Computational biology analysis of platelet signaling reveals roles of feedbacks through phospholipase C and inositol 1,4,5-trisphosphate 3-kinase in controlling amplitude and duration of calcium oscillations

Mathematical Biosciences

Volumn 276, Issue , 2016, Pages 67-74

  Balabin, Fedor A ^a   Sveshnikova, Anastasia N ^a,b,c  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b CENTER FOR THEORETICAL PROBLEMS OF PHYSICOCHEMICAL PHARMACOLOGY   (Russian Federation)

^c Clinical Center of Pediatric Hematology Oncology and Immunology   (Russian Federation)

Author keywords

Blood platelet; Calcium signaling; Negative feedback; Positive feedback

Indexed keywords

ALCOHOLS; BIOINFORMATICS; BLOOD; CALCIUM; CHEMICAL ACTIVATION; CYTOLOGY; ENZYMES; PHYSIOLOGICAL MODELS; PLANTS (BOTANY); PLATELETS; POLYOLS; SIGNALING; STOCHASTIC MODELS; STOCHASTIC SYSTEMS; SUGARS;

BLOOD PLATELETS; CALCIUM OSCILLATION; CALCIUM SIGNALING; COMPUTATIONAL BIOLOGY; COMPUTATIONAL MODEL; INTRACELLULAR CALCIUM CONCENTRATION; PLATELET ACTIVATION; STOCHASTIC SIMULATIONS;

FEEDBACK;

CALCIUM; INOSITOL TRISPHOSPHATE 3 KINASE; PHOSPHOLIPASE C; PHOSPHOLIPASE C BETA2; THROMBIN; INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE; PHOSPHOTRANSFERASE;

AMPLITUDE; BLOOD; CALCIUM; ENZYME; PHOSPHATE; PHOSPHOLIPID; SIGNALING;

ARTICLE; CALCIUM SIGNALING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOLOGY; CYTOSOL; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; NEGATIVE FEEDBACK; POSITIVE FEEDBACK; PREDICTION; PROBABILITY; SIMULATION; STOCHASTIC MODEL; THROMBOCYTE ACTIVATION; ANIMAL; BIOLOGY; ENZYMOLOGY; HUMAN; METABOLISM; PHYSIOLOGICAL FEEDBACK; PHYSIOLOGY; PROCEDURES; THROMBOCYTE;

ANIMALS; BLOOD PLATELETS; CALCIUM SIGNALING; COMPUTATIONAL BIOLOGY; FEEDBACK, PHYSIOLOGICAL; HUMANS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); TYPE C PHOSPHOLIPASES;

EID: 84962343576     PISSN: 00255564     EISSN: 18793134     Source Type: Journal    
DOI: 10.1016/j.mbs.2016.03.006     Document Type: Article

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