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Volumn 72, Issue 6, 2012, Pages 457-465

Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress

Author keywords

Anxiety; depression; ghrelin; hypothalamic pituitary adrenal axis; knockout; stress

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR; PROOPIOMELANOCORTIN;

EID: 84865205876     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.03.010     Document Type: Article
Times cited : (198)

References (54)
  • 1
    • 34347359491 scopus 로고    scopus 로고
    • The acute ghrelin response to a psychological stress challenge does not predict the post-stress urge to eat
    • DOI 10.1016/j.psyneuen.2007.04.010, PII S0306453007000923
    • V. Rouach, M. Bloch, N. Rosenberg, S. Gilad, R. Limor, N. Stern, Y. Greenman The acute ghrelin response to a psychological stress challenge does not predict the post-stress urge to eat Psychoneuroendocrinology 32 2007 693 702 (Pubitemid 47017588)
    • (2007) Psychoneuroendocrinology , vol.32 , Issue.6 , pp. 693-702
    • Rouach, V.1    Bloch, M.2    Rosenberg, N.3    Gilad, S.4    Limor, R.5    Stern, N.6    Greenman, Y.7
  • 2
    • 67349287047 scopus 로고    scopus 로고
    • Ghrelin, paraoxonase and arylesterase levels in depressive patients before and after citalopram treatment
    • A.O. Barim, S. Aydin, R. Colak, E. Dag, O. Deniz, I. Sahin Ghrelin, paraoxonase and arylesterase levels in depressive patients before and after citalopram treatment Clin Biochem 42 2009 1076 1081
    • (2009) Clin Biochem , vol.42 , pp. 1076-1081
    • Barim, A.O.1    Aydin, S.2    Colak, R.3    Dag, E.4    Deniz, O.5    Sahin, I.6
  • 3
    • 84865260196 scopus 로고    scopus 로고
    • The extra-hypothalamic actions of ghrelin on neuronal function
    • Z.B. Andrews The extra-hypothalamic actions of ghrelin on neuronal function Trends Neurosci 93 2010 48 57
    • (2010) Trends Neurosci , vol.93 , pp. 48-57
    • Andrews, Z.B.1
  • 7
    • 57349119295 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-adrenal axis activity of newborn mice rapidly desensitizes to repeated maternal absence but becomes highly responsive to novelty
    • L. Enthoven, M.S. Oitzl, N. Koning, M. van der Mark, E.R. de Kloet Hypothalamic-pituitary-adrenal axis activity of newborn mice rapidly desensitizes to repeated maternal absence but becomes highly responsive to novelty Endocrinology 149 2008 6366 6377
    • (2008) Endocrinology , vol.149 , pp. 6366-6377
    • Enthoven, L.1    Oitzl, M.S.2    Koning, N.3    Van Der Mark, M.4    De Kloet, E.R.5
  • 10
    • 21244504248 scopus 로고    scopus 로고
    • Plasma leptin and ghrelin in the neonatal rat: Interaction of dexamethasone and hypoxia
    • DOI 10.1677/joe.1.06159
    • E.D. Bruder, L. Jacobson, H. Raff Plasma leptin and ghrelin in the neonatal rat: interaction of dexamethasone and hypoxia J Endocrinology 185 2005 477 484 (Pubitemid 40883393)
    • (2005) Journal of Endocrinology , vol.185 , Issue.3 , pp. 477-484
    • Bruder, E.D.1    Jacobson, L.2    Raff, H.3
  • 15
    • 70449673061 scopus 로고    scopus 로고
    • Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism
    • Z.B. Andrews, D. Erion, R. Beiler, Z.W. Liu, A. Abizaid, J. Zigman Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism J Neurosci 29 2009 14057 14065
    • (2009) J Neurosci , vol.29 , pp. 14057-14065
    • Andrews, Z.B.1    Erion, D.2    Beiler, R.3    Liu, Z.W.4    Abizaid, A.5    Zigman, J.6
  • 16
    • 25144463897 scopus 로고    scopus 로고
    • Early life immune challenge - Effects on behavioural indices of adult rat fear and anxiety
    • DOI 10.1016/j.bbr.2005.06.032, PII S0166432805002822
    • S.J. Spencer, J.G. Heida, Q.J. Pittman Early life immune challenge-effects on behavioural indices of adult rat fear and anxiety Behav Brain Res 164 2005 231 238 (Pubitemid 41337878)
    • (2005) Behavioural Brain Research , vol.164 , Issue.2 , pp. 231-238
    • Spencer, S.J.1    Heida, J.G.2    Pittman, Q.J.3
  • 17
    • 67650627773 scopus 로고    scopus 로고
    • Neonatal overfeeding alters adult anxiety and stress responsiveness
    • S.J. Spencer, A. Tilbrook Neonatal overfeeding alters adult anxiety and stress responsiveness Psychoneuroendocrinology 34 2009 1133 1143
    • (2009) Psychoneuroendocrinology , vol.34 , pp. 1133-1143
    • Spencer, S.J.1    Tilbrook, A.2
  • 18
    • 79960602160 scopus 로고    scopus 로고
    • Anxiety and hypothalamic-pituitary-adrenal axis responses to psychological stress are attenuated in male rats made lean by large litter rearing
    • L. Bulfin, M. Clarke, K. Buller, S. Spencer Anxiety and hypothalamic-pituitary-adrenal axis responses to psychological stress are attenuated in male rats made lean by large litter rearing Psychoneuroendocrinology 36 2011 1080 1091
    • (2011) Psychoneuroendocrinology , vol.36 , pp. 1080-1091
    • Bulfin, L.1    Clarke, M.2    Buller, K.3    Spencer, S.4
  • 19
    • 0024467529 scopus 로고
    • Neuropharmacological and physiological validation of a computer-controlled two-compartment black and white box for the assessment of anxiety
    • E.S. Onaivi, B.R. Martin Neuropharmacological and physiological validation of a computer-controlled two-compartment black and white box for the assessment of anxiety Prog Neuropsychopharmacol Biol Psyc 13 1989 963 976 (Pubitemid 19238705)
    • (1989) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.13 , Issue.6 , pp. 963-976
    • Onaivi, E.S.1    Martin, B.R.2
  • 20
    • 12444343039 scopus 로고    scopus 로고
    • Medial prefrontal cortex control of the paraventricular hypothalamic nucleus response to psychological stress: Possible role of the bed nucleus of the stria terminalis
    • S.J. Spencer, K.M. Buller, T.A. Day Medial prefrontal cortex control of the paraventricular hypothalamic nucleus response to psychological stress: Possible role of the bed nucleus of the stria terminalis J Comp Neurol 481 2005 363 376
    • (2005) J Comp Neurol , vol.481 , pp. 363-376
    • Spencer, S.J.1    Buller, K.M.2    Day, T.A.3
  • 21
    • 84857410384 scopus 로고    scopus 로고
    • Postnatal overfeeding leads to obesity and exacerbated febrile responses to lipopolysaccharide throughout life
    • M.A. Clarke, A. Stefanidis, S.J. Spencer Postnatal overfeeding leads to obesity and exacerbated febrile responses to lipopolysaccharide throughout life J Neuroendocrinol 24 2012 511 524
    • (2012) J Neuroendocrinol , vol.24 , pp. 511-524
    • Clarke, M.A.1    Stefanidis, A.2    Spencer, S.J.3
  • 22
    • 44949231424 scopus 로고    scopus 로고
    • T method
    • DOI 10.1038/nprot.2008.73, PII NPROT.2008.73
    • T.D. Schmittgen, K.J. Livak Analyzing real-time PCR data by the comparative C(T) method Nat Protoc 3 2008 1101 1108 (Pubitemid 351818697)
    • (2008) Nature Protocols , vol.3 , Issue.6 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 23
    • 0035710746 scopus 로고    scopus 로고
    • -ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • K.J. Livak, T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 25 2001 402 408 (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 24
    • 77953512334 scopus 로고    scopus 로고
    • Early life activation of toll-like receptor 4 reprograms neural anti-inflammatory pathways
    • A. Mouihate, M.A. Galic, S.L. Ellis, S.J. Spencer, S. Tsutsui, Q.J. Pittman Early life activation of toll-like receptor 4 reprograms neural anti-inflammatory pathways J Neurosci 30 2010 7975 7983
    • (2010) J Neurosci , vol.30 , pp. 7975-7983
    • Mouihate, A.1    Galic, M.A.2    Ellis, S.L.3    Spencer, S.J.4    Tsutsui, S.5    Pittman, Q.J.6
  • 25
    • 70349774217 scopus 로고    scopus 로고
    • Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats
    • M.A. Galic, K. Riazi, A.K. Henderson, S. Tsutsui, Q.J. Pittman Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats Neurobiol Dis 36 2009 343 351
    • (2009) Neurobiol Dis , vol.36 , pp. 343-351
    • Galic, M.A.1    Riazi, K.2    Henderson, A.K.3    Tsutsui, S.4    Pittman, Q.J.5
  • 26
    • 16244368778 scopus 로고    scopus 로고
    • The grooming analysis algorithm discriminates between different levels of anxiety in rats: Potential utility for neurobehavioural stress research
    • DOI 10.1016/j.jneumeth.2004.10.001
    • A.V. Kalueff, P. Tuohimaa The grooming analysis algorithm discriminates between different levels of anxiety in rats: potential utility for neurobehavioural stress research J Neurosci Methods 143 2005 169 177 (Pubitemid 40462262)
    • (2005) Journal of Neuroscience Methods , vol.143 , Issue.2 , pp. 169-177
    • Kalueff, A.V.1    Tuohimaa, P.2
  • 27
    • 0035783476 scopus 로고    scopus 로고
    • Stressor categorization: Acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups
    • DOI 10.1046/j.0953-816X.2001.01733.x
    • C.V. Dayas, K.M. Buller, J.W. Crane, Y. Xu, T.A. Day Stressor categorization: Acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups Eur J Neurosci 14 2001 1143 1152 (Pubitemid 35463758)
    • (2001) European Journal of Neuroscience , vol.14 , Issue.7 , pp. 1143-1152
    • Dayas, C.V.1    Buller, K.M.2    Crane, J.W.3    Xu, Y.4    Day, T.A.5
  • 28
    • 0033046214 scopus 로고    scopus 로고
    • Neuroendocrine responses to an emotional stressor: Evidence for involvement of the medial but not the central amygdala
    • DOI 10.1046/j.1460-9568.1999.00645.x
    • C.V. Dayas, K.M. Buller, T.A. Day Neuroendocrine responses to an emotional stressor: Evidence for involvement of the medial but not the central amygdala Eur J Neurosci 11 1999 2312 2322 (Pubitemid 29292325)
    • (1999) European Journal of Neuroscience , vol.11 , Issue.7 , pp. 2312-2322
    • Dayas, C.V.1    Buller, K.M.2    Day, T.A.3
  • 31
    • 34548683270 scopus 로고    scopus 로고
    • On the role of urocortin 1 in the non-preganglionic Edinger-Westphal nucleus in stress adaptation
    • DOI 10.1016/j.ygcen.2007.04.005, PII S0016648007001438
    • T. Kozicz On the role of urocortin 1 in the non-preganglionic Edinger-Westphal nucleus in stress adaptation Gen Comp Endocrinol 153 2007 235 240 (Pubitemid 47411523)
    • (2007) General and Comparative Endocrinology , vol.153 , Issue.1-3 , pp. 235-240
    • Kozicz, T.1
  • 33
    • 52149118907 scopus 로고    scopus 로고
    • Leptin inhibits and ghrelin augments hypothalamic noradrenaline release after stress
    • A. Kawakami, N. Okada, K. Rokkaku, K. Honda, S. Ishibashi, T. Onaka Leptin inhibits and ghrelin augments hypothalamic noradrenaline release after stress Stress 11 2008 363 369
    • (2008) Stress , vol.11 , pp. 363-369
    • Kawakami, A.1    Okada, N.2    Rokkaku, K.3    Honda, K.4    Ishibashi, S.5    Onaka, T.6
  • 34
    • 8844255454 scopus 로고    scopus 로고
    • Urocortinergic neurons respond in a differentiated manner to various acute stressors in the Edinger-Westphal nucleus in the rat
    • DOI 10.1002/cne.20343
    • B. Gaszner, V. Csernus, T. Kozicz Urocortinergic neurons respond in a differentiated manner to various acute stressors in the Edinger-Westphal nucleus in the rat J Comp Neurol 480 2004 170 179 (Pubitemid 39536624)
    • (2004) Journal of Comparative Neurology , vol.480 , Issue.2 , pp. 170-179
    • Gaszner, B.1    Csernus, V.2    Kozicz, T.3
  • 35
    • 79958783516 scopus 로고    scopus 로고
    • Does midbrain urocortin 1 matter?: A 15-year journey from stress (mal)adaptation to energy metabolism
    • T. Kozicz, L. Sterrenburg, L. Xu Does midbrain urocortin 1 matter? A 15-year journey from stress (mal)adaptation to energy metabolism Stress 14 2011 376 383
    • (2011) Stress , vol.14 , pp. 376-383
    • Kozicz, T.1    Sterrenburg, L.2    Xu, L.3
  • 36
    • 0027321185 scopus 로고
    • Spinal and hindbrain structures involved in visceroception and visceronociception as revealed by the expression of Fos, Jun and Krox-24 proteins
    • DOI 10.1016/0306-4522(93)90439-M
    • M. Lanteri-Minet, P. Isnardon, J. de Pommery, D. Menetrey Spinal and hindbrain structures involved in visceroception and visceronociception as revealed by the expression of Fos, Jun and Krox-24 proteins Neuroscience 55 1993 737 753 (Pubitemid 23226119)
    • (1993) Neuroscience , vol.55 , Issue.3 , pp. 737-753
    • Lanteri-Minet, M.1    Isnardon, P.2    De Pommery, J.3    Menetrey, D.4
  • 38
    • 0034464740 scopus 로고    scopus 로고
    • Urocortin expression in the Edinger-Westphal nucleus is up-regulated by stress and corticotropin-releasing hormone deficiency
    • DOI 10.1210/en.141.1.256
    • S.C. Weninger, L.L. Peters, J.A. Majzoub Urocortin expression in the Edinger-Westphal nucleus is up-regulated by stress and corticotropin-releasing hormone deficiency Endocrinology 141 2000 256 263 (Pubitemid 32260366)
    • (2000) Endocrinology , vol.141 , Issue.1 , pp. 256-263
    • Weninger, S.C.1    Peters, L.L.2    Majzoub, J.A.3
  • 39
    • 79955599565 scopus 로고    scopus 로고
    • Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain
    • T. Rouwette, K. Klemann, B. Gaszner, G.J. Scheffer, E.W. Roubos, W.J. Scheenen Differential responses of corticotropin-releasing factor and urocortin 1 to acute pain stress in the rat brain Neuroscience 183 2011 15 24
    • (2011) Neuroscience , vol.183 , pp. 15-24
    • Rouwette, T.1    Klemann, K.2    Gaszner, B.3    Scheffer, G.J.4    Roubos, E.W.5    Scheenen, W.J.6
  • 40
    • 0034809087 scopus 로고    scopus 로고
    • The activation of urocortin immunoreactive neurons in the Edinger-Westphal nucleus following acute pain stress in rats
    • L.T. Kozicz, L. Min, A. Arimura The activation of urocortin immunoreactive neurons in the Edinger-Westphal nucelus following acute pain stress in rats Stress 4 2001 85 90 (Pubitemid 32905867)
    • (2001) Stress , vol.4 , Issue.2 , pp. 85-90
    • Kozicz, T.1    Li, M.2    Arimura, A.3
  • 41
    • 0037089839 scopus 로고    scopus 로고
    • Hypophysiotropic neurons of the paraventricular nucleus respond in spatially, temporally, and phenotypically differentiated manners to acute vs. repeated restraint stress
    • DOI 10.1002/cne.10178
    • V. Viau, P.E. Sawchenko Hypophysiotropic neurons of the paraventricular nucleus respond in spatially, temporally, and phenotypically differentiated manners to acute vs. repeated restraint stress: Rapid publication J Comp Neurol 445 2002 293 307 (Pubitemid 34252853)
    • (2002) Journal of Comparative Neurology , vol.445 , Issue.4 , pp. 293-307
    • Viau, V.1    Sawchenko, P.E.2
  • 42
    • 67349151166 scopus 로고    scopus 로고
    • The neuro-symphony of stress
    • M. Joels, T.Z. Baram The neuro-symphony of stress Nat Rev Neurosci 10 2009 459 466
    • (2009) Nat Rev Neurosci , vol.10 , pp. 459-466
    • Joels, M.1    Baram, T.Z.2
  • 43
    • 20044395965 scopus 로고    scopus 로고
    • Stress and the brain: From adaptation to disease
    • DOI 10.1038/nrn1683
    • E.R. de Kloet, M. Joels, F. Holsboer Stress and the brain: from adaptation to disease Nat Rev Neurosci 6 2005 463 475 (Pubitemid 40769171)
    • (2005) Nature Reviews Neuroscience , vol.6 , Issue.6 , pp. 463-475
    • De Kloet, E.R.1    Joels, M.2    Holsboer, F.3
  • 44
    • 79954588304 scopus 로고    scopus 로고
    • The Edinger-Westphal nucleus: A historical, structural, and functional perspective on a dichotomous terminology
    • T. Kozicz, J.C. Bittencourt, P.J. May, A. Reiner, P.D. Gamlin, M. Palkovits The Edinger-Westphal nucleus: a historical, structural, and functional perspective on a dichotomous terminology J Comp Neurol 519 2011 1413 1434
    • (2011) J Comp Neurol , vol.519 , pp. 1413-1434
    • Kozicz, T.1    Bittencourt, J.C.2    May, P.J.3    Reiner, A.4    Gamlin, P.D.5    Palkovits, M.6
  • 45
    • 33746106504 scopus 로고    scopus 로고
    • Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: Specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus
    • DOI 10.1016/j.neuropharm.2006.03.014, PII S0028390806000712
    • A.M. Linden, M. Baez, M. Bergeron, D.D. Schoepp Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: Specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus Neuropharmacology 51 2006 213 228 (Pubitemid 44081793)
    • (2006) Neuropharmacology , vol.51 , Issue.2 , pp. 213-228
    • Linden, A.-M.1    Baez, M.2    Bergeron, M.3    Schoepp, D.D.4
  • 46
    • 1642266343 scopus 로고    scopus 로고
    • Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions
    • DOI 10.1038/sj.npp.1300321
    • A.M. Linden, S.J. Greene, M. Bergeron, D.D. Schoepp Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions Neuropsychopharmacology 29 2004 502 513 (Pubitemid 38365926)
    • (2004) Neuropsychopharmacology , vol.29 , Issue.3 , pp. 502-513
    • Linden, A.-M.1    Greene, S.J.2    Bergeron, M.3    Schoepp, D.D.4
  • 47
    • 7044239186 scopus 로고    scopus 로고
    • Spontaneous withdrawal from the triazolobenzodiazepine alprazolam increases cortical corticotropin-releasing factor mRNA expression
    • DOI 10.1523/JNEUROSCI.1737-04.2004
    • K.H. Skelton, C.B. Nemeroff, M.J. Owens Spontaneous withdrawal from the triazolobenzodiazepine alprazolam increases cortical corticotropin-releasing factor mRNA expression J Neurosci 24 2004 9303 9312 (Pubitemid 39426167)
    • (2004) Journal of Neuroscience , vol.24 , Issue.42 , pp. 9303-9312
    • Skelton, K.H.1    Nemeroff, C.B.2    Owens, M.J.3
  • 48
    • 0032472858 scopus 로고    scopus 로고
    • Distribution of urocortin-like immunoreactivity in the central nervous system of the rat
    • DOI 10.1002/(SICI)1096-9861 (19980202)391:1<1::AID-CNE1>3.0.CO;2-6
    • T. Kozicz, H. Yanaihara, A. Arimura Distribution of urocortin-like immunoreactivity in the central nervous system of the rat J Comp Neurol 391 1998 1 10 (Pubitemid 28109615)
    • (1998) Journal of Comparative Neurology , vol.391 , Issue.1 , pp. 1-10
    • Kozicz, T.1    Yanaihara, H.2    Arimura, A.3
  • 49
    • 0033590247 scopus 로고    scopus 로고
    • Urocortin expression in rat brain: Evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors
    • J.C. Bittencourt, J. Vaughan, C. Arias, R.A. Rissman, W.W. Vale, P.E. Sawchenko Urocortin expression in rat brain: Evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors J Comp Neurol 415 1999 285 312
    • (1999) J Comp Neurol , vol.415 , pp. 285-312
    • Bittencourt, J.C.1    Vaughan, J.2    Arias, C.3    Rissman, R.A.4    Vale, W.W.5    Sawchenko, P.E.6
  • 51
    • 77956363616 scopus 로고    scopus 로고
    • Relationship between plasma ghrelin levels and insulin resistance and blood pressure in octogenarians
    • Y. Zhao, L. Shao, L. Teng, D. Zhang, H. Zhang Relationship between plasma ghrelin levels and insulin resistance and blood pressure in octogenarians J Huazhong Univ Sci Technolog Med Sci 30 2010 307 311
    • (2010) J Huazhong Univ Sci Technolog Med Sci , vol.30 , pp. 307-311
    • Zhao, Y.1    Shao, L.2    Teng, L.3    Zhang, D.4    Zhang, H.5
  • 52
    • 77957274035 scopus 로고    scopus 로고
    • Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons
    • D.I. Briggs, P.J. Enriori, M.B. Lemus, M.A. Cowley, Z.B. Andrews Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons Endocrinology 151 2010 4745 4755
    • (2010) Endocrinology , vol.151 , pp. 4745-4755
    • Briggs, D.I.1    Enriori, P.J.2    Lemus, M.B.3    Cowley, M.A.4    Andrews, Z.B.5
  • 54
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • M. Tschop, D.L. Smiley, M.L. Heiman Ghrelin induces adiposity in rodents Nature 407 2000 908 913
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschop, M.1    Smiley, D.L.2    Heiman, M.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.