Solution structural study of a DNA duplex containing the guanine-N7 adduct formed by a cytotoxic platinum - Acridine hybrid agent

Biochemistry

Volumn 44, Issue 16, 2005, Pages 6059-6070

  Baruah, Hemanta ^a   Wright, Marcus W ^a   Bierbach, Ulrich ^a  

^a WAKE FOREST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCENTRATION (PROCESS); DRUG DOSAGE; ETHANE; MATRIX ALGEBRA; MOLECULAR DYNAMICS; SOLUTIONS; THERMODYNAMIC STABILITY;

BINDING DRUGS; CYTOTOXICITY; DNA DUPLEX; NANOMOLAR CONCENTRATIONS;

DNA;

ACRIDINE DERIVATIVE; CISPLATIN; DEOXYRIBOSE; DNA A; DNA B; DNA FRAGMENT; DNA HYBRID; DOUBLE STRANDED DNA; GUANINE DERIVATIVE; NUCLEIC ACID BASE; PLATINUM DERIVATIVE; PLATINUM ETHANE 1,2 DIAMINE 1 [2 (ACRIDIN 9 YLAMINO)ETHYL 1,3 DIMETHYLTHIOUREA; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; CALCULATION; CHEMICAL STRUCTURE; CHROMATOPHORE; CROSS LINKING; CYTOTOXICITY; DNA ADDUCT; DRUG DNA BINDING; GEOMETRY; HYDROGEN BOND; INTERCALATION COMPLEX; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; SYNTHESIS; THERMOSTABILITY;

ACRIDINES; BASE SEQUENCE; CIRCULAR DICHROISM; DNA; DNA ADDUCTS; GUANINE; HYDROGEN BONDING; INTERCALATING AGENTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID CONFORMATION; ORGANOPLATINUM COMPOUNDS; SOLUTIONS; THERMODYNAMICS; UREA;

EID: 17644390241     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050021b     Document Type: Article

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