Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages

Neurobiology of Aging

Volumn 38, Issue , 2016, Pages 1-10

  An, Ye Won ^a   Jhang, Kyoung A ^a   Woo, So Youn ^a   Kang, Jihee Lee ^a   Chong, Young Hae ^a  

^a Ewha Womans University School of Medicine   (South Korea)

Author keywords

Alzheimer's disease; MiRNA 146a; NLRP3 inflammasome; Nrf2 HO 1; STAT 1; Sulforaphane

Indexed keywords

ACETYLCYSTEINE; AMYLOID BETA PROTEIN[1-42]; CATHEPSIN B; CRYOPYRIN; DEFEROXAMINE; HEME OXYGENASE 1; HERBIMYCIN A; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MICRORNA; MICRORNA 146A; SMALL INTERFERING RNA; STAT1 PROTEIN; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; TROLOX C; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); ANTIINFLAMMATORY AGENT; HMOX1 PROTEIN, HUMAN; ISOTHIOCYANIC ACID DERIVATIVE; NFE2L2 PROTEIN, HUMAN; NLRP3 PROTEIN, HUMAN; PEPTIDE FRAGMENT; STAT1 PROTEIN, HUMAN; SULFORAFAN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HIPPOCAMPUS; HUMAN; HUMAN CELL; MACROPHAGE; MICROGLIA; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; TEMPORAL CORTEX; UPREGULATION; ALZHEIMER DISEASE; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; PHYTOTHERAPY; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANTI-INFLAMMATORY AGENTS; CATHEPSIN B; CELL LINE; HEME OXYGENASE-1; HUMANS; ISOTHIOCYANATES; MACROPHAGES; NF-E2-RELATED FACTOR 2; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PHYTOTHERAPY; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR;

EID: 84962220301     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2015.10.016     Document Type: Article

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