Replacement of a thiourea with an amidine group in a monofunctional platinum-acridine antitumor agent. Effect on DNA interactions, DNA adduct recognition and repair

Molecular Pharmaceutics

Volumn 8, Issue 5, 2011, Pages 1941-1954

  Kostrhunova, Hana ^a   Malina, Jaroslav ^a   Pickard, Amanda J ^b   Stepankova, Jana ^a   Vojtiskova, Marie ^a   Kasparkova, Jana ^a   Muchova, Tereza ^c   Rohlfing, Matthew L ^b   Bierbach, Ulrich ^b   Brabec, Viktor ^a  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b WAKE FOREST UNIVERSITY   (United States)

^c PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

antitumor; conformational distortion; DNA binding; DNA repair; platinum drug

Indexed keywords

1 [2 (ACRIDIN 9 YLAMINO)ETHYL] 1,3 DIMETHYLTHIOUREA; ACRIDINE; ADENINE; AMIDINE; CISPLATIN; DNA BINDING PROTEIN; DOUBLE STRANDED DNA; GUANINE; N [2 (ACRIDIN 9 YLAMINO)ETHYL] N METHYLPROPIONAMIDINE; PLATINUM; RNA POLYMERASE II; THIOUREA; UNCLASSIFIED DRUG;

ARTICLE; CALORIMETRY; CIRCULAR DICHROISM; DENSITY FUNCTIONAL THEORY; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; DRUG DNA INTERACTION; DRUG STRUCTURE; HUMAN; HUMAN CELL; LINEAR DICHROISM; PRIORITY JOURNAL; THERMOSTABILITY; VISCOSITY;

EID: 84962367317     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200309x     Document Type: Article

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