메뉴 건너뛰기




Volumn 28, Issue 3, 2016, Pages 158-163

Mitochondrial DNA as a biomarker for in-vitro fertilization outcome

Author keywords

fertility; mitochondria; oocyte; reproduction

Indexed keywords

BIOLOGICAL MARKER; MITOCHONDRIAL DNA;

EID: 84963575209     PISSN: 1040872X     EISSN: 1473656X     Source Type: Journal    
DOI: 10.1097/GCO.0000000000000274     Document Type: Review
Times cited : (39)

References (63)
  • 3
    • 84876357442 scopus 로고    scopus 로고
    • Cumulus and granulosa cell markers of oocyte and embryo quality
    • Uyar A, Torrealday S, Seli E. Cumulus and granulosa cell markers of oocyte and embryo quality. Fertil Steril 2013; 99: 979-997
    • (2013) Fertil Steril , vol.99 , pp. 979-997
    • Uyar, A.1    Torrealday, S.2    Seli, E.3
  • 4
    • 77955139167 scopus 로고    scopus 로고
    • OMICS in assisted reproduction: Possibilities and pitfalls
    • Seli E, Robert C, Sirard MA. OMICS in assisted reproduction: possibilities and pitfalls. Mol Hum Reprod 2010; 16: 513-530
    • (2010) Mol Hum Reprod , vol.16 , pp. 513-530
    • Seli, E.1    Robert, C.2    Sirard, M.A.3
  • 5
    • 84907623415 scopus 로고    scopus 로고
    • Metabolomic assessment of embryo viability
    • Uyar A, Seli E. Metabolomic assessment of embryo viability. Semin Reprod Med 2014; 32: 141-152
    • (2014) Semin Reprod Med , vol.32 , pp. 141-152
    • Uyar, A.1    Seli, E.2
  • 6
    • 84883453649 scopus 로고    scopus 로고
    • Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: A randomized controlled trial
    • Scott RTJ, Upham KM, Forman EJ, et al. Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial. Fertil Steril 2013; 100: 697-703
    • (2013) Fertil Steril , vol.100 , pp. 697-703
    • Scott, R.T.J.1    Upham, K.M.2    Forman, E.J.3
  • 7
    • 84870037455 scopus 로고    scopus 로고
    • Day 3 embryo selection by metabolomic profiling of culture medium with near infrared spectroscopy as an adjunct to morphology: A randomized controlled trial
    • Vergouw CG, Kieslinger DC, Kostelijk EH, et al. Day 3 embryo selection by metabolomic profiling of culture medium with near infrared spectroscopy as an adjunct to morphology: a randomized controlled trial. Hum Reprod 2012; 27: 2304-2311
    • (2012) Hum Reprod , vol.27 , pp. 2304-2311
    • Vergouw, C.G.1    Kieslinger, D.C.2    Kostelijk, E.H.3
  • 8
    • 83755224712 scopus 로고    scopus 로고
    • Non-invasive metabolomic profiling of Day 2 and 5 embryo culture medium: A prospective randomized trial
    • Hardarson T, Ahlstrom A, Rogberg L, et al. Non-invasive metabolomic profiling of Day 2 and 5 embryo culture medium: a prospective randomized trial. Hum Reprod 2012; 27: 89-96
    • (2012) Hum Reprod , vol.27 , pp. 89-96
    • Hardarson, T.1    Ahlstrom, A.2    Rogberg, L.3
  • 9
    • 84937805476 scopus 로고    scopus 로고
    • Altered levels of mitochondrial DNA are associated with female age, aneuploidy, and provide an independent measure of embryonic implantation potential
    • Fragouli E, Spath K, Alfarawati S, et al. Altered levels of mitochondrial DNA are associated with female age, aneuploidy, and provide an independent measure of embryonic implantation potential. PLoS Genet 2015; 11: e1005241
    • (2015) PLoS Genet , vol.11 , pp. e1005241
    • Fragouli, E.1    Spath, K.2    Alfarawati, S.3
  • 10
    • 84940718065 scopus 로고    scopus 로고
    • Mitochondrial DNA content as a viability score in human euploid embryos: Less is better
    • Diez-Juan A, Rubio C, Marin C, et al. Mitochondrial DNA content as a viability score in human euploid embryos: less is better. Fertil Steril 2015; 104: 534-541
    • (2015) Fertil Steril , vol.104 , pp. 534-541
    • Diez-Juan, A.1    Rubio, C.2    Marin, C.3
  • 11
    • 84929458184 scopus 로고    scopus 로고
    • Oocyte mitochondria function and reproduction
    • Babayev E, Seli E. Oocyte mitochondria function and reproduction. CurrOpin Obstet Gynecol 2015; 27: 175-181
    • (2015) CurrOpin Obstet Gynecol , vol.27 , pp. 175-181
    • Babayev, E.1    Seli, E.2
  • 12
    • 0030035039 scopus 로고    scopus 로고
    • Archaeal-eubacterial mergers in the origin of Eukarya: Phylogenetic classification of life
    • Margulis L. Archaeal-eubacterial mergers in the origin of Eukarya: phylogenetic classification of life. Proc Natl Acad Sci U S A 1996; 93: 1071-1076
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 1071-1076
    • Margulis, L.1
  • 13
    • 0014070709 scopus 로고
    • On the origin of mitosing cells
    • Sagan L. On the origin of mitosing cells. J Theor Biol 1967; 14: 255-274
    • (1967) J Theor Biol , vol.14 , pp. 255-274
    • Sagan, L.1
  • 14
    • 84862556334 scopus 로고    scopus 로고
    • Biochemistry and evolution of anaerobic energy metabolism in eukaryotes
    • Müller M, Mentel M, van Hellemond JJ, et al. Biochemistry and evolution of anaerobic energy metabolism in eukaryotes. Microbiol Mol Biol Rev 2012; 76: 444-495
    • (2012) Microbiol Mol Biol Rev , vol.76 , pp. 444-495
    • Müller, M.1    Mentel, M.2    Van Hellemond, J.J.3
  • 15
    • 84937905503 scopus 로고    scopus 로고
    • Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing
    • Otten ABC, Smeets HJM. Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing. Hum Reprod Update 2015; 21: 671-689
    • (2015) Hum Reprod Update , vol.21 , pp. 671-689
    • Otten, A.B.C.1    Smeets, H.J.M.2
  • 16
    • 0013957553 scopus 로고
    • The circularity of mitochondrial DNA
    • Nass M. The circularity of mitochondrial DNA. Proc Natl Acad Sci USA 1966; 56: 1215-1222
    • (1966) Proc Natl Acad Sci USA , vol.56 , pp. 1215-1222
    • Nass, M.1
  • 18
    • 84864308607 scopus 로고    scopus 로고
    • Mitochondrial DNA structure
    • Bogenhagen DF. Mitochondrial DNA structure. Biochim Biophys Acta 2012; 1819: 914-920
    • (2012) Biochim Biophys Acta , vol.1819 , pp. 914-920
    • Bogenhagen, D.F.1
  • 19
    • 0032076536 scopus 로고    scopus 로고
    • Linear mitochondrial genomes: 30 years down the line
    • Nosek J, Tomáška L, Fukuhara H, et al. Linear mitochondrial genomes: 30 years down the line. Trends Genet 1998; 14: 184-188
    • (1998) Trends Genet , vol.14 , pp. 184-188
    • Nosek, J.1    Tomáška, L.2    Fukuhara, H.3
  • 20
    • 0026554863 scopus 로고
    • Counting target molecules by exponential polymerase chain reaction: Copy number of mitochondrial DNA in rat tissues
    • Wiesner RJ, Rüegg JC, Morano I. Counting target molecules by exponential polymerase chain reaction: copy number of mitochondrial DNA in rat tissues. Biochem Biophys Res Commun 1992; 183: 553-559
    • (1992) Biochem Biophys Res Commun , vol.183 , pp. 553-559
    • Wiesner, R.J.1    Rüegg, J.C.2    Morano, I.3
  • 21
    • 75749102229 scopus 로고    scopus 로고
    • A predominantly neolithic origin for European paternal lineages
    • Balaresque P, Bowden GR, Adams SM, et al. A predominantly neolithic origin for European paternal lineages. PLoS Biol 2010; 8: e1000285
    • (2010) PLoS Biol , vol.8 , pp. e1000285
    • Balaresque, P.1    Bowden, G.R.2    Adams, S.M.3
  • 22
    • 0019441235 scopus 로고
    • The mitochondrial genome is large and variable in a family of plants (Cucurbitaceae
    • Ward BL, Anderson RS, Bendich AJ. The mitochondrial genome is large and variable in a family of plants (Cucurbitaceae). Cell 1981; 25: 793-803
    • (1981) Cell , vol.25 , pp. 793-803
    • Ward, B.L.1    Anderson, R.S.2    Bendich, A.J.3
  • 23
    • 0016353724 scopus 로고
    • Maternal inheritance of mammalian mitochondrial DNA
    • Hutchison CAI, Newbold JE, Potter SS, et al. Maternal inheritance of mammalian mitochondrial DNA. Nature 1974; 251: 536-539
    • (1974) Nature , vol.251 , pp. 536-539
    • Hutchison, C.A.I.1    Newbold, J.E.2    Potter, S.S.3
  • 24
    • 0000204255 scopus 로고
    • Maternal inheritance of human mitochondrial DNA
    • Giles RE, Blanc H, Cann HM, et al. Maternal inheritance of human mitochondrial DNA. Proc Natl Acad Sci U S A 1980; 77: 6715-6719
    • (1980) Proc Natl Acad Sci U S A , vol.77 , pp. 6715-6719
    • Giles, R.E.1    Blanc, H.2    Cann, H.M.3
  • 25
    • 0032129884 scopus 로고    scopus 로고
    • Fate of microinjected spermatid mitochondria in the mouse oocyte and embryo
    • Cummins JM, Wakayama T, Yanagimachi R. Fate of microinjected spermatid mitochondria in the mouse oocyte and embryo. Zygote 1998; 6: 213-222
    • (1998) Zygote , vol.6 , pp. 213-222
    • Cummins, J.M.1    Wakayama, T.2    Yanagimachi, R.3
  • 26
    • 84897655223 scopus 로고    scopus 로고
    • Dual roles for ubiquitination in the processing of sperm organelles after fertilization
    • Hajjar C, Sampuda KM, Boyd L. Dual roles for ubiquitination in the processing of sperm organelles after fertilization. BMC Dev Biol 2014; 14: 6
    • (2014) BMC Dev Biol , vol.14 , pp. 6
    • Hajjar, C.1    Sampuda, K.M.2    Boyd, L.3
  • 27
    • 84878785222 scopus 로고    scopus 로고
    • Germline energetics, aging, and female infertility
    • Tilly JL, Sinclair DA. Germline energetics, aging, and female infertility. Cell Metab 2013; 17: 838-850
    • (2013) Cell Metab , vol.17 , pp. 838-850
    • Tilly, J.L.1    Sinclair, D.A.2
  • 29
    • 84877123228 scopus 로고    scopus 로고
    • The maintenance of mitochondrial DNA integrity-critical analysis and update
    • Alexeyev M, Shokolenko I, Wilson G, et al. The maintenance of mitochondrial DNA integrity-critical analysis and update. Cold Spring Harb Perspect Biol 2013; 5: a012641
    • (2013) Cold Spring Harb Perspect Biol , vol.5 , pp. a012641
    • Alexeyev, M.1    Shokolenko, I.2    Wilson, G.3
  • 30
    • 33745410626 scopus 로고    scopus 로고
    • Mitochondrial disease
    • Schapira AH. Mitochondrial disease. Lancet 2006; 368: 70-82
    • (2006) Lancet , vol.368 , pp. 70-82
    • Schapira, A.H.1
  • 31
    • 1942425084 scopus 로고    scopus 로고
    • Mother's curse: The effect of mtDNA on individual fitness and population viability
    • Gemmell NJ, Metcalf VJ, Allendorf FW. Mother's curse: the effect of mtDNA on individual fitness and population viability. Trends Ecol Evol 2004; 19: 238-244
    • (2004) Trends Ecol Evol , vol.19 , pp. 238-244
    • Gemmell, N.J.1    Metcalf, V.J.2    Allendorf, F.W.3
  • 32
    • 84908292423 scopus 로고    scopus 로고
    • Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA
    • Rebolledo-Jaramillo B, Su MS, Stoler N, et al. Maternal age effect and severe germ-line bottleneck in the inheritance of human mitochondrial DNA. Proc Natl Acad Sci U S A 2014; 111: 15474-15479
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 15474-15479
    • Rebolledo-Jaramillo, B.1    Su, M.S.2    Stoler, N.3
  • 33
    • 0032231467 scopus 로고    scopus 로고
    • Evidence from human oocytes for a genetic bottleneck in an mtDNA disease
    • Marchington DR, Macaulay V, Hartshorne GM, et al. Evidence from human oocytes for a genetic bottleneck in an mtDNA disease. Am J Hum Genet 1998; 63: 769-775
    • (1998) Am J Hum Genet , vol.63 , pp. 769-775
    • Marchington, D.R.1    MacAulay, V.2    Hartshorne, G.M.3
  • 34
    • 56749180593 scopus 로고    scopus 로고
    • The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes
    • Wai T, Teoli D, Shoubridge EA. The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes. Nat Genet 2008; 40: 1484-1488
    • (2008) Nat Genet , vol.40 , pp. 1484-1488
    • Wai, T.1    Teoli, D.2    Shoubridge, E.A.3
  • 35
    • 33847248347 scopus 로고    scopus 로고
    • The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells
    • Cao L, Shitara H, Horii T, et al. The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells. Nat Genet 2007; 39: 386-390
    • (2007) Nat Genet , vol.39 , pp. 386-390
    • Cao, L.1    Shitara, H.2    Horii, T.3
  • 36
    • 38649091334 scopus 로고    scopus 로고
    • A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes
    • Cree LM, Samuels DC, de Sousa Lopes SC, et al. A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes. Nat Genet 2008; 40: 249-254
    • (2008) Nat Genet , vol.40 , pp. 249-254
    • Cree, L.M.1    Samuels, D.C.2    De Sousa Lopes, S.C.3
  • 37
    • 84868211657 scopus 로고    scopus 로고
    • Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission
    • Freyer C, Cree LM, Mourier A, et al. Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission. Nat Genet 2012; 44: 1282-1285
    • (2012) Nat Genet , vol.44 , pp. 1282-1285
    • Freyer, C.1    Cree, L.M.2    Mourier, A.3
  • 38
    • 0023874053 scopus 로고
    • Human gene expression first occurs between the four-And eight-cell stages of preimplantation development
    • Braude P, Bolton V, Moore S. Human gene expression first occurs between the four-And eight-cell stages of preimplantation development. Nature 1988; 332: 459-461
    • (1988) Nature , vol.332 , pp. 459-461
    • Braude, P.1    Bolton, V.2    Moore, S.3
  • 39
    • 0033660134 scopus 로고    scopus 로고
    • Mitochondrial morphology in human fetal and adult female germ cells
    • Motta PM, Nottola SA, Makabe S, et al. Mitochondrial morphology in human fetal and adult female germ cells. Hum Reprod 2000; 15 (Suppl 2): 129-147
    • (2000) Hum Reprod , vol.15 , pp. 129-147
    • Motta, P.M.1    Nottola, S.A.2    Makabe, S.3
  • 40
    • 0028918729 scopus 로고
    • ATP content of human oocytes and developmental potential and outcome after in-vitro fertilization and embryo transfer
    • Van Blerkom J, Davis PW, Lee J. ATP content of human oocytes and developmental potential and outcome after in-vitro fertilization and embryo transfer. Hum Reprod 1995; 10: 415-424
    • (1995) Hum Reprod , vol.10 , pp. 415-424
    • Van Blerkom, J.1    Davis, P.W.2    Lee, J.3
  • 41
    • 33846096853 scopus 로고    scopus 로고
    • The role of mitochondrial function in the oocyte and embryo
    • Dumollard R, Duchen M, Carroll J. The role of mitochondrial function in the oocyte and embryo. Curr Top Dev Biol 2007; 77: 21-49
    • (2007) Curr Top Dev Biol , vol.77 , pp. 21-49
    • Dumollard, R.1    Duchen, M.2    Carroll, J.3
  • 42
    • 79961207245 scopus 로고    scopus 로고
    • Mitochondrial function in the human oocyte and embryo and their role in developmental competence
    • Van Blerkom J. Mitochondrial function in the human oocyte and embryo and their role in developmental competence. Mitochondrion 2011; 11: 797-813
    • (2011) Mitochondrion , vol.11 , pp. 797-813
    • Van Blerkom, J.1
  • 43
    • 0033653708 scopus 로고    scopus 로고
    • Mitochondrial morphology during preimplantational human embryogenesis
    • Sathananthan AH, Trounson AO. Mitochondrial morphology during preimplantational human embryogenesis. Hum Reprod 2000; 15 (Suppl 2): 148-159
    • (2000) Hum Reprod , vol.15 , pp. 148-159
    • Sathananthan, A.H.1    Trounson, A.O.2
  • 44
    • 79959404400 scopus 로고    scopus 로고
    • Age related changes in mitochondrial function and new approaches to study redox regulation in mammalian oocytes in response to age or maturation conditions
    • Eichenlaub-Ritter U, Wieczorek M, Lüke S, et al. Age related changes in mitochondrial function and new approaches to study redox regulation in mammalian oocytes in response to age or maturation conditions. Mitochondrion 2011; 11: 783-796
    • (2011) Mitochondrion , vol.11 , pp. 783-796
    • Eichenlaub-Ritter, U.1    Wieczorek, M.2    Lüke, S.3
  • 45
    • 0034252008 scopus 로고    scopus 로고
    • Quantification of mtDNA in single oocytes, polar bodies and subcellular components by real-Time rapid cycle fluorescence monitored PCR
    • Steuerwald N, Barritt JA, Adler R, et al. Quantification of mtDNA in single oocytes, polar bodies and subcellular components by real-Time rapid cycle fluorescence monitored PCR. Zygote 2000; 8: 209-215
    • (2000) Zygote , vol.8 , pp. 209-215
    • Steuerwald, N.1    Barritt, J.A.2    Adler, R.3
  • 46
    • 0035004163 scopus 로고    scopus 로고
    • Mitochondrial DNA content affects the fertilizability of human oocytes
    • Reynier P, May-Panloup P, Chré tien MF, et al. Mitochondrial DNA content affects the fertilizability of human oocytes. Mol Hum Reprod 2001; 7: 425-429
    • (2001) Mol Hum Reprod , vol.7 , pp. 425-429
    • Reynier, P.1    May-Panloup, P.2    Chrétien, M.F.3
  • 47
    • 0029059278 scopus 로고
    • Rearranged mitochondrial genomes are present in human oocytes
    • Chen X, Prosser R, Simonetti S, et al. Rearranged mitochondrial genomes are present in human oocytes. Am J Hum Genet 1995; 57: 239-247
    • (1995) Am J Hum Genet , vol.57 , pp. 239-247
    • Chen, X.1    Prosser, R.2    Simonetti, S.3
  • 48
    • 0023518420 scopus 로고
    • Amounts of mitochondrial DNA and abundance of some mitochondrial gene transcripts in early mouse embryos
    • Pikó L, Taylor KD. Amounts of mitochondrial DNA and abundance of some mitochondrial gene transcripts in early mouse embryos. Dev Biol 1987; 123: 364-374
    • (1987) Dev Biol , vol.123 , pp. 364-374
    • Pikó, L.1    Taylor, K.D.2
  • 49
    • 33645060505 scopus 로고    scopus 로고
    • Mitochondrial DNA content and 4977 bp deletion in unfertilized oocytes
    • Chan CC, Liu VW, Lau EY, et al. Mitochondrial DNA content and 4977 bp deletion in unfertilized oocytes. Mol Hum Reprod 2005; 11: 843-846
    • (2005) Mol Hum Reprod , vol.11 , pp. 843-846
    • Chan, C.C.1    Liu, V.W.2    Lau, E.Y.3
  • 50
    • 0017238516 scopus 로고
    • Number of mitochondria and some properties of mitochondrial DNA in the mouse egg
    • Piko L, Matsumoto L. Number of mitochondria and some properties of mitochondrial DNA in the mouse egg. Dev Biol 1976; 49: 1-10
    • (1976) Dev Biol , vol.49 , pp. 1-10
    • Piko, L.1    Matsumoto, L.2
  • 51
    • 0023912796 scopus 로고
    • Mitochondrial DNA in the mouse preimplantation embryo
    • Ebert KM, Liem H, Hecht NB. Mitochondrial DNA in the mouse preimplantation embryo. J Reprod Fertil 1988; 82: 145-149
    • (1988) J Reprod Fertil , vol.82 , pp. 145-149
    • Ebert, K.M.1    Liem, H.2    Hecht, N.B.3
  • 52
    • 84895560707 scopus 로고    scopus 로고
    • The control of mtDNA replication during differentiation and development
    • St John J. The control of mtDNA replication during differentiation and development. Biochim Biophys Acta 2014; 1840: 1345-1354
    • (2014) Biochim Biophys Acta , vol.1840 , pp. 1345-1354
    • St John, J.1
  • 53
    • 77955593985 scopus 로고    scopus 로고
    • Mitochondrial DNA transmission, replication and inheritance: A journey from the gamete through the embryo and into offspring and embryonic stem cells
    • St John JC, Facucho-Oliveira J, Jiang Y, et al. Mitochondrial DNA transmission, replication and inheritance: a journey from the gamete through the embryo and into offspring and embryonic stem cells. Hum Reprod Update 2010; 16: 488-509
    • (2010) Hum Reprod Update , vol.16 , pp. 488-509
    • St John, J.C.1    Facucho-Oliveira, J.2    Jiang, Y.3
  • 54
    • 33644946111 scopus 로고    scopus 로고
    • Energy metabolism of the inner cell mass and trophectoderm of the mouse blastocyst
    • Houghton F. Energy metabolism of the inner cell mass and trophectoderm of the mouse blastocyst. Differentiation 2006; 74: 11-18
    • (2006) Differentiation , vol.74 , pp. 11-18
    • Houghton, F.1
  • 55
    • 84887987827 scopus 로고    scopus 로고
    • Embryo developmental capability and pregnancy outcome are related to the mitochondrial DNA copy number and ooplasmic volume
    • Murakoshi Y, Sueoka K, Takahashi K, et al. Embryo developmental capability and pregnancy outcome are related to the mitochondrial DNA copy number and ooplasmic volume. J Assist Reprod Genet 2013; 30: 1367-1375
    • (2013) J Assist Reprod Genet , vol.30 , pp. 1367-1375
    • Murakoshi, Y.1    Sueoka, K.2    Takahashi, K.3
  • 56
    • 21544471197 scopus 로고    scopus 로고
    • Molecular control of mitochondrial function in preimplantation mouse embryos
    • Thundathil J, Filion F, Smith LC. Molecular control of mitochondrial function in preimplantation mouse embryos. Mol Reprod Dev 2005; 71: 405-413
    • (2005) Mol Reprod Dev , vol.71 , pp. 405-413
    • Thundathil, J.1    Filion, F.2    Smith, L.C.3
  • 57
    • 33846869260 scopus 로고    scopus 로고
    • Regulated mitochondrial DNA replication during oocyte maturation is essential for successful porcine embryonic development
    • Spikings EC, Alderson J, St John JC. Regulated mitochondrial DNA replication during oocyte maturation is essential for successful porcine embryonic development. Biol Reprod 2007; 76: 327-335
    • (2007) Biol Reprod , vol.76 , pp. 327-335
    • Spikings, E.C.1    Alderson, J.2    St John, J.C.3
  • 58
    • 0030325756 scopus 로고    scopus 로고
    • Morphological-cytochemical and molecular genetic analyses of mitochondria in isolated human oocytes in the reproductive age
    • Müller-Höcker J, Schäfer S, Weis S, et al. Morphological-cytochemical and molecular genetic analyses of mitochondria in isolated human oocytes in the reproductive age. Mol Hum Reprod 1996; 2: 951-958
    • (1996) Mol Hum Reprod , vol.2 , pp. 951-958
    • Müller-Höcker, J.1    Schäfer, S.2    Weis, S.3
  • 59
    • 84922106699 scopus 로고    scopus 로고
    • Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform
    • Konstantinidis M, Alfarawati S, Hurd D, et al. Simultaneous assessment of aneuploidy, polymorphisms, and mitochondrial DNA content in human polar bodies and embryos with the use of a novel microarray platform. Fertil Steril 2014; 102: 1385-1392
    • (2014) Fertil Steril , vol.102 , pp. 1385-1392
    • Konstantinidis, M.1    Alfarawati, S.2    Hurd, D.3
  • 60
    • 84936817547 scopus 로고    scopus 로고
    • Relationship between diminished ovarian reserve and mitochondrial biogenesis in cumulus cells
    • Boucret L, Chao de la Barca JM, Morinière C, et al. Relationship between diminished ovarian reserve and mitochondrial biogenesis in cumulus cells. Hum Reprod 2015; 30: 1653-1664
    • (2015) Hum Reprod , vol.30 , pp. 1653-1664
    • Boucret, L.1    Chao De La Barca, J.M.2    Morinière, C.3
  • 61
    • 84951566842 scopus 로고    scopus 로고
    • Mitochondrial DNA assessment to determine oocyte and embryo viability
    • Fragouli E, Wells D. Mitochondrial DNA assessment to determine oocyte and embryo viability. Semin Reprod Med 2015; 33: 401-409
    • (2015) Semin Reprod Med , vol.33 , pp. 401-409
    • Fragouli, E.1    Wells, D.2
  • 62
    • 84882628481 scopus 로고    scopus 로고
    • The origin and impact of embryonic aneuploidy
    • Fragouli E, Alfarawati S, Spath K, et al. The origin and impact of embryonic aneuploidy. Hum Genet 2013; 132: 1001-1013
    • (2013) Hum Genet , vol.132 , pp. 1001-1013
    • Fragouli, E.1    Alfarawati, S.2    Spath, K.3
  • 63
    • 84859155553 scopus 로고    scopus 로고
    • Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: A prospective, blinded, nonselection study
    • Scott RTJ, Ferry K, Su J, et al. Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study. Fertil Steril 2012; 97: 870-875
    • (2012) Fertil Steril , vol.97 , pp. 870-875
    • Scott, R.T.J.1    Ferry, K.2    Su, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.