Intranasal administration of mouse [D-Leu-4]OB3, a synthetic peptide amide with leptin-like activity, enhances total uptake and bioavailability in Swiss Webster mice when compared to intraperitoneal, subcutaneous, and intramuscular delivery systems

Regulatory Peptides

Volumn 154, Issue 1-3, 2009, Pages 107-111

  Novakovic, Zachary M ^a   Leinung, Matthew C ^a   Lee, Daniel W ^a   Grasso, Patricia ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Drug delivery; Energy balance; Leptin; Pharmacokinetics; Synthetic peptides

Indexed keywords

[DEXTRO LEUCINE 4]OB 3 PEPTIDE; AMIDE; LEPTIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG UPTAKE; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SWISS WEBSTER MOUSE;

ADMINISTRATION, INTRANASAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; HALF-LIFE; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; LEPTIN; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED STRAINS; PEPTIDE FRAGMENTS;

MUS;

EID: 63249116770     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2009.01.002     Document Type: Article

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