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Volumn 173, Issue 2, 2016, Pages 452-464

Role of Zinc Supplementation in Testicular and Epididymal Damages in Diabetic Rat: Involvement of Nrf2, SOD1, and GPX5

Author keywords

Diabetes; Epididymis; GPX5; Nrf2; SOD1; Testes; Zinc

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLINE; CYCLOOXYGENASE 2; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 5; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MALONALDEHYDE; METALLOTHIONEIN; MITOGEN ACTIVATED PROTEIN KINASE; NITROGEN; PROTEIN BCL 2; TESTOSTERONE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; UREA; ZINC; ZINC SULFATE; NFE2L2 PROTEIN, RAT; SELENIUM-INDEPENDENT GLUTATHIONE PEROXIDASE; SOD1 PROTEIN, RAT;

EID: 84962277907     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-016-0674-7     Document Type: Article
Times cited : (51)

References (63)
  • 1
    • 77951536164 scopus 로고    scopus 로고
    • Impact of the discovery of human zinc deficiency on health
    • COI: 1:CAS:528:DC%2BC3cXhtVWmt70%3D, PID: 20150599
    • Prasad AS (2009) Impact of the discovery of human zinc deficiency on health. J Am Coll Nutr 28(3):257–265
    • (2009) J Am Coll Nutr , vol.28 , Issue.3 , pp. 257-265
    • Prasad, A.S.1
  • 2
    • 84940166442 scopus 로고    scopus 로고
    • Impact of the discovery of human zinc deficiency on health
    • COI: 1:CAS:528:DC%2BC2cXhsFGltbnL, PID: 25260885
    • Prasad AS (2014) Impact of the discovery of human zinc deficiency on health. J Trace Elem Med Biol 28(4):357–363. doi:10.1016/j.jtemb.2014.09.002
    • (2014) J Trace Elem Med Biol , vol.28 , Issue.4 , pp. 357-363
    • Prasad, A.S.1
  • 3
    • 0345096663 scopus 로고    scopus 로고
    • Trace elements in human physiology and pathology: zinc and metallothioneins
    • COI: 1:CAS:528:DC%2BD3sXptlOltrY%3D, PID: 14652165
    • Tapiero H, Tew KD (2003) Trace elements in human physiology and pathology: zinc and metallothioneins. Biomed Pharmacother 57(9):399–411
    • (2003) Biomed Pharmacother , vol.57 , Issue.9 , pp. 399-411
    • Tapiero, H.1    Tew, K.D.2
  • 4
    • 0015188668 scopus 로고
    • Changes in activities of zinc-dependent enzymes in zinc-deficient tissues of rats
    • COI: 1:CAS:528:DyaE38XksV2itA%3D%3D, PID: 5166313
    • Prasad AS, Oberleas D (1971) Changes in activities of zinc-dependent enzymes in zinc-deficient tissues of rats. J Appl Physiol 31(6):842–846
    • (1971) J Appl Physiol , vol.31 , Issue.6 , pp. 842-846
    • Prasad, A.S.1    Oberleas, D.2
  • 5
    • 0031953045 scopus 로고    scopus 로고
    • Effects of zinc supplementation on the plasma glucose level and insulin activity in genetically obese (ob/ob) mice
    • COI: 1:CAS:528:DyaK1cXitFCjsbc%3D, PID: 9533568
    • Chen M-D, Liou S-J, Lin P-Y, Yang VC, Alexander PS, Lin W-H (1998) Effects of zinc supplementation on the plasma glucose level and insulin activity in genetically obese (ob/ob) mice. Biol Trace Elem Res 61(3):303–311
    • (1998) Biol Trace Elem Res , vol.61 , Issue.3 , pp. 303-311
    • Chen, M.-D.1    Liou, S.-J.2    Lin, P.-Y.3    Yang, V.C.4    Alexander, P.S.5    Lin, W.-H.6
  • 6
    • 84890787373 scopus 로고    scopus 로고
    • Blood metals concentration in type 1 and type 2 diabetics
    • COI: 1:CAS:528:DC%2BC3sXhslGltr7M, PID: 24222606
    • Forte G, Bocca B, Peruzzu A, Tolu F, Asara Y, Farace C, et al. (2013) Blood metals concentration in type 1 and type 2 diabetics. Biol Trace Elem Res 156(1–3):79–90
    • (2013) Biol Trace Elem Res , vol.156 , Issue.1-3 , pp. 79-90
    • Forte, G.1    Bocca, B.2    Peruzzu, A.3    Tolu, F.4    Asara, Y.5    Farace, C.6
  • 7
    • 17944362911 scopus 로고    scopus 로고
    • Zinc and diabetes mellitus: is there a need of zinc supplementation in diabetes mellitus patients?
    • COI: 1:CAS:528:DC%2BD3MXnt12hsro%3D, PID: 11575679
    • Salgueiro MJ, Krebs N, Zubillaga MB, Weill R, Postaire E, Lysionek AE, et al. (2001) Zinc and diabetes mellitus: is there a need of zinc supplementation in diabetes mellitus patients? Biol Trace Elem Res 81(3):215–228. doi:10.1385/bter:81:3:215
    • (2001) Biol Trace Elem Res , vol.81 , Issue.3 , pp. 215-228
    • Salgueiro, M.J.1    Krebs, N.2    Zubillaga, M.B.3    Weill, R.4    Postaire, E.5    Lysionek, A.E.6
  • 9
    • 84862205290 scopus 로고    scopus 로고
    • Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC38XhslOiu7fP, PID: 22515411
    • Jayawardena R, Ranasinghe P, Galappatthy P, Malkanthi R, Constantine G, Katulanda P (2012) Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. Diabetol Metab Syndr 4(1):13. doi:10.1186/1758-5996-4-13
    • (2012) Diabetol Metab Syndr , vol.4 , Issue.1 , pp. 13
    • Jayawardena, R.1    Ranasinghe, P.2    Galappatthy, P.3    Malkanthi, R.4    Constantine, G.5    Katulanda, P.6
  • 10
    • 77949567615 scopus 로고    scopus 로고
    • Antioxidant systems and oxidative stress in the testes
    • Aitken RJ, Roman SD (2008) Antioxidant systems and oxidative stress in the testes. Oxidative Med Cell Longev 1(1):15–24
    • (2008) Oxidative Med Cell Longev , vol.1 , Issue.1 , pp. 15-24
    • Aitken, R.J.1    Roman, S.D.2
  • 11
    • 78751662679 scopus 로고    scopus 로고
    • Type 1 diabetes: etiology, immunology, and therapeutic strategies
    • PID: 21248163
    • van Belle TL, Coppieters KT, von Herrath MG (2011) Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev 91(1):79–118. doi:10.1152/physrev.00003.2010
    • (2011) Physiol Rev , vol.91 , Issue.1 , pp. 79-118
    • van Belle, T.L.1    Coppieters, K.T.2    von Herrath, M.G.3
  • 12
    • 0037386902 scopus 로고    scopus 로고
    • Resorption of the element zinc from spermatozoa by the epididymal epithelium
    • COI: 1:CAS:528:DC%2BD3sXktVWntb0%3D, PID: 12654019
    • Henkel R, Baldauf C, Schill WB (2003) Resorption of the element zinc from spermatozoa by the epididymal epithelium. Reprod Domest Anim 38(2):97–101
    • (2003) Reprod Domest Anim , vol.38 , Issue.2 , pp. 97-101
    • Henkel, R.1    Baldauf, C.2    Schill, W.B.3
  • 13
    • 0023445728 scopus 로고
    • Zinc content in epididymal spermatozoa of metoclopramide-treated rats
    • COI: 1:CAS:528:DyaL1cXht1Clur0%3D, PID: 3434858
    • Kaminska B, Rozewicka L, Dominiak B, Mielnicka M, Mikulska D (1987) Zinc content in epididymal spermatozoa of metoclopramide-treated rats. Andrologia 19(6):677–683
    • (1987) Andrologia , vol.19 , Issue.6 , pp. 677-683
    • Kaminska, B.1    Rozewicka, L.2    Dominiak, B.3    Mielnicka, M.4    Mikulska, D.5
  • 14
    • 0020696190 scopus 로고
    • Zinc content of maturing spermatozoa in oestrogen treated rats
    • COI: 1:CAS:528:DyaL3sXhsFGgtL4%3D, PID: 6840876
    • Srivastava A, Chowdhury AR, Setty BS (1983) Zinc content of maturing spermatozoa in oestrogen treated rats. Int J Androl 6(1):103–108
    • (1983) Int J Androl , vol.6 , Issue.1 , pp. 103-108
    • Srivastava, A.1    Chowdhury, A.R.2    Setty, B.S.3
  • 15
    • 84903892521 scopus 로고    scopus 로고
    • Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function
    • COI: 1:CAS:528:DC%2BC2cXhtlGmtLjF, PID: 24967692
    • Jiang X, Bai Y, Zhang Z, Xin Y, Cai L (2014) Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function. Toxicol Appl Pharmacol 279(2):198–210. doi:10.1016/j.taap.2014.06.009
    • (2014) Toxicol Appl Pharmacol , vol.279 , Issue.2 , pp. 198-210
    • Jiang, X.1    Bai, Y.2    Zhang, Z.3    Xin, Y.4    Cai, L.5
  • 16
    • 84875608972 scopus 로고    scopus 로고
    • Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress-dependent pathways in the mouse model
    • COI: 1:CAS:528:DC%2BC3sXltVCrur0%3D, PID: 23499715
    • Jiang X, Zhang C, Xin Y, Huang Z, Tan Y, Huang Y, et al. (2013) Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress-dependent pathways in the mouse model. Toxicol Lett 219(1):65–76. doi:10.1016/j.toxlet.2013.02.022
    • (2013) Toxicol Lett , vol.219 , Issue.1 , pp. 65-76
    • Jiang, X.1    Zhang, C.2    Xin, Y.3    Huang, Z.4    Tan, Y.5    Huang, Y.6
  • 17
    • 84903644519 scopus 로고    scopus 로고
    • Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function
    • COI: 1:CAS:528:DC%2BC2cXht1ygsbvI, PID: 24801392
    • Wang Y, Zhang Z, Guo W, Sun W, Miao X, Wu H, et al. (2014) Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function. Am J Physiol Endocrinol Metab 307(1):E14–E23. doi:10.1152/ajpendo.00702.2013
    • (2014) Am J Physiol Endocrinol Metab , vol.307 , Issue.1 , pp. 14-23
    • Wang, Y.1    Zhang, Z.2    Guo, W.3    Sun, W.4    Miao, X.5    Wu, H.6
  • 18
    • 78650177805 scopus 로고    scopus 로고
    • Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice
    • COI: 1:CAS:528:DC%2BC3cXhsFylu7%2FJ, PID: 21078376
    • Zhao Y, Tan Y, Dai J, Li B, Guo L, Cui J, et al. (2011) Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice. Toxicol Lett 200(1–2):100–106. doi:10.1016/j.toxlet.2010.11.001
    • (2011) Toxicol Lett , vol.200 , Issue.1-2 , pp. 100-106
    • Zhao, Y.1    Tan, Y.2    Dai, J.3    Li, B.4    Guo, L.5    Cui, J.6
  • 19
    • 84864014670 scopus 로고    scopus 로고
    • Zinc deficiency exacerbates diabetic down-regulation of akt expression and function in the testis: essential roles of PTEN, PTP1B and TRB3
    • COI: 1:CAS:528:DC%2BC38XhtVymsLzL, PID: 22000581
    • Zhao Y, Tan Y, Dai J, Wang B, Li B, Guo L, et al. (2012) Zinc deficiency exacerbates diabetic down-regulation of akt expression and function in the testis: essential roles of PTEN, PTP1B and TRB3. J Nutr Biochem 23(8):1018–1026. doi:10.1016/j.jnutbio.2011.05.011
    • (2012) J Nutr Biochem , vol.23 , Issue.8 , pp. 1018-1026
    • Zhao, Y.1    Tan, Y.2    Dai, J.3    Wang, B.4    Li, B.5    Guo, L.6
  • 20
    • 84871455786 scopus 로고    scopus 로고
    • Effects of Zn deficiency, antioxidants, and low-dose radiation on diabetic oxidative damage and cell death in the testis
    • COI: 1:CAS:528:DC%2BC38XhvVClu7zE, PID: 22992206
    • Zhao Y, Zhao H, Zhai X, Dai J, Jiang X, Wang G, et al. (2013) Effects of Zn deficiency, antioxidants, and low-dose radiation on diabetic oxidative damage and cell death in the testis. Toxicol Mech Methods 23(1):42–47. doi:10.3109/15376516.2012.731437
    • (2013) Toxicol Mech Methods , vol.23 , Issue.1 , pp. 42-47
    • Zhao, Y.1    Zhao, H.2    Zhai, X.3    Dai, J.4    Jiang, X.5    Wang, G.6
  • 21
    • 0033842759 scopus 로고    scopus 로고
    • Zinc sulphate induces metallothionein in pancreatic islets of mice and protects against diabetes induced by multiple low doses of streptozotocin
    • COI: 1:CAS:528:DC%2BD3cXlsVWrurY%3D, PID: 10990080
    • Ohly P, Dohle C, Abel J, Seissler J, Gleichmann H (2000) Zinc sulphate induces metallothionein in pancreatic islets of mice and protects against diabetes induced by multiple low doses of streptozotocin. Diabetologia 43(8):1020–1030. doi:10.1007/s001250050009
    • (2000) Diabetologia , vol.43 , Issue.8 , pp. 1020-1030
    • Ohly, P.1    Dohle, C.2    Abel, J.3    Seissler, J.4    Gleichmann, H.5
  • 22
    • 0035130899 scopus 로고    scopus 로고
    • Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice
    • COI: 1:CAS:528:DC%2BD3MXpvFyrsw%3D%3D
    • Ho E, Quan N, Tsai YH, Lai W, Bray TM (2001) Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice. Exp Biol Med (Maywood) 226(2):103–111
    • (2001) Exp Biol Med (Maywood) , vol.226 , Issue.2 , pp. 103-111
    • Ho, E.1    Quan, N.2    Tsai, Y.H.3    Lai, W.4    Bray, T.M.5
  • 23
    • 0029825075 scopus 로고    scopus 로고
    • Evidence of a relationship between childhood-onset type I diabetes and low groundwater concentration of zinc
    • COI: 1:STN:280:DyaK28vktVaqtw%3D%3D, PID: 8842606
    • Haglund B, Ryckenberg K, Selinus O, Dahlquist G (1996) Evidence of a relationship between childhood-onset type I diabetes and low groundwater concentration of zinc. Diabetes Care 19(8):873–875
    • (1996) Diabetes Care , vol.19 , Issue.8 , pp. 873-875
    • Haglund, B.1    Ryckenberg, K.2    Selinus, O.3    Dahlquist, G.4
  • 24
    • 1542344892 scopus 로고    scopus 로고
    • Zinc and nitrate in the ground water and the incidence of type 1 diabetes in Finland
    • COI: 1:CAS:528:DC%2BD2cXislOnsbg%3D, PID: 15008836
    • Moltchanova E, Rytkonen M, Kousa A, Taskinen O, Tuomilehto J, Karvonen M (2004) Zinc and nitrate in the ground water and the incidence of type 1 diabetes in Finland. Diabet Med 21(3):256–261
    • (2004) Diabet Med , vol.21 , Issue.3 , pp. 256-261
    • Moltchanova, E.1    Rytkonen, M.2    Kousa, A.3    Taskinen, O.4    Tuomilehto, J.5    Karvonen, M.6
  • 25
    • 0030940140 scopus 로고    scopus 로고
    • Incidence of childhood diabetes mellitus in Yorkshire, Northern England, is associated with nitrate in drinking water: an ecological analysis
    • COI: 1:STN:280:DyaK2szgsl2qtQ%3D%3D, PID: 9165223
    • Parslow RC, McKinney PA, Law GR, Staines A, Williams R, Bodansky HJ (1997) Incidence of childhood diabetes mellitus in Yorkshire, Northern England, is associated with nitrate in drinking water: an ecological analysis. Diabetologia 40(5):550–556. doi:10.1007/s001250050714
    • (1997) Diabetologia , vol.40 , Issue.5 , pp. 550-556
    • Parslow, R.C.1    McKinney, P.A.2    Law, G.R.3    Staines, A.4    Williams, R.5    Bodansky, H.J.6
  • 26
    • 79955408432 scopus 로고    scopus 로고
    • Low zinc in drinking water is associated with the risk of type 1 diabetes in children
    • COI: 1:CAS:528:DC%2BC3MXot1yjs74%3D, PID: 20920146
    • Samuelsson U, Oikarinen S, Hyoty H, Ludvigsson J (2011) Low zinc in drinking water is associated with the risk of type 1 diabetes in children. Pediatr Diabetes 12(3 Pt 1):156–164. doi:10.1111/j.1399-5448.2010.00678.x
    • (2011) Pediatr Diabetes , vol.12 , Issue.3 , pp. 156-164
    • Samuelsson, U.1    Oikarinen, S.2    Hyoty, H.3    Ludvigsson, J.4
  • 27
    • 0036730726 scopus 로고    scopus 로고
    • Acidic drinking water and risk of childhood-onset type 1 diabetes
    • COI: 1:CAS:528:DC%2BD38XntlegsLc%3D, PID: 12196423
    • Stene LC, Hongve D, Magnus P, Ronningen KS, Joner G (2002) Acidic drinking water and risk of childhood-onset type 1 diabetes. Diabetes Care 25(9):1534–1538
    • (2002) Diabetes Care , vol.25 , Issue.9 , pp. 1534-1538
    • Stene, L.C.1    Hongve, D.2    Magnus, P.3    Ronningen, K.S.4    Joner, G.5
  • 28
    • 0034797962 scopus 로고    scopus 로고
    • Drinking water composition and childhood-onset type 1 diabetes mellitus in Devon and Cornwall, England
    • COI: 1:CAS:528:DC%2BD3MXnvVygs7g%3D, PID: 11606168
    • Zhao HX, Mold MD, Stenhouse EA, Bird SC, Wright DE, Demaine AG, et al. (2001) Drinking water composition and childhood-onset type 1 diabetes mellitus in Devon and Cornwall, England. Diabet Med 18(9):709–717
    • (2001) Diabet Med , vol.18 , Issue.9 , pp. 709-717
    • Zhao, H.X.1    Mold, M.D.2    Stenhouse, E.A.3    Bird, S.C.4    Wright, D.E.5    Demaine, A.G.6
  • 29
    • 84871439111 scopus 로고    scopus 로고
    • The role of zinc in the prevention of diabetic cardiomyopathy and nephropathy
    • COI: 1:CAS:528:DC%2BC38XhvVClu7zI, PID: 23039870
    • Li B, Tan Y, Sun W, Fu Y, Miao L, Cai L (2013) The role of zinc in the prevention of diabetic cardiomyopathy and nephropathy. Toxicol Mech Methods 23(1):27–33. doi:10.3109/15376516.2012.735277
    • (2013) Toxicol Mech Methods , vol.23 , Issue.1 , pp. 27-33
    • Li, B.1    Tan, Y.2    Sun, W.3    Fu, Y.4    Miao, L.5    Cai, L.6
  • 30
    • 84875283820 scopus 로고    scopus 로고
    • Zinc protects against diabetes-induced pathogenic changes in the aorta: roles of metallothionein and nuclear factor (erythroid-derived 2)-like 2
    • COI: 1:CAS:528:DC%2BC3sXotFCltL0%3D, PID: 23536959
    • Miao X, Wang Y, Sun J, Sun W, Tan Y, Cai L, et al. (2013) Zinc protects against diabetes-induced pathogenic changes in the aorta: roles of metallothionein and nuclear factor (erythroid-derived 2)-like 2. Cardiovasc Diabetol 12:54. doi:10.1186/1475-2840-12-54
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 54
    • Miao, X.1    Wang, Y.2    Sun, J.3    Sun, W.4    Tan, Y.5    Cai, L.6
  • 31
    • 84900557344 scopus 로고    scopus 로고
    • Zinc is essential for the transcription function of Nrf2 in human renal tubule cells in vitro and mouse kidney in vivo under the diabetic condition
    • COI: 1:CAS:528:DC%2BC2cXotFOnsro%3D, PID: 24597671
    • Li B, Cui W, Tan Y, Luo P, Chen Q, Zhang C, et al. (2014) Zinc is essential for the transcription function of Nrf2 in human renal tubule cells in vitro and mouse kidney in vivo under the diabetic condition. J Cell Mol Med 18(5):895–906. doi:10.1111/jcmm.12239
    • (2014) J Cell Mol Med , vol.18 , Issue.5 , pp. 895-906
    • Li, B.1    Cui, W.2    Tan, Y.3    Luo, P.4    Chen, Q.5    Zhang, C.6
  • 32
    • 0038150155 scopus 로고    scopus 로고
    • Zinc-induced NF-kappaB inhibition can be modulated by changes in the intracellular metallothionein level
    • COI: 1:CAS:528:DC%2BD3sXls1Cjsb0%3D, PID: 12878048
    • Kim CH, Kim JH, Lee J, Ahn YS (2003) Zinc-induced NF-kappaB inhibition can be modulated by changes in the intracellular metallothionein level. Toxicol Appl Pharmacol 190(2):189–196
    • (2003) Toxicol Appl Pharmacol , vol.190 , Issue.2 , pp. 189-196
    • Kim, C.H.1    Kim, J.H.2    Lee, J.3    Ahn, Y.S.4
  • 33
    • 84857033317 scopus 로고    scopus 로고
    • Enalapril reduces germ cell toxicity in streptozotocin-induced diabetic rat: investigation on possible mechanisms
    • COI: 1:CAS:528:DC%2BC38Xhtlyqtro%3D
    • Kushwaha S, Jena GB (2012) Enalapril reduces germ cell toxicity in streptozotocin-induced diabetic rat: investigation on possible mechanisms. Naunyn Schmiedeberg’s Arch Pharmacol 385(2):111–124. doi:10.1007/s00210-011-0707-x
    • (2012) Naunyn Schmiedeberg’s Arch Pharmacol , vol.385 , Issue.2 , pp. 111-124
    • Kushwaha, S.1    Jena, G.B.2
  • 34
    • 84864359151 scopus 로고    scopus 로고
    • Perrotta I, Santoro M, Guido C, Avena P, Tripepi S, De Amicis F, et al. (2012) Expression of cyclooxygenase-1 (COX-1) and COX-2 in human male gametes from normal patients, and those with varicocele and diabetes: a potential molecular marker for diagnosing male infertility disorders. J Anat 221(3):209–220. doi:10.1111/j.1469-7580.2012.01534.x
  • 35
    • 0019379118 scopus 로고
    • Comparative labelling of rat epididymal spermatozoa by intratesticularly administered 65ZnCl2 and [35S] cysteine
    • COI: 1:CAS:528:DyaL3MXmt1Glsw%3D%3D, PID: 7452627
    • Calvin HI (1981) Comparative labelling of rat epididymal spermatozoa by intratesticularly administered 65ZnCl2 and [35S] cysteine. J Reprod Fertil 61(1):65–73
    • (1981) J Reprod Fertil , vol.61 , Issue.1 , pp. 65-73
    • Calvin, H.I.1
  • 36
    • 84896315184 scopus 로고    scopus 로고
    • Zinc protects cyclophosphamide-induced testicular damage in rat: involvement of metallothionein, tesmin and Nrf2
    • COI: 1:CAS:528:DC%2BC2cXjsVKru7Y%3D, PID: 24565835
    • Maremanda KP, Khan S, Jena G (2014) Zinc protects cyclophosphamide-induced testicular damage in rat: involvement of metallothionein, tesmin and Nrf2. Biochem Biophys Res Commun 445(3):591–596. doi:10.1016/j.bbrc.2014.02.055
    • (2014) Biochem Biophys Res Commun , vol.445 , Issue.3 , pp. 591-596
    • Maremanda, K.P.1    Khan, S.2    Jena, G.3
  • 37
    • 77949683207 scopus 로고    scopus 로고
    • Mammalian glutathione peroxidases control acquisition and maintenance of spermatozoa integrity
    • COI: 1:CAS:528:DC%2BC3cXksVCgu7g%3D, PID: 20042549
    • Chabory E, Damon C, Lenoir A, Henry-Berger J, Vernet P, Cadet R, et al. (2010) Mammalian glutathione peroxidases control acquisition and maintenance of spermatozoa integrity. J Anim Sci 88(4):1321–1331. doi:10.2527/jas.2009-2583
    • (2010) J Anim Sci , vol.88 , Issue.4 , pp. 1321-1331
    • Chabory, E.1    Damon, C.2    Lenoir, A.3    Henry-Berger, J.4    Vernet, P.5    Cadet, R.6
  • 38
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • COI: 1:CAS:528:DyaE1MXksFaisbk%3D, PID: 36810
    • Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351–358
    • (1979) Anal Biochem , vol.95 , Issue.2 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 39
    • 84880039923 scopus 로고    scopus 로고
    • Telmisartan ameliorates germ cell toxicity in the STZ-induced diabetic rat: studies on possible molecular mechanisms
    • COI: 1:CAS:528:DC%2BC3sXot1Krtb0%3D
    • Kushwaha S, Jena GB (2013) Telmisartan ameliorates germ cell toxicity in the STZ-induced diabetic rat: studies on possible molecular mechanisms. Mutat Res Genet Toxicol Environ Mutagen 755(1):11–23. doi:10.1016/j.mrgentox.2013.04.013
    • (2013) Mutat Res Genet Toxicol Environ Mutagen , vol.755 , Issue.1 , pp. 11-23
    • Kushwaha, S.1    Jena, G.B.2
  • 40
    • 0018646269 scopus 로고
    • Direct measurement of zinc in plasma by atomic absorption spectroscopy
    • Spencer H (1979) Direct measurement of zinc in plasma by atomic absorption spectroscopy. Clin Chem 25(8):1487–1491
    • (1979) Clin Chem , vol.25 , Issue.8 , pp. 1487-1491
    • Spencer, H.1
  • 41
    • 0018235391 scopus 로고
    • Zinc content of human ejaculate and the motility of sperm cells
    • COI: 1:CAS:528:DyaE1MXhtFylsLg%3D
    • Danscher G, Hammen R, Fjerdingstad E, Rebbe H (1978) Zinc content of human ejaculate and the motility of sperm cells. Int J Androl 1(1–6):576–581
    • (1978) Int J Androl , vol.1 , Issue.1-6 , pp. 576-581
    • Danscher, G.1    Hammen, R.2    Fjerdingstad, E.3    Rebbe, H.4
  • 42
    • 80055014296 scopus 로고    scopus 로고
    • Investigation on sodium valproate induced germ cell damage, oxidative stress and genotoxicity in male Swiss mice
    • COI: 1:CAS:528:DC%2BC3MXhsFegtrnK, PID: 22001255
    • Khan S, Ahmad T, Parekh CV, Trivedi PP, Kushwaha S, Jena G (2011) Investigation on sodium valproate induced germ cell damage, oxidative stress and genotoxicity in male Swiss mice. Reprod Toxicol 32(4):385–394
    • (2011) Reprod Toxicol , vol.32 , Issue.4 , pp. 385-394
    • Khan, S.1    Ahmad, T.2    Parekh, C.V.3    Trivedi, P.P.4    Kushwaha, S.5    Jena, G.6
  • 43
    • 0031684511 scopus 로고    scopus 로고
    • Expression of extracellular glutathione peroxidase type 5 (GPX5) in the rat male reproductive tract
    • COI: 1:CAS:528:DyaK1cXmvVSrs7g%3D, PID: 9783843
    • Williams K, Frayne J, Hall L (1998) Expression of extracellular glutathione peroxidase type 5 (GPX5) in the rat male reproductive tract. Mol Hum Reprod 4(9):841–848
    • (1998) Mol Hum Reprod , vol.4 , Issue.9 , pp. 841-848
    • Williams, K.1    Frayne, J.2    Hall, L.3
  • 44
    • 0037076907 scopus 로고    scopus 로고
    • Dietary zinc deficiency induced-changes in the activity of enzymes and the levels of free radicals, lipids and protein electrophoretic behavior in growing rats
    • COI: 1:CAS:528:DC%2BD38XktFKht78%3D, PID: 12049850
    • Yousef MI, El-Hendy HA, El-Demerdash FM, Elagamy EI (2002) Dietary zinc deficiency induced-changes in the activity of enzymes and the levels of free radicals, lipids and protein electrophoretic behavior in growing rats. Toxicology 175(1–3):223–234
    • (2002) Toxicology , vol.175 , Issue.1-3 , pp. 223-234
    • Yousef, M.I.1    El-Hendy, H.A.2    El-Demerdash, F.M.3    Elagamy, E.I.4
  • 45
    • 84924798483 scopus 로고    scopus 로고
    • Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat
    • COI: 1:CAS:528:DC%2BC2MXnslOqtQ%3D%3D, PID: 25576297
    • Khan S, Jena G, Tikoo K (2015) Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat. Exp Mol Pathol 98(2):230–239
    • (2015) Exp Mol Pathol , vol.98 , Issue.2 , pp. 230-239
    • Khan, S.1    Jena, G.2    Tikoo, K.3
  • 46
    • 85027943216 scopus 로고    scopus 로고
    • Effect of zinc supplementation on the distribution of various elements in the serum of diabetic rats subjected to an acute swimming exercise
    • COI: 1:CAS:528:DC%2BC3MXhsVeitLnM, PID: 21607732
    • Bicer M, Akil M, Sivrikaya A, Kara E, Baltaci AK, Mogulkoc R (2011) Effect of zinc supplementation on the distribution of various elements in the serum of diabetic rats subjected to an acute swimming exercise. J Physiol Biochem 67(4):511–517. doi:10.1007/s13105-011-0096-0
    • (2011) J Physiol Biochem , vol.67 , Issue.4 , pp. 511-517
    • Bicer, M.1    Akil, M.2    Sivrikaya, A.3    Kara, E.4    Baltaci, A.K.5    Mogulkoc, R.6
  • 47
    • 33745010751 scopus 로고    scopus 로고
    • Antihyperlipidemic and antidiabetic effects of umbelliferone in streptozotocin diabetic rats
    • COI: 1:CAS:528:DC%2BD28XmsFelsL0%3D, PID: 16720013
    • Ramesh B, Pugalendi KV (2005) Antihyperlipidemic and antidiabetic effects of umbelliferone in streptozotocin diabetic rats. Yale J Biol Med 78(4):189–196
    • (2005) Yale J Biol Med , vol.78 , Issue.4 , pp. 189-196
    • Ramesh, B.1    Pugalendi, K.V.2
  • 48
    • 32544448369 scopus 로고    scopus 로고
    • Effects of parsley (Petroselinum crispum) extract versus glibornuride on the liver of streptozotocin-induced diabetic rats
    • PID: 16223573
    • Ozsoy-Sacan O, Yanardag R, Orak H, Ozgey Y, Yarat A, Tunali T (2006) Effects of parsley (Petroselinum crispum) extract versus glibornuride on the liver of streptozotocin-induced diabetic rats. J Ethnopharmacol 104(1–2):175–181. doi:10.1016/j.jep.2005.08.069
    • (2006) J Ethnopharmacol , vol.104 , Issue.1-2 , pp. 175-181
    • Ozsoy-Sacan, O.1    Yanardag, R.2    Orak, H.3    Ozgey, Y.4    Yarat, A.5    Tunali, T.6
  • 49
    • 84961291031 scopus 로고    scopus 로고
    • Zinc treatment prevents type 1 diabetes-induced hepatic oxidative damage, endoplasmic reticulum stress, and cell death, and even prevents possible steatohepatitis in the OVE26 mouse model: important role of metallothionein
    • COI: 1:CAS:528:DC%2BC2MXhtlWht7k%3D, PID: 25617602
    • Liang T, Zhang Q, Sun W, Xin Y, Zhang Z, Tan Y, et al. (2015) Zinc treatment prevents type 1 diabetes-induced hepatic oxidative damage, endoplasmic reticulum stress, and cell death, and even prevents possible steatohepatitis in the OVE26 mouse model: important role of metallothionein. Toxicol Lett 233(2):114–124. doi:10.1016/j.toxlet.2015.01.010
    • (2015) Toxicol Lett , vol.233 , Issue.2 , pp. 114-124
    • Liang, T.1    Zhang, Q.2    Sun, W.3    Xin, Y.4    Zhang, Z.5    Tan, Y.6
  • 50
    • 0021176374 scopus 로고
    • Oral zinc supplementation improves hepatic encephalopathy. Results of a randomised controlled trial
    • COI: 1:STN:280:DyaL2c3psVeguw%3D%3D, PID: 6147551
    • Reding P, Duchateau J, Bataille C (1984) Oral zinc supplementation improves hepatic encephalopathy. Results of a randomised controlled trial. Lancet 2(8401):493–495
    • (1984) Lancet , vol.2 , Issue.8401 , pp. 493-495
    • Reding, P.1    Duchateau, J.2    Bataille, C.3
  • 51
    • 0031837619 scopus 로고    scopus 로고
    • Zinc supplementation improves glucose disposal in patients with cirrhosis
    • COI: 1:CAS:528:DyaK1cXksFCgtb8%3D, PID: 9667223
    • Marchesini G, Bugianesi E, Ronchi M, Flamia R, Thomaseth K, Pacini G (1998) Zinc supplementation improves glucose disposal in patients with cirrhosis. Metabolism 47(7):792–798
    • (1998) Metabolism , vol.47 , Issue.7 , pp. 792-798
    • Marchesini, G.1    Bugianesi, E.2    Ronchi, M.3    Flamia, R.4    Thomaseth, K.5    Pacini, G.6
  • 52
    • 28744454890 scopus 로고    scopus 로고
    • Effects of streptozotocin-diabetes and insulin replacement on the epididymis of prepubertal rats: histological and histomorphometric studies
    • COI: 1:CAS:528:DC%2BD2MXht1Gltb3E, PID: 16353669
    • Soudamani S, Malini T, Balasubramanian K (2005) Effects of streptozotocin-diabetes and insulin replacement on the epididymis of prepubertal rats: histological and histomorphometric studies. Endocr Res 31(2):81–98
    • (2005) Endocr Res , vol.31 , Issue.2 , pp. 81-98
    • Soudamani, S.1    Malini, T.2    Balasubramanian, K.3
  • 53
    • 0031945836 scopus 로고    scopus 로고
    • Zinc, insulin and diabetes
    • COI: 1:CAS:528:DyaK1cXisFaju7g%3D, PID: 9550453
    • Chausmer AB (1998) Zinc, insulin and diabetes. J Am Coll Nutr 17(2):109–115
    • (1998) J Am Coll Nutr , vol.17 , Issue.2 , pp. 109-115
    • Chausmer, A.B.1
  • 54
    • 0024787936 scopus 로고
    • Zinc in kidney disease
    • COI: 1:STN:280:DyaL1MzotFWgug%3D%3D, PID: 2674256
    • Mahajan SK (1989) Zinc in kidney disease. J Am Coll Nutr 8(4):296–304
    • (1989) J Am Coll Nutr , vol.8 , Issue.4 , pp. 296-304
    • Mahajan, S.K.1
  • 55
    • 84870703488 scopus 로고    scopus 로고
    • Zinc supplementation attenuates metallothionein and oxidative stress changes in kidney of streptozotocin-induced diabetic rats
    • PID: 23054862
    • Ozcelik D, Naziroglu M, Tuncdemir M, Celik O, Ozturk M, Flores-Arce MF (2012) Zinc supplementation attenuates metallothionein and oxidative stress changes in kidney of streptozotocin-induced diabetic rats. Biol Trace Elem Res 150(1–3):342–349. doi:10.1007/s12011-012-9508-4
    • (2012) Biol Trace Elem Res , vol.150 , Issue.1-3 , pp. 342-349
    • Ozcelik, D.1    Naziroglu, M.2    Tuncdemir, M.3    Celik, O.4    Ozturk, M.5    Flores-Arce, M.F.6
  • 56
    • 51649083321 scopus 로고    scopus 로고
    • Expression of E-SOD, GPX5 mRNAs and immunoexpression of Cu/ZnSOD in epididymal epithelial cells of finasteride-treated rats
    • COI: 1:CAS:528:DC%2BD1cXht1Omt7zL, PID: 18811921
    • Kolasa A, Marchlewicz M, Adler G, Ciechanowicz A, Glabowski W, Wiszniewska B (2008) Expression of E-SOD, GPX5 mRNAs and immunoexpression of Cu/ZnSOD in epididymal epithelial cells of finasteride-treated rats. Andrologia 40(5):303–311. doi:10.1111/j.1439-0272.2008.00858.x
    • (2008) Andrologia , vol.40 , Issue.5 , pp. 303-311
    • Kolasa, A.1    Marchlewicz, M.2    Adler, G.3    Ciechanowicz, A.4    Glabowski, W.5    Wiszniewska, B.6
  • 57
    • 79951968919 scopus 로고    scopus 로고
    • Tolerance of spermatogonia to oxidative stress is due to high levels of Zn and Cu/Zn superoxide dismutase
    • COI: 1:CAS:528:DC%2BC3MXisl2hu7k%3D, PID: 21364994
    • Celino FT, Yamaguchi S, Miura C, Ohta T, Tozawa Y, Iwai T, et al. (2011) Tolerance of spermatogonia to oxidative stress is due to high levels of Zn and Cu/Zn superoxide dismutase. PLoS one 6(2):e16938. doi:10.1371/journal.pone.0016938
    • (2011) PLoS one , vol.6 , Issue.2
    • Celino, F.T.1    Yamaguchi, S.2    Miura, C.3    Ohta, T.4    Tozawa, Y.5    Iwai, T.6
  • 58
    • 0028930275 scopus 로고
    • Lipid peroxidation in insulin-dependent diabetic patients with early retina degenerative lesions: effects of an oral zinc supplementation
    • COI: 1:STN:280:DyaK2MzhslaktA%3D%3D, PID: 7796786
    • Faure P, Benhamou PY, Perard A, Halimi S, Roussel AM (1995) Lipid peroxidation in insulin-dependent diabetic patients with early retina degenerative lesions: effects of an oral zinc supplementation. Eur J Clin Nutr 49(4):282–288
    • (1995) Eur J Clin Nutr , vol.49 , Issue.4 , pp. 282-288
    • Faure, P.1    Benhamou, P.Y.2    Perard, A.3    Halimi, S.4    Roussel, A.M.5
  • 59
    • 84906562845 scopus 로고    scopus 로고
    • The role of metallothionein-3 in streptozotocin-induced beta-islet cell death and diabetes in mice
    • COI: 1:CAS:528:DC%2BC2cXhtFOksb7K, PID: 25054451
    • Byun HR, Choi JA, Koh JY (2014) The role of metallothionein-3 in streptozotocin-induced beta-islet cell death and diabetes in mice. Metallomics 6(9):1748–1757. doi:10.1039/c4mt00143e
    • (2014) Metallomics , vol.6 , Issue.9 , pp. 1748-1757
    • Byun, H.R.1    Choi, J.A.2    Koh, J.Y.3
  • 60
    • 84883149012 scopus 로고    scopus 로고
    • Epididymal specific, selenium-independent GPX5 protects cells from oxidative stress-induced lipid peroxidation and DNA mutation
    • COI: 1:CAS:528:DC%2BC3sXhtlGmsrnK, PID: 23696541
    • Taylor A, Robson A, Houghton BC, Jepson CA, Ford WC, Frayne J (2013) Epididymal specific, selenium-independent GPX5 protects cells from oxidative stress-induced lipid peroxidation and DNA mutation. Hum Reprod 28(9):2332–2342. doi:10.1093/humrep/det237
    • (2013) Hum Reprod , vol.28 , Issue.9 , pp. 2332-2342
    • Taylor, A.1    Robson, A.2    Houghton, B.C.3    Jepson, C.A.4    Ford, W.C.5    Frayne, J.6
  • 61
    • 0029962409 scopus 로고    scopus 로고
    • Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen and estrogen receptors in rat liver
    • COI: 1:CAS:528:DyaK28XhvFanu74%3D, PID: 8613886
    • Om AS, Chung KW (1996) Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen and estrogen receptors in rat liver. J Nutr 126(4):842–848
    • (1996) J Nutr , vol.126 , Issue.4 , pp. 842-848
    • Om, A.S.1    Chung, K.W.2
  • 62
    • 80455178791 scopus 로고    scopus 로고
    • Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability
    • COI: 1:CAS:528:DC%2BC3MXhsVCru73P, PID: 21441427
    • Noblanc A, Kocer A, Chabory E, Vernet P, Saez F, Cadet R, et al. (2011) Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability. J Androl 32(6):641–650. doi:10.2164/jandrol.110.012823
    • (2011) J Androl , vol.32 , Issue.6 , pp. 641-650
    • Noblanc, A.1    Kocer, A.2    Chabory, E.3    Vernet, P.4    Saez, F.5    Cadet, R.6
  • 63
    • 0027584177 scopus 로고
    • Zinc-silicon interactions influencing sperm chromatin integrity and testicular cell development in the rat as measured by flow cytometry
    • COI: 1:CAS:528:DyaK3sXkt1Oitrc%3D, PID: 8478295
    • Evenson DP, Emerick RJ, Jost LK, Kayongo-Male H, Stewart SR (1993) Zinc-silicon interactions influencing sperm chromatin integrity and testicular cell development in the rat as measured by flow cytometry. J Anim Sci 71(4):955–962
    • (1993) J Anim Sci , vol.71 , Issue.4 , pp. 955-962
    • Evenson, D.P.1    Emerick, R.J.2    Jost, L.K.3    Kayongo-Male, H.4    Stewart, S.R.5


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