Novel apidaecin 1b analogs with superior serum stabilities for treatment of infections by Gram-negative pathogens

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 1, 2013, Pages 402-409

  Berthold, Nicole ^a   Czihal, Patricia ^a   Fritsche, Stefanie ^a   Sauer, Ute ^b   Schiffer, Guido ^b   Knappe, Daniel ^a   Alber, Gottfried ^a   Hoffmann, Ralf ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b AiCuris GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; APIDAECIN 1B; ARGININE; CHAPERONE; HOMOARGININE; ORNITHINE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL INFECTION; BACTERIAL STRAIN; CELL STRAIN HEK293; DRUG STABILITY; ERYTHROCYTE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SERUM;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; ARGININE; CELL LINE, TUMOR; CELL SURVIVAL; DENDRITIC CELLS; ERYTHROCYTES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HALF-LIFE; HOMOARGININE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; ORNITHINE; PROTEIN STABILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872048892     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01923-12     Document Type: Article

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