메뉴 건너뛰기




Volumn 3, Issue 5, 2014, Pages 507-517

Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection

Author keywords

Cardiomyopathy; Glucagon like peptide 1; Glucagon like peptide 1 receptor; Heart failure; Incretin; Ischemia; Myocardial infarction

Indexed keywords

DOXORUBICIN; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; LIRAGLUTIDE;

EID: 84904283347     PISSN: 22128778     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmet.2014.04.009     Document Type: Article
Times cited : (110)

References (52)
  • 2
    • 34247122261 scopus 로고    scopus 로고
    • Fluid retention with thiazolidinediones: does the mechanism influence the outcome?
    • Lindenfeld J., Masoudi F.A. Fluid retention with thiazolidinediones: does the mechanism influence the outcome?. Journal of the American College of Cardiology 2007, 49(16):1705-1707.
    • (2007) Journal of the American College of Cardiology , vol.49 , Issue.16 , pp. 1705-1707
    • Lindenfeld, J.1    Masoudi, F.A.2
  • 4
    • 1442311383 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion
    • Nikolaidis L.A., Mankad S., Sokos G.G., Miske G., Shah A., Elahi D., et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004, 109(8):962-965.
    • (2004) Circulation , vol.109 , Issue.8 , pp. 962-965
    • Nikolaidis, L.A.1    Mankad, S.2    Sokos, G.G.3    Miske, G.4    Shah, A.5    Elahi, D.6
  • 5
    • 84883295202 scopus 로고    scopus 로고
    • Cardioprotective effects of exenatide in patients with ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of exenatide myocardial protection in revascularization study
    • Woo J.S., Kim W., Ha S.J., Kim J.B., Kim S.J., Kim W.S., et al. Cardioprotective effects of exenatide in patients with ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of exenatide myocardial protection in revascularization study. Arteriosclerosis, Thrombosis, and Vascular Biology 2013, 33(9):2252-2260.
    • (2013) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.33 , Issue.9 , pp. 2252-2260
    • Woo, J.S.1    Kim, W.2    Ha, S.J.3    Kim, J.B.4    Kim, S.J.5    Kim, W.S.6
  • 6
    • 33845293219 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure
    • Sokos G.G., Nikolaidis L.A., Mankad S., Elahi D., Shannon R.P. Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. Journal of Cardiac Failure 2006, 12(9):694-699.
    • (2006) Journal of Cardiac Failure , vol.12 , Issue.9 , pp. 694-699
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3    Elahi, D.4    Shannon, R.P.5
  • 7
    • 84863560602 scopus 로고    scopus 로고
    • Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction
    • Lonborg J., Vejlstrup N., Kelbaek H., Botker H.E., Kim W.Y., Mathiasen A.B., et al. Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction. European Heart Journal 2012, 33(12):1491-1499.
    • (2012) European Heart Journal , vol.33 , Issue.12 , pp. 1491-1499
    • Lonborg, J.1    Vejlstrup, N.2    Kelbaek, H.3    Botker, H.E.4    Kim, W.Y.5    Mathiasen, A.B.6
  • 8
    • 84860204551 scopus 로고    scopus 로고
    • Cardiovascular biology of the incretin system
    • Ussher J.R., Drucker D.J. Cardiovascular biology of the incretin system. Endocrine Reviews 2012, 33(2):187-215.
    • (2012) Endocrine Reviews , vol.33 , Issue.2 , pp. 187-215
    • Ussher, J.R.1    Drucker, D.J.2
  • 10
    • 84877317750 scopus 로고    scopus 로고
    • GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
    • Kim M., Platt M., Shibasaki T., Quaggin S., Backx P.H., Seino S., et al. GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nature Medicine 2013, 19(5):567-575.
    • (2013) Nature Medicine , vol.19 , Issue.5 , pp. 567-575
    • Kim, M.1    Platt, M.2    Shibasaki, T.3    Quaggin, S.4    Backx, P.H.5    Seino, S.6
  • 11
    • 0029958404 scopus 로고    scopus 로고
    • Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide receptor gene
    • Scrocchi L.A., Brown T.J., MacLusky N., Brubaker P.L., Auerbach A.B., Joyner A.L., et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide receptor gene. Nature Medicine 1996, 21254-21258.
    • (1996) Nature Medicine , pp. 21254-21258
    • Scrocchi, L.A.1    Brown, T.J.2    MacLusky, N.3    Brubaker, P.L.4    Auerbach, A.B.5    Joyner, A.L.6
  • 12
    • 84880743041 scopus 로고    scopus 로고
    • Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like peptide-1 receptor deficiency
    • Wilson-Pérez H.E., Chambers A.P., Ryan K.K., Li B., Sandoval D.A., Stoffers D., et al. Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like peptide-1 receptor deficiency. Diabetes 2013, 62(7):2380-2385.
    • (2013) Diabetes , vol.62 , Issue.7 , pp. 2380-2385
    • Wilson-Pérez, H.E.1    Chambers, A.P.2    Ryan, K.K.3    Li, B.4    Sandoval, D.A.5    Stoffers, D.6
  • 13
    • 67949100572 scopus 로고    scopus 로고
    • Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion models
    • Koitabashi N., Bedja D., Zaiman A.L., Pinto Y.M., Zhang M., Gabrielson K.L., et al. Avoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion models. Circulation Research 2009, 105(1):12-15.
    • (2009) Circulation Research , vol.105 , Issue.1 , pp. 12-15
    • Koitabashi, N.1    Bedja, D.2    Zaiman, A.L.3    Pinto, Y.M.4    Zhang, M.5    Gabrielson, K.L.6
  • 14
    • 64649102619 scopus 로고    scopus 로고
    • GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
    • Noyan-Ashraf M.H., Momen M.A., Ban K., Sadi A.M., Zhou Y.Q., Riazi A.M., et al. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 2009, 58(4):975-983.
    • (2009) Diabetes , vol.58 , Issue.4 , pp. 975-983
    • Noyan-Ashraf, M.H.1    Momen, M.A.2    Ban, K.3    Sadi, A.M.4    Zhou, Y.Q.5    Riazi, A.M.6
  • 15
    • 34548403111 scopus 로고    scopus 로고
    • Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin
    • Neilan T.G., Blake S.L., Ichinose F., Raher M.J., Buys E.S., Jassal D.S., et al. Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin. Circulation 2007, 116(5):506-514.
    • (2007) Circulation , vol.116 , Issue.5 , pp. 506-514
    • Neilan, T.G.1    Blake, S.L.2    Ichinose, F.3    Raher, M.J.4    Buys, E.S.5    Jassal, D.S.6
  • 16
    • 77951168113 scopus 로고    scopus 로고
    • Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes following myocardial infarction in mice
    • Sauve M., Ban K., Momen A., Zhou Y.-Q., Henkelman R.M., Husain M., et al. Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes following myocardial infarction in mice. Diabetes 2010, 59(4):1063-1073.
    • (2010) Diabetes , vol.59 , Issue.4 , pp. 1063-1073
    • Sauve, M.1    Ban, K.2    Momen, A.3    Zhou, Y.-Q.4    Henkelman, R.M.5    Husain, M.6
  • 17
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25(4):402-408.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 18
    • 84861316681 scopus 로고    scopus 로고
    • Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance
    • Ussher J.R., Folmes C.D., Keung W., Fillmore N., Jaswal J.S., Cadete V.J., et al. Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance. PLoS One 2012, 7(5):e37703.
    • (2012) PLoS One , vol.7 , Issue.5
    • Ussher, J.R.1    Folmes, C.D.2    Keung, W.3    Fillmore, N.4    Jaswal, J.S.5    Cadete, V.J.6
  • 19
    • 0038577144 scopus 로고    scopus 로고
    • Cardiac function in mice lacking the glucagon-like peptide-1 receptor
    • Gros R., You X., Baggio L.L., Kabir M.G., Sadi A.M., Mungrue I.N., et al. Cardiac function in mice lacking the glucagon-like peptide-1 receptor. Endocrinology 2003, 144(6):2242-2252.
    • (2003) Endocrinology , vol.144 , Issue.6 , pp. 2242-2252
    • Gros, R.1    You, X.2    Baggio, L.L.3    Kabir, M.G.4    Sadi, A.M.5    Mungrue, I.N.6
  • 20
    • 58949102483 scopus 로고    scopus 로고
    • Chronic glucagon-like peptide-1 infusion sustains left ventricular systolic function and prolongs survival in the spontaneously hypertensive, heart failure-prone rat
    • Poornima I., Brown S.B., Bhashyam S., Parikh P., Bolukoglu H., Shannon R.P. Chronic glucagon-like peptide-1 infusion sustains left ventricular systolic function and prolongs survival in the spontaneously hypertensive, heart failure-prone rat. Circulation Heart Failure 2008, 1(3):153-160.
    • (2008) Circulation Heart Failure , vol.1 , Issue.3 , pp. 153-160
    • Poornima, I.1    Brown, S.B.2    Bhashyam, S.3    Parikh, P.4    Bolukoglu, H.5    Shannon, R.P.6
  • 21
    • 78149493266 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure
    • Liu Q., Anderson C., Broyde A., Polizzi C., Fernandez R., Baron A., et al. Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure. Cardiovascular Diabetology 2010, 9:76.
    • (2010) Cardiovascular Diabetology , vol.9 , pp. 76
    • Liu, Q.1    Anderson, C.2    Broyde, A.3    Polizzi, C.4    Fernandez, R.5    Baron, A.6
  • 22
    • 84878525375 scopus 로고    scopus 로고
    • Effect of additional treatment with EXenatide in patients with an acute myocardial infarction: the EXAMI study
    • Bernink F.J., Timmers L., Diamant M., Scholte M., Beek A.M., Kamp O., et al. Effect of additional treatment with EXenatide in patients with an acute myocardial infarction: the EXAMI study. International Journal of Cardiology 2013, 167(1):289-290.
    • (2013) International Journal of Cardiology , vol.167 , Issue.1 , pp. 289-290
    • Bernink, F.J.1    Timmers, L.2    Diamant, M.3    Scholte, M.4    Beek, A.M.5    Kamp, O.6
  • 23
    • 79951979265 scopus 로고    scopus 로고
    • Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy
    • Vyas A.K., Yang K.C., Woo D., Tzekov A., Kovacs A., Jay P.Y., et al. Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy. PLoS One 2011, 6(2):e17178.
    • (2011) PLoS One , vol.6 , Issue.2
    • Vyas, A.K.1    Yang, K.C.2    Woo, D.3    Tzekov, A.4    Kovacs, A.5    Jay, P.Y.6
  • 24
    • 84862521094 scopus 로고    scopus 로고
    • Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: a double-blind, randomised controlled clinical trial of efficacy and safety
    • Nathanson D., Ullman B., Lofstrom U., Hedman A., Frick M., Sjoholm A., et al. Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: a double-blind, randomised controlled clinical trial of efficacy and safety. Diabetologia 2012, 55(4):926-935.
    • (2012) Diabetologia , vol.55 , Issue.4 , pp. 926-935
    • Nathanson, D.1    Ullman, B.2    Lofstrom, U.3    Hedman, A.4    Frick, M.5    Sjoholm, A.6
  • 25
    • 0031747107 scopus 로고    scopus 로고
    • Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor-/- mice
    • Pederson R.A., Satkunarajah M., McIntosh C.H., Scrocchi L.A., Flamez D., Schuit F., et al. Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor-/- mice. Diabetes 1998, 47(7):1046-1052.
    • (1998) Diabetes , vol.47 , Issue.7 , pp. 1046-1052
    • Pederson, R.A.1    Satkunarajah, M.2    McIntosh, C.H.3    Scrocchi, L.A.4    Flamez, D.5    Schuit, F.6
  • 26
    • 33845997750 scopus 로고    scopus 로고
    • Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure
    • Hansotia T., Maida A., Flock G., Yamada Y., Tsukiyama K., Seino Y., et al. Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure. Journal of Clinical Investigation 2007, 117(1):143-152.
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.1 , pp. 143-152
    • Hansotia, T.1    Maida, A.2    Flock, G.3    Yamada, Y.4    Tsukiyama, K.5    Seino, Y.6
  • 27
    • 77957259261 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor knockout mice are protected from high-fat diet-induced insulin resistance
    • Ayala J.E., Bracy D.P., James F.D., Burmeister M.A., Wasserman D.H., Drucker D.J. Glucagon-like peptide-1 receptor knockout mice are protected from high-fat diet-induced insulin resistance. Endocrinology 2010, 151(10):4678-4687.
    • (2010) Endocrinology , vol.151 , Issue.10 , pp. 4678-4687
    • Ayala, J.E.1    Bracy, D.P.2    James, F.D.3    Burmeister, M.A.4    Wasserman, D.H.5    Drucker, D.J.6
  • 29
    • 84897852105 scopus 로고    scopus 로고
    • GLP-1 receptor localization in monkey and human tissue; novel distribution revealed with extensively validated monoclonal antibody
    • Pyke C., Heller R.S., Kirk R.K., Orskov C., Reedtz-Runge S., Kaastrup P., et al. GLP-1 receptor localization in monkey and human tissue; novel distribution revealed with extensively validated monoclonal antibody. Endocrinology 2014, 155(4):1280-1290.
    • (2014) Endocrinology , vol.155 , Issue.4 , pp. 1280-1290
    • Pyke, C.1    Heller, R.S.2    Kirk, R.K.3    Orskov, C.4    Reedtz-Runge, S.5    Kaastrup, P.6
  • 31
    • 77950267745 scopus 로고    scopus 로고
    • GLP-1(9-36) protects cardiomyocytes and endothelial cells from ischemia-reperfusion injury via cytoprotective pathways independent of the GLP-1 receptor
    • Ban K., Kim H., Cho J., Diamandis E., Backx P.H., Drucker D.J., et al. GLP-1(9-36) protects cardiomyocytes and endothelial cells from ischemia-reperfusion injury via cytoprotective pathways independent of the GLP-1 receptor. Endocrinology 2010, 151(4):1520-1531.
    • (2010) Endocrinology , vol.151 , Issue.4 , pp. 1520-1531
    • Ban, K.1    Kim, H.2    Cho, J.3    Diamandis, E.4    Backx, P.H.5    Drucker, D.J.6
  • 32
    • 43249089631 scopus 로고    scopus 로고
    • Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
    • Ban K., Noyan-Ashraf M.H., Hoefer J., Bolz S.S., Drucker D.J., Husain M. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 2008, 117(18):2340-2350.
    • (2008) Circulation , vol.117 , Issue.18 , pp. 2340-2350
    • Ban, K.1    Noyan-Ashraf, M.H.2    Hoefer, J.3    Bolz, S.S.4    Drucker, D.J.5    Husain, M.6
  • 33
    • 84872055241 scopus 로고    scopus 로고
    • Aglucagon-like peptide-1 analogue reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity
    • Noyan-Ashraf M.H., Shikatani E.A., Schuiki I., Mukovozov I., Wu J., Li R.K., et al. Aglucagon-like peptide-1 analogue reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity. Circulation 2013, 127(1):74-85.
    • (2013) Circulation , vol.127 , Issue.1 , pp. 74-85
    • Noyan-Ashraf, M.H.1    Shikatani, E.A.2    Schuiki, I.3    Mukovozov, I.4    Wu, J.5    Li, R.K.6
  • 35
    • 28144441354 scopus 로고    scopus 로고
    • Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy
    • Nikolaidis L.A., Elahi D., Shen Y.T., Shannon R.P. Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy. American Journal of Physiology. Heart and Circulatory Physiology 2005, 289(6):H2401-H2408.
    • (2005) American Journal of Physiology. Heart and Circulatory Physiology , vol.289 , Issue.6
    • Nikolaidis, L.A.1    Elahi, D.2    Shen, Y.T.3    Shannon, R.P.4
  • 38
    • 84897883235 scopus 로고    scopus 로고
    • Identification and characterisation of glucagon-like peptide-1 receptor expressing cells using a new transgenic mouse model
    • Richards P., Parker H.E., Adriaenssens A.E., Hodgson J.M., Cork S.C., Trapp S., et al. Identification and characterisation of glucagon-like peptide-1 receptor expressing cells using a new transgenic mouse model. Diabetes 2014, 63(4):1224-1233.
    • (2014) Diabetes , vol.63 , Issue.4 , pp. 1224-1233
    • Richards, P.1    Parker, H.E.2    Adriaenssens, A.E.3    Hodgson, J.M.4    Cork, S.C.5    Trapp, S.6
  • 39
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • Nikolaidis L.A., Elahi D., Hentosz T., Doverspike A., Huerbin R., Zourelias L., et al. Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 2004, 110(8):955-961.
    • (2004) Circulation , vol.110 , Issue.8 , pp. 955-961
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3    Doverspike, A.4    Huerbin, R.5    Zourelias, L.6
  • 40
    • 12144260853 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) can directly protect the heart against ischemia/reperfusion injury
    • Bose A.K., Mocanu M.M., Carr R.D., Brand C.L., Yellon D.M. Glucagon-like peptide-1 (GLP-1) can directly protect the heart against ischemia/reperfusion injury. Diabetes 2005, 54(1):146-151.
    • (2005) Diabetes , vol.54 , Issue.1 , pp. 146-151
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Brand, C.L.4    Yellon, D.M.5
  • 41
    • 35448998412 scopus 로고    scopus 로고
    • Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials
    • Kitakaze M., Asakura M., Kim J., Shintani Y., Asanuma H., Hamasaki T., et al. Human atrial natriuretic peptide and nicorandil as adjuncts to reperfusion treatment for acute myocardial infarction (J-WIND): two randomised trials. Lancet 2007, 370(9597):1483-1493.
    • (2007) Lancet , vol.370 , Issue.9597 , pp. 1483-1493
    • Kitakaze, M.1    Asakura, M.2    Kim, J.3    Shintani, Y.4    Asanuma, H.5    Hamasaki, T.6
  • 42
    • 80052072913 scopus 로고    scopus 로고
    • Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: evidence for improving cardiac metabolic efficiency
    • Bao W., Aravindhan K., Alsaid H., Chendrimada T., Szapacs M., Citerone D.R., et al. Albiglutide, a long lasting glucagon-like peptide-1 analog, protects the rat heart against ischemia/reperfusion injury: evidence for improving cardiac metabolic efficiency. PLoS One 2011, 6(8):e23570.
    • (2011) PLoS One , vol.6 , Issue.8
    • Bao, W.1    Aravindhan, K.2    Alsaid, H.3    Chendrimada, T.4    Szapacs, M.5    Citerone, D.R.6
  • 43
    • 84896092380 scopus 로고    scopus 로고
    • Molecular mechanisms of diabetic cardiomyopathy
    • Bugger H., Abel E.D. Molecular mechanisms of diabetic cardiomyopathy. Diabetologia 2014, 57(4):660-671.
    • (2014) Diabetologia , vol.57 , Issue.4 , pp. 660-671
    • Bugger, H.1    Abel, E.D.2
  • 44
    • 84903177155 scopus 로고    scopus 로고
    • Impact of acute hyperglycemia on myocardial infarct size, area at risk and salvage in patients with ST elevation myocardial infarction and the association with exenatide treatment - results from a randomized study
    • Lønborg J., Vejlstrup N., Kelbæk H., Nepper-Christensen L., Jørgensen E., Helqvist S., et al. Impact of acute hyperglycemia on myocardial infarct size, area at risk and salvage in patients with ST elevation myocardial infarction and the association with exenatide treatment - results from a randomized study. Diabetes 2014, 10.2337/db13-1849.
    • (2014) Diabetes
    • Lønborg, J.1    Vejlstrup, N.2    Kelbæk, H.3    Nepper-Christensen, L.4    Jørgensen, E.5    Helqvist, S.6
  • 45
    • 84855465547 scopus 로고    scopus 로고
    • Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice
    • Lamont B.J., Li Y., Kwan E., Brown T.J., Gaisano H., Drucker D.J. Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice. Journal of Clinical Investigation 2012, 122(1):388-402.
    • (2012) Journal of Clinical Investigation , vol.122 , Issue.1 , pp. 388-402
    • Lamont, B.J.1    Li, Y.2    Kwan, E.3    Brown, T.J.4    Gaisano, H.5    Drucker, D.J.6
  • 46
    • 84878808238 scopus 로고    scopus 로고
    • Pharmacology physiology and mechanisms of incretin hormone action
    • Campbell J.E., Drucker D.J. Pharmacology physiology and mechanisms of incretin hormone action. Cell Metabolism 2013, 17(4):819-837.
    • (2013) Cell Metabolism , vol.17 , Issue.4 , pp. 819-837
    • Campbell, J.E.1    Drucker, D.J.2
  • 47
    • 84859529626 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism
    • Chai W., Dong Z., Wang N., Wang W., Tao L., Cao W., et al. Glucagon-like peptide 1 recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism. Diabetes 2012, 61(4):888-896.
    • (2012) Diabetes , vol.61 , Issue.4 , pp. 888-896
    • Chai, W.1    Dong, Z.2    Wang, N.3    Wang, W.4    Tao, L.5    Cao, W.6
  • 48
    • 84898787394 scopus 로고    scopus 로고
    • GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans
    • Subaran S.C., Sauder M.A., Chai W., Jahn L.A., Fowler D.E., Aylor K.W., et al. GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans. Clinical Science (London) 2014, 127(3):163-170.
    • (2014) Clinical Science (London) , vol.127 , Issue.3 , pp. 163-170
    • Subaran, S.C.1    Sauder, M.A.2    Chai, W.3    Jahn, L.A.4    Fowler, D.E.5    Aylor, K.W.6
  • 49
    • 77952889531 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) attenuates post-resuscitation myocardial microcirculatory dysfunction
    • Dokken B.B., Hilwig W.R., Teachey M.K., Panchal R.A., Hubner K., Allen D., et al. Glucagon-like peptide-1 (GLP-1) attenuates post-resuscitation myocardial microcirculatory dysfunction. Resuscitation 2010, 81(6):755-760.
    • (2010) Resuscitation , vol.81 , Issue.6 , pp. 755-760
    • Dokken, B.B.1    Hilwig, W.R.2    Teachey, M.K.3    Panchal, R.A.4    Hubner, K.5    Allen, D.6
  • 50
    • 84863580185 scopus 로고    scopus 로고
    • Exenatide alters myocardial glucose transport and uptake depending on insulin resistance and increases myocardial blood flow in patients with type 2 diabetes
    • Gejl M., Sondergaard H.M., Stecher C., Bibby B.M., Moller N., Botker H.E., et al. Exenatide alters myocardial glucose transport and uptake depending on insulin resistance and increases myocardial blood flow in patients with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism 2012, 97(7):E1165-E1169.
    • (2012) Journal of Clinical Endocrinology and Metabolism , vol.97 , Issue.7
    • Gejl, M.1    Sondergaard, H.M.2    Stecher, C.3    Bibby, B.M.4    Moller, N.5    Botker, H.E.6
  • 51
    • 0036307872 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
    • Yamamoto H., Lee C.E., Marcus J.N., Williams T.D., Overton J.M., Lopez M.E., et al. Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. Journal of Clinical Investigation 2002, 110(1):43-52.
    • (2002) Journal of Clinical Investigation , vol.110 , Issue.1 , pp. 43-52
    • Yamamoto, H.1    Lee, C.E.2    Marcus, J.N.3    Williams, T.D.4    Overton, J.M.5    Lopez, M.E.6
  • 52
    • 78650507366 scopus 로고    scopus 로고
    • GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons
    • Griffioen K.J., Wan R., Okun E., Wang X., Lovett-Barr M.R., Li Y., et al. GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons. Cardiovascular Research 2011, 89(1):72-78.
    • (2011) Cardiovascular Research , vol.89 , Issue.1 , pp. 72-78
    • Griffioen, K.J.1    Wan, R.2    Okun, E.3    Wang, X.4    Lovett-Barr, M.R.5    Li, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.