Quantification and evaluation of thymoquinone loaded mucoadhesive nanoemulsion for treatment of cerebral ischemia

International Journal of Biological Macromolecules

Volumn 88, Issue , 2016, Pages 320-332

  Ahmad, Niyaz ^a   Ahmad, Rizwan ^a   Alam, Md Aftab ^b   Samim, Mohd ^c   Iqbal, Zeenat ^d   Ahmad, Farhan Jalees ^d  

^a IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY   (Saudi Arabia)

^b GALGOTIAS UNIVERSITY   (India)

^c HAMDARD UNIVERSITY   (India)

^d HAMDARD UNIVERSITY   (India)

Author keywords

Brain pharmacokinetics; Cerebral ischemia; Nanoemulsion; Thymoquinone; UPLC PDA method validation

Indexed keywords

THYMOQUINONE; ANTIOXIDANT; BENZOQUINONE DERIVATIVE; DRUG CARRIER; EMULSION; NANOPARTICLE; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD SAMPLING; BRAIN ISCHEMIA; BRAIN PERFUSION; CALIBRATION; CEREBROVASCULAR ACCIDENT; COGNITION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; DRUG PENETRATION; DRUG RELEASE; DRUG RETENTION; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; GELATION; GRIP STRENGTH; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; LOCOMOTION; MAXIMUM PLASMA CONCENTRATION; MUCOADHESION; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PROCESS OPTIMIZATION; RAT; REFRACTION INDEX; REPERFUSION; THERMODYNAMICS; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ZETA POTENTIAL; ANIMAL; ANIMAL BEHAVIOR; BIOAVAILABILITY; CHEMISTRY; CORONARY ARTERY OCCLUSION; DRUG EFFECTS; EMULSION; INTRANASAL DRUG ADMINISTRATION; MALE; MIDDLE CEREBRAL ARTERY; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; SURGERY; TISSUE DISTRIBUTION; ULTRASTRUCTURE;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIOXIDANTS; BEHAVIOR, ANIMAL; BENZOQUINONES; BIOLOGICAL AVAILABILITY; BRAIN ISCHEMIA; CORONARY OCCLUSION; DRUG CARRIERS; DRUG COMPOUNDING; EMULSIONS; MALE; MIDDLE CEREBRAL ARTERY; NANOPARTICLES; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PARTICLE SIZE; PSYCHOMOTOR PERFORMANCE; RATS; TISSUE DISTRIBUTION;

EID: 84962704827     PISSN: 01418130     EISSN: 18790003     Source Type: Journal    
DOI: 10.1016/j.ijbiomac.2016.03.019     Document Type: Article

References (44)

1. Ahmad N., Umar S., Ashafaq M., Akhtar M., Iqbal Z., Samim M., Ahmad F.J. Protoplasma 2013, 250:1327-1338.
2. Ahmad N., Ahmad I., Umar S., Iqbal Z., Samim M., Ahmad F.J. Drug Deliv. 2015, 21:1-20.
3. Ahmad N., Warsi M.H., Iqbal Z., Samim M., Ahmad F.J. Drug Test Anal. 2014, 6:257-267.
4. Katsura K., Kristián T., Smith M.L., Siesjö B.K. J. Cereb. Blood Flow Metab. 1994, 14:243-250.
5. Iadecola C., Pelligrino D.A., Moskowitz M.A., Lassen N.A. J. Cereb. Blood Flow Metab. 1994, 14:175-192.
6. Ashafaq M., Khan M.M., Raza S.S., Ahmad A., Khuwaja G., Javed H., Khan A., Islam F., Siddiqui M.S., Safhi M.M. Nutr. Res. 2012, 32:133-143.
7. Imaizumi S., Kayama T., Suzuki J. Stroke 1984, 15:1061-1065.
8. Akhtar M., Pillai K., Vohora D. Hum. Exp. Toxicol. 2008, 27:761-767.
9. Al-Majed A.A., Al-Omar F.A., Nagi M.N. Eur. J. Pharmacol. 2006, 543:40-47.
10. Hosseinzadeh H., Parvardeh S., Asl M.N., Sadeghnia H.R., Ziaee T. Phytomedicine 2007, 14:621-627.
11. Ganea G.M., Fakayode S.O., Losso J.N., van Nostrum C.F., Sabliov C.M., Warner I.M. Nanotechnology 2010, 21:285104.
12. Odeh F., Ismail S.I., Abu-Dahab R., Mahmoud I.S., Al Bawab A. Drug Deliv. 2012, 19:371-377.
13. Mistry A., Stolnik S., Illum L. Int. J. Pharm. 2009, 379:146-157.
14. Hanson L.R., Frey W.H. BMC Neurosci. 2008, 3:S5.
15. Debnath S., Satayanarayana, Kumar G.V. Pharmanest 2011, 2:72-83.
16. Anton N., Benoit J.P., Saulnier P. J. Control. Release 2008, 128:185-199.
17. Mason T.G., Wilking J.N., Meleson K., Chang C.B., Graves S.M. J. Phys. 2006, 18:R635-R666.
18. Turner P.V., Brabb T., Pekow C., Vasbinder M.A. J. Am. Assoc. Lab. Anim. Sci. 2011, 50:600-613.
19. D. Marx, G. Williams, M. Birkhoff, Drug Discovery and Development-From Molecules to Medicine INTECH open Sciences, 2015, 301-320 (Chapter 13). , . http://cdn.intechopen.com/pdfs-wm/48052.pdf.
20. Li Y., Zheng J., Xiao H., McClements D.J. Food Hydrocoll. 2012, 27:517-528.
21. Kovacevic A., Savic S., Vuleta G., Müller R.H., Keck C.M. Int. J. Pharm. 2011, 406:163-172.
22. Morille M., Montier T., Legras P., Carmoy N., Brodin P., Pitard B., Benoît J.P., Passirani C. Biomaterials 2010, 31:321-329.
23. Vyas T.K., Shahiwala A., Amiji M.M. Int. J. Pharm. 2008, 347:93-101.
24. Ramadan A., Lagarce F., Tessier-Marteau A., Thomas O., Legras P., Macchi L., Saulnier P., Benoit J.P. Int. J. Nanomed. 2011, 6:2941-2951.
25. Baboota S., Shakeel F., Ahuja A., Ali J., Shafiq S. Acta Pharm. 2007, 57:315-332.
26. Babbar A.K., Singh A.K., Goel H.C., Chauhan U.P., Sharma R.K. Nucl. Med. Biol. 2000, 27:419-426.
27. Kumar M., Misra A., Babbar A.K., Mishra A.K., Mishra P., Pathak K. Int. J. Pharm. 2008, 358:285-291.
28. Lannert H., Hoyer S. Behav. Neurosci. 1998, 112:1199-1208.
29. Lawrence M.J., Rees G.D. Adv. Drug Deliv. Rev. 2000, 45:89-121.
30. Warisnoicharoen W., Lansley A.B., Lawrence M.J. AAPS PharmSciTech 2002, 2:E12.
31. Li P., Ghosh A., Wagner R.F., Krill S., Joshi Y.M., Serajuddin A.T.M. Int. J. Pharm. 2005, 288:27-34.
32. Rhee Y.S., Choi J.G., Park E.S., Chi S.C. Int. J. Pharm. 2001, 228:161-170.
33. Puranjoti P., Kasina R., Tenjarla S. J. Clin. Pharm. Therap. 1999, 24:445-450.
34. Hadgraft J. Skin Pharmacol. Appl. Skin Physiol. 2001, 14:72-81.
35. P.M. Williams, G. Payne, Bioaccumulation potential of surfactants: a review, Presented at Chemistry in the Oil Industry VII, Royal Society of Chemistry & EOSCA, Manchester, 2001.
36. Jones N.S., Quraishi S., Mason J.D.T. Int. J. Clin. Pract. 1997, 51:308-311.
37. Duchêne D., Touchard F., Peppas N.A. Drug Dev. Ind. Pharm. 1988, 14:283-318.
38. Dodane V., Khan M.A., Merwin J.R. Int. J. Pharm. 1999, 182:21-32.
39. Dhuria S.V., Hanson L.R., Frey W.H. J. Pharm. Sci. 2010, 99:1654-1673.
40. Wang X., Chi N., Tang X. Eur. J. Pharm. Biopharm. 2008, 70:735-740.
41. Zhang Q., Jiang X., Jiang W., Lu W., Su L., Shi Z. Int. J. Pharm. 2004, 275:85-96.
42. Shadab M., Khan R.A., Mustafa G., Chuttani K., Baboota S., Sahni J.K., Ali J. Eur. J. Pharm. Sci. 2013, 48:393-405.
43. Seju U., Kumar A., Sawant K.K. Acta Biomater. 2011, 7:4169-4176.
44. Longa E.Z., Weinstein P.R., Carlson S., Cummins R. Stroke 1989, 20:84-91.