Enhanced trypsin activity in pancreatic acinar cells deficient for serine protease inhibitor Kazal type 3 [4]

Pancreas

Volumn 33, Issue 1, 2006, Pages 104-106

  Ohmuraya, Masaki ^a   Hirota, Masahiko ^a   Araki, Kimi ^a   Baba, Hideo ^a   Yamamura, Ken Ichi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SERINE PROTEASE INHIBITOR KAZAL TYPE 3; SERINE PROTEINASE INHIBITOR; TRYPSIN; UNCLASSIFIED DRUG;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL TISSUE; AUTOPHAGY; CELL DEATH; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE; LETTER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SPINK3 GENE;

ANIMALS; GLYCOPROTEINS; MICE; MICE, KNOCKOUT; PANCREAS; PANCREATITIS; PROSTATIC SECRETORY PROTEINS; TRYPSIN;

EID: 33745699252     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpa.0000226889.86322.9b     Document Type: Letter

References (8)

1. Rinderknecht H. Pancreatic secretory enzymes. In: Go VLW, Di-Magno JD, Gardner JD, Lebenthal E, Reber HA, Scheele G eds. The pancreas: biology, pathophysiology, and disease. New York, NY: Raven Press, 1993:219-251.
2. Ohmuraya M, Hirota M, Araki M, et al. Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology. 2005;129:696-705.
3. Krüger B, Lerch MM, Tessenow W. Direct detection of premature protease activation in living pancreatic acinar cells. Lab Invest. 1998;78:763-764.
4. Grosfils K, Métioui M, Tiouli M, et al. Isolation of rat pancreatic acini with crude collagenase and permeabilization of these acini with streptolysin O. Res Commun Chem Pathol Pharmacol. 1993;79:99-115.
5. Leytus SP, Melhado LL, Mangel WF. Rhodamine-based compounds as fluorogenic substrates for serine proteinases. Biochem J. 1983;209:299-307.
6. Figarella C, Miszczuk-Jamska B, Barrett AJ. Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid. Activation of human trypsinogen 1. Biol Chem Hoppe Seyler. 1988;369:293-298.
7. Greenbaum LM, Hirshkowitz A, Shoichet I. The activation of trypsinogen by cathepsin B. J Biol Chem. 1959;234:2885-2890.
8. Kassell B, Kay J. Zymogens of proteolytic enzymes. Science. 1973;180:1022-1027.