859-2866
    • Theil, M.M.1    Miyake, S.2    Mizuno, M.3
  • 46
    • 39149099430 scopus 로고    scopus 로고
    • Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways
    • Waseem T., Duxbury M., Ito H., Ashley S. W., and, Robinson M. K., (2008) Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery 143, 334-342.
    • (2008) Surgery , vol.143 , pp. 334-342
    • Waseem, T.1    Duxbury, M.2    Ito, H.3    Ashley, S.W.4    Robinson, M.K.5
  • 47
    • 2542597708 scopus 로고    scopus 로고
    • Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference
    • Wortley K. E., Anderson K. D., Garcia K., et al,. (2004) Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc. Natl Acad. Sci. USA 101, 8227-8232.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 8227-8232
    • Wortley, K.E.1    Anderson, K.D.2    Garcia, K.3
  • 49
    • 0033711116 scopus 로고    scopus 로고
    • The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion
    • Wren A. M., Small C. J., Ward H. L., et al,. (2000) The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141, 4325-4328.
    • (2000) Endocrinology , vol.141 , pp. 4325-4328
    • Wren, A.M.1    Small, C.J.2    Ward, H.L.3
  • 51
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    • Yang J., Brown M. S., Liang G., Grishin N. V., and, Goldstein J. L., (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132, 387-396.
    • (2008) Cell , vol.132 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 52
    • 79960884919 scopus 로고    scopus 로고
    • Pro- and anti-inflammatory cytokines expression in rat's brain and spleen exposed to chronic mild stress: Involvement in depression
    • You Z., Luo C., Zhang W., Chen Y., He J., Zhao Q., Zuo R., and, Wu Y., (2011) Pro- and anti-inflammatory cytokines expression in rat's brain and spleen exposed to chronic mild stress: involvement in depression. Behav. Brain Res. 225, 135-141.
    • (2011) Behav. Brain Res. , vol.225 , pp. 135-141
    • You, Z.1    Luo, C.2    Zhang, W.3    Chen, Y.4    He, J.5    Zhao, Q.6    Zuo, R.7    Wu, Y.8
  • 53
    • 77952165770 scopus 로고    scopus 로고
    • Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
    • Zhao T. J., Liang G., Li R. L., et al,. (2010) Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc. Natl Acad. Sci. USA 107, 7467-7472.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 7467-7472
    • Zhao, T.J.1    Liang, G.2    Li, R.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.