Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): A novel antibacterial peptide optimized against gram-negative human pathogens

Journal of Medicinal Chemistry

Volumn 53, Issue 14, 2010, Pages 5240-5247

  Knappe, Daniel ^a   Piantavigna, Stefania ^b   Hansen, Anne ^a   Mechler, Adam ^b   Binas, Annegret ^c   Nolte, Oliver ^c   Martin, Lisandra L ^b   Hoffmann, Ralf ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b MONASH UNIVERSITY   (Australia)

^c AiCuris GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOCIN; ONCOCIN DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; PEPTIDE;

ACINETOBACTER BAUMANNII; AMINO ACID SUBSTITUTION; ARTICLE; CELL LINE; DRUG PENETRATION; ENTEROBACTERIACEAE; ERYTHROCYTE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; LIPID MEMBRANE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PSEUDOMONAS AERUGINOSA; ROOM TEMPERATURE; AMINO ACID SEQUENCE; ANIMAL; ARTIFICIAL MEMBRANE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; HEMOLYSIS; MICROBIOLOGICAL EXAMINATION; MOLECULAR GENETICS; PERMEABILITY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL LINE, TUMOR; CELL SURVIVAL; GRAM-NEGATIVE BACTERIA; HEMOLYSIS; HUMANS; MEMBRANES, ARTIFICIAL; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PEPTIDES; PERMEABILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77954725852     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100378b     Document Type: Article

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