Norepinephrine differentially modulates the innate inflammatory response provoked by amyloid-β peptide via action at β-adrenoceptors and activation of cAMP/PKA pathway in human THP-1 macrophages

Experimental Neurology

Volumn 236, Issue 2, 2012, Pages 199-206

  Yang, Ji Hye ^a   Lee, Eun Ok ^a   Kim, Sang Eun ^a   Suh, Yoo Hun ^b   Chong, Young Hae ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Adrenoceptors; A 1 42; Alzheimer's disease; IL 1 ; MCP 1; MTT; Norepinephrine

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; BETA ADRENERGIC RECEPTOR; CHEMOKINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOKINE; FORSKOLIN; INTERLEUKIN 1BETA; ISOPRENALINE; MONOCYTE CHEMOTACTIC PROTEIN 1; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NORADRENALIN; PROPRANOLOL;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN; CELL STRAIN THP 1; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG CYTOTOXICITY; DRUG EFFICACY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; INNATE IMMUNITY; MACROPHAGE; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION;

AMYLOID BETA-PEPTIDES; CELL LINE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; HUMANS; IMMUNITY, INNATE; INFLAMMATION MEDIATORS; MACROPHAGES; MONOCYTES; NOREPINEPHRINE; PEPTIDE FRAGMENTS; RECEPTORS, ADRENERGIC, BETA; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 84861734808     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.05.008     Document Type: Article

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