Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 12, 2016, Pages 3359-3364

  Wang, Guohao ^a,b,c   Liu, Xudong ^a,b,c   Gaertig, Marta A ^b   Li, Shihua ^b   Li, Xiao Jiang ^a,b  

^a INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Acinus; Aging; Degeneration; Huntingtin; Pancreas

Indexed keywords

ALPHA AMYLASE PANCREAS ISOENZYME; AMYLASE; CASPASE 3; ELASTASE; ELASTASE 3B; HUNTINGTIN; MICROSOMAL AMINOPEPTIDASE; NESTIN; PANCREAS ENZYME; PROTEIN; PROTEIN P62; SERINE PROTEINASE INHIBITOR; SPINK3 PROTEIN; TAMOXIFEN; TRIACYLGLYCEROL LIPASE; TRYPSIN; UNCLASSIFIED DRUG; ZYMOGEN GRANULE; HTT PROTEIN, MOUSE; NERVE PROTEIN; NUCLEAR PROTEIN;

ACINAR CELL; ACUTE PANCREATITIS; ADULT; AMYLASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASCITES; BODY WEIGHT; BRAIN SIZE; CELL LYSATE; CHROMATIN; COMPARATIVE STUDY; CONTROLLED STUDY; DEATH; ELECTRON TOMOGRAPHY; ENZYME ACTIVITY; FEMALE; GENETIC TRANSFECTION; HISTOPATHOLOGY; HYPEREMIA; ILEUS; IMMUNOFLUORESCENCE TEST; MALE; MOUSE; NERVE CELL; NERVE CELL DEGENERATION; NERVE DEGENERATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ROTAROD TEST; TRIACYLGLYCEROL LIPASE BLOOD LEVEL; WEIGHT GAIN; WESTERN BLOTTING; ACUTE DISEASE; ANIMAL; GENETICS; KNOCKOUT MOUSE; METABOLISM; PANCREATITIS;

ACUTE DISEASE; ANIMALS; HUNTINGTIN PROTEIN; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PANCREATITIS;

EID: 84962327593     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1524575113     Document Type: Article

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