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Volumn 22, Issue 2, 2016, Pages 201-212

Modulatory effects of gut microbiota on the central nervous system: How gut could play a role in neuropsychiatric health and diseases

Author keywords

Anxiety; Brain Gut axis; Depression; Gut microbiota; Stress

Indexed keywords

4 AMINOBUTYRIC ACID; ANTIINFLAMMATORY AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CYTOKINE; G PROTEIN COUPLED RECEPTOR; GAMMA INTERFERON; GLUCAGON LIKE PEPTIDE 2; GLUCOCORTICOID RECEPTOR; HIPPURIC ACID; HISTAMINE; HISTIDINE DECARBOXYLASE; HORMONE; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 4; KYNURENINE; LIPOPOLYSACCHARIDE; MINOCYCLINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NORADRENALIN; PEPTIDE; PROBIOTIC AGENT; SEROTONIN; SEROTONIN 1A RECEPTOR; SHORT CHAIN FATTY ACID; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

EID: 84963621215     PISSN: 20930879     EISSN: 20930887     Source Type: Journal    
DOI: 10.5056/jnm15146     Document Type: Review
Times cited : (203)

References (150)
  • 1
    • 79960645242 scopus 로고    scopus 로고
    • Gut feelings: the emerging biology of gut-brain communication
    • Mayer EA. Gut feelings: the emerging biology of gut-brain communication. Nat Rev Neurosci 2011;12:453-466
    • (2011) Nat Rev Neurosci , vol.12 , pp. 453-466
    • Mayer, E.A.1
  • 2
    • 65449159712 scopus 로고    scopus 로고
    • The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease
    • Collins SM, Bercik P. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology 2009;136:2003-2014
    • (2009) Gastroenterology , vol.136 , pp. 2003-2014
    • Collins, S.M.1    Bercik, P.2
  • 3
    • 84898777631 scopus 로고    scopus 로고
    • Brain-gut microbiome interactions and functional bowel disorders
    • Mayer EA, Savidge T, Shulman RJ. Brain-gut microbiome interactions and functional bowel disorders. Gastroenterology 2014;146:1500-1512
    • (2014) Gastroenterology , vol.146 , pp. 1500-1512
    • Mayer, E.A.1    Savidge, T.2    Shulman, R.J.3
  • 5
    • 84908582347 scopus 로고    scopus 로고
    • The impact of microbiota on brain and behavior: mechanisms & therapeutic potential
    • Borre YE, Moloney RD, Clarke G, Dinan TG, Cryan JF. The impact of microbiota on brain and behavior: mechanisms & therapeutic potential. Adv Exp Med Biol 2014;817:373-403
    • (2014) Adv Exp Med Biol , vol.817 , pp. 373-403
    • Borre, Y.E.1    Moloney, R.D.2    Clarke, G.3    Dinan, T.G.4    Cryan, J.F.5
  • 6
    • 84870548338 scopus 로고    scopus 로고
    • Communication between gastrointestinal bacteria and the nervous system
    • Bravo JA, Julio-Pieper M, Forsythe P, et al. Communication between gastrointestinal bacteria and the nervous system. Curr Opin Pharmacol 2012;12:667-672
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 667-672
    • Bravo, J.A.1    Julio-Pieper, M.2    Forsythe, P.3
  • 7
    • 84867845255 scopus 로고    scopus 로고
    • The interplay between the intestinal microbiota and the brain
    • Collins SM, Surette M, Bercik P. The interplay between the intestinal microbiota and the brain. Nat Rev Microbiol 2012;10:735-742
    • (2012) Nat Rev Microbiol , vol.10 , pp. 735-742
    • Collins, S.M.1    Surette, M.2    Bercik, P.3
  • 8
    • 84866546211 scopus 로고    scopus 로고
    • Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
    • Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 2012;13:701-712
    • (2012) Nat Rev Neurosci , vol.13 , pp. 701-712
    • Cryan, J.F.1    Dinan, T.G.2
  • 9
    • 79551694651 scopus 로고    scopus 로고
    • The microbiome-gut-brain axis: from bowel to behavior
    • Cryan JF, O'Mahony SM. The microbiome-gut-brain axis: from bowel to behavior. Neurogastroenterol Motil 2011;23:187-192
    • (2011) Neurogastroenterol Motil , vol.23 , pp. 187-192
    • Cryan, J.F.1    O'Mahony, S.M.2
  • 11
    • 67650333217 scopus 로고    scopus 로고
    • Principles and clinical implications of the brain-gut-enteric microbiota axis
    • Rhee SH, Pothoulakis C, Mayer EA. Principles and clinical implications of the brain-gut-enteric microbiota axis. Nat Rev Gastroenterol Hepatol 2009;6:306-314
    • (2009) Nat Rev Gastroenterol Hepatol , vol.6 , pp. 306-314
    • Rhee, S.H.1    Pothoulakis, C.2    Mayer, E.A.3
  • 13
    • 84875150368 scopus 로고    scopus 로고
    • Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months
    • Azad MB, Konya T, Maughan H, et al. Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. CMAJ 2013;185:385-394
    • (2013) CMAJ , vol.185 , pp. 385-394
    • Azad, M.B.1    Konya, T.2    Maughan, H.3
  • 14
    • 77955386857 scopus 로고    scopus 로고
    • Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns
    • Dominguez-Bello MG, Costello EK, Contreras M, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA 2010;107: 11971-11975
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11971-11975
    • Dominguez-Bello, M.G.1    Costello, E.K.2    Contreras, M.3
  • 15
    • 33748415364 scopus 로고    scopus 로고
    • Factors influencing the composition of the intestinal microbiota in early infancy
    • Penders J, Thijs C, Vink C, et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 2006;118:511-521
    • (2006) Pediatrics , vol.118 , pp. 511-521
    • Penders, J.1    Thijs, C.2    Vink, C.3
  • 16
    • 79952742717 scopus 로고    scopus 로고
    • Human milk glycobiome and its impact on the infant gastrointestinal microbiota
    • Zivkovic AM, German JB, Lebrilla CB, Mills DA. Human milk glycobiome and its impact on the infant gastrointestinal microbiota. Proc Natl Acad Sci USA 2011;108(suppl 1):4653-4658
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4653-4658
    • Zivkovic, A.M.1    German, J.B.2    Lebrilla, C.B.3    Mills, D.A.4
  • 18
    • 84871776844 scopus 로고    scopus 로고
    • The intestinal microbiome, probiotics and prebiotics in neurogastroenterology
    • Saulnier DM, Ringel Y, Heyman MB, et al. The intestinal microbiome, probiotics and prebiotics in neurogastroenterology. Gut Microbes 2013;4:17-27
    • (2013) Gut Microbes , vol.4 , pp. 17-27
    • Saulnier, D.M.1    Ringel, Y.2    Heyman, M.B.3
  • 20
    • 84905042357 scopus 로고    scopus 로고
    • Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour
    • Clarke G, O'Mahony SM, Dinan TG, Cryan JF. Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour. Acta Paediatr 2014;103:812-819
    • (2014) Acta Paediatr , vol.103 , pp. 812-819
    • Clarke, G.1    O'Mahony, S.M.2    Dinan, T.G.3    Cryan, J.F.4
  • 21
    • 62649151803 scopus 로고    scopus 로고
    • Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
    • WikoffWR, Anfora AT, Liu J, et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci USA 2009;106:3698-3703
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 3698-3703
    • Wikoff, W.R.1    Anfora, A.T.2    Liu, J.3
  • 22
    • 0030772344 scopus 로고    scopus 로고
    • Serotonin promotes the differentiation of glutamate neurons in organotypic slice cultures of the developing cerebral cortex
    • Lavdas AA, Blue ME, Lincoln J, Parnavelas JG. Serotonin promotes the differentiation of glutamate neurons in organotypic slice cultures of the developing cerebral cortex. J Neurosci 1997;17:7872-7880
    • (1997) J Neurosci , vol.17 , pp. 7872-7880
    • Lavdas, A.A.1    Blue, M.E.2    Lincoln, J.3    Parnavelas, J.G.4
  • 23
    • 68549123001 scopus 로고    scopus 로고
    • 5-HT4 receptormediated neuroprotection and neurogenesis in the enteric nervous system of adult mice
    • Liu MT, Kuan YH, Wang J, Hen R, Gershon MD. 5-HT4 receptormediated neuroprotection and neurogenesis in the enteric nervous system of adult mice. J Neurosci 2009;29:9683-9699
    • (2009) J Neurosci , vol.29 , pp. 9683-9699
    • Liu, M.T.1    Kuan, Y.H.2    Wang, J.3    Hen, R.4    Gershon, M.D.5
  • 25
    • 33646265743 scopus 로고    scopus 로고
    • The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota
    • Liévin-Le Moal V, Servin AL. The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota. Clin Microbiol Rev 2006;19:315-337
    • (2006) Clin Microbiol Rev , vol.19 , pp. 315-337
    • Liévin-Le Moal, V.1    Servin, A.L.2
  • 26
    • 77951468091 scopus 로고    scopus 로고
    • Multiple facets of intestinal permeability and epithelial handling of dietary antigens
    • Ménard S, Cerf-Bensussan N, Heyman M. Multiple facets of intestinal permeability and epithelial handling of dietary antigens. Mucosal Immunol 2010;3:247-259
    • (2010) Mucosal Immunol , vol.3 , pp. 247-259
    • Ménard, S.1    Cerf-Bensussan, N.2    Heyman, M.3
  • 27
    • 79954919685 scopus 로고    scopus 로고
    • Roadblocks in the gut: barriers to enteric infection
    • Gill N, Wlodarska M, Finlay BB. Roadblocks in the gut: barriers to enteric infection. Cell Microbiol 2011;13:660-669
    • (2011) Cell Microbiol , vol.13 , pp. 660-669
    • Gill, N.1    Wlodarska, M.2    Finlay, B.B.3
  • 28
    • 84888217565 scopus 로고    scopus 로고
    • Microbial endocrinology in the microbiome-gut-brain axis: how bacterial production and utilization of neurochemicals influence behavior
    • Lyte M. Microbial endocrinology in the microbiome-gut-brain axis: how bacterial production and utilization of neurochemicals influence behavior. PLoS Pathog 2013;9:e1003726
    • (2013) PLoS Pathog , vol.9
    • Lyte, M.1
  • 29
    • 0024204607 scopus 로고
    • Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers
    • Hecht G, Pothoulakis C, LaMont JT, Madara JL. Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers. J Clin Invest 1988;82:1516-1524
    • (1988) J Clin Invest , vol.82 , pp. 1516-1524
    • Hecht, G.1    Pothoulakis, C.2    LaMont, J.T.3    Madara, J.L.4
  • 30
    • 43349107838 scopus 로고    scopus 로고
    • Effect of Lactobacillus plantarum enteral feeding on the gut permeability and septic complications in the patients with acute pancreatitis
    • Qin HL, Zheng JJ, Tong DN, et al. Effect of Lactobacillus plantarum enteral feeding on the gut permeability and septic complications in the patients with acute pancreatitis. Eur J Clin Nutr 2008;62:923-930
    • (2008) Eur J Clin Nutr , vol.62 , pp. 923-930
    • Qin, H.L.1    Zheng, J.J.2    Tong, D.N.3
  • 31
    • 33846894974 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair
    • Zyrek AA, Cichon C, Helms S, Enders C, Sonnenborn U, Schmidt MA. Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair. Cell Microbiol 2007;9:804-816
    • (2007) Cell Microbiol , vol.9 , pp. 804-816
    • Zyrek, A.A.1    Cichon, C.2    Helms, S.3    Enders, C.4    Sonnenborn, U.5    Schmidt, M.A.6
  • 32
    • 84855987758 scopus 로고    scopus 로고
    • Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function
    • Patel RM, Myers LS, Kurundkar AR, Maheshwari A, Nusrat A, Lin PW. Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function. Am J Pathol 2012;180:626-635
    • (2012) Am J Pathol , vol.180 , pp. 626-635
    • Patel, R.M.1    Myers, L.S.2    Kurundkar, A.R.3    Maheshwari, A.4    Nusrat, A.5    Lin, P.W.6
  • 33
    • 55849134077 scopus 로고    scopus 로고
    • The probiotic Lactobacillus GG may augment intestinal host defense by regulating apoptosis and promoting cytoprotective responses in the developing murine gut
    • Lin PW, Nasr TR, Berardinelli AJ, Kumar A, Neish AS. The probiotic Lactobacillus GG may augment intestinal host defense by regulating apoptosis and promoting cytoprotective responses in the developing murine gut. Pediatr Res 2008;64:511-516
    • (2008) Pediatr Res , vol.64 , pp. 511-516
    • Lin, P.W.1    Nasr, T.R.2    Berardinelli, A.J.3    Kumar, A.4    Neish, A.S.5
  • 34
    • 84866914800 scopus 로고    scopus 로고
    • Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunction
    • Dicksved J, Schreiber O, Willing B, et al. Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunction. PLoS One 2012;7:e46399
    • (2012) PLoS One , vol.7
    • Dicksved, J.1    Schreiber, O.2    Willing, B.3
  • 35
    • 44949153787 scopus 로고    scopus 로고
    • Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity
    • Ukena SN, Singh A, Dringenberg U, et al. Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity. PLoS One 2007;2:e1308
    • (2007) PLoS One , vol.2
    • Ukena, S.N.1    Singh, A.2    Dringenberg, U.3
  • 36
    • 65249099918 scopus 로고    scopus 로고
    • Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
    • Cani PD, Possemiers S, Van de Wiele T, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 2009;58:1091-1103
    • (2009) Gut , vol.58 , pp. 1091-1103
    • Cani, P.D.1    Possemiers, S.2    Van de Wiele, T.3
  • 37
    • 84855174006 scopus 로고    scopus 로고
    • Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice
    • Caricilli AM, Picardi PK, de Abreu LL, et al. Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. PLoS Biol 2011;9:e1001212
    • (2011) PLoS Biol , vol.9
    • Caricilli, A.M.1    Picardi, P.K.2    de Abreu, L.L.3
  • 38
    • 48049084135 scopus 로고    scopus 로고
    • The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression
    • Maes M. The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression. Neuro Endocrinol Lett 2008;29:287-291
    • (2008) Neuro Endocrinol Lett , vol.29 , pp. 287-291
    • Maes, M.1
  • 39
    • 47249141324 scopus 로고    scopus 로고
    • Pathophysiological mechanisms of stress-induced intestinal damage
    • Gareau MG, Silva MA, Perdue MH. Pathophysiological mechanisms of stress-induced intestinal damage. Curr Mol Med 2008;8:274-281
    • (2008) Curr Mol Med , vol.8 , pp. 274-281
    • Gareau, M.G.1    Silva, M.A.2    Perdue, M.H.3
  • 40
    • 6344294887 scopus 로고    scopus 로고
    • Vagal afferent input from the acid-challenged rat stomach to the brainstem: enhancement by interleukin-1beta
    • Holzer P, Danzer M, Schicho R, Samberger C, Painsipp E, Lippe IT. Vagal afferent input from the acid-challenged rat stomach to the brainstem: enhancement by interleukin-1beta. Neuroscience 2004;129:439-445
    • (2004) Neuroscience , vol.129 , pp. 439-445
    • Holzer, P.1    Danzer, M.2    Schicho, R.3    Samberger, C.4    Painsipp, E.5    Lippe, I.T.6
  • 41
    • 75649093343 scopus 로고    scopus 로고
    • Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
    • Abreu MT. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol 2010;10:131-144
    • (2010) Nat Rev Immunol , vol.10 , pp. 131-144
    • Abreu, M.T.1
  • 42
    • 70449730854 scopus 로고    scopus 로고
    • Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia
    • Barajon I, Serrao G, Arnaboldi F, et al. Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia. J Histochem Cytochem 2009;57:1013-1023
    • (2009) J Histochem Cytochem , vol.57 , pp. 1013-1023
    • Barajon, I.1    Serrao, G.2    Arnaboldi, F.3
  • 43
    • 84866677472 scopus 로고    scopus 로고
    • Gut microbial products regulate murine gastrointestinal motility via Tolllike receptor 4 signaling
    • Anitha M, Vijay-Kumar M, Sitaraman SV, Gewirtz AT, Srinivasan S. Gut microbial products regulate murine gastrointestinal motility via Tolllike receptor 4 signaling. Gastroenterology 2012;143:1006-1016, e4
    • (2012) Gastroenterology , vol.143 , pp. 1006-1016
    • Anitha, M.1    Vijay-Kumar, M.2    Sitaraman, S.V.3    Gewirtz, A.T.4    Srinivasan, S.5
  • 44
    • 67849102209 scopus 로고    scopus 로고
    • Toll-like receptors in the CNS: implications for neurodegeneration and repair
    • van Noort JM, Bsibsi M. Toll-like receptors in the CNS: implications for neurodegeneration and repair. Prog Brain Res 2009;175:139-148
    • (2009) Prog Brain Res , vol.175 , pp. 139-148
    • van Noort, J.M.1    Bsibsi, M.2
  • 45
    • 0028066768 scopus 로고
    • Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine
    • Saunders PR, Kosecka U, McKay DM, Perdue MH. Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine. Am J Physiol 1994;267(5 Pt 1):G794-G799
    • (1994) Am J Physiol , vol.267 , Issue.5 , pp. G794-G799
    • Saunders, P.R.1    Kosecka, U.2    McKay, D.M.3    Perdue, M.H.4
  • 46
    • 0023224993 scopus 로고
    • Effect of psychological stress on salt and wa ter transport in the human jejunum
    • Barclay GR, Turnberg LA. Effect of psychological stress on salt and wa ter transport in the human jejunum. Gastroenterology 1987;93:91-97
    • (1987) Gastroenterology , vol.93 , pp. 91-97
    • Barclay, G.R.1    Turnberg, L.A.2
  • 47
    • 0023932010 scopus 로고
    • Effect of cold-induced pain on salt and water transport in the human jejunum
    • Barclay GR, Turnberg LA. Effect of cold-induced pain on salt and water transport in the human jejunum. Gastroenterology 1988;94:994-998
    • (1988) Gastroenterology , vol.94 , pp. 994-998
    • Barclay, G.R.1    Turnberg, L.A.2
  • 49
    • 79959831052 scopus 로고    scopus 로고
    • Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress
    • Vicario M, Guilarte M, Alonso C, et al. Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress. Brain Behav Immun 2010;24: 1166-1175
    • (2010) Brain Behav Immun , vol.24 , pp. 1166-1175
    • Vicario, M.1    Guilarte, M.2    Alonso, C.3
  • 50
    • 0033774021 scopus 로고    scopus 로고
    • Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat
    • Meddings JB, Swain MG. Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat. Gastroenterology 2000;119:1019-1028
    • (2000) Gastroenterology , vol.119 , pp. 1019-1028
    • Meddings, J.B.1    Swain, M.G.2
  • 51
    • 0036145259 scopus 로고    scopus 로고
    • Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH
    • Saunders PR, Santos J, Hanssen NP, Yates D, Groot JA, Perdue MH. Physical and psychological stress in rats enhances colonic epithelial permeability via peripheral CRH. Dig Dis Sci 2002;47:208-215
    • (2002) Dig Dis Sci , vol.47 , pp. 208-215
    • Saunders, P.R.1    Santos, J.2    Hanssen, N.P.3    Yates, D.4    Groot, J.A.5    Perdue, M.H.6
  • 52
    • 0042324629 scopus 로고    scopus 로고
    • Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in mice
    • Ferrier L, Mazelin L, Cenac N, et al. Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in mice. Gastroenterology 2003;125:795-804
    • (2003) Gastroenterology , vol.125 , pp. 795-804
    • Ferrier, L.1    Mazelin, L.2    Cenac, N.3
  • 53
    • 38349087186 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro
    • Wallon C, Yang PC, Keita AV, et al. Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro. Gut 2008;57:50-58
    • (2008) Gut , vol.57 , pp. 50-58
    • Wallon, C.1    Yang, P.C.2    Keita, A.V.3
  • 54
    • 84904052767 scopus 로고    scopus 로고
    • Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism
    • Vanuytsel T, van Wanrooy S, Vanheel H, et al. Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut 2014;63:1293-1299
    • (2014) Gut , vol.63 , pp. 1293-1299
    • Vanuytsel, T.1    van Wanrooy, S.2    Vanheel, H.3
  • 55
    • 0031765616 scopus 로고    scopus 로고
    • Stress stimulates transepithelial macromolecular uptake in rat jejunum
    • Kiliaan AJ, Saunders PR, Bijlsma PB, et al. Stress stimulates transepithelial macromolecular uptake in rat jejunum. Am J Physiol 1998;275(5 Pt 1):G1037-G1044
    • (1998) Am J Physiol , vol.275 , Issue.5 , pp. G1037-G1044
    • Kiliaan, A.J.1    Saunders, P.R.2    Bijlsma, P.B.3
  • 56
    • 1642354455 scopus 로고    scopus 로고
    • Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats
    • Velin AK, Ericson AC, Braaf Y, Wallon C, Soderholm JD. Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats. Gut 2004;53:494-500
    • (2004) Gut , vol.53 , pp. 494-500
    • Velin, A.K.1    Ericson, A.C.2    Braaf, Y.3    Wallon, C.4    Soderholm, J.D.5
  • 57
    • 0033191047 scopus 로고    scopus 로고
    • Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys
    • Bailey MT, Coe CL. Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys. Dev Psychobiol 1999;35:146-155
    • (1999) Dev Psychobiol , vol.35 , pp. 146-155
    • Bailey, M.T.1    Coe, C.L.2
  • 58
    • 79551681952 scopus 로고    scopus 로고
    • Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation
    • Bailey MT, Dowd SE, Galley JD, Hufnagle AR, Allen RG, Lyte M. Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav Immun 2011;25:397-407
    • (2011) Brain Behav Immun , vol.25 , pp. 397-407
    • Bailey, M.T.1    Dowd, S.E.2    Galley, J.D.3    Hufnagle, A.R.4    Allen, R.G.5    Lyte, M.6
  • 59
    • 35648944209 scopus 로고    scopus 로고
    • Role of probiotics in correcting abnormalities of colonic flora induced by stress
    • Eutamene H, Bueno L. Role of probiotics in correcting abnormalities of colonic flora induced by stress. Gut 2007;56:1495-1497
    • (2007) Gut , vol.56 , pp. 1495-1497
    • Eutamene, H.1    Bueno, L.2
  • 60
    • 34547111846 scopus 로고    scopus 로고
    • Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation
    • Gareau MG, Jury J, MacQueen G, Sherman PM, Perdue MH. Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation. Gut 2007;56:1522-1528
    • (2007) Gut , vol.56 , pp. 1522-1528
    • Gareau, M.G.1    Jury, J.2    MacQueen, G.3    Sherman, P.M.4    Perdue, M.H.5
  • 61
    • 84908152766 scopus 로고    scopus 로고
    • Altered brain-gut axis in autism: comorbidity or causative mechanisms?
    • Mayer EA, Padua D, Tillisch K. Altered brain-gut axis in autism: comorbidity or causative mechanisms? Bioessays 2014;36:933-939
    • (2014) Bioessays , vol.36 , pp. 933-939
    • Mayer, E.A.1    Padua, D.2    Tillisch, K.3
  • 65
    • 84867616398 scopus 로고    scopus 로고
    • High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway
    • Kim KA, Gu W, Lee IA, Joh EH, Kim DH. High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway. PLoS One 2012;7:e47713
    • (2012) PLoS One , vol.7
    • Kim, K.A.1    Gu, W.2    Lee, I.A.3    Joh, E.H.4    Kim, D.H.5
  • 66
    • 84857369969 scopus 로고    scopus 로고
    • Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome
    • Maes M, Twisk FN, Kubera M, Ringel K, Leunis JC, Geffard M. Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome. J Affect Disord 2012;136:909-917
    • (2012) J Affect Disord , vol.136 , pp. 909-917
    • Maes, M.1    Twisk, F.N.2    Kubera, M.3    Ringel, K.4    Leunis, J.C.5    Geffard, M.6
  • 67
    • 35148896954 scopus 로고    scopus 로고
    • Phagocyte-derived catecholamines enhance acute inflammatory injury
    • Flierl MA, Rittirsch D, Nadeau BA, et al. Phagocyte-derived catecholamines enhance acute inflammatory injury. Nature 2007;449:721-725
    • (2007) Nature , vol.449 , pp. 721-725
    • Flierl, M.A.1    Rittirsch, D.2    Nadeau, B.A.3
  • 68
    • 0037509909 scopus 로고    scopus 로고
    • Regulation of short-chain fatty acid production
    • Macfarlane S, Macfarlane GT. Regulation of short-chain fatty acid production. Proc Nutr Soc 2003;62:67-72
    • (2003) Proc Nutr Soc , vol.62 , pp. 67-72
    • Macfarlane, S.1    Macfarlane, G.T.2
  • 69
    • 0038363378 scopus 로고    scopus 로고
    • The Orphan G proteincoupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    • Brown AJ, Goldsworthy SM, Barnes AA, et al. The Orphan G proteincoupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 2003;278:11312-11319
    • (2003) J Biol Chem , vol.278 , pp. 11312-11319
    • Brown, A.J.1    Goldsworthy, S.M.2    Barnes, A.A.3
  • 70
    • 84878579044 scopus 로고    scopus 로고
    • The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
    • Kimura I, Ozawa K, Inoue D, et al. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun 2013;4:1829
    • (2013) Nat Commun , vol.4 , pp. 1829
    • Kimura, I.1    Ozawa, K.2    Inoue, D.3
  • 71
    • 0742305675 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41
    • Xiong Y, Miyamoto N, Shibata K, et al. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci USA 2004;101:1045-1050
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1045-1050
    • Xiong, Y.1    Miyamoto, N.2    Shibata, K.3
  • 72
    • 84880620577 scopus 로고    scopus 로고
    • Shortchain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice
    • e1-e10
    • Kim MH, Kang SG, Park JH, Yanagisawa M, Kim CH. Shortchain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology 2013;145:396-406, e1-e10
    • (2013) Gastroenterology , vol.145 , pp. 396-406
    • Kim, M.H.1    Kang, S.G.2    Park, J.H.3    Yanagisawa, M.4    Kim, C.H.5
  • 73
    • 0036715032 scopus 로고    scopus 로고
    • Effects of short-chain fatty acid-supplemented total parenteral nutrition on intestinal pro-inflammatory cytokine abundance
    • Milo LA, Reardon KA, Tappenden KA. Effects of short-chain fatty acid-supplemented total parenteral nutrition on intestinal pro-inflammatory cytokine abundance. Dig Dis Sci 2002;47:2049-2055
    • (2002) Dig Dis Sci , vol.47 , pp. 2049-2055
    • Milo, L.A.1    Reardon, K.A.2    Tappenden, K.A.3
  • 74
    • 79956348319 scopus 로고    scopus 로고
    • Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)
    • Kimura I, Inoue D, Maeda T, et al. Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41). Proc Natl Acad Sci USA 2011;108:8030-8035
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 8030-8035
    • Kimura, I.1    Inoue, D.2    Maeda, T.3
  • 75
    • 84899892790 scopus 로고    scopus 로고
    • The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism
    • Frost G, Sleeth ML, Sahuri-Arisoylu M, et al. The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nat Commun 2014;5:3611
    • (2014) Nat Commun , vol.5 , pp. 3611
    • Frost, G.1    Sleeth, M.L.2    Sahuri-Arisoylu, M.3
  • 76
    • 79954988524 scopus 로고    scopus 로고
    • Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells
    • Mitchell RW, On NH, Del Bigio MR, Miller DW, Hatch GM. Fatty acid transport protein expression in human brain and potential role in fatty acid transport across human brain microvessel endothelial cells. J Neurochem 2011;117:735-746
    • (2011) J Neurochem , vol.117 , pp. 735-746
    • Mitchell, R.W.1    On, N.H.2    Del Bigio, M.R.3    Miller, D.W.4    Hatch, G.M.5
  • 77
    • 27844586830 scopus 로고    scopus 로고
    • Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway
    • DeCastro M, Nankova BB, Shah P, et al. Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway. Brain Res Mol Brain Res 2005;142:28-38
    • (2005) Brain Res Mol Brain Res , vol.142 , pp. 28-38
    • DeCastro, M.1    Nankova, B.B.2    Shah, P.3
  • 78
    • 79551713705 scopus 로고    scopus 로고
    • Reduced anxiety-like behavior and central neurochemical change in germ-free mice
    • Neufeld KM, Kang N, Bienenstock J, Foster JA. Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil 2011;23:255-264, e119
    • (2011) Neurogastroenterol Motil , vol.23 , pp. 255-264
    • Neufeld, K.M.1    Kang, N.2    Bienenstock, J.3    Foster, J.A.4
  • 79
    • 84878241830 scopus 로고    scopus 로고
    • The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sexdependent manner
    • Clarke G, Grenham S, Scully P, et al. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sexdependent manner. Mol Psychiatry 2013;18:666-673
    • (2013) Mol Psychiatry , vol.18 , pp. 666-673
    • Clarke, G.1    Grenham, S.2    Scully, P.3
  • 80
    • 84927131694 scopus 로고    scopus 로고
    • Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
    • Yano JM, Yu K, Donaldson GP, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell 2015;161:264-276
    • (2015) Cell , vol.161 , pp. 264-276
    • Yano, J.M.1    Yu, K.2    Donaldson, G.P.3
  • 81
    • 84879367045 scopus 로고    scopus 로고
    • The histaminergic network in the brain: basic organization and role in disease
    • Panula P, Nuutinen S. The histaminergic network in the brain: basic organization and role in disease. Nat Rev Neurosci 2013;14:472-487
    • (2013) Nat Rev Neurosci , vol.14 , pp. 472-487
    • Panula, P.1    Nuutinen, S.2
  • 82
    • 84857469966 scopus 로고    scopus 로고
    • Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling
    • Thomas CM, Hong T, van Pijkeren JP, et al. Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. PLoS One 2012;7:e31951
    • (2012) PLoS One , vol.7
    • Thomas, C.M.1    Hong, T.2    van Pijkeren, J.P.3
  • 83
    • 63649111659 scopus 로고    scopus 로고
    • Amino acids: metabolism, functions, and nutrition
    • Wu G. Amino acids: metabolism, functions, and nutrition. Amino Acids 2009;37:1-17
    • (2009) Amino Acids , vol.37 , pp. 1-17
    • Wu, G.1
  • 85
    • 53049087266 scopus 로고    scopus 로고
    • The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat
    • Desbonnet L, Garrett L, Clarke G, Bienenstock J, Dinan TG. The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat. J Psychiatr Res 2008;43:164-174
    • (2008) J Psychiatr Res , vol.43 , pp. 164-174
    • Desbonnet, L.1    Garrett, L.2    Clarke, G.3    Bienenstock, J.4    Dinan, T.G.5
  • 86
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • Tremaroli V, BäckhedF. Functional interactions between the gut microbiota and host metabolism. Nature 2012;489:242-249
    • (2012) Nature , vol.489 , pp. 242-249
    • Tremaroli, V.1    Bäckhed, F.2
  • 87
    • 84861978076 scopus 로고    scopus 로고
    • Host-gut microbiota metabolic interactions
    • Nicholson JK, Holmes E, Kinross J, et al. Host-gut microbiota metabolic interactions. Science 2012;336:1262-1267
    • (2012) Science , vol.336 , pp. 1262-1267
    • Nicholson, J.K.1    Holmes, E.2    Kinross, J.3
  • 88
    • 20444374493 scopus 로고    scopus 로고
    • Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni
    • Goehler LE, Gaykema RP, Opitz N, Reddaway R, Badr N, Lyte M. Activation in vagal afferents and central autonomic pathways: early responses to intestinal infection with Campylobacter jejuni. Brain Behav Immun 2005;19:334-344
    • (2005) Brain Behav Immun , vol.19 , pp. 334-344
    • Goehler, L.E.1    Gaykema, R.P.2    Opitz, N.3    Reddaway, R.4    Badr, N.5    Lyte, M.6
  • 89
    • 81855194317 scopus 로고    scopus 로고
    • The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication
    • Bercik P, Park AJ, Sinclair D, et al. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol Motil 2011;23:1132-1139
    • (2011) Neurogastroenterol Motil , vol.23 , pp. 1132-1139
    • Bercik, P.1    Park, A.J.2    Sinclair, D.3
  • 90
    • 80052965474 scopus 로고    scopus 로고
    • Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
    • Bravo JA, Forsythe P, Chew MV, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA 2011;108:16050-16055
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16050-16055
    • Bravo, J.A.1    Forsythe, P.2    Chew, M.V.3
  • 91
    • 0028245198 scopus 로고
    • Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism
    • Bluthe RM, Walter V, Parnet P, et al. Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism. C R Acad Sci III 1994;317:499-503
    • (1994) C R Acad Sci III , vol.317 , pp. 499-503
    • Bluthe, R.M.1    Walter, V.2    Parnet, P.3
  • 92
    • 0029012168 scopus 로고
    • Subdiaphragmatic vagotomy blocks induction of IL-1 beta mRNA in mice brain in response to peripheral LPS
    • Laye S, Bluthé RM, Kent S, et al. Subdiaphragmatic vagotomy blocks induction of IL-1 beta mRNA in mice brain in response to peripheral LPS. Am J Physiol 1995;268(5 Pt 2):R1327-R1331
    • (1995) Am J Physiol , vol.268 , Issue.5 , pp. R1327-R1331
    • Laye, S.1    Bluthé, R.M.2    Kent, S.3
  • 93
    • 0034695185 scopus 로고    scopus 로고
    • Vagotomy attenuates the behavioural but not the pyrogenic effects of interleukin-1 in rats
    • Luheshi GN, Bluthé RM, Rushforth D, et al. Vagotomy attenuates the behavioural but not the pyrogenic effects of interleukin-1 in rats. Auton Neurosci 2000;85:127-132
    • (2000) Auton Neurosci , vol.85 , pp. 127-132
    • Luheshi, G.N.1    Bluthé, R.M.2    Rushforth, D.3
  • 94
    • 0034502517 scopus 로고    scopus 로고
    • The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis
    • Konsman JP, Luheshi GN, Bluthé RM, Dantzer R. The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis. Eur J Neurosci 2000;12:4434-4446
    • (2000) Eur J Neurosci , vol.12 , pp. 4434-4446
    • Konsman, J.P.1    Luheshi, G.N.2    Bluthé, R.M.3    Dantzer, R.4
  • 95
    • 78149501207 scopus 로고    scopus 로고
    • Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice
    • Bercik P, Verdu EF, Foster JA, et al. Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice. Gastroenterology 2010;139:2102-2112, e1
    • (2010) Gastroenterology , vol.139 , pp. 2102-2112
    • Bercik, P.1    Verdu, E.F.2    Foster, J.A.3
  • 96
    • 4043161248 scopus 로고    scopus 로고
    • Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice
    • Sudo N, Chida Y, Aiba Y, et al. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol 2004;558(Pt 1):263-275
    • (2004) J Physiol , vol.558 , pp. 263-275
    • Sudo, N.1    Chida, Y.2    Aiba, Y.3
  • 97
    • 84897834610 scopus 로고    scopus 로고
    • Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease
    • Zeissig S, Blumberg RS. Life at the beginning: perturbation of the microbiota by antibiotics in early life and its role in health and disease. Nat Immunol 2014;15:307-310
    • (2014) Nat Immunol , vol.15 , pp. 307-310
    • Zeissig, S.1    Blumberg, R.S.2
  • 98
    • 84877803915 scopus 로고    scopus 로고
    • Ingestion of Mycobacterium vaccae decreases anxiety-related behavior and improves learning in mice
    • Matthews DM, Jenks SM. Ingestion of Mycobacterium vaccae decreases anxiety-related behavior and improves learning in mice. Behav Processes 2013;96:27-35
    • (2013) Behav Processes , vol.96 , pp. 27-35
    • Matthews, D.M.1    Jenks, S.M.2
  • 99
    • 84895864348 scopus 로고    scopus 로고
    • Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats
    • Crumeyrolle-Arias M, Jaglin M, Bruneau A, et al. Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats. Psychoneuroendocrinology 2014;42:207-217
    • (2014) Psychoneuroendocrinology , vol.42 , pp. 207-217
    • Crumeyrolle-Arias, M.1    Jaglin, M.2    Bruneau, A.3
  • 100
    • 34249998928 scopus 로고    scopus 로고
    • Long-term behavioural and molecular alterations associated with maternal separation in rats
    • Lippmann M, Bress A, NemeroffCB, Plotsky PM, Monteggia LM. Long-term behavioural and molecular alterations associated with maternal separation in rats. Eur J Neurosci 2007;25:3091-3098
    • (2007) Eur J Neurosci , vol.25 , pp. 3091-3098
    • Lippmann, M.1    Bress, A.2    Nemeroff, C.B.3    Plotsky, P.M.4    Monteggia, L.M.5
  • 102
    • 58149291318 scopus 로고    scopus 로고
    • Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses
    • O'Mahony SM, Marchesi JR, Scully P, et al. Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses. Biol Psychiatry 2009;65:263-267
    • (2009) Biol Psychiatry , vol.65 , pp. 263-267
    • O'Mahony, S.M.1    Marchesi, J.R.2    Scully, P.3
  • 103
    • 38649118544 scopus 로고    scopus 로고
    • Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: possible anatomical substrates for viscerosensory modulation of exploratory behavior
    • Goehler LE, Park SM, Opitz N, Lyte M, Gaykema RP. Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: possible anatomical substrates for viscerosensory modulation of exploratory behavior. Brain Behav Immun 2008;22:354-366
    • (2008) Brain Behav Immun , vol.22 , pp. 354-366
    • Goehler, L.E.1    Park, S.M.2    Opitz, N.3    Lyte, M.4    Gaykema, R.P.5
  • 104
    • 0032144624 scopus 로고    scopus 로고
    • Anxiogenic effect of subclinical bacterial infection in mice in the absence of overt immune activation
    • Lyte M, Varcoe JJ, Bailey MT. Anxiogenic effect of subclinical bacterial infection in mice in the absence of overt immune activation. Physiol Behav 1998;65:63-68
    • (1998) Physiol Behav , vol.65 , pp. 63-68
    • Lyte, M.1    Varcoe, J.J.2    Bailey, M.T.3
  • 105
    • 85046980563 scopus 로고    scopus 로고
    • Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers
    • Messaoudi M, Violle N, Bisson JF, Desor D, Javelot H, Rougeot C. Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes 2011;2:256-261
    • (2011) Gut Microbes , vol.2 , pp. 256-261
    • Messaoudi, M.1    Violle, N.2    Bisson, J.F.3    Desor, D.4    Javelot, H.5    Rougeot, C.6
  • 106
    • 80051535923 scopus 로고    scopus 로고
    • The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice
    • 609, e1-e3
    • Bercik P, Denou E, Collins J, et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 2011;141:599-609, 609, e1-e3
    • (2011) Gastroenterology , vol.141 , pp. 599-609
    • Bercik, P.1    Denou, E.2    Collins, J.3
  • 107
    • 84881316043 scopus 로고    scopus 로고
    • Altered colonic function and microbiota profile in a mouse model of chronic depression
    • Park AJ, Collins J, Blennerhassett PA, et al. Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastroenterol Motil 2013;25:733, e575
    • (2013) Neurogastroenterol Motil , vol.25 , pp. 733
    • Park, A.J.1    Collins, J.2    Blennerhassett, P.A.3
  • 108
    • 84881295719 scopus 로고    scopus 로고
    • Melancholic microbes: a link between gut microbiota and depression?
    • Dinan TG, Cryan JF. Melancholic microbes: a link between gut microbiota and depression? Neurogastroenterol Motil 2013;25:713-719
    • (2013) Neurogastroenterol Motil , vol.25 , pp. 713-719
    • Dinan, T.G.1    Cryan, J.F.2
  • 109
  • 110
    • 84942984411 scopus 로고    scopus 로고
    • Altered fecal microbiota composition in patients with major depressive disorder
    • Jiang H, Ling Z, Zhang Y, et al. Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun 2015;48:186-194
    • (2015) Brain Behav Immun , vol.48 , pp. 186-194
    • Jiang, H.1    Ling, Z.2    Zhang, Y.3
  • 111
    • 77957142793 scopus 로고    scopus 로고
    • Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
    • Desbonnet L, Garrett L, Clarke G, Kiely B, Cryan JF, Dinan TG. Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 2010;170:1179-1188
    • (2010) Neuroscience , vol.170 , pp. 1179-1188
    • Desbonnet, L.1    Garrett, L.2    Clarke, G.3    Kiely, B.4    Cryan, J.F.5    Dinan, T.G.6
  • 112
    • 84862529501 scopus 로고    scopus 로고
    • Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model
    • Arseneault-Breard J, Rondeau I, Gilbert K, et al. Combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 reduces post-myocardial infarction depression symptoms and restores intestinal permeability in a rat model. Br J Nutr 2012;107:1793-1799
    • (2012) Br J Nutr , vol.107 , pp. 1793-1799
    • Arseneault-Breard, J.1    Rondeau, I.2    Gilbert, K.3
  • 113
    • 84872016650 scopus 로고    scopus 로고
    • Attenuation of post-myocardial infarction depression in rats by n-3 fatty acids or probiotics starting after the onset of reperfusion
    • Gilbert K, Arseneault-BréardJ, Flores Monaco F, et al. Attenuation of post-myocardial infarction depression in rats by n-3 fatty acids or probiotics starting after the onset of reperfusion. Br J Nutr 2013;109:50-56
    • (2013) Br J Nutr , vol.109 , pp. 50-56
    • Gilbert, K.1    Arseneault-Bréard, J.2    Flores Monaco, F.3
  • 114
    • 84881556812 scopus 로고    scopus 로고
    • Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration
    • Mello BS, Monte AS, McIntyre RS, et al. Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration. J Psychiatr Res 2013;47:1521-1529
    • (2013) J Psychiatr Res , vol.47 , pp. 1521-1529
    • Mello, B.S.1    Monte, A.S.2    McIntyre, R.S.3
  • 115
    • 84865583011 scopus 로고    scopus 로고
    • Novel therapeutic targets in depression: minocycline as a candidate treatment
    • Soczynska JK, Mansur RB, Brietzke E, et al. Novel therapeutic targets in depression: minocycline as a candidate treatment. Behav Brain Res 2012;235:302-317
    • (2012) Behav Brain Res , vol.235 , pp. 302-317
    • Soczynska, J.K.1    Mansur, R.B.2    Brietzke, E.3
  • 116
    • 84909606798 scopus 로고    scopus 로고
    • Microbiota-gut-brain axis and cognitive function
    • Gareau MG. Microbiota-gut-brain axis and cognitive function. Adv Exp Med Biol 2014;817:357-371
    • (2014) Adv Exp Med Biol , vol.817 , pp. 357-371
    • Gareau, M.G.1
  • 117
    • 79851494165 scopus 로고    scopus 로고
    • Bacterial infection causes stress-induced memory dysfunction in mice
    • Gareau MG, Wine E, Rodrigues DM, et al. Bacterial infection causes stress-induced memory dysfunction in mice. Gut 2011;60:307-317
    • (2011) Gut , vol.60 , pp. 307-317
    • Gareau, M.G.1    Wine, E.2    Rodrigues, D.M.3
  • 118
    • 60249084991 scopus 로고    scopus 로고
    • Memory and learning behavior in mice is temporally associated with diet-induced alterations in gut bacteria
    • Li W, Dowd SE, Scurlock B, Acosta-Martinez V, Lyte M. Memory and learning behavior in mice is temporally associated with diet-induced alterations in gut bacteria. Physiol Behav 2009;96:557-567
    • (2009) Physiol Behav , vol.96 , pp. 557-567
    • Li, W.1    Dowd, S.E.2    Scurlock, B.3    Acosta-Martinez, V.4    Lyte, M.5
  • 119
    • 23644461185 scopus 로고    scopus 로고
    • The effect of short duration streptozotocin-induced diabetes mellitus on the late phase and threshold of long-term potentiation induction in the rat
    • Kamal A, Biessels GJ, Ramakers GM, Hendrik Gispen W. The effect of short duration streptozotocin-induced diabetes mellitus on the late phase and threshold of long-term potentiation induction in the rat. Brain Res 2005;1053:126-130
    • (2005) Brain Res , vol.1053 , pp. 126-130
    • Kamal, A.1    Biessels, G.J.2    Ramakers, G.M.3    Hendrik Gispen, W.4
  • 120
    • 84876404010 scopus 로고    scopus 로고
    • Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: behavioral and electrophysiological proofs for microbiome-gut-brain axis
    • Davari S, Talaei SA, Alaei H, Salami M. Probiotics treatment improves diabetes-induced impairment of synaptic activity and cognitive function: behavioral and electrophysiological proofs for microbiome-gut-brain axis. Neuroscience 2013;240:287-296
    • (2013) Neuroscience , vol.240 , pp. 287-296
    • Davari, S.1    Talaei, S.A.2    Alaei, H.3    Salami, M.4
  • 121
    • 84878287270 scopus 로고    scopus 로고
    • Consumption of fermented milk product with probiotic modulates brain activity
    • Tillisch K, Labus J, Kilpatrick L, et al. Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology 2013;144:1394-1401, e4
    • (2013) Gastroenterology , vol.144 , pp. 1394-1401
    • Tillisch, K.1    Labus, J.2    Kilpatrick, L.3
  • 122
    • 84881023923 scopus 로고    scopus 로고
    • Discordant patterns of bacterial translocation markers and implications for innate immune imbalances in schizophrenia
    • Severance EG, Gressitt KL, Stallings CR, et al. Discordant patterns of bacterial translocation markers and implications for innate immune imbalances in schizophrenia. Schizophr Res 2013;148:130-137
    • (2013) Schizophr Res , vol.148 , pp. 130-137
    • Severance, E.G.1    Gressitt, K.L.2    Stallings, C.R.3
  • 124
    • 77956595644 scopus 로고    scopus 로고
    • Migration, ethnicity, and psychosis: toward a sociodevelopmental model
    • Morgan C, Charalambides M, Hutchinson G, Murray RM. Migration, ethnicity, and psychosis: toward a sociodevelopmental model. Schizophr Bull 2010;36:655-664
    • (2010) Schizophr Bull , vol.36 , pp. 655-664
    • Morgan, C.1    Charalambides, M.2    Hutchinson, G.3    Murray, R.M.4
  • 126
    • 84927177716 scopus 로고    scopus 로고
    • Genomics of schizophrenia: time to consider the gut microbiome?
    • Dinan TG, Borre YE, Cryan JF. Genomics of schizophrenia: time to consider the gut microbiome? Mol Psychiatry 2014;19:1252-1257
    • (2014) Mol Psychiatry , vol.19 , pp. 1252-1257
    • Dinan, T.G.1    Borre, Y.E.2    Cryan, J.F.3
  • 127
    • 84897929745 scopus 로고    scopus 로고
    • Effect of probiotic supplementation on schizophrenia symptoms and association with gastrointestinal functioning: a randomized, placebo-controlled trial
    • Dickerson FB, Stallings C, Origoni A, et al. Effect of probiotic supplementation on schizophrenia symptoms and association with gastrointestinal functioning: a randomized, placebo-controlled trial. Prim Care Companion CNS Disord 2014;16
    • (2014) Prim Care Companion CNS Disord , vol.16
    • Dickerson, F.B.1    Stallings, C.2    Origoni, A.3
  • 128
    • 84894118144 scopus 로고    scopus 로고
    • Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • Hsiao EY, McBride SW, Hsien S, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 2013;155:1451-1463
    • (2013) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1    McBride, S.W.2    Hsien, S.3
  • 129
    • 84896728399 scopus 로고    scopus 로고
    • Altered gut microbiota and activity in a murine model of autism spectrum disorders
    • de Theije CG, Wopereis H, Ramadan M, et al. Altered gut microbiota and activity in a murine model of autism spectrum disorders. Brain Behav Immun 2014;37:197-206
    • (2014) Brain Behav Immun , vol.37 , pp. 197-206
    • de Theije, C.G.1    Wopereis, H.2    Ramadan, M.3
  • 130
    • 78049463483 scopus 로고    scopus 로고
    • Effects of the enteric bacterial metabolic product propionic acid on objectdirected behavior, social behavior, cognition, and neuroinflammation in adolescent rats: relevance to autism spectrum disorder
    • MacFabe DF, Cain NE, Boon F, Ossenkopp KP, Cain DP. Effects of the enteric bacterial metabolic product propionic acid on objectdirected behavior, social behavior, cognition, and neuroinflammation in adolescent rats: relevance to autism spectrum disorder. Behav Brain Res 2011;217:47-54
    • (2011) Behav Brain Res , vol.217 , pp. 47-54
    • MacFabe, D.F.1    Cain, N.E.2    Boon, F.3    Ossenkopp, K.P.4    Cain, D.P.5
  • 131
    • 84863094856 scopus 로고    scopus 로고
    • The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders
    • Thomas RH, Meeking MM, Mepham JR, et al. The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders. J Neuroinflammation 2012;9:153
    • (2012) J Neuroinflammation , vol.9 , pp. 153
    • Thomas, R.H.1    Meeking, M.M.2    Mepham, J.R.3
  • 132
    • 62649112890 scopus 로고    scopus 로고
    • Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism
    • Shultz SR, Macfabe DF, Martin S, et al. Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism. Behav Brain Res 2009;200:33-41
    • (2009) Behav Brain Res , vol.200 , pp. 33-41
    • Shultz, S.R.1    Macfabe, D.F.2    Martin, S.3
  • 133
    • 41949122947 scopus 로고    scopus 로고
    • Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism
    • Shultz SR, MacFabe DF, Ossenkopp KP, et al. Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism. Neuropharmacology 2008;54:901-911
    • (2008) Neuropharmacology , vol.54 , pp. 901-911
    • Shultz, S.R.1    MacFabe, D.F.2    Ossenkopp, K.P.3
  • 134
    • 77956057409 scopus 로고    scopus 로고
    • Pyrosequencing study of fecal microflora of autistic and control children
    • Finegold SM, Dowd SE, Gontcharova V, et al. Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe 2010;16:444-453
    • (2010) Anaerobe , vol.16 , pp. 444-453
    • Finegold, S.M.1    Dowd, S.E.2    Gontcharova, V.3
  • 135
    • 25844467765 scopus 로고    scopus 로고
    • Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children
    • Parracho HM, Bingham MO, Gibson GR, McCartney AL. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol 2005;54(Pt 1): 987-991
    • (2005) J Med Microbiol , vol.54 , pp. 987-991
    • Parracho, H.M.1    Bingham, M.O.2    Gibson, G.R.3    McCartney, A.L.4
  • 136
    • 8744264007 scopus 로고    scopus 로고
    • Real-time PCR quantitation of clostridia in feces of autistic children
    • Song Y, Liu C, Finegold SM. Real-time PCR quantitation of clostridia in feces of autistic children. Appl Environ Microbiol 2004;70:6459-6465
    • (2004) Appl Environ Microbiol , vol.70 , pp. 6459-6465
    • Song, Y.1    Liu, C.2    Finegold, S.M.3
  • 137
    • 84870884483 scopus 로고    scopus 로고
    • Metabolic perturbance in autism spectrum disorders: a metabolomics study
    • Ming X, Stein TP, Barnes V, Rhodes N, Guo L. Metabolic perturbance in autism spectrum disorders: a metabolomics study. J Proteome Res 2012;11:5856-5862
    • (2012) J Proteome Res , vol.11 , pp. 5856-5862
    • Ming, X.1    Stein, T.P.2    Barnes, V.3    Rhodes, N.4    Guo, L.5
  • 138
    • 84878289530 scopus 로고    scopus 로고
    • GC-MS-based urine metabolic profiling of autism spectrum disorders
    • Emond P, Mavel S, Aïdoud N, et al. GC-MS-based urine metabolic profiling of autism spectrum disorders. Anal Bioanal Chem 2013;405:5291-5300
    • (2013) Anal Bioanal Chem , vol.405 , pp. 5291-5300
    • Emond, P.1    Mavel, S.2    Aïdoud, N.3
  • 140
    • 77954592502 scopus 로고    scopus 로고
    • Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls
    • Yap IK, Angley M, Veselkov KA, Holmes E, Lindon JC, Nicholson JK. Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls. J Proteome Res 2010;9:2996-3004
    • (2010) J Proteome Res , vol.9 , pp. 2996-3004
    • Yap, I.K.1    Angley, M.2    Veselkov, K.A.3    Holmes, E.4    Lindon, J.C.5    Nicholson, J.K.6
  • 142
    • 79954994053 scopus 로고    scopus 로고
    • Impaired plasma phospholipids and relative amounts of essential polyunsaturated fatty acids in autistic patients from Saudi Arabia
    • El-Ansary AK, Bacha AG, Al-Ayahdi LY. Impaired plasma phospholipids and relative amounts of essential polyunsaturated fatty acids in autistic patients from Saudi Arabia. Lipids Health Dis 2011;10:63
    • (2011) Lipids Health Dis , vol.10 , pp. 63
    • El-Ansary, A.K.1    Bacha, A.G.2    Al-Ayahdi, L.Y.3
  • 143
    • 79960629891 scopus 로고    scopus 로고
    • Desulfovibrio species are potentially important in regressive autism
    • Finegold SM. Desulfovibrio species are potentially important in regressive autism. Med Hypotheses 2011;77:270-274
    • (2011) Med Hypotheses , vol.77 , pp. 270-274
    • Finegold, S.M.1
  • 144
    • 76749146019 scopus 로고    scopus 로고
    • Low-grade endotoxemia in patients with severe autism
    • Emanuele E, Orsi P, Boso M, et al. Low-grade endotoxemia in patients with severe autism. Neurosci Lett 2010;471:162-165
    • (2010) Neurosci Lett , vol.471 , pp. 162-165
    • Emanuele, E.1    Orsi, P.2    Boso, M.3
  • 145
    • 33744811963 scopus 로고    scopus 로고
    • The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trial
    • Elder JH, Shankar M, Shuster J, Theriaque D, Burns S, Sherrill L. The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trial. J Autism Dev Disord 2006;36:413-420
    • (2006) J Autism Dev Disord , vol.36 , pp. 413-420
    • Elder, J.H.1    Shankar, M.2    Shuster, J.3    Theriaque, D.4    Burns, S.5    Sherrill, L.6
  • 147
    • 79952601424 scopus 로고    scopus 로고
    • Normal gut microbiota modulates brain development and behavior
    • Diaz Heijtz R, Wang S, Anuar F, et al. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci USA 2011;108:3047-3052
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 3047-3052
    • Diaz Heijtz, R.1    Wang, S.2    Anuar, F.3
  • 148
    • 84868617840 scopus 로고    scopus 로고
    • Gastrointestinal conditions in children with autism spectrum disorder: developing a research agenda
    • Coury DL, Ashwood P, Fasano A, et al. Gastrointestinal conditions in children with autism spectrum disorder: developing a research agenda. Pediatrics 2012;130(suppl 2):S160-S168
    • (2012) Pediatrics , vol.130 , pp. S160-S168
    • Coury, D.L.1    Ashwood, P.2    Fasano, A.3
  • 149
    • 84899816726 scopus 로고    scopus 로고
    • Gastrointestinal symptoms in autism spectrum disorder: a meta-analysis
    • McElhanon BO, McCracken C, Karpen S, Sharp WG. Gastrointestinal symptoms in autism spectrum disorder: a meta-analysis. Pediatrics 2014;133:872-883
    • (2014) Pediatrics , vol.133 , pp. 872-883
    • McElhanon, B.O.1    McCracken, C.2    Karpen, S.3    Sharp, W.G.4
  • 150
    • 0033929819 scopus 로고    scopus 로고
    • Short-term benefit from oral vancomycin treatment of regressive-onset autism
    • Sandler RH, Finegold SM, Bolte ER, et al. Short-term benefit from oral vancomycin treatment of regressive-onset autism. J Child Neurol 2000;15:429-435
    • (2000) J Child Neurol , vol.15 , pp. 429-435
    • Sandler, R.H.1    Finegold, S.M.2    Bolte, E.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.