Unprecedented monofunctional metalation of adenine nucleobase in guanine- and thymine-containing dinucleotide sequences by a cytotoxic platinum-acridine hybrid agent

Journal of the American Chemical Society

Volumn 125, Issue 32, 2003, Pages 9629-9637

  Barry, Colin G ^a   Baruah, Hemanta ^a   Bierbach, Ulrich ^a  

^a WAKE FOREST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOFUNCTIONAL METALATION;

CELLS; DNA; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; UREA;

ENZYMES;

1 [2 (ACRIDIN 9 YLAMINO)ETHYL] 1,3 DIMETHYLTHIOUREA; AMINOACRIDINE DERIVATIVE; DOUBLE STRANDED DNA; GUANINE NUCLEOTIDE; NITRIC ACID DERIVATIVE; NUCLEIC ACID BASE; PLATINUM DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CROSS LINKING; CYTOTOXICITY; DNA ADDUCT; DNA DAMAGE; DNA DRUG COMPLEX; DNA SEQUENCE; DRUG ACTIVITY; DRUG BINDING SITE; DRUG CONJUGATION; DRUG DNA BINDING; GENE TARGETING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERCALATION COMPLEX; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE SEQUENCE; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE;

ACRIDINES; ADENINE; ANIMALS; CATTLE; CHROMATOGRAPHY, LIQUID; DEOXYGUANOSINE; DNA; DNA ADDUCTS; KINETICS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEOTIDES; ORGANOPLATINUM COMPOUNDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY; THYMIDINE;

EID: 0043127198     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0351443     Document Type: Article

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