Liraglutide attenuates high glucose-induced abnormal cell migration, proliferation, and apoptosis of vascular smooth muscle cells by activating the GLP-1 receptor, and inhibiting ERK1/2 and PI3K/Akt signaling pathways

Cardiovascular Diabetology

Volumn 14, Issue 1, 2015, Pages

  Shi, Lili ^a   Ji, Ye ^b   Jiang, Xiaoyan ^a   Zhou, Lihong ^a   Xu, Ying ^a   Li, Yanbo ^a   Jiang, Wei ^a   Meng, Ping ^a   Liu, Xiaomin ^a  

^a THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Akt; ERK1 2; Glucagon like peptide receptor; High glucose; Liraglutide; Vascular smooth muscle cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANTIDIABETIC AGENT; CASPASE 3; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE; LIRAGLUTIDE; MANNITOL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; APOPTOSIS; ARTICLE; CELL COUNT; CELL ISOLATION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CUTANEOUS PARAMETERS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE; WOUND HEALING; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL MOTION; CYTOLOGY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; SMOOTH MUSCLE CELL; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; GLUCOSE; HYPOGLYCEMIC AGENTS; LIRAGLUTIDE; MALE; MAP KINASE SIGNALING SYSTEM; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84924286044     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/s12933-015-0177-4     Document Type: Article

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