Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed

Free Radical Biology and Medicine

Volumn 95, Issue , 2016, Pages 333-348

  Tomalin, Lewis Elwood ^a   Day, Alison Michelle ^a   Underwood, Zoe Elizabeth ^a   Smith, Graham Robert ^b   Dalle Pezze, Piero ^a   Rallis, Charalampos ^c   Patel, Waseema ^a   Dickinson, Bryan Craig ^d   Bähler, Jürg ^c   Brewer, Thomas Francis ^e   Chang, Christopher Joh Leung ^e   Shanley, Daryl Pierson ^a   Veal, Elizabeth Ann ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF CHICAGO   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Computational model; Hydrogenperoxide; Oxidation; Peroxiredoxin; Signaling; Thiol; Thioredoxin

Indexed keywords

CYSTEINE; HYDROGEN PEROXIDE; PEROXIREDOXIN; PROTEOME; REACTIVE OXYGEN METABOLITE; THIOL PROTEOME; THIOREDOXIN PEROXIDASE; UNCLASSIFIED DRUG; THIOREDOXIN;

AGING; ARTICLE; CELL DAMAGE; CELL DIFFERENTIATION; CELL MIGRATION; EMBRYO; ENZYME ACTIVITY; GENOMIC INSTABILITY; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VIVO STUDY; INTRACELLULAR SPACE; MOLECULAR WEIGHT; NEOPLASM; NONHUMAN; OXIDATION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCHIZOSACCHAROMYCES POMBE; CHEMICAL MODEL; CHEMISTRY; CYTOPLASM; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; SIGNAL TRANSDUCTION;

CYTOPLASM; HYDROGEN PEROXIDE; MODELS, CHEMICAL; OXIDATION-REDUCTION; PEROXIREDOXINS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIOREDOXINS;

EID: 84963731147     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2016.02.035     Document Type: Article

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