Molecular mechanisms involved in tumor repopulation after radiotherapy

Translational Cancer Research

Volumn 2, Issue 5, 2013, Pages 442-448

  Ng, Wooi Loon ^a   Huang, Qian ^a   Liu, Xinjian ^a   Zimmerman, Mary ^a   Li, Fang ^a   Li, Chuan Yuan ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

4"R"s; Phoenix rising pathway; Radiation therapy; Tumor repopulation; Vasculogenesis

Indexed keywords

EID: 84962678153     PISSN: 2218676X     EISSN: 22196803     Source Type: Journal    
DOI: 10.3978/j.issn.2218-676X.2013.10.03     Document Type: Article

References (39)

1. Regaud C, Ferroux R. Disordance des effets de rayons X, d'une part dans le testicule, par le fractionnenment de la dose. Comptes Rendus Societe Biologique 1927;97:431.
2. Withers HR. The 4 R's of radiotherapy, in Advances in radiation biology. Lett JT, Alder H. eds. Vol 5. New York: Academic Press, 1975;5:241-71.
3. Sinclair WK. Cyclic x-ray responses in mammalian cells in vitro. Radiat Res 1968;33:620-43.
4. Hall EJ. Radiobiology for the radiologist. 4 ed. Philadelphia: Lippincott, 1994.
5. Withers RH. Treatment-induced accelerated human tumor growth. Semin Radiat Oncol 1993;3:135-43.
6. Garcia-Barros M, Paris F, Cordon-Cardo C, et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 2003;300:1155-9.
7. Budach W, Taghian A, Freeman J, et al. Impact of stromal sensitivity on radiation response of tumors. J Natl Cancer Inst 1993;85:988-93.
8. Gerweck LE, Vijayappa S, Kurimasa A, et al. Tumor cell radiosensitivity is a major determinant of tumor response to radiation. Cancer Res 2006;66:8352-5.
9. Ogawa K, Boucher Y, Kashiwagi S, et al. Influence of tumor cell and stroma sensitivity on tumor response to radiation. Cancer Res 2007;67:4016-21.
10. Ahn GO, Brown JM. Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells. Cancer Cell 2008;13:193-205.
11. Heissig B, Hattori K, Friedrich M, et al. Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases. Curr Opin Hematol 2003;10:136-41.
12. Lyden D, Hattori K, Dias S, et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 2001;7:1194-201.
13. Du R, Lu KV, Petritsch C, et al. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 2008;13:206-20.
14. Kubota Y, Takubo K, Shimizu T, et al. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med 2009;206:1089-102.
15. Beck H, Raab S, Copanaki E, et al. VEGFR-1 signaling regulates the homing of bone marrow-derived cells in a mouse stroke model. J Neuropathol Exp Neurol 2010;69:168-75.
16. Ikeda O, Sekine Y, Muromoto R, et al. Enhanced c-Fms/M-CSF receptor signaling and wound-healing process in bone marrow-derived macrophages of signal-transducing adaptor protein-2 (STAP-2) deficient mice. Biol Pharm Bull 2008;31:1790-3.
17. Kioi M, Vogel H, Schultz G, et al. Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest 2010;120:694-705.
18. Rofstad EK, Danielsen T. Hypoxia-induced metastasis of human melanoma cells: involvement of vascular endothelial growth factor-mediated angiogenesis. Br J Cancer 1999;80:1697-707.
19. Rofstad EK, Halsør EF. Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8. Br J Cancer 2002;86:301-8.
20. Harris AL. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2002;2:38-47.
21. Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 1995;92:5510-4.
22. Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci U S A 1993;90:4304-8.
23. Jaakkola P, Mole DR, Tian YM, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001;292:468-72.
24. Moeller BJ, Cao Y, Li CY, et al. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 2004;5:429-41.
25. Li F, Sonveaux P, Rabbani ZN, et al. Regulation of HIF-1alpha stability through S-nitrosylation. Mol Cell 2007;26:63-74.
26. Huang Q, Li F, Liu X, et al. Caspase 3-mediated stimulation of tumor cell repopulation during Cancer radiotherapy. Nat Med 2011;17:860-6.
27. Li F, Huang Q, Chen J, et al. Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration. Sci Signal 2010;3: ra13.
28. Ryoo HD, Gorenc T, Steller H. Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways. Dev Cell 2004;7:491-501.
29. Chera S, Ghila L, Dobretz K, et al. Apoptotic cells provide an unexpected source of Wnt3 signaling to drive hydra head regeneration. Dev Cell 2009;17:279-89.
30. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-7.
31. Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast Cancer cells. Proc Natl Acad Sci U S A 2003;100:3983-8.
32. Bao S, Wu Q, Mclendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006;444:756-60.
33. Phillips TM, Mcbride WH, Pajonk F. The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J Natl Cancer Inst 2006;98:1777-85.
34. Quintana E, Shackleton M, Sabel MS, et al. Efficient tumour formation by single human melanoma cells. Nature 2008;456:593-8.
35. Quintana E, Shackleton M, Foster HR, et al. Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell 2010;18:510-23.
36. Lagadec C, Vlashi E, Della Donna L, et al. Radiation-induced reprogramming of breast Cancer cells. Stem Cells 2012;30:833-44.
37. Heddleston JM, Li Z, Mclendon RE, et al. The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a Cancer stem cell phenotype. Cell Cycle 2009;8:3274-84.
38. Charles N, Ozawa T, Squatrito M, et al. Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell 2010;6:141-52.
39. Li F, He Z, Shen J, et al. Apoptotic caspases regulate induction of iPSCs from human fibroblasts. Cell Stem Cell 2010;7:508-20.