A BAFF/APRIL-dependent TLR3-stimulated pathway enhances the capacity of rheumatoid synovial fibroblasts to induce AID expression and Ig class-switching in B cells

Annals of the Rheumatic Diseases

Volumn 70, Issue 10, 2011, Pages 1857-1865

  Bombardieri, Michele ^a   Kam, Ngar Woon ^a   Brentano, Fabia ^b   Choi, Ken ^a   Filer, Andrew ^c   Kyburz, Diego ^b   McInnes, Iain B ^d   Gay, Steffen ^b   Buckley, Christopher ^c   Pitzalis, Costantino ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; APRIL PROTEIN; B CELL ACTIVATING FACTOR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MESSENGER RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4;

ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CLINICAL ARTICLE; COCULTURE; CONNECTIVE TISSUE CELL; CONTROLLED STUDY; GENE REARRANGEMENT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN PRODUCTION; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; SYNOVIAL FIBROBLAST; SYNOVIOCYTE;

AGED; ARTHRITIS, RHEUMATOID; B-CELL ACTIVATING FACTOR; B-LYMPHOCYTES; COCULTURE TECHNIQUES; CYTIDINE DEAMINASE; FEMALE; FIBROBLASTS; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN D; IMMUNOGLOBULIN G; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SKIN; SYNOVIAL MEMBRANE; TOLL-LIKE RECEPTOR 3; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13;

EID: 80052502019     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2011.150219     Document Type: Article

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