Effects of common pesticides on prostaglandin D2 (PGD2) inhibition in SC5 mouse sertoli cells, evidence of binding at the cox-2 active site, and implications for endocrine disruption

Environmental Health Perspectives

Volumn 124, Issue 4, 2016, Pages 452-459

  Kugathas, Subramaniam ^a   Audouze, Karine ^b   Ermler, Sibylle ^a   Orton, Frances ^c   Rosivatz, Erika ^d   Scholze, Martin ^a   Kortenkamp, Andreas ^a  

^a BRUNEL UNIVERSITY   (United Kingdom)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c UNIVERSITY OF EXETER   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANDROGEN RECEPTOR; ARACHIDONIC ACID; BOSCALID; CHLORPROPHAM; CYCLOOXYGENASE 2; CYPERMETHRIN; CYPRODINIL; ENILCONAZOLE; FENHEXAMID; FLUDIOXONIL; HYDROXYBIPHENYL; IBUPROFEN; IMIDACLOPRID; IPRODIONE; LINURON; METHIOCARB; NONSTEROID ANTIINFLAMMATORY AGENT; PESTICIDE; PHOSPHOLIPASE A2; PIRIMIPHOSMETHYL; PROSTAGLANDIN D2; PYRIMETHANIL; TEBUCONAZOLE; UNCLASSIFIED DRUG; ANDROGEN RECEPTOR ANTAGONIST; ENDOCRINE DISRUPTOR; PROTEIN BINDING;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; ENDOCRINE SYSTEM; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; HYDROGEN BOND; IC50; MALE; MOLECULAR BIOLOGY; MOLECULAR MODEL; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; RAT; SCORING SYSTEM; SERTOLI CELL; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYME ACTIVE SITE; METABOLISM; MOUSE;

ANDROGEN RECEPTOR ANTAGONISTS; ANIMALS; ARACHIDONIC ACID; CATALYTIC DOMAIN; CYCLOOXYGENASE 2; ENDOCRINE DISRUPTORS; MALE; MICE; MODELS, MOLECULAR; PESTICIDES; PROSTAGLANDIN D2; PROTEIN BINDING; SERTOLI CELLS;

EID: 84962190580     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1409544     Document Type: Article

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