-
2
-
-
70149108335
-
An estimate of the burden of Chagas disease in the United States
-
Bern C, Montgomery SP. An estimate of the burden of Chagas disease in the United States. Clin Infect Dis. 2009;49(5):e52-e54. doi:10.1086/605091.
-
(2009)
Clin Infect Dis
, vol.49
, Issue.5
, pp. e52-e54
-
-
Bern, C.1
Montgomery, S.P.2
-
3
-
-
84928113423
-
The main sceneries of Chagas disease transmission. the vectors, blood and oral transmissions-a comprehensive review
-
Coura JR. The main sceneries of Chagas disease transmission. The vectors, blood and oral transmissions-a comprehensive review. Mem Inst Oswaldo Cruz. 2015;110(3):277-282. doi:10.1590/0074- 0276140362.
-
(2015)
Mem Inst Oswaldo Cruz
, vol.110
, Issue.3
, pp. 277-282
-
-
Coura, J.R.1
-
4
-
-
33644855027
-
Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: Implications for transfusion medicine in the United States
-
Kirchhoff LV, Paredes P, Lomeli-Guerrero A, et al. Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States. Transfusion. 2006;46(2):298-304. doi:10.1111/j.1537-2995.2006.00715.x.
-
(2006)
Transfusion
, vol.46
, Issue.2
, pp. 298-304
-
-
Kirchhoff, L.V.1
Paredes, P.2
Lomeli-Guerrero, A.3
-
5
-
-
84906940485
-
Chagas disease in solid organ and heart transplantation
-
Kransdorf EP, Zakowski PC, Kobashigawa JA. Chagas disease in solid organ and heart transplantation. Curr Opin Infect Dis. 2014;27(5):418-424. doi:10.1097/QCO.0000000000000088.
-
(2014)
Curr Opin Infect Dis
, vol.27
, Issue.5
, pp. 418-424
-
-
Kransdorf, E.P.1
Zakowski, P.C.2
Kobashigawa, J.A.3
-
6
-
-
84873350621
-
Congenital and oral transmission ofAmerican trypanosomiasis: An overview of physiopathogenic aspects
-
Sánchez LV, Ramirez JD. Congenital and oral transmission ofAmerican trypanosomiasis: an overview of physiopathogenic aspects. Parasitology. 2013;140(2):147-159. doi:10.1017/S0031182012001394.
-
(2013)
Parasitology
, vol.140
, Issue.2
, pp. 147-159
-
-
Sánchez, L.V.1
Ramirez, J.D.2
-
7
-
-
71149119832
-
A new consensus for Trypanosoma cruzi intraspecific nomenclature: Second revision meeting recommends TcI to TcVI
-
Zingales B, Andrade SG, Briones MRS, et al. A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI. Mem Inst Oswaldo Cruz. 2009;104:1051-1054.
-
(2009)
Mem Inst Oswaldo Cruz
, vol.104
, pp. 1051-1054
-
-
Zingales, B.1
Andrade, S.G.2
Briones, M.R.S.3
-
8
-
-
0033835153
-
Genetic characterization of Trypanosoma cruzi directly from tissues of patients with chronic Chagas disease: Differential distribution of genetic types into diverse organs
-
Vago AR, Andrade LO, Leite AA, et al. Genetic characterization of Trypanosoma cruzi directly from tissues of patients with chronic Chagas disease: differential distribution of genetic types into diverse organs. Am J Pathol. 2000;156(5):1805-1809.
-
(2000)
Am J Pathol
, vol.156
, Issue.5
, pp. 1805-1809
-
-
Vago, A.R.1
Andrade, L.O.2
Leite, A.A.3
-
9
-
-
80055084610
-
Recent, independent and anthropogenic origins of Trypanosoma cruzi hybrids
-
Lewis MD, Llewellyn MS, Yeo M, et al. Recent, independent and anthropogenic origins of Trypanosoma cruzi hybrids. PLoS Negl Trop Dis. 2011;5(10):e1363. doi:10.1371/journal.pntd.0001363.
-
(2011)
PLoS Negl Trop Dis
, vol.5
, Issue.10
-
-
Lewis, M.D.1
Llewellyn, M.S.2
Yeo, M.3
-
10
-
-
1642444868
-
Trypanosoma cruzi: Genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease
-
Macedo AEAM, Machado CR, Oliveira RP, et al. Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease. Mem Inst Oswaldo Cruz. 2004;99(1):1-12. doi:S0074-02762004000100001.
-
(2004)
Mem Inst Oswaldo Cruz
, vol.99
, Issue.1
, pp. 1-12
-
-
Macedo, A.E.A.M.1
Machado, C.R.2
Oliveira, R.P.3
-
11
-
-
70350439244
-
The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: Looking back and to the future
-
Miles MA, Llewellyn MS, Lewis MD, et al. The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: looking back and to the future. Parasitology. 2009;136(12):1509-1528. doi:10.1017/S0031182009990977.
-
(2009)
Parasitology
, vol.136
, Issue.12
, pp. 1509-1528
-
-
Miles, M.A.1
Llewellyn, M.S.2
Lewis, M.D.3
-
14
-
-
80052399477
-
Real-time PCR in HIV/ Trypanosoma cruzi coinfection with and without Chagas disease reactivation: Association with HIV viral load and CD4 level
-
de Freitas VLT, da Silva SCV, Sartori AM, et al. Real-time PCR in HIV/ Trypanosoma cruzi coinfection with and without Chagas disease reactivation: association with HIV viral load and CD4 level. PLoS Negl Trop Dis. 2011;5(8):e1277. DOI:10.1371/journal.pntd.0001370.
-
(2011)
PLoS Negl Trop Dis
, vol.5
, Issue.8
-
-
De Freitas, V.L.T.1
Da Silva, S.C.V.2
Sartori, A.M.3
-
15
-
-
33646847271
-
Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: A nonrandomized trial
-
Viotti R, Vigliano C, Lococo B, et al. Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial. Ann Intern Med. 2006;144 (10):724-734.
-
(2006)
Ann Intern Med
, vol.144
, Issue.10
, pp. 724-734
-
-
Viotti, R.1
Vigliano, C.2
Lococo, B.3
-
16
-
-
84873512107
-
Immunosuppression and Chagas disease: A management challenge
-
Pinazo MI-JUS, Espinosa G, Cortes-Lletget C, et al. Immunosuppression and Chagas disease: a management challenge. PLoS Negl Trop Dis. 2013;7(1):e1965. doi:10.1371/journal.pntd.0001965.
-
(2013)
PLoS Negl Trop Dis
, vol.7
, Issue.1
-
-
Mi-Jus, P.1
Espinosa, G.2
Cortes-Lletget, C.3
-
17
-
-
73249149372
-
Use of benznidazole to treat chronic Chagas' disease: A systematic review with a meta-analysis
-
Pérez-Molina JA, Pérez-Ayala A, Moreno S, et al. Use of benznidazole to treat chronic Chagas' disease: a systematic review with a meta-analysis. J Antimicrob Chemother. 2009;64(6):1139-1147. doi:10.1093/jac/dkp357.
-
(2009)
J Antimicrob Chemother
, vol.64
, Issue.6
, pp. 1139-1147
-
-
Pérez-Molina, J.A.1
Pérez-Ayala, A.2
Moreno, S.3
-
18
-
-
70449566766
-
Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of medecins sans frontieres
-
Yun O, Lima MA, Ellman T, et al. Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of medecins sans frontieres. PLoS Negl Trop Dis. 2009;3(7):e488. doi:10.1371/journal.pntd.0000488.
-
(2009)
PLoS Negl Trop Dis
, vol.3
, Issue.7
-
-
Yun, O.1
Lima, M.A.2
Ellman, T.3
-
19
-
-
84942265029
-
Randomized trial of benznidazole for chronic Chagas' cardiomyopathy
-
Morillo CA, Marin-Neto JA, Avezum A, et al. Randomized trial of benznidazole for chronic Chagas' cardiomyopathy. N Engl J Med. 2015;373(14):1295-1306. doi:10.1056/NEJMoa1507574.
-
(2015)
N Engl J Med
, vol.373
, Issue.14
, pp. 1295-1306
-
-
Morillo, C.A.1
Marin-Neto, J.A.2
Avezum, A.3
-
20
-
-
84900311830
-
Randomized trial of posaconazole and benznidazole for chronic Chagas' disease
-
Molina I, Gomez I Prat J, Salvador F, et al. Randomized trial of posaconazole and benznidazole for chronic Chagas' disease. N Engl J Med. 2014;370(20):1899-1908. doi:10.1056/NEJMoa1313122.
-
(2014)
N Engl J Med
, vol.370
, Issue.20
, pp. 1899-1908
-
-
Molina, I.1
Gomez Prat, J.2
Salvador, F.3
-
21
-
-
84907201083
-
Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
-
Zingales B, Zingales B, Miles MA, et al. Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity. Mem Inst Oswaldo Cruz. 2014;109(6):828-833. doi:10.1590/0074- 0276140156.
-
(2014)
Mem Inst Oswaldo Cruz
, vol.109
, Issue.6
, pp. 828-833
-
-
Zingales, B.1
Zingales, B.2
Miles, M.A.3
-
22
-
-
0029861640
-
Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase
-
Buckner FS, Verlinde CL, La Flamme AC, et al. Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase. Antimicrob Agents Chemother. 1996;40(11):2592-2597.
-
(1996)
Antimicrob Agents Chemother
, vol.40
, Issue.11
, pp. 2592-2597
-
-
Buckner, F.S.1
Verlinde, C.L.2
La Flamme, A.C.3
-
23
-
-
77957374117
-
Trypanocidal activity of aziridinyl nitrobenzamide prodrugs
-
Bot C, Hall BS, Bashir N, et al. Trypanocidal activity of aziridinyl nitrobenzamide prodrugs. Antimicrob Agents Chemother. 2010;54 (10):4246-4252. doi:10.1128/AAC.00800-10.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, Issue.10
, pp. 4246-4252
-
-
Bot, C.1
Hall, B.S.2
Bashir, N.3
-
24
-
-
77957157882
-
In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds
-
Canavaci AMC, Bustamante JM, Padilla AM, et al. In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds. PLoS Negl Trop Dis. 2010;4:e740. doi:10.1371/journal. pntd.0000740.g007.
-
(2010)
PLoS Negl Trop Dis
, vol.4
-
-
Canavaci, A.M.C.1
Bustamante, J.M.2
Padilla, A.M.3
-
25
-
-
22244453726
-
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
-
El-Sayed NM, Myler PJ, Bartholomeu DC, et al. The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science. 2005;309(5733):409-415. doi:10.1126/science.1112631.
-
(2005)
Science
, vol.309
, Issue.5733
, pp. 409-415
-
-
El-Sayed, N.M.1
Myler, P.J.2
Bartholomeu, D.C.3
-
26
-
-
84867337640
-
Antiparasitic agents: New drugs on the horizon
-
Maser P, Wittlin S, Rottmann M, et al. Antiparasitic agents: new drugs on the horizon. Curr Opin Pharmacol. 2012;12(5):562-566. doi:10.1016/j.coph.2012.05.001.
-
(2012)
Curr Opin Pharmacol
, vol.12
, Issue.5
, pp. 562-566
-
-
Maser, P.1
Wittlin, S.2
Rottmann, M.3
-
27
-
-
84861468840
-
Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it?
-
Freitas-Junior LH, Chatelain E, Kim HA, et al. Visceral leishmaniasis treatment: what do we have, what do we need and how to deliver it? Int J Parasitol Drugs Drug Resist 2012;2:11-19. doi:10.1016/j. ijpddr.2012.01.003.
-
(2012)
Int J Parasitol Drugs Drug Resist
, vol.2
, pp. 11-19
-
-
Freitas-Junior, L.H.1
Chatelain, E.2
Kim, H.A.3
-
28
-
-
84891838984
-
Antimalarial drug discovery - The path towards eradication
-
Burrows JN, Burlot E, Campo B, et al. Antimalarial drug discovery - the path towards eradication. Parasitology. 2014;141(1):128-139. doi:10.1017/S0031182013000826.
-
(2014)
Parasitology
, vol.141
, Issue.1
, pp. 128-139
-
-
Burrows, J.N.1
Burlot, E.2
Campo, B.3
-
29
-
-
84891846341
-
Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections
-
Don R, Ioset J-R. Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections. Parasitology. 2014;141(1):140-146. doi:10.1017/S003118201300142X.
-
(2014)
Parasitology
, vol.141
, Issue.1
, pp. 140-146
-
-
Don, R.1
Ioset, J.-R.2
-
30
-
-
26044468809
-
Opportunities and challenges in antiparasitic drug discovery
-
Pink R, Hudson A, Mouriès M-A BM. Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005;4(9):727-740. doi:10.1038/nrd1824.
-
(2005)
Nat Rev Drug Discov
, vol.4
, Issue.9
, pp. 727-740
-
-
Pink, R.1
Hudson, A.2
Mouriès, M.-A.B.M.3
-
31
-
-
33845903833
-
Drugs for bad bugs: Confronting the challenges of antibacterial discovery
-
Payne DJ, Gwynn MN, Holmes DJ, et al. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov. 2006;6(1):29-40. doi:10.1038/nrd2201.
-
(2006)
Nat Rev Drug Discov
, vol.6
, Issue.1
, pp. 29-40
-
-
Payne, D.J.1
Gwynn, M.N.2
Holmes, D.J.3
-
32
-
-
79959929769
-
How were new medicines discovered?
-
Swinney DC, Anthony J. How were new medicines discovered? Nat Rev Drug Discov. 2011;10(7):507-519. doi:10.1038/nrd3480.
-
(2011)
Nat Rev Drug Discov
, vol.10
, Issue.7
, pp. 507-519
-
-
Swinney, D.C.1
Anthony, J.2
-
33
-
-
79961014405
-
Anti-infectives: Can cellular screening deliver?
-
Keller TH, Shi P-Y, Wang Q-Y. Anti-infectives: can cellular screening deliver? Curr Opin Chem Biol 2011;15(4):529-533. doi:10.1016/j. cbpa.2011.06.007.
-
(2011)
Curr Opin Chem Biol
, vol.15
, Issue.4
, pp. 529-533
-
-
Keller, T.H.1
Shi, P.-Y.2
Wang, Q.-Y.3
-
34
-
-
84886542459
-
Drug discovery for neglected diseases: Molecular targetbased and phenotypic approaches
-
Gilbert IH. Drug discovery for neglected diseases: molecular targetbased and phenotypic approaches. J Med Chem. 2013;56(20):7719-7726. doi:10.1021/jm400362b.
-
(2013)
J Med Chem
, vol.56
, Issue.20
, pp. 7719-7726
-
-
Gilbert, I.H.1
-
35
-
-
84937622522
-
Developing predictive assays: The phenotypic screening "rule of 3
-
Vincent F, Loria P, Pregel M, et al. Developing predictive assays: the phenotypic screening "rule of 3". Sci Transl Med. 2015;7 (293):293ps15-293ps15. doi:10.1126/scitranslmed.aab1201.
-
(2015)
Sci Transl Med
, vol.7
, Issue.293
, pp. 293ps15-293ps15
-
-
Vincent, F.1
Loria, P.2
Pregel, M.3
-
36
-
-
84886571969
-
Phenotypic screening as a strategic component of drug discovery programs targeting novel antiparasitic and antimycobacterial agents: An editorial
-
Butera JA. Phenotypic screening as a strategic component of drug discovery programs targeting novel antiparasitic and antimycobacterial agents: an editorial. J Med Chem. 2013;56(20):7715-7718. doi:10.1021/jm400443k.
-
(2013)
J Med Chem
, vol.56
, Issue.20
, pp. 7715-7718
-
-
Butera, J.A.1
-
37
-
-
77951975169
-
High content screening: Seeing is believing
-
Zanella F, Lorens JB, Link W. High content screening: seeing is believing. Trends Biotechnol. 2010;28(5):237-245. doi:10.1016/j. tibtech.2010.02.005.
-
(2010)
Trends Biotechnol
, vol.28
, Issue.5
, pp. 237-245
-
-
Zanella, F.1
Lorens, J.B.2
Link, W.3
-
38
-
-
77958509445
-
High-content imaging for automated determination of host-cell infection rate by the intracellular parasite
-
Nohara LL, Lema C, Bader JO, et al. High-content imaging for automated determination of host-cell infection rate by the intracellular parasite. Trypanosoma Cruzi. Parasitol Int. 2010;59(4):565-570. doi:10.1016/j.parint.2010.07.007.
-
(2010)
Trypanosoma Cruzi. Parasitol Int
, vol.59
, Issue.4
, pp. 565-570
-
-
Nohara, L.L.1
Lema, C.2
Bader, J.O.3
-
39
-
-
84895199058
-
An image-based algorithm for precise and accurate high throughput assessment of drug activity against the human parasite
-
Moon S, Siqueira-Neto JL, Moraes CB, et al. An image-based algorithm for precise and accurate high throughput assessment of drug activity against the human parasite. Trypanosoma Cruzi. Plos ONE. 2014;9(2):e87188. doi:10.1371/journal.pone.0087188.
-
(2014)
Trypanosoma Cruzi. Plos ONE
, vol.9
, Issue.2
-
-
Moon, S.1
Siqueira-Neto, J.L.2
Moraes, C.B.3
-
40
-
-
72949114340
-
A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei bloodstream form strain 427
-
Sykes ML, Avery VM. A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei bloodstream form strain 427. Parasit Vectors. 2009;2(1):54. doi:10.1186/1756-3305-2-54.
-
(2009)
Parasit Vectors
, vol.2
, Issue.1
, pp. 54
-
-
Sykes, M.L.1
Avery, V.M.2
-
41
-
-
84922260982
-
Automated high-content assay for compounds selectively toxic to Trypanosoma cruzi in a myoblastic cell line
-
Alonso-Padilla J, Cotillo I, Presa JL, et al. Automated high-content assay for compounds selectively toxic to Trypanosoma cruzi in a myoblastic cell line. PLoS Negl Trop Dis. 2015;9(1):e0003493. doi:10.1371/journal.pntd.0003493.
-
(2015)
PLoS Negl Trop Dis
, vol.9
, Issue.1
-
-
Alonso-Padilla, J.1
Cotillo, I.2
Presa, J.L.3
-
42
-
-
84920095260
-
Lead identification to clinical candidate selection: Drugs for Chagas disease
-
Neitz RJ, Chen S, Supek F, et al. Lead identification to clinical candidate selection: drugs for Chagas disease. J Biomol Screen. 2015;20(1):101-111. doi:10.1177/1087057114553103.
-
(2015)
J Biomol Screen
, vol.20
, Issue.1
, pp. 101-111
-
-
Neitz, R.J.1
Chen, S.2
Supek, F.3
-
43
-
-
65549111678
-
Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening
-
Bettiol E, Samanovic M, Murkin AS, et al. Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening. PLoS Negl Trop Dis. 2009;3(2):e384. doi:10.1371/journal.pntd.0000384.t001.
-
(2009)
PLoS Negl Trop Dis
, vol.3
, Issue.2
-
-
Bettiol, E.1
Samanovic, M.2
Murkin, A.S.3
-
44
-
-
84924658062
-
New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: An open resource
-
Pena I, Pilar Manzano M, Cantizani J, et al. New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource. Sci Rep. 2015;5:8771. doi:10.1038/srep08771.
-
(2015)
Sci Rep
, vol.5
, pp. 8771
-
-
Pena, I.1
Pilar Manzano, M.2
Cantizani, J.3
-
45
-
-
84886540022
-
Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi
-
Keenan M, Alexander PW, Chaplin JH, et al. Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi. Future Med Chem. 2013;5(15):1733-1752. doi:10.4155/fmc.13.139.
-
(2013)
Future Med Chem
, vol.5
, Issue.15
, pp. 1733-1752
-
-
Keenan, M.1
Alexander, P.W.2
Chaplin, J.H.3
-
46
-
-
0033844976
-
In vitro antiproliferative effects and mechanism of action of the new triazole derivative UR-9825 against the protozoan parasite Trypanosoma (Schizotrypanum) cruzi
-
Urbina JA, Lira R, Visbal G, et al. In vitro antiproliferative effects and mechanism of action of the new triazole derivative UR-9825 against the protozoan parasite Trypanosoma (Schizotrypanum) cruzi. Antimicrob Agents Chemother. 2000;44(9):2498-2502.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, Issue.9
, pp. 2498-2502
-
-
Urbina, J.A.1
Lira, R.2
Visbal, G.3
-
47
-
-
84898824975
-
Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: Implications for Chagas disease drug discovery and development
-
Moraes CB, Giardini MA, Kim H, et al. Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development. Sci Rep. 2014;4:4703. doi:10.1038/srep04703.
-
(2014)
Sci Rep
, vol.4
, pp. 4703
-
-
Moraes, C.B.1
Giardini, M.A.2
Kim, H.3
-
48
-
-
84908239030
-
Sequence variation in CYP51A from the y strain of Trypanosoma cruzi alters its sensitivity to inhibition
-
Cherkesova TS, Hargrove TY, Vanrell MC, et al. Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition. FEBS Letters. 2014;588(21):3878-3885. doi:10.1016/j. febslet.2014.08.030.
-
(2014)
FEBS Letters
, vol.588
, Issue.21
, pp. 3878-3885
-
-
Cherkesova, T.S.1
Hargrove, T.Y.2
Vanrell, M.C.3
-
49
-
-
0031807492
-
Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: In vitro and in vivo studies
-
Urbina JA, Payares G, Contreras LM, et al. Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. Antimicrob Agents Chemother. 1998;42(7):1771-1777.
-
(1998)
Antimicrob Agents Chemother
, vol.42
, Issue.7
, pp. 1771-1777
-
-
Urbina, J.A.1
Payares, G.2
Contreras, L.M.3
-
50
-
-
0037220817
-
In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease
-
Urbina JA, Payares G, Sanoja C, et al. In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease. Int J Antimicrob Agents. 2003;21(1):27-38.
-
(2003)
Int J Antimicrob Agents
, vol.21
, Issue.1
, pp. 27-38
-
-
Urbina, J.A.1
Payares, G.2
Sanoja, C.3
-
51
-
-
77953021818
-
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease
-
Olivieri BP, Molina JT, de Castro SL, et al. A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease. Int J Antimicrob Agents. 2010;36(1):79-83. doi:10.1016/j.ijantimicag.2010.03.006.
-
(2010)
Int J Antimicrob Agents
, vol.36
, Issue.1
, pp. 79-83
-
-
Olivieri, B.P.1
Molina, J.T.2
De Castro, S.L.3
-
52
-
-
84939817804
-
Limited ability of posaconazole to cure both acute and chronic Trypanosoma cruzi infections revealed by highly sensitive in vivo imaging
-
Francisco AF, Lewis MD, Jayawardhana S, et al. Limited ability of posaconazole to cure both acute and chronic Trypanosoma cruzi infections revealed by highly sensitive in vivo imaging. Antimicrob Agents Chemother. 2015;59(8):4653-4661. doi:10.1128/AAC.00520-15.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, Issue.8
, pp. 4653-4661
-
-
Francisco, A.F.1
Lewis, M.D.2
Jayawardhana, S.3
-
53
-
-
84942889762
-
Antitrypanosomal treatment with benznidazole is superior to posaconazole regimens in mouse models of Chagas disease
-
Khare S, Liu X, Stinson M, et al. Antitrypanosomal treatment with benznidazole is superior to posaconazole regimens in mouse models of Chagas disease. Antimicrob Agents Chemother. 2015;59 (10):6385-6394. doi:10.1128/AAC.00689-15.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, Issue.10
, pp. 6385-6394
-
-
Khare, S.1
Liu, X.2
Stinson, M.3
-
54
-
-
84920081179
-
Chagas disease drug discovery: Toward a new era
-
Chatelain E. Chagas disease drug discovery: toward a new era. J Biomol Screen. 2015;20(1):22-35. doi:10.1177/1087057114550585.
-
(2015)
J Biomol Screen
, vol.20
, Issue.1
, pp. 22-35
-
-
Chatelain, E.1
-
55
-
-
0000416948
-
Variações morfológicas observadas em diferentes amostras de Trypanosoma cruzi
-
Brener Z, Chiari E. Variações morfológicas observadas em diferentes amostras de Trypanosoma cruzi. Rev Inst Med Trop Sao Paulo. 1963;5:220-244.
-
(1963)
Rev Inst Med Trop Sao Paulo
, vol.5
, pp. 220-244
-
-
Brener, Z.1
Chiari, E.2
-
56
-
-
0023609713
-
Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease
-
Filardi LS, Brener Z. Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease. Trans R Society Trop Med Hyg. 1987;81(5):755-759. DOI:10.1016/ 0035-9203(87)90020-4.
-
(1987)
Trans R Society Trop Med Hyg
, vol.81
, Issue.5
, pp. 755-759
-
-
Filardi, L.S.1
Brener, Z.2
-
57
-
-
0023804393
-
Comparative studies of drug susceptibility of five strains of Trypanosoma cruzi in vivo and in vitro
-
Neal RA, Van Bueren J. Comparative studies of drug susceptibility of five strains of Trypanosoma cruzi in vivo and in vitro. Trans R Society Trop Med Hyg. 1988;82(5):709-714. doi:10.1016/0035-9203 (88)90208-8.
-
(1988)
Trans R Society Trop Med Hyg
, vol.82
, Issue.5
, pp. 709-714
-
-
Neal, R.A.1
Van Bueren, J.2
-
58
-
-
0038538181
-
Trypanosoma cruzi: Susceptibility to chemotherapy with benznidazole of clones isolated from the highly resistant Colombian strain
-
Camandaroba ELP, Reis EAG, Gonçalves MS, et al. Trypanosoma cruzi: susceptibility to chemotherapy with benznidazole of clones isolated from the highly resistant Colombian strain. Rev Soc Bras Med Trop. 2003;36(2):201-209.
-
(2003)
Rev Soc Bras Med Trop
, vol.36
, Issue.2
, pp. 201-209
-
-
Camandaroba, E.L.P.1
Reis, E.A.G.2
Gonçalves, M.S.3
-
59
-
-
78149233944
-
In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi
-
Chen YT, Brinen LS, Kerr ID, et al. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. PLoS Negl Trop Dis. 2010;4(9):e825. doi:10.1371/journal.pntd.0000825.
-
(2010)
PLoS Negl Trop Dis
, vol.4
, Issue.9
-
-
Chen, Y.T.1
Brinen, L.S.2
Kerr, I.D.3
-
60
-
-
84886501314
-
Approaches to protozoan drug discovery: Phenotypic screening
-
Sykes ML, Avery VM. Approaches to protozoan drug discovery: phenotypic screening. J Med Chem. 2013;56(20):7727-7740. doi:10.1021/jm4004279.
-
(2013)
J Med Chem
, vol.56
, Issue.20
, pp. 7727-7740
-
-
Sykes, M.L.1
Avery, V.M.2
-
61
-
-
84893436816
-
Towards a paradigm shift in the treatment of chronic Chagas disease
-
Viotti R, Alarcon de Noya B, Araujo-Jorge T, et al. Towards a paradigm shift in the treatment of chronic Chagas disease. Antimicrob Agents Chemother. 2014;58(2):635-639. doi:10.1128/AAC.01662-13.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, Issue.2
, pp. 635-639
-
-
Viotti, R.1
Alarcon De Noya, B.2
Araujo-Jorge, T.3
-
62
-
-
35748983210
-
Target deconvolution strategies in drug discovery
-
Terstappen GC, Schlüpen C, Raggiaschi R, et al. Target deconvolution strategies in drug discovery. Nat Rev Drug Discov. 2007;6 (11):891-903. doi:10.1038/nrd2410.
-
(2007)
Nat Rev Drug Discov
, vol.6
, Issue.11
, pp. 891-903
-
-
Terstappen, G.C.1
Schlüpen, C.2
Raggiaschi, R.3
-
63
-
-
84938767845
-
Utilizing chemical genomics to identify cytochrome b as a novel drug target for Chagas disease
-
Khare S, Roach SL, Barnes SW, et al. Utilizing chemical genomics to identify cytochrome b as a novel drug target for Chagas disease. PLoS Pathog. 2015;11(7):e1005058. doi:10.1371/journal. ppat.1005058.
-
(2015)
PLoS Pathog
, vol.11
, Issue.7
-
-
Khare, S.1
Roach, S.L.2
Barnes, S.W.3
-
64
-
-
69249093873
-
Using small molecules to dissect mechanisms of microbial pathogenesis
-
Puri AW, Bogyo M. Using small molecules to dissect mechanisms of microbial pathogenesis. ACS Chem Biol. 2009;4(8):603-616. doi:10.1021/cb9001409.
-
(2009)
ACS Chem Biol
, vol.4
, Issue.8
, pp. 603-616
-
-
Puri, A.W.1
Bogyo, M.2
-
65
-
-
79851515870
-
Proteomics accelerating the identification of the target molecule of bioactive small molecules
-
Wierzba K,Muroi M, Osada H. Proteomics accelerating the identification of the target molecule of bioactive small molecules. Curr Opin Chem Biol. 2011;15(1):57-65. doi:10.1016/j.cbpa.2010.10.009.
-
(2011)
Curr Opin Chem Biol
, vol.15
, Issue.1
, pp. 57-65
-
-
Wierzba Kmuroi, M.1
Osada, H.2
-
66
-
-
84874263173
-
Lapatinib-binding protein kinases in the African trypanosome: Identification of cellular targets for kinase-directed chemical scaffolds
-
Katiyar S, Kufareva I, Behera R, et al. Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds. PLoS ONE. 2013;8(2):e56150. doi:10.1371/journal.pone.0056150.
-
(2013)
PLoS ONE
, vol.8
, Issue.2
-
-
Katiyar, S.1
Kufareva, I.2
Behera, R.3
-
67
-
-
76049084586
-
Target identification using drug affinity responsive target stability (DARTS)
-
Lomenick B, Hao R, Jonai N, et al. Target identification using drug affinity responsive target stability (DARTS). PNAS. 2009;106 (51):21984-21989. doi:10.1073/pnas.0910040106.
-
(2009)
PNAS
, vol.106
, Issue.51
, pp. 21984-21989
-
-
Lomenick, B.1
Hao, R.2
Jonai, N.3
-
68
-
-
84875241586
-
Target deconvolution techniques in modern phenotypic profiling
-
Lee J, Bogyo M. Target deconvolution techniques in modern phenotypic profiling. Curr Opin Chem Biol. 2013;17(1):118-126. doi:10.1016/j.cbpa.2012.12.022.
-
(2013)
Curr Opin Chem Biol
, vol.17
, Issue.1
, pp. 118-126
-
-
Lee, J.1
Bogyo, M.2
-
69
-
-
79960566893
-
Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion
-
Hall CI, Reese ML, Weerapana E, et al. Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion. Proc Natl Acad Sci USA. 2011;108 (26):10568-10573. doi:10.1073/pnas.1105622108.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.26
, pp. 10568-10573
-
-
Hall, C.I.1
Reese, M.L.2
Weerapana, E.3
-
70
-
-
43749109597
-
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
-
Kato N, Sakata T, Breton G, et al. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol. 2008;4(6):347-356. doi:10.1038/nchembio.87.
-
(2008)
Nat Chem Biol
, vol.4
, Issue.6
, pp. 347-356
-
-
Kato, N.1
Sakata, T.2
Breton, G.3
-
71
-
-
84856955769
-
High-throughput decoding of antitrypanosomal drug efficacy and resistance
-
Alsford S, Eckert S, Baker N, et al. High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature. 2012;482 (7384):232-236. doi:10.1038/nature10771.
-
(2012)
Nature
, vol.482
, Issue.7384
, pp. 232-236
-
-
Alsford, S.1
Eckert, S.2
Baker, N.3
-
72
-
-
84893808671
-
Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen
-
Jones NG, Thomas EB, Brown E, et al. Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen. PLoS Pathog. 2014;10(1):e1003886. doi:10.1371/journal.ppat.1003886.
-
(2014)
PLoS Pathog
, vol.10
, Issue.1
-
-
Jones, N.G.1
Thomas, E.B.2
Brown, E.3
-
73
-
-
79956326721
-
Visual genome-wide RNAi screening to identify human host factors required for Trypanosoma cruzi infection
-
Genovesio A, Giardini MA, Kwon Y-J, et al. Visual genome-wide RNAi screening to identify human host factors required for Trypanosoma cruzi infection. PLoS ONE. 2011;6(5):e19733. doi:10.1371/journal.pone.0019733.t001.
-
(2011)
PLoS ONE
, vol.6
, Issue.5
-
-
Genovesio, A.1
Giardini, M.A.2
Kwon, Y.-J.3
-
74
-
-
84872553101
-
Host metabolism regulates intracellular growth of Trypanosoma cruzi
-
Caradonna KL, Engel JC, Jacobi D, et al. Host metabolism regulates intracellular growth of Trypanosoma cruzi. Cell Host Microbe. 2013;13(1):108-117. doi:10.1016/j.chom.2012.11.011.
-
(2013)
Cell Host Microbe
, vol.13
, Issue.1
, pp. 108-117
-
-
Caradonna, K.L.1
Engel, J.C.2
Jacobi, D.3
-
75
-
-
84863012787
-
Functional genomics of trypanosomatids
-
Choi J, El-Sayed NM. Functional genomics of trypanosomatids. Parasite Immunol. 2012;34(2-3):72-79. doi:10.1111/j.1365- 3024.2011.01347.x.
-
(2012)
Parasite Immunol
, vol.34
, Issue.2-3
, pp. 72-79
-
-
Choi, J.1
El-Sayed, N.M.2
-
76
-
-
80052432770
-
The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing
-
Diaz-Gonzalez R, Kuhlmann FM, Galan-Rodriguez C, et al. The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing. PLoS Negl Trop Dis. 2011;5(8):e1297. doi:10.1371/journal. pntd.0001297.
-
(2011)
PLoS Negl Trop Dis
, vol.5
, Issue.8
-
-
Diaz-Gonzalez, R.1
Kuhlmann, F.M.2
Galan-Rodriguez, C.3
|