Oncocin Onc72 is efficacious against antibiotic-susceptible Klebsiella pneumoniae ATCC 43816 in a murine thigh infection model

Biopolymers

Volumn 104, Issue 6, 2015, Pages 707-711

  Knappe, Daniel ^a,b   Adermann, Knut ^b   Hoffmann, Ralf ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b AMP Therapeutics GmbH   (Germany)

Author keywords

antimicrobial peptide; Klebsiella pneumonia; meropenem; oncocin; proline rich; thigh infection

Indexed keywords

ANTIBIOTICS; COMPARATOR CIRCUITS; COMPARATORS (OPTICAL); ESCHERICHIA COLI; MAMMALS; MICROORGANISMS; PEPTIDES; POLYPEPTIDES;

ANTIMICROBIAL PEPTIDE; KLEBSIELLA PNEUMONIA; MEROPENEM; ONCOCIN; PROLINE-RICH; THIGH INFECTION;

BACTERIA;

ANTIBIOTIC AGENT; CYCLOPHOSPHAMIDE; MEROPENEM; ONC72; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; ONCOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL COUNT; BACTERIAL STRAIN; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERABILITY; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LEG DISEASE; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THIGH INFECTION; ANIMAL; BACTERIAL INFECTIONS; DISEASE MODEL; DRUG EFFECTS; MICROBIOLOGY; SKELETAL MUSCLE;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIAL INFECTIONS; DISEASE MODELS, ANIMAL; KLEBSIELLA PNEUMONIAE; MICE; MUSCLE, SKELETAL;

EID: 84962301669     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.22668     Document Type: Article

References (27)

1. Otvos, L.,;, Bokonyi, K.,;, Varga, I.,;, Otvos, B. I.,;, Hoffmann, R.,;, Ertl, H. C. J.,;, Wade, J. D.,;, McManus, A. M.,;, Craik, D.,;, Bulet, P., Protein Sci 2000, 9, 742-749.
2. Otvos, L.,;, Wade, J. D.,;, Lin, F.,;, Condie, B. A.,;, Hanrieder, J.,;, Hoffmann, R., J Med Chem 2005, 48, 5349-5359.
3. Berthold, N.,;, Czihal, P.,;, Fritsche, S.,;, Sauer, U.,;, Schiffer, G.,;, Knappe, D.,;, Alber, G.,;, Hoffmann, R., Antimicrob Agents Chemother 2013, 57, 402-409.
4. Knappe, D.,;, Piantavigna, S.,;, Hansen, A.,;, Mechler, A.,;, Binas, A.,;, Nolte, O.,;, Martin, L. L.,;, Hoffmann, R., J Med Chem 2010, 53, 5240-5247.
5. Benincasa, M.,;, Scocchi, M.,;, Podda, E.,;, Skerlavaj, B.,;, Dolzani, L.,;, Gennaro, R., Peptides 2004, 25, 2055-2061.
6. Knappe, D.,;, Kabankov, N.,;, Hoffmann, R., Int J Antimicrob Agents 2011, 37, 166-170.
7. Czihal, P.,;, Knappe, D.,;, Fritsche, S.,;, Zahn, M.,;, Berthold, N.,;, Piantavigna, S.,;, Muller, U.,;, Van Dorpe, S.,;, Herth, N.,;, Binas, A.,;, Kohler, G.,;, De Spiegeleer, B.,;, Martin, L. L.,;, Nolte, O.,;, Strater, N.,;, Alber, G.,;, Hoffmann, R., ACS Chemical Biology 2012, 7, 1281-1291.
8. Ostorhazi, E.,;, Holub, M. C.,;, Ferenc, R.,;, Ferenc, H.,;, Cassone, M.,;, Wade, J. D.,;, Otvos, L., Int J Antimicrob Agents 2011, 37, 480-484.
9. Ostorhazi, E.,;, Rozgonyi, F.,;, Sztodola, A.,;, Harmos, F.,;, Kovalszky, I.,;, Szabo, D.,;, Knappe, D.,;, Hoffmann, R.,;, Cassone, M.,;, Wade, J. D.,;, Bonomo, R. A.,;, Otvos, L., J Antimicrob Chemother 2010, 65, 2416-2422.
10. Ostorhazi, E.,;, Rozgonyi, F.,;, Szabo, D.,;, Binas, A.,;, Cassone, M.,;, Wade, J. D.,;, Nolte, O.,;, Bethel, C. R.,;, Bonomo, R. A.,;, Otvos, L., Biopolymers 2011, 96, 126-129.
11. Knappe, D.,;, Fritsche, S.,;, Alber, G.,;, Kohler, G.,;, Hoffmann, R.,;, Muller, U., J Antimicrob Chemother 2012, 67, 2445-2451.
12. Ostorhazi, E.,;, Nemes-Nikodem, E.,;, Knappe, D.,;, Hoffmann, R., Protein Pept Lett 2014, 21, 368-373.
13. Krizsan, A.,;, Volke, D.,;, Weinert, S.,;, Strater, N.,;, Knappe, D.,;, Hoffmann, R., Angew Chem Int Ed 2014, 53, 12236-12239.
14. Knappe, D.,;, Zahn, M.,;, Sauer, U.,;, Schiffer, G.,;, Strater, N.,;, Hoffmann, R., ChemBioChem 2011, 12, 874-876.
15. Vogelman, B.,;, Gudmundsson, S.,;, Leggett, J.,;, Turnidge, J.,;, Ebert, S.,;, Craig, W. A., J Infect Dis 1988, 158, 831-847.
16. Ryan, D. M.,;, Cars, O., Scand J Infect Dis 1980, 12, 307-309.
17. Vogelman, B.,;, Gudmundsson, S.,;, Turnidge, J.,;, Leggett, J.,;, Craig, W. A., J Infect Dis 1988, 157, 287-298.
18. Fritsche, S.,;, Knappe, D.,;, Berthold, N.,;, von Buttlar, H.,;, Hoffmann, R.,;, Alber, G., J Pept Sci 2012, 18, 599-608.
19. Keitel, U.,;, Schilling, E.,;, Knappe, D.,;, Al-Mekhlafi, M.,;, Petersen, F.,;, Hoffmann, R.,;, Hauschildt, S., Innate Immunity 2013, 19, 355-367.
20. Tavano, R.,;, Segat, D.,;, Gobbo, M.,;, Papini, E., J Innate Immun 2011, 3, 614-622.
21. Ostorhazi, E.,;, Voros, E.,;, Nemes-Nikodem, E.,;, Pinter, D.,;, Sillo, P.,;, Mayer, B.,;, Wade, J. D.,;, Otvos, L., Int J Antimicrob Agents 2013, 42, 537-543.
22. Clinical and Laboratory Standards Institute Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically: M07-A8; CLSI: Wayne, PA, USA, 2009.
23. Craig, W. A.,;, Andes, D. R., Antimicrob Agents Chemother 2013, 57, 1577-1582.
24. Novakovic, Z. M.,;, Leinung, M. C.,;, Lee, D. W.,;, Grasso, P., Regul Pept 2009, 154, 107-111.
25. Kjellev, S.,;, Vestergaard, E. M.,;, Nexo, E.,;, Thygesen, P.,;, Ehoj, M. S.,;, Jeppesen, P. B.,;, Thim, L.,;, Pedersen, N. B.,;, Poulsen, S. S., Peptides 2007, 28, 1197-1206.
26. Noto, P. B.,;, Abbadessa, G.,;, Cassone, M.,;, Mateo, G. D.,;, Agelan, A.,;, Wade, J. D.,;, Szabo, D.,;, Kocsis, B.,;, Nagy, K.,;, Rozgonyi, F.,;, Otvos, L., Protein Sci 2008, 17, 1249-1255.
27. Reagan-Shaw, S.,;, Nihal, M.,;, Ahmad, N., Faseb J 2008, 22, 659-661.