Dietary zinc deficiency alters 5α-reduction and aromatization of testosterone and androgen and estrogen receptors in rat liver

Journal of Nutrition

Volumn 126, Issue 4, 1996, Pages 842-848

  Om, Ae Son ^a,b   Chung, Kyung Won ^b  

^a Hanyang University   (South Korea)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

rats; receptors; sex hormones; trace elements; zinc deficiency

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; ESTRADIOL; ESTROGEN RECEPTOR; FOLLITROPIN; TESTOSTERONE; ZINC;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; AROMATIZATION; ARTICLE; BINDING SITE; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; HORMONAL REGULATION; LIVER METABOLISM; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MALE GENITAL SYSTEM FUNCTION; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; RECEPTOR BINDING; TESTOSTERONE BLOOD LEVEL; ZINC DEFICIENCY;

EID: 0029962409     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/126.4.842     Document Type: Article

References (32)

1. Bedwal, R. S. & Bahuguna, A. (1994) Zinc, copper, selenium in reproduction. Experientia 50: 626-640.
2. Chammess, G. C., Huff, K. & McGuire, W. (1975) Protamine-precipitated estrogen receptor: a solid-phase ligand exchange assay. Steroids 25: 627-635.
3. Chung, K. W. (1990) Effects of chronic ethanol intake on aromatization of androgens and concentration of estrogen and androgen receptors in rat liver. Toxicology 62: 285-295.
4. Chung, K. W., Kim, S. Y., Chan, W. Y. & Rennert, O. M. (1986) Androgen receptors in ventral prostate glands of zinc deficient rats. Life Sci. 38: 351-356.
5. Coleman, J. E. (1992) Zinc proteins: enzymes, storage proteins, transcription factors, and replication proteins. Annu. Rev. Biochem. 61: 897-946.
6. Colvard, D. S. & Wilson, E. M. (1984) Zinc potentiation of androgen receptor binding to nuclei in vitro. Biochemistry 23: 3471-3478.
7. Cousins, R. J. (1986) Toward a molecular understanding of zinc metabolism. Clin. Physiol. Biochem. 4: 20-30.
8. Eisenfeld, A. J., Aten, R., Haselbacher, G., Halpern, K. & Krakoff, L. (1976) Estrogen receptor in the mammalian liver. Science (Washington, DC) 191: 862-865.
9. Evans, R. M. & Hollenberg, S. M. (1988) Zinc fingers: gilt by association. Cell 52: 1-3.
10. Gordon, G. G., Olivo, J., Rafii, F. & Southern, A. L. (1975) Conversion of androgens to estrogens in cirrhosis of the liver. J. Clin. Endocrinol. Metab. 40: 1018-1026.
11. Habib, F. K. (1978) Zinc and the steroid endocrinology of the human prostate. J. Steroid Biochem. 9: 403-407.
12. Hartoma, R. J., Nahoul, K. &. Netter, A. (1977) Zinc, plasma androgens and male sterility. Lancet 2: 1125-1126.
13. Hicks, S. E. & Wallwork, J. C. (1987) Effect of dietary zinc deficiency on protein synthesis in cell-free systems isolated from rat liver. J. Nutr. 117: 1234-1240.
14. Kao, L.W.L., Lloret, A. P. & Weisz, J. (1977) Metabolism in vitro of dihydrotestosterone, 5α-androstane-3α, 17β-diol and its 3β-epimer, three metabolites of testosterone, by three of its target tissues, the anterior pituitary, the medial basal hypothalamus and the seminiferous tubules. J. Steroid Biochem. 8: 1109-1115.
15. Kimball, S. R., Chen, S., Risica, R., Jefferson, L. S. & Leure-duPree, A. E. (1995) Effects of zinc deficiency on protein synthesis and expression of specific mRNAs in rat liver. Metabolism 44: 126-133.
16. Leake, A., Chisholm, G. D. & Habib, F. K. (1984) The effect of zinc on the 5α-reduction of testosterone by the hyperplastic human prostate gland. J. Steroid Biochem. 20: 651-655.
17. Lei, K. Y., Abbasi, A. & Prasad, A. S. (1976) Function of the pituitary gonadal axis in zinc deficient rats. Am. J. Physiol. 230:1730-1732.
18. Long, C. L. & Lowry, S. F. (1990) Hormonal regulation of protein metabolism. J. Parent. Enteral Nutr. 14: 555-562.
19. Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
20. Moore, D. S. & McCabe, G. P. (1993) Introduction to the Practice of Statistics. W. H. Freeman & Company, New York, NY.
21. Moudgal, N. R. & Madhwa Raj, H. G. (1974) Pituitary gonadotropins. In: Methods of Hormone Radioimmunoassay (Jeffe, B. M. & Behrman, H. R., eds.), pp. 57-85. Academic Press, New York, NY.
22. Murono, E. P. & Fisher-Simpson, V. (1984) Ethanol directly increases dihydrotestosterone conversion to 5α-androstane-3α, 17β-diol and 5α-androstan-3β, 17β-diol in rat Leydig cells. Biochem. Biophys. Res. Commun. 121: 558-565.
23. National Research Council (1985) Guide for the Care and Use of Laboratory Animals. Publication no. 85-23 (rev.). National Institutes of Health, Bethesda, MD.
24. Prasad, A. S. (1983) Zinc deficiency in human subjects. Prog. Clin. Biol. Res. 129: 1-33.
25. Prasad, A. S. & Oberleas, D. (1973) Ribonuclease and deoxyribonuclease activities in zinc deficient tissues. J. Lab. Clin. Med. 82: 461-466.
26. Scatchard, G. (1949) The attractions of proteins for small molecules and ions. Ann. N.Y. Acad. Sci. 51: 660-672.
27. Slater, J. P., Mildvan, A. S. & Loeb, L. A. (1971) Zinc in DNA polymerases. Biochem. Biophys. Res. Commun. 44: 37-43.
28. Smanik, E. J., Barkoukis, H., Mullen, K. D. & McCullough, A. J. (1993) The liver and its effect on endocrine function in health and disease. In: Disease of the Liver (Schiff, L. & Schiff, E. R., eds.), pp. 1373-1410. J. B. Lippincott Co., Philadelphia, PA.
29. Smith, D. F. & Toft, D. O. (1993) Steroid receptors and their associated proteins. Mol. Endocrinol. 7: 4-11.
30. Takimoto, G. S., Tasset, D. M., Eppert, E. C. & Horwitz, K. B. (1992) Hormone induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages Analysis with zinc-finger mutants and the progesterone antagonist ZK-98299. Proc. Natl. Acad. Sci. U.S.A. 89: 3050-3052.
31. Underwood, E. (1977) Trace Elements in Human and Animal Nutrition, 4th ed. Academic Press, New York, NY.
32. Wu, F.Y.H. & Wu, C.W. (1983) The role of zinc in DNA and RNA polymerases. In: Metal Ions in Biological Systems (Sigel, H., ed.), vol. 5, pp. 157-192. Dekker, New York, NY.