Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs

Annals of the Rheumatic Diseases

Volumn 75, Issue 10, 2016, Pages 1866-1875

  Corsiero, Elisa ^a   Bombardieri, Michele ^a   Carlotti, Emanuela ^a   Pratesi, Federico ^b   Robinson, William ^c   Migliorini, Paola ^b   Pitzalis, Costantino ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF PISA   (Italy)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CD19 ANTIBODY; CXCL13 CHEMOKINE; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; FIBRINOGEN; HISTONE; HISTONE ANTIBODY; HISTONE H2A; HISTONE H2B; LYMPHOTOXIN BETA; RECOMBINANT ANTIBODY; RECOMBINANT MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; VIMENTIN; AUTOANTIBODY; CITRULLINE; MONOCLONAL ANTIBODY;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CELL CLONING; CELL DAMAGE; CELL DIFFERENTIATION; CELL ISOLATION; CELL MATURATION; CELLULAR IMMUNITY; CITRULLINATION; CONTROLLED STUDY; EXTRACELLULAR TRAP; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE SEQUENCE; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN GENE; IMMUNOHISTOLOGY; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RHEUMATOID ARTHRITIS; SCID MOUSE; SOMATIC HYPERMUTATION; SYNOVIUM; TERTIARY LYMPHOID STRUCTURE; AUTOIMMUNITY; IMMUNOLOGY; JOINT; METABOLISM; MIDDLE AGED;

AGED; ANTIBODIES, MONOCLONAL; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; B-LYMPHOCYTES; CITRULLINE; EXTRACELLULAR TRAPS; FEMALE; HISTONES; HUMANS; JOINTS; MIDDLE AGED; SYNOVIAL MEMBRANE;

EID: 84962175403     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2015-208356     Document Type: Article

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