메뉴 건너뛰기




Volumn 27, Issue 6, 2016, Pages 427-438

Perspectives in GLP-1 Research: New Targets, New Receptors

Author keywords

Cardioprotection; GLP 1 receptor agonists; Glucagon like peptide 1; Incretins

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOSE; INCRETIN; GLUCAGON LIKE PEPTIDE 1 RECEPTOR;

EID: 84963622915     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2016.03.017     Document Type: Review
Times cited : (71)

References (86)
  • 1
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio L.L., et al. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007, 132:2131-2157.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1
  • 2
    • 84926648779 scopus 로고    scopus 로고
    • Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease
    • Sandoval D.A., et al. Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease. Physiol. Rev. 2015, 295:513-548.
    • (2015) Physiol. Rev. , vol.295 , pp. 513-548
    • Sandoval, D.A.1
  • 3
    • 0024359370 scopus 로고
    • Complete sequences of glucagon-like peptide-1 from human and pig small intestine
    • Orskov C., et al. Complete sequences of glucagon-like peptide-1 from human and pig small intestine. J. Biol. Chem. 1989, 264:12826-12829.
    • (1989) J. Biol. Chem. , vol.264 , pp. 12826-12829
    • Orskov, C.1
  • 4
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • Deacon C.F., et al. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J. Clin. Endocrinol. Metab. 1995, 80:952-957.
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 952-957
    • Deacon, C.F.1
  • 5
    • 0029118049 scopus 로고
    • Degradation of glucose dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • Kieffer T.J., et al. Degradation of glucose dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 1995, 136:3585-3596.
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1
  • 6
    • 84962730836 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 analogs and their effects on pancreatic islets
    • Tudurí E., et al. Glucagon-like peptide 1 analogs and their effects on pancreatic islets. Trends Endocrinol. Metab. 2016, 27:304-318.
    • (2016) Trends Endocrinol. Metab. , vol.27 , pp. 304-318
    • Tudurí, E.1
  • 7
    • 84959871979 scopus 로고    scopus 로고
    • A review of head-to-head comparisons of glucagon-like peptide-1 receptor agonists
    • Madsbad S. A review of head-to-head comparisons of glucagon-like peptide-1 receptor agonists. Diabetes Obes. Metab. 2016, 18:317-332.
    • (2016) Diabetes Obes. Metab. , vol.18 , pp. 317-332
    • Madsbad, S.1
  • 8
    • 20044374696 scopus 로고    scopus 로고
    • Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release
    • Franklin I., et al. Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes 2005, 54:1808-1815.
    • (2005) Diabetes , vol.54 , pp. 1808-1815
    • Franklin, I.1
  • 9
    • 84897883235 scopus 로고    scopus 로고
    • Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model
    • Richards P., et al. Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model. Diabetes 2014, 63:1224-1233.
    • (2014) Diabetes , vol.63 , pp. 1224-1233
    • Richards, P.1
  • 10
    • 64649102619 scopus 로고    scopus 로고
    • GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
    • Noyan-Ashraf M.H., et al. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 2009, 58:975-983.
    • (2009) Diabetes , vol.58 , pp. 975-983
    • Noyan-Ashraf, M.H.1
  • 11
    • 84877252041 scopus 로고    scopus 로고
    • Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a
    • Younce C.W., et al. Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a. Am. J. Physiol. Cell. Physiol. 2013, 304:C508-C518.
    • (2013) Am. J. Physiol. Cell. Physiol. , vol.304 , pp. C508-C518
    • Younce, C.W.1
  • 12
    • 38149083367 scopus 로고    scopus 로고
    • Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemia-reperfusion injury in rat heart
    • Sonne D.P., et al. Protective effects of GLP-1 analogues exendin-4 and GLP-1(9-36) amide against ischemia-reperfusion injury in rat heart. Regul. Pept. 2008, 146:243-249.
    • (2008) Regul. Pept. , vol.146 , pp. 243-249
    • Sonne, D.P.1
  • 13
    • 84861131970 scopus 로고    scopus 로고
    • Incretin-based therapies and cardiovascular risk
    • Mannucci E., et al. Incretin-based therapies and cardiovascular risk. Curr. Med. Res. Opin. 2012, 28:715-721.
    • (2012) Curr. Med. Res. Opin. , vol.28 , pp. 715-721
    • Mannucci, E.1
  • 14
    • 84954571387 scopus 로고    scopus 로고
    • Cardiovascular effects of incretin-based therapies
    • White W.B., et al. Cardiovascular effects of incretin-based therapies. Annu. Rev. Med. 2016, 67:245-260.
    • (2016) Annu. Rev. Med. , vol.67 , pp. 245-260
    • White, W.B.1
  • 15
    • 84878525375 scopus 로고    scopus 로고
    • Effect of additional treatment with EXenatide in patients with an Acute Myocardial Infarction: the EXAMI study
    • Bernink F.J., et al. Effect of additional treatment with EXenatide in patients with an Acute Myocardial Infarction: the EXAMI study. Int. J. Cardiol. 2013, 167:289-290.
    • (2013) Int. J. Cardiol. , vol.167 , pp. 289-290
    • Bernink, F.J.1
  • 16
    • 84863560602 scopus 로고    scopus 로고
    • Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction
    • Lønborg J., et al. Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction. Eur. Heart J. 2012, 33:1491-1499.
    • (2012) Eur. Heart J. , vol.33 , pp. 1491-1499
    • Lønborg, J.1
  • 17
    • 84948740668 scopus 로고    scopus 로고
    • ELIXA Investigators. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome
    • Pfeffer M.A., et al. ELIXA Investigators. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N. Engl. J. Med. 2015, 373:2247-2257.
    • (2015) N. Engl. J. Med. , vol.373 , pp. 2247-2257
    • Pfeffer, M.A.1
  • 18
    • 84856485110 scopus 로고    scopus 로고
    • GLP-1 analogue, liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress
    • Schisano B., et al. GLP-1 analogue, liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress. Regul. Pept. 2012, 174:46-52.
    • (2012) Regul. Pept. , vol.174 , pp. 46-52
    • Schisano, B.1
  • 19
    • 84874931230 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects against cardiac microvascular injury in diabetes via a cAMP/PKA/Rho-dependent mechanism
    • Wang D., et al. Glucagon-like peptide-1 protects against cardiac microvascular injury in diabetes via a cAMP/PKA/Rho-dependent mechanism. Diabetes 2013, 62:1697-1708.
    • (2013) Diabetes , vol.62 , pp. 1697-1708
    • Wang, D.1
  • 20
    • 84938882227 scopus 로고    scopus 로고
    • Effect of glucagon-like peptide-1 on high-glucose-induced oxidative stress and cell apoptosis in human endothelial cells and its underlying mechanism
    • Wang R., et al. Effect of glucagon-like peptide-1 on high-glucose-induced oxidative stress and cell apoptosis in human endothelial cells and its underlying mechanism. Cardiovasc. Pharmacol. 2015, 66:135-140.
    • (2015) Cardiovasc. Pharmacol. , vol.66 , pp. 135-140
    • Wang, R.1
  • 21
    • 84879783953 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetes
    • Ceriello A., et al. Glucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetes. Diabetes Care 2013, 36:2346-2350.
    • (2013) Diabetes Care , vol.36 , pp. 2346-2350
    • Ceriello, A.1
  • 22
    • 84949110416 scopus 로고    scopus 로고
    • Exenatide protects against glucose- and lipid-induced endothelial dysfunction: evidence for direct vasodilation effect of GLP-1 receptor agonists in humans
    • Koska J., et al. Exenatide protects against glucose- and lipid-induced endothelial dysfunction: evidence for direct vasodilation effect of GLP-1 receptor agonists in humans. Diabetes 2015, 64:2624-2635.
    • (2015) Diabetes , vol.64 , pp. 2624-2635
    • Koska, J.1
  • 23
    • 84859529626 scopus 로고    scopus 로고
    • Glucagon-like peptide recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism
    • Chai W., et al. Glucagon-like peptide recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism. Diabetes 2012, 61:888-896.
    • (2012) Diabetes , vol.61 , pp. 888-896
    • Chai, W.1
  • 24
    • 0028900758 scopus 로고
    • Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences
    • Wei Y., et al. Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett. 1995, 358:219-224.
    • (1995) FEBS Lett. , vol.358 , pp. 219-224
    • Wei, Y.1
  • 25
    • 84858713174 scopus 로고    scopus 로고
    • Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis
    • Hunter K., et al. Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC Neurosci. 2012, 13:33.
    • (2012) BMC Neurosci. , vol.13 , pp. 33
    • Hunter, K.1
  • 26
    • 77956301808 scopus 로고    scopus 로고
    • Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides
    • Vrang N., et al. Preproglucagon derived peptides GLP-1, GLP-2 and oxyntomodulin in the CNS: role of peripherally secreted and centrally produced peptides. Prog. Neurobiol. 2010, 92:442-462.
    • (2010) Prog. Neurobiol. , vol.92 , pp. 442-462
    • Vrang, N.1
  • 27
    • 84907494651 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight
    • Baggio L.L., et al. Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight. J. Clin. Invest. 2014, 124:4223-4226.
    • (2014) J. Clin. Invest. , vol.124 , pp. 4223-4226
    • Baggio, L.L.1
  • 28
    • 0030967436 scopus 로고    scopus 로고
    • Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat
    • Larsen P.J., et al. Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat. Endocrinology 1997, 138:4445-4455.
    • (1997) Endocrinology , vol.138 , pp. 4445-4455
    • Larsen, P.J.1
  • 29
    • 84888134187 scopus 로고    scopus 로고
    • Hormones and diet, but not body weight, control hypothalamic microglial activity
    • Gao Y., et al. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia 2014, 62:17-25.
    • (2014) Glia , vol.62 , pp. 17-25
    • Gao, Y.1
  • 30
    • 76449115696 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor stimulation as a means of neuroprotection
    • Harkavyi A., et al. Glucagon-like peptide 1 receptor stimulation as a means of neuroprotection. Br. J. Pharmacol. 2010, 159:495-501.
    • (2010) Br. J. Pharmacol. , vol.159 , pp. 495-501
    • Harkavyi, A.1
  • 31
    • 80052737323 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, diabetes, and cognitive decline: possible pathophysiological links and therapeutic opportunities
    • Mossello E., et al. Glucagon-like peptide-1, diabetes, and cognitive decline: possible pathophysiological links and therapeutic opportunities. Exp. Diabetes Res. 2011, 2011:281674.
    • (2011) Exp. Diabetes Res. , vol.2011
    • Mossello, E.1
  • 32
    • 84862299162 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on body weight: a meta-analysis
    • Monami M., et al. Effects of glucagon-like peptide-1 receptor agonists on body weight: a meta-analysis. Exp. Diabetes Res. 2012, 2012:672658.
    • (2012) Exp. Diabetes Res. , vol.2012
    • Monami, M.1
  • 33
    • 79960741385 scopus 로고    scopus 로고
    • Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4
    • Kanoski S.E., et al. Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology 2011, 152:3103-3112.
    • (2011) Endocrinology , vol.152 , pp. 3103-3112
    • Kanoski, S.E.1
  • 34
    • 84902208322 scopus 로고    scopus 로고
    • Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect
    • Sisley S., et al. Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. J. Clin. Invest. 2014, 124:2456-2463.
    • (2014) J. Clin. Invest. , vol.124 , pp. 2456-2463
    • Sisley, S.1
  • 35
    • 12244303683 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide 1 on the hepatic glucose metabolism
    • D'Alessio D., et al. Effects of glucagon-like peptide 1 on the hepatic glucose metabolism. Horm. Metab. Res. 2004, 36:837-841.
    • (2004) Horm. Metab. Res. , vol.36 , pp. 837-841
    • D'Alessio, D.1
  • 36
    • 0028021735 scopus 로고
    • Glucagon-like peptide 1: a potent glycogenic hormone
    • Valverde I., et al. Glucagon-like peptide 1: a potent glycogenic hormone. FEBS Lett. 1994, 349:313-316.
    • (1994) FEBS Lett. , vol.349 , pp. 313-316
    • Valverde, I.1
  • 37
    • 0038445987 scopus 로고    scopus 로고
    • Cell signalling of the GLP-1 action in rat liver
    • Redondo A., et al. Cell signalling of the GLP-1 action in rat liver. Mol. Cell. Endocrinol. 2003, 204:43-50.
    • (2003) Mol. Cell. Endocrinol. , vol.204 , pp. 43-50
    • Redondo, A.1
  • 38
    • 0037471358 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits glucagon-induced glycogenolysis in perivenous hepatocytes specifically
    • Ikezawa Y., et al. Glucagon-like peptide-1 inhibits glucagon-induced glycogenolysis in perivenous hepatocytes specifically. Regul. Pept. 2003, 111:207-210.
    • (2003) Regul. Pept. , vol.111 , pp. 207-210
    • Ikezawa, Y.1
  • 39
    • 84941932514 scopus 로고    scopus 로고
    • GLP-1 contributes to increases in PGC-1α expression by downregulating miR-23a to reduce apoptosis
    • Wang C., et al. GLP-1 contributes to increases in PGC-1α expression by downregulating miR-23a to reduce apoptosis. Biochem. Biophys. Res. Commun. 2015, 466:33-39.
    • (2015) Biochem. Biophys. Res. Commun. , vol.466 , pp. 33-39
    • Wang, C.1
  • 40
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • Ding X., et al. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 2006, 43:173-181.
    • (2006) Hepatology , vol.43 , pp. 173-181
    • Ding, X.1
  • 41
    • 79955675087 scopus 로고    scopus 로고
    • Characteristic of GLP-1 effects on glucose metabolism in human skeletal muscle from obese patients
    • Villanueva-Peñacarrillo M.L., et al. Characteristic of GLP-1 effects on glucose metabolism in human skeletal muscle from obese patients. Regul. Pept. 2011, 168:39-44.
    • (2011) Regul. Pept. , vol.168 , pp. 39-44
    • Villanueva-Peñacarrillo, M.L.1
  • 42
    • 84924286044 scopus 로고    scopus 로고
    • Liraglutide attenuates high glucose-induced abnormal cell migration, proliferation, and apoptosis of vascular smooth muscle cells by activating the GLP-1 receptor, and inhibiting ERK1/2 and PI3 K/Akt signaling pathways
    • Shi L., et al. Liraglutide attenuates high glucose-induced abnormal cell migration, proliferation, and apoptosis of vascular smooth muscle cells by activating the GLP-1 receptor, and inhibiting ERK1/2 and PI3 K/Akt signaling pathways. Cardiovasc. Diabetol. 2015, 14:18.
    • (2015) Cardiovasc. Diabetol. , vol.14 , pp. 18
    • Shi, L.1
  • 43
    • 84945914015 scopus 로고    scopus 로고
    • Exendin-4 prevents vascular smooth muscle cell proliferation and migration by angiotensin II via the inhibition of ERK1/2 and JNK signaling pathways
    • Nagayama K., et al. Exendin-4 prevents vascular smooth muscle cell proliferation and migration by angiotensin II via the inhibition of ERK1/2 and JNK signaling pathways. PLoS ONE 2015, 10:e0137960.
    • (2015) PLoS ONE , vol.10
    • Nagayama, K.1
  • 44
    • 84959228554 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation
    • Torres G., et al. Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation. Biochem. Pharmacol. 2016, 104:52-61.
    • (2016) Biochem. Pharmacol. , vol.104 , pp. 52-61
    • Torres, G.1
  • 45
    • 84878808238 scopus 로고    scopus 로고
    • Pharmacology, physiology, and mechanisms of incretin hormone action
    • Campbell J.E., et al. Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab. 2013, 17:819-837.
    • (2013) Cell Metab. , vol.17 , pp. 819-837
    • Campbell, J.E.1
  • 46
    • 70349279885 scopus 로고    scopus 로고
    • Four-month treatment with GLP-2 significantly increases hip BMD: a randomized, placebo-controlled, dose-ranging study in postmenopausal women with low BMD
    • Henriksen D.B., et al. Four-month treatment with GLP-2 significantly increases hip BMD: a randomized, placebo-controlled, dose-ranging study in postmenopausal women with low BMD. Bone 2009, 45:833-842.
    • (2009) Bone , vol.45 , pp. 833-842
    • Henriksen, D.B.1
  • 47
    • 84954404245 scopus 로고    scopus 로고
    • Effects of diabetes drugs on the skeleton
    • Meier C., et al. Effects of diabetes drugs on the skeleton. Bone 2016, 82:93-100.
    • (2016) Bone , vol.82 , pp. 93-100
    • Meier, C.1
  • 48
    • 84863663100 scopus 로고    scopus 로고
    • Bone: incretin hormones perceiver or receiver?
    • Dicembrini I., et al. Bone: incretin hormones perceiver or receiver?. Exp. Diabetes Res. 2012, 2012:519784.
    • (2012) Exp. Diabetes Res. , vol.2012
    • Dicembrini, I.1
  • 49
    • 84884175131 scopus 로고    scopus 로고
    • Optimal bone mechanical and material properties require a functional glucagon-like peptide-1 receptor
    • Mabilleau G., et al. Optimal bone mechanical and material properties require a functional glucagon-like peptide-1 receptor. J. Endocrinol. 2013, 219:59-68.
    • (2013) J. Endocrinol. , vol.219 , pp. 59-68
    • Mabilleau, G.1
  • 50
    • 84925466790 scopus 로고    scopus 로고
    • Expression of glucagon-like peptide 1 receptor during osteogenic differentiation of adipose-derived stem cells
    • Jeon Y.K., et al. Expression of glucagon-like peptide 1 receptor during osteogenic differentiation of adipose-derived stem cells. Endocrinol. Metab. (Seoul) 2014, 29:567-573.
    • (2014) Endocrinol. Metab. (Seoul) , vol.29 , pp. 567-573
    • Jeon, Y.K.1
  • 51
    • 84966861231 scopus 로고    scopus 로고
    • Effect of glucagon-like peptide-1 on the differentiation of adipose-derived stem cells into osteoblasts and adipocytes
    • Lee H.M., et al. Effect of glucagon-like peptide-1 on the differentiation of adipose-derived stem cells into osteoblasts and adipocytes. J. Menopausal Med. 2015, 21:93-103.
    • (2015) J. Menopausal Med. , vol.21 , pp. 93-103
    • Lee, H.M.1
  • 52
    • 84857095236 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibitors and bone fractures: a meta-analysis of randomized clinical trials
    • Monami M., et al. Dipeptidyl peptidase-4 inhibitors and bone fractures: a meta-analysis of randomized clinical trials. Diabetes Care 2011, 34:2474-2476.
    • (2011) Diabetes Care , vol.34 , pp. 2474-2476
    • Monami, M.1
  • 53
    • 84962368213 scopus 로고    scopus 로고
    • Incidence of fractures in patients with type 2 diabetes in the SAVOR-TIMI 53 trial
    • Mosenzon O., et al. Incidence of fractures in patients with type 2 diabetes in the SAVOR-TIMI 53 trial. Diabetes Care 2015, 38:2142-2150.
    • (2015) Diabetes Care , vol.38 , pp. 2142-2150
    • Mosenzon, O.1
  • 54
    • 79951870602 scopus 로고    scopus 로고
    • Exenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2 diabetes
    • Bunck M.C., et al. Exenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2 diabetes. Diabetes Obes. Metab. 2011, 213:374-377.
    • (2011) Diabetes Obes. Metab. , vol.213 , pp. 374-377
    • Bunck, M.C.1
  • 55
    • 84945540155 scopus 로고    scopus 로고
    • Drugs for type 2 diabetes: role in the regulation of bone metabolism
    • Mannucci E., et al. Drugs for type 2 diabetes: role in the regulation of bone metabolism. Clin. Cases Miner. Bone Metab. 2015, 12:130-134.
    • (2015) Clin. Cases Miner. Bone Metab. , vol.12 , pp. 130-134
    • Mannucci, E.1
  • 56
    • 84936166069 scopus 로고    scopus 로고
    • SCALE Obesity and Prediabetes NN8022-1839 Study Group. A randomized, controlled trial of 3.0 mg of liraglutide in weight management
    • Pi-Sunyer X., et al. SCALE Obesity and Prediabetes NN8022-1839 Study Group. A randomized, controlled trial of 3.0 mg of liraglutide in weight management. N. Engl. J. Med. 2015, 373:11-22.
    • (2015) N. Engl. J. Med. , vol.373 , pp. 11-22
    • Pi-Sunyer, X.1
  • 57
    • 84870054636 scopus 로고    scopus 로고
    • GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus
    • Meier J.J. GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus. Nat. Rev. Endocrinol. 2012, 8:728-742.
    • (2012) Nat. Rev. Endocrinol. , vol.8 , pp. 728-742
    • Meier, J.J.1
  • 58
    • 36949030831 scopus 로고    scopus 로고
    • GLP-1 amplifies insulin signaling by up-regulation of IRβ, IRS-1 and Glut4 in 3T3-L1 adipocytes
    • Gao H., et al. GLP-1 amplifies insulin signaling by up-regulation of IRβ, IRS-1 and Glut4 in 3T3-L1 adipocytes. Endocrine 2007, 32:90-95.
    • (2007) Endocrine , vol.32 , pp. 90-95
    • Gao, H.1
  • 59
    • 23844526330 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats
    • Sancho V., et al. Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats. J. Mol. Endocrinol. 2005, 35:27-38.
    • (2005) J. Mol. Endocrinol. , vol.35 , pp. 27-38
    • Sancho, V.1
  • 60
    • 84857461922 scopus 로고    scopus 로고
    • Regulation of adipocyte formation by GLP-1/GLP-1R signaling
    • Challa T.D., et al. Regulation of adipocyte formation by GLP-1/GLP-1R signaling. J. Biol. Chem. 2012, 287:6421-6430.
    • (2012) J. Biol. Chem. , vol.287 , pp. 6421-6430
    • Challa, T.D.1
  • 61
    • 84876362365 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 regulates adipogenesis in 3T3-L1 preadipocytes
    • Yang J., et al. Glucagon-like peptide 1 regulates adipogenesis in 3T3-L1 preadipocytes. Int. J. Mol. Med. 2013, 31:1429-1435.
    • (2013) Int. J. Mol. Med. , vol.31 , pp. 1429-1435
    • Yang, J.1
  • 62
    • 70449701437 scopus 로고    scopus 로고
    • Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression
    • Kim Chung le T., et al. Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression. Biochem. Biophys. Res. Commun. 2009, 390:613-618.
    • (2009) Biochem. Biophys. Res. Commun. , vol.390 , pp. 613-618
    • Kim Chung le, T.1
  • 63
    • 84865368343 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation
    • Shiraishi D., et al. Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation. Biochem. Biophys. Res. Commun. 2012, 425:304-308.
    • (2012) Biochem. Biophys. Res. Commun. , vol.425 , pp. 304-308
    • Shiraishi, D.1
  • 64
    • 84921280464 scopus 로고    scopus 로고
    • Effect of liraglutide on proliferation and differentiation of human adipose stem cells
    • Cantini G., et al. Effect of liraglutide on proliferation and differentiation of human adipose stem cells. Mol. Cell. Endocrinol. 2007, 402:43-50.
    • (2007) Mol. Cell. Endocrinol. , vol.402 , pp. 43-50
    • Cantini, G.1
  • 65
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • Ban K., et al. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 2008, 117:2340-2350.
    • (2008) Circulation , vol.117 , pp. 2340-2350
    • Ban, K.1
  • 66
    • 77950267745 scopus 로고    scopus 로고
    • Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor
    • Ban K., et al. Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor. Endocrinology 2010, 151:1520-1531.
    • (2010) Endocrinology , vol.151 , pp. 1520-1531
    • Ban, K.1
  • 67
    • 84877317750 scopus 로고    scopus 로고
    • GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
    • Kim M., et al. GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat. Med. 2013, 19:567-575.
    • (2013) Nat. Med. , vol.19 , pp. 567-575
    • Kim, M.1
  • 68
    • 84904283347 scopus 로고    scopus 로고
    • Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection
    • Ussher J.R., et al. Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection. Mol. Metab. 2014, 3:507-517.
    • (2014) Mol. Metab. , vol.3 , pp. 507-517
    • Ussher, J.R.1
  • 69
    • 84897852105 scopus 로고    scopus 로고
    • GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody
    • Pyke C., et al. GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody. Endocrinology 2014, 155:1280-1290.
    • (2014) Endocrinology , vol.155 , pp. 1280-1290
    • Pyke, C.1
  • 70
    • 75249100556 scopus 로고    scopus 로고
    • Insulin-like actions of glucagon-like peptide-1: a dual receptor hypothesis
    • Tomas E., et al. Insulin-like actions of glucagon-like peptide-1: a dual receptor hypothesis. Trends Endocrinol. Metab. 2010, 21:59-67.
    • (2010) Trends Endocrinol. Metab. , vol.21 , pp. 59-67
    • Tomas, E.1
  • 71
    • 0029944047 scopus 로고    scopus 로고
    • Regulation of glucagon receptor expression
    • Nishimura E., et al. Regulation of glucagon receptor expression. Acta Physiol. Scand. 1996, 157:329-332.
    • (1996) Acta Physiol. Scand. , vol.157 , pp. 329-332
    • Nishimura, E.1
  • 72
    • 0036305993 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes
    • Luque M.A., et al. Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes. J. Endocrinol. 2002, 173:465-473.
    • (2002) J. Endocrinol. , vol.173 , pp. 465-473
    • Luque, M.A.1
  • 73
    • 77956496046 scopus 로고    scopus 로고
    • Presence of a functional receptor for GLP-1 in osteoblastic cells, independent of the cAMP-linked GLP-1 receptor
    • Nuche-Berenguer B., et al. Presence of a functional receptor for GLP-1 in osteoblastic cells, independent of the cAMP-linked GLP-1 receptor. J. Cell. Physiol. 2010, 225:585-592.
    • (2010) J. Cell. Physiol. , vol.225 , pp. 585-592
    • Nuche-Berenguer, B.1
  • 74
    • 0030884317 scopus 로고    scopus 로고
    • Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes
    • Montrose-Rafizadeh C., et al. Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes. J. Cell Physiol. 1997, 172:275-283.
    • (1997) J. Cell Physiol. , vol.172 , pp. 275-283
    • Montrose-Rafizadeh, C.1
  • 75
    • 35948941910 scopus 로고    scopus 로고
    • The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion
    • El-Ouaghlidi A., et al. The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion. J. Clin. Endocrinol. Metab. 2007, 92:4165-4171.
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 4165-4171
    • El-Ouaghlidi, A.1
  • 76
    • 84939536418 scopus 로고    scopus 로고
    • Does GLP-1 suppress its own basal secretion?
    • Elahi D., et al. Does GLP-1 suppress its own basal secretion?. Endocr. Res. 2016, 41:16-20.
    • (2016) Endocr. Res. , vol.41 , pp. 16-20
    • Elahi, D.1
  • 77
    • 84862746869 scopus 로고    scopus 로고
    • Regulation of mouse intestinal L cell progenitors proliferation by the glucagon family of peptides
    • Grigoryan M., et al. Regulation of mouse intestinal L cell progenitors proliferation by the glucagon family of peptides. Endocrinology 2012, 153:3076-3088.
    • (2012) Endocrinology , vol.153 , pp. 3076-3088
    • Grigoryan, M.1
  • 78
    • 68049106367 scopus 로고    scopus 로고
    • Stimulation of incretin secretion by dietary lipid: is it dose dependent?
    • Yoder S.M., et al. Stimulation of incretin secretion by dietary lipid: is it dose dependent?. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 297:G299-G305.
    • (2009) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.297 , pp. G299-G305
    • Yoder, S.M.1
  • 79
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker D.J., et al. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006, 368:1696-1705.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1
  • 80
    • 34748898831 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats
    • Vahl T.P., et al. Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats. Endocrinology 2007, 148:4965-4973.
    • (2007) Endocrinology , vol.148 , pp. 4965-4973
    • Vahl, T.P.1
  • 81
    • 84857772149 scopus 로고    scopus 로고
    • The structure and function of the glucagon-like peptide-1 receptor and its ligands
    • Donnelly D. The structure and function of the glucagon-like peptide-1 receptor and its ligands. Br. J. Pharmacol. 2012, 166:27-41.
    • (2012) Br. J. Pharmacol. , vol.166 , pp. 27-41
    • Donnelly, D.1
  • 82
    • 84938206842 scopus 로고    scopus 로고
    • The regions within the N-terminus critical for human glucagon like peptide-1 receptor (hGLP-1R) cell surface expression
    • Thompson A., et al. The regions within the N-terminus critical for human glucagon like peptide-1 receptor (hGLP-1R) cell surface expression. Sci. Rep. 2014, 4:7410.
    • (2014) Sci. Rep. , vol.4 , pp. 7410
    • Thompson, A.1
  • 83
    • 74549200267 scopus 로고    scopus 로고
    • Role of the signal peptide in the synthesis and processing of the glucagon-like peptide-1 receptor
    • Huang Y., et al. Role of the signal peptide in the synthesis and processing of the glucagon-like peptide-1 receptor. Br. J. Pharmacol. 2010, 159:237-251.
    • (2010) Br. J. Pharmacol. , vol.159 , pp. 237-251
    • Huang, Y.1
  • 84
    • 45549086826 scopus 로고    scopus 로고
    • Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain
    • Runge S., et al. Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J. Biol. Chem. 2008, 283:11340-11347.
    • (2008) J. Biol. Chem. , vol.283 , pp. 11340-11347
    • Runge, S.1
  • 85
    • 84857853130 scopus 로고    scopus 로고
    • Regulation of GIP and GLP-1 receptor cell surface expression by N-glycosylation and receptor heteromerization
    • Whitaker G.M., et al. Regulation of GIP and GLP-1 receptor cell surface expression by N-glycosylation and receptor heteromerization. PLoS ONE 2012, 7:e32675.
    • (2012) PLoS ONE , vol.7
    • Whitaker, G.M.1
  • 86
    • 77953448152 scopus 로고    scopus 로고
    • Role of N-linked glycosylation in biosynthesis, trafficking, and function of the human glucagon-like peptide 1 receptor
    • Chen Q., et al. Role of N-linked glycosylation in biosynthesis, trafficking, and function of the human glucagon-like peptide 1 receptor. Am. J. Physiol. Endocrinol. Metab. 2010, 299:E62-E68.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.299 , pp. E62-E68
    • Chen, Q.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.