Development and evaluation of olanzapine-loaded PLGA nanoparticles for nose-to-brain delivery: In vitro and in vivo studies

Acta Biomaterialia

Volumn 7, Issue 12, 2011, Pages 4169-4176

  Seju, U ^a   Kumar, A ^a   Sawant, K K ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

Nanoparticles; Nasal toxicity; Nose to brain delivery; Olanzapine; PLGA

Indexed keywords

BIOCHEMISTRY; CONTROLLED DRUG DELIVERY; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSION; EFFICIENCY; NEUROPHYSIOLOGY; PARTICLE SIZE; PHARMACOKINETICS; TARGETED DRUG DELIVERY; TOXICITY; X RAY DIFFRACTION;

BRAIN DELIVERY; ENTRAPMENT EFFICIENCY; IN-VITRO; NASAL TOXICITY; NOSE-TO-BRAIN DELIVERY; OLANZAPINE; POLY LACTIC-CO-GLYCOLIC ACID; POLY(LACTIC-CO-GLYCOLIC ACID); SUSTAINED RELEASE;

NANOPARTICLES;

CARBONYL DERIVATIVE; NANOPARTICLE; OLANZAPINE; POLYGLACTIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG TISSUE LEVEL; DRUG TRANSPORT; EX VIVO STUDY; HISTOPATHOLOGY; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR INTERACTION; NONHUMAN; NOSE MUCOSA; PARTICLE SIZE; PLASTICITY; PRECIPITATION; PRIORITY JOURNAL; SHEEP; SUSTAINED DRUG RELEASE; TARGET ORGAN; X RAY DIFFRACTION; ZETA POTENTIAL;

OVIS ARIES;

EID: 80055118993     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2011.07.025     Document Type: Article

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