Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential

PLoS Genetics

Volumn 11, Issue 6, 2015, Pages

  Fragouli, Elpida ^a   Spath, Katharina ^b   Alfarawati, Samer ^a   Kaper, Fiona ^c   Craig, Andrew ^c   Michel, Claude Edouard ^c   Kokocinski, Felix ^c   Cohen, Jacques ^a   Munne, Santiago ^a   Wells, Dagan ^a,b  

^a Reprogenetics LLC   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c ILLUMINA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; MITOCHONDRIAL DNA;

ADULT; AGE DISTRIBUTION; AGING; ANEUPLOIDY; ARTICLE; BLASTOCYST; CELL ENERGY; CELL FUNCTION; CELL METABOLISM; CELL VIABILITY; CHROMOSOME; COMPARATIVE GENOMIC HYBRIDIZATION; DNA CONTENT; DNA POLYMORPHISM; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; FERTILIZATION IN VITRO; GENE DELETION; GENE DOSAGE; GENE MUTATION; GENETIC ASSOCIATION; GENOME ANALYSIS; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MITOCHONDRIAL DNA REPLICATION; MITOCHONDRIAL GENOME; NEXT GENERATION SEQUENCING; NIDATION; OOCYTE CLEAVAGE; POLYMERASE CHAIN REACTION; PREDICTION; PREGNANCY; PREIMPLANTATION EMBRYO; QUANTITATIVE ANALYSIS; UPREGULATION; UTERUS; AGE; GENETICS;

ADULT; AGE FACTORS; ANEUPLOIDY; DNA, MITOCHONDRIAL; EMBRYO IMPLANTATION; FEMALE; HUMANS;

EID: 84937805476     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005241     Document Type: Article

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