Biokinetic studies of non-complexed siRNA versus nano-sized PEI F25-LMW/siRNA polyplexes following intratracheal instillation into mice

International Journal of Pharmaceutics

Volumn 500, Issue 1-2, 2016, Pages 227-235

  Lipka, Jens ^a,b   Semmler Behnke, Manuela ^a   Wenk, Alexander ^a   Burkhardt, Jana ^c   Aigner, Achim ^d   Kreyling, Wolfgang ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

^d UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Biokinetics; Lung therapy; Radiolabeled polyethyleneimine (PEI) siRNA polyplexes

Indexed keywords

PHOSPHORUS 32; POLYETHYLENEIMINE; SMALL INTERFERING RNA; LUCIFERASE; NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DEGRADATION; DRUG DISTRIBUTION; DRUG LABELING; DRUG RETENTION; IN VIVO STUDY; INFLAMMATION; LIQUID SCINTILLATION COUNTING; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; CHEMISTRY; CYTOLOGY; GENE TRANSFER; GENETICS; INHALATIONAL DRUG ADMINISTRATION; MOLECULAR WEIGHT; NUDE MOUSE;

ADMINISTRATION, INHALATION; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; GENE TRANSFER TECHNIQUES; LUCIFERASES; MALE; MICE, NUDE; MOLECULAR WEIGHT; NANOPARTICLES; POLYETHYLENEIMINE; RNA, SMALL INTERFERING;

EID: 84962240878     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.01.038     Document Type: Article

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