The suitability of concentration addition for predicting the effects of multi-component mixtures of up to 17 anti-androgens with varied structural features in an in vitro AR antagonist assay

Toxicology and Applied Pharmacology

Volumn 257, Issue 2, 2011, Pages 189-197

  Ermler, Sibylle ^a   Scholze, Martin ^a   Kortenkamp, Andreas ^a  

^a BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

Androgen receptor antagonists; Anti androgen; Concentration addition; Endocrine disruption; MDA kb2; Mixtures

Indexed keywords

4 HYDROXYBENZOIC ACID ESTER; 4,4' ISOPROPYLIDENEDIPHENOL; ANDROGEN; ANDROGEN RECEPTOR; ANDROGEN RECEPTOR ANTAGONIST; ANTIOXIDANT; BENZO[A]PYRENE; CYTOCHROME P450 ISOENZYME; PERFLUORO COMPOUND; POLYBROMINATED BIPHENYL;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; PREDICTION; RECEPTOR BLOCKING;

ANDROGEN RECEPTOR ANTAGONISTS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; PREDICTIVE VALUE OF TESTS; RECEPTORS, ANDROGEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 81855194082     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.09.005     Document Type: Article

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