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Volumn 11, Issue 5, 2016, Pages 447-455

Novel drug discovery for Chagas disease

Author keywords

Chagas disease drug discovery; high content screening; target deconvolution; Trypanosoma cruzi

Indexed keywords

STEROL 14ALPHA DEMETHYLASE INHIBITOR; ANTITRYPANOSOMAL AGENT;

EID: 84962074599     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2016.1160883     Document Type: Review
Times cited : (18)

References (76)
  • 2
    • 70149108335 scopus 로고    scopus 로고
    • An estimate of the burden of Chagas disease in the United States
    • Bern C, Montgomery SP. An estimate of the burden of Chagas disease in the United States. Clin Infect Dis. 2009;49(5):e52-e54. doi:10.1086/605091.
    • (2009) Clin Infect Dis , vol.49 , Issue.5 , pp. e52-e54
    • Bern, C.1    Montgomery, S.P.2
  • 3
    • 84928113423 scopus 로고    scopus 로고
    • The main sceneries of Chagas disease transmission. the vectors, blood and oral transmissions-a comprehensive review
    • Coura JR. The main sceneries of Chagas disease transmission. The vectors, blood and oral transmissions-a comprehensive review. Mem Inst Oswaldo Cruz. 2015;110(3):277-282. doi:10.1590/0074- 0276140362.
    • (2015) Mem Inst Oswaldo Cruz , vol.110 , Issue.3 , pp. 277-282
    • Coura, J.R.1
  • 4
    • 33644855027 scopus 로고    scopus 로고
    • Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: Implications for transfusion medicine in the United States
    • Kirchhoff LV, Paredes P, Lomeli-Guerrero A, et al. Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States. Transfusion. 2006;46(2):298-304. doi:10.1111/j.1537-2995.2006.00715.x.
    • (2006) Transfusion , vol.46 , Issue.2 , pp. 298-304
    • Kirchhoff, L.V.1    Paredes, P.2    Lomeli-Guerrero, A.3
  • 5
    • 84906940485 scopus 로고    scopus 로고
    • Chagas disease in solid organ and heart transplantation
    • Kransdorf EP, Zakowski PC, Kobashigawa JA. Chagas disease in solid organ and heart transplantation. Curr Opin Infect Dis. 2014;27(5):418-424. doi:10.1097/QCO.0000000000000088.
    • (2014) Curr Opin Infect Dis , vol.27 , Issue.5 , pp. 418-424
    • Kransdorf, E.P.1    Zakowski, P.C.2    Kobashigawa, J.A.3
  • 6
    • 84873350621 scopus 로고    scopus 로고
    • Congenital and oral transmission ofAmerican trypanosomiasis: An overview of physiopathogenic aspects
    • Sánchez LV, Ramirez JD. Congenital and oral transmission ofAmerican trypanosomiasis: an overview of physiopathogenic aspects. Parasitology. 2013;140(2):147-159. doi:10.1017/S0031182012001394.
    • (2013) Parasitology , vol.140 , Issue.2 , pp. 147-159
    • Sánchez, L.V.1    Ramirez, J.D.2
  • 7
    • 71149119832 scopus 로고    scopus 로고
    • A new consensus for Trypanosoma cruzi intraspecific nomenclature: Second revision meeting recommends TcI to TcVI
    • Zingales B, Andrade SG, Briones MRS, et al. A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI. Mem Inst Oswaldo Cruz. 2009;104:1051-1054.
    • (2009) Mem Inst Oswaldo Cruz , vol.104 , pp. 1051-1054
    • Zingales, B.1    Andrade, S.G.2    Briones, M.R.S.3
  • 8
    • 0033835153 scopus 로고    scopus 로고
    • Genetic characterization of Trypanosoma cruzi directly from tissues of patients with chronic Chagas disease: Differential distribution of genetic types into diverse organs
    • Vago AR, Andrade LO, Leite AA, et al. Genetic characterization of Trypanosoma cruzi directly from tissues of patients with chronic Chagas disease: differential distribution of genetic types into diverse organs. Am J Pathol. 2000;156(5):1805-1809.
    • (2000) Am J Pathol , vol.156 , Issue.5 , pp. 1805-1809
    • Vago, A.R.1    Andrade, L.O.2    Leite, A.A.3
  • 9
    • 80055084610 scopus 로고    scopus 로고
    • Recent, independent and anthropogenic origins of Trypanosoma cruzi hybrids
    • Lewis MD, Llewellyn MS, Yeo M, et al. Recent, independent and anthropogenic origins of Trypanosoma cruzi hybrids. PLoS Negl Trop Dis. 2011;5(10):e1363. doi:10.1371/journal.pntd.0001363.
    • (2011) PLoS Negl Trop Dis , vol.5 , Issue.10
    • Lewis, M.D.1    Llewellyn, M.S.2    Yeo, M.3
  • 10
    • 1642444868 scopus 로고    scopus 로고
    • Trypanosoma cruzi: Genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease
    • Macedo AEAM, Machado CR, Oliveira RP, et al. Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease. Mem Inst Oswaldo Cruz. 2004;99(1):1-12. doi:S0074-02762004000100001.
    • (2004) Mem Inst Oswaldo Cruz , vol.99 , Issue.1 , pp. 1-12
    • Macedo, A.E.A.M.1    Machado, C.R.2    Oliveira, R.P.3
  • 11
    • 70350439244 scopus 로고    scopus 로고
    • The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: Looking back and to the future
    • Miles MA, Llewellyn MS, Lewis MD, et al. The molecular epidemiology and phylogeography of Trypanosoma cruzi and parallel research on Leishmania: looking back and to the future. Parasitology. 2009;136(12):1509-1528. doi:10.1017/S0031182009990977.
    • (2009) Parasitology , vol.136 , Issue.12 , pp. 1509-1528
    • Miles, M.A.1    Llewellyn, M.S.2    Lewis, M.D.3
  • 14
    • 80052399477 scopus 로고    scopus 로고
    • Real-time PCR in HIV/ Trypanosoma cruzi coinfection with and without Chagas disease reactivation: Association with HIV viral load and CD4 level
    • de Freitas VLT, da Silva SCV, Sartori AM, et al. Real-time PCR in HIV/ Trypanosoma cruzi coinfection with and without Chagas disease reactivation: association with HIV viral load and CD4 level. PLoS Negl Trop Dis. 2011;5(8):e1277. DOI:10.1371/journal.pntd.0001370.
    • (2011) PLoS Negl Trop Dis , vol.5 , Issue.8
    • De Freitas, V.L.T.1    Da Silva, S.C.V.2    Sartori, A.M.3
  • 15
    • 33646847271 scopus 로고    scopus 로고
    • Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: A nonrandomized trial
    • Viotti R, Vigliano C, Lococo B, et al. Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial. Ann Intern Med. 2006;144 (10):724-734.
    • (2006) Ann Intern Med , vol.144 , Issue.10 , pp. 724-734
    • Viotti, R.1    Vigliano, C.2    Lococo, B.3
  • 16
    • 84873512107 scopus 로고    scopus 로고
    • Immunosuppression and Chagas disease: A management challenge
    • Pinazo MI-JUS, Espinosa G, Cortes-Lletget C, et al. Immunosuppression and Chagas disease: a management challenge. PLoS Negl Trop Dis. 2013;7(1):e1965. doi:10.1371/journal.pntd.0001965.
    • (2013) PLoS Negl Trop Dis , vol.7 , Issue.1
    • Mi-Jus, P.1    Espinosa, G.2    Cortes-Lletget, C.3
  • 17
    • 73249149372 scopus 로고    scopus 로고
    • Use of benznidazole to treat chronic Chagas' disease: A systematic review with a meta-analysis
    • Pérez-Molina JA, Pérez-Ayala A, Moreno S, et al. Use of benznidazole to treat chronic Chagas' disease: a systematic review with a meta-analysis. J Antimicrob Chemother. 2009;64(6):1139-1147. doi:10.1093/jac/dkp357.
    • (2009) J Antimicrob Chemother , vol.64 , Issue.6 , pp. 1139-1147
    • Pérez-Molina, J.A.1    Pérez-Ayala, A.2    Moreno, S.3
  • 18
    • 70449566766 scopus 로고    scopus 로고
    • Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of medecins sans frontieres
    • Yun O, Lima MA, Ellman T, et al. Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of medecins sans frontieres. PLoS Negl Trop Dis. 2009;3(7):e488. doi:10.1371/journal.pntd.0000488.
    • (2009) PLoS Negl Trop Dis , vol.3 , Issue.7
    • Yun, O.1    Lima, M.A.2    Ellman, T.3
  • 19
    • 84942265029 scopus 로고    scopus 로고
    • Randomized trial of benznidazole for chronic Chagas' cardiomyopathy
    • Morillo CA, Marin-Neto JA, Avezum A, et al. Randomized trial of benznidazole for chronic Chagas' cardiomyopathy. N Engl J Med. 2015;373(14):1295-1306. doi:10.1056/NEJMoa1507574.
    • (2015) N Engl J Med , vol.373 , Issue.14 , pp. 1295-1306
    • Morillo, C.A.1    Marin-Neto, J.A.2    Avezum, A.3
  • 20
    • 84900311830 scopus 로고    scopus 로고
    • Randomized trial of posaconazole and benznidazole for chronic Chagas' disease
    • Molina I, Gomez I Prat J, Salvador F, et al. Randomized trial of posaconazole and benznidazole for chronic Chagas' disease. N Engl J Med. 2014;370(20):1899-1908. doi:10.1056/NEJMoa1313122.
    • (2014) N Engl J Med , vol.370 , Issue.20 , pp. 1899-1908
    • Molina, I.1    Gomez Prat, J.2    Salvador, F.3
  • 21
    • 84907201083 scopus 로고    scopus 로고
    • Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
    • Zingales B, Zingales B, Miles MA, et al. Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity. Mem Inst Oswaldo Cruz. 2014;109(6):828-833. doi:10.1590/0074- 0276140156.
    • (2014) Mem Inst Oswaldo Cruz , vol.109 , Issue.6 , pp. 828-833
    • Zingales, B.1    Zingales, B.2    Miles, M.A.3
  • 22
    • 0029861640 scopus 로고    scopus 로고
    • Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase
    • Buckner FS, Verlinde CL, La Flamme AC, et al. Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase. Antimicrob Agents Chemother. 1996;40(11):2592-2597.
    • (1996) Antimicrob Agents Chemother , vol.40 , Issue.11 , pp. 2592-2597
    • Buckner, F.S.1    Verlinde, C.L.2    La Flamme, A.C.3
  • 23
    • 77957374117 scopus 로고    scopus 로고
    • Trypanocidal activity of aziridinyl nitrobenzamide prodrugs
    • Bot C, Hall BS, Bashir N, et al. Trypanocidal activity of aziridinyl nitrobenzamide prodrugs. Antimicrob Agents Chemother. 2010;54 (10):4246-4252. doi:10.1128/AAC.00800-10.
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.10 , pp. 4246-4252
    • Bot, C.1    Hall, B.S.2    Bashir, N.3
  • 24
    • 77957157882 scopus 로고    scopus 로고
    • In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds
    • Canavaci AMC, Bustamante JM, Padilla AM, et al. In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds. PLoS Negl Trop Dis. 2010;4:e740. doi:10.1371/journal. pntd.0000740.g007.
    • (2010) PLoS Negl Trop Dis , vol.4
    • Canavaci, A.M.C.1    Bustamante, J.M.2    Padilla, A.M.3
  • 25
    • 22244453726 scopus 로고    scopus 로고
    • The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease
    • El-Sayed NM, Myler PJ, Bartholomeu DC, et al. The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science. 2005;309(5733):409-415. doi:10.1126/science.1112631.
    • (2005) Science , vol.309 , Issue.5733 , pp. 409-415
    • El-Sayed, N.M.1    Myler, P.J.2    Bartholomeu, D.C.3
  • 26
    • 84867337640 scopus 로고    scopus 로고
    • Antiparasitic agents: New drugs on the horizon
    • Maser P, Wittlin S, Rottmann M, et al. Antiparasitic agents: new drugs on the horizon. Curr Opin Pharmacol. 2012;12(5):562-566. doi:10.1016/j.coph.2012.05.001.
    • (2012) Curr Opin Pharmacol , vol.12 , Issue.5 , pp. 562-566
    • Maser, P.1    Wittlin, S.2    Rottmann, M.3
  • 27
    • 84861468840 scopus 로고    scopus 로고
    • Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it?
    • Freitas-Junior LH, Chatelain E, Kim HA, et al. Visceral leishmaniasis treatment: what do we have, what do we need and how to deliver it? Int J Parasitol Drugs Drug Resist 2012;2:11-19. doi:10.1016/j. ijpddr.2012.01.003.
    • (2012) Int J Parasitol Drugs Drug Resist , vol.2 , pp. 11-19
    • Freitas-Junior, L.H.1    Chatelain, E.2    Kim, H.A.3
  • 28
    • 84891838984 scopus 로고    scopus 로고
    • Antimalarial drug discovery - The path towards eradication
    • Burrows JN, Burlot E, Campo B, et al. Antimalarial drug discovery - the path towards eradication. Parasitology. 2014;141(1):128-139. doi:10.1017/S0031182013000826.
    • (2014) Parasitology , vol.141 , Issue.1 , pp. 128-139
    • Burrows, J.N.1    Burlot, E.2    Campo, B.3
  • 29
    • 84891846341 scopus 로고    scopus 로고
    • Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections
    • Don R, Ioset J-R. Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections. Parasitology. 2014;141(1):140-146. doi:10.1017/S003118201300142X.
    • (2014) Parasitology , vol.141 , Issue.1 , pp. 140-146
    • Don, R.1    Ioset, J.-R.2
  • 30
    • 26044468809 scopus 로고    scopus 로고
    • Opportunities and challenges in antiparasitic drug discovery
    • Pink R, Hudson A, Mouriès M-A BM. Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005;4(9):727-740. doi:10.1038/nrd1824.
    • (2005) Nat Rev Drug Discov , vol.4 , Issue.9 , pp. 727-740
    • Pink, R.1    Hudson, A.2    Mouriès, M.-A.B.M.3
  • 31
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: Confronting the challenges of antibacterial discovery
    • Payne DJ, Gwynn MN, Holmes DJ, et al. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov. 2006;6(1):29-40. doi:10.1038/nrd2201.
    • (2006) Nat Rev Drug Discov , vol.6 , Issue.1 , pp. 29-40
    • Payne, D.J.1    Gwynn, M.N.2    Holmes, D.J.3
  • 32
    • 79959929769 scopus 로고    scopus 로고
    • How were new medicines discovered?
    • Swinney DC, Anthony J. How were new medicines discovered? Nat Rev Drug Discov. 2011;10(7):507-519. doi:10.1038/nrd3480.
    • (2011) Nat Rev Drug Discov , vol.10 , Issue.7 , pp. 507-519
    • Swinney, D.C.1    Anthony, J.2
  • 33
    • 79961014405 scopus 로고    scopus 로고
    • Anti-infectives: Can cellular screening deliver?
    • Keller TH, Shi P-Y, Wang Q-Y. Anti-infectives: can cellular screening deliver? Curr Opin Chem Biol 2011;15(4):529-533. doi:10.1016/j. cbpa.2011.06.007.
    • (2011) Curr Opin Chem Biol , vol.15 , Issue.4 , pp. 529-533
    • Keller, T.H.1    Shi, P.-Y.2    Wang, Q.-Y.3
  • 34
    • 84886542459 scopus 로고    scopus 로고
    • Drug discovery for neglected diseases: Molecular targetbased and phenotypic approaches
    • Gilbert IH. Drug discovery for neglected diseases: molecular targetbased and phenotypic approaches. J Med Chem. 2013;56(20):7719-7726. doi:10.1021/jm400362b.
    • (2013) J Med Chem , vol.56 , Issue.20 , pp. 7719-7726
    • Gilbert, I.H.1
  • 35
    • 84937622522 scopus 로고    scopus 로고
    • Developing predictive assays: The phenotypic screening "rule of 3
    • Vincent F, Loria P, Pregel M, et al. Developing predictive assays: the phenotypic screening "rule of 3". Sci Transl Med. 2015;7 (293):293ps15-293ps15. doi:10.1126/scitranslmed.aab1201.
    • (2015) Sci Transl Med , vol.7 , Issue.293 , pp. 293ps15-293ps15
    • Vincent, F.1    Loria, P.2    Pregel, M.3
  • 36
    • 84886571969 scopus 로고    scopus 로고
    • Phenotypic screening as a strategic component of drug discovery programs targeting novel antiparasitic and antimycobacterial agents: An editorial
    • Butera JA. Phenotypic screening as a strategic component of drug discovery programs targeting novel antiparasitic and antimycobacterial agents: an editorial. J Med Chem. 2013;56(20):7715-7718. doi:10.1021/jm400443k.
    • (2013) J Med Chem , vol.56 , Issue.20 , pp. 7715-7718
    • Butera, J.A.1
  • 37
    • 77951975169 scopus 로고    scopus 로고
    • High content screening: Seeing is believing
    • Zanella F, Lorens JB, Link W. High content screening: seeing is believing. Trends Biotechnol. 2010;28(5):237-245. doi:10.1016/j. tibtech.2010.02.005.
    • (2010) Trends Biotechnol , vol.28 , Issue.5 , pp. 237-245
    • Zanella, F.1    Lorens, J.B.2    Link, W.3
  • 38
    • 77958509445 scopus 로고    scopus 로고
    • High-content imaging for automated determination of host-cell infection rate by the intracellular parasite
    • Nohara LL, Lema C, Bader JO, et al. High-content imaging for automated determination of host-cell infection rate by the intracellular parasite. Trypanosoma Cruzi. Parasitol Int. 2010;59(4):565-570. doi:10.1016/j.parint.2010.07.007.
    • (2010) Trypanosoma Cruzi. Parasitol Int , vol.59 , Issue.4 , pp. 565-570
    • Nohara, L.L.1    Lema, C.2    Bader, J.O.3
  • 39
    • 84895199058 scopus 로고    scopus 로고
    • An image-based algorithm for precise and accurate high throughput assessment of drug activity against the human parasite
    • Moon S, Siqueira-Neto JL, Moraes CB, et al. An image-based algorithm for precise and accurate high throughput assessment of drug activity against the human parasite. Trypanosoma Cruzi. Plos ONE. 2014;9(2):e87188. doi:10.1371/journal.pone.0087188.
    • (2014) Trypanosoma Cruzi. Plos ONE , vol.9 , Issue.2
    • Moon, S.1    Siqueira-Neto, J.L.2    Moraes, C.B.3
  • 40
    • 72949114340 scopus 로고    scopus 로고
    • A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei bloodstream form strain 427
    • Sykes ML, Avery VM. A luciferase based viability assay for ATP detection in 384-well format for high throughput whole cell screening of Trypanosoma brucei bloodstream form strain 427. Parasit Vectors. 2009;2(1):54. doi:10.1186/1756-3305-2-54.
    • (2009) Parasit Vectors , vol.2 , Issue.1 , pp. 54
    • Sykes, M.L.1    Avery, V.M.2
  • 41
    • 84922260982 scopus 로고    scopus 로고
    • Automated high-content assay for compounds selectively toxic to Trypanosoma cruzi in a myoblastic cell line
    • Alonso-Padilla J, Cotillo I, Presa JL, et al. Automated high-content assay for compounds selectively toxic to Trypanosoma cruzi in a myoblastic cell line. PLoS Negl Trop Dis. 2015;9(1):e0003493. doi:10.1371/journal.pntd.0003493.
    • (2015) PLoS Negl Trop Dis , vol.9 , Issue.1
    • Alonso-Padilla, J.1    Cotillo, I.2    Presa, J.L.3
  • 42
    • 84920095260 scopus 로고    scopus 로고
    • Lead identification to clinical candidate selection: Drugs for Chagas disease
    • Neitz RJ, Chen S, Supek F, et al. Lead identification to clinical candidate selection: drugs for Chagas disease. J Biomol Screen. 2015;20(1):101-111. doi:10.1177/1087057114553103.
    • (2015) J Biomol Screen , vol.20 , Issue.1 , pp. 101-111
    • Neitz, R.J.1    Chen, S.2    Supek, F.3
  • 43
    • 65549111678 scopus 로고    scopus 로고
    • Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening
    • Bettiol E, Samanovic M, Murkin AS, et al. Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening. PLoS Negl Trop Dis. 2009;3(2):e384. doi:10.1371/journal.pntd.0000384.t001.
    • (2009) PLoS Negl Trop Dis , vol.3 , Issue.2
    • Bettiol, E.1    Samanovic, M.2    Murkin, A.S.3
  • 44
    • 84924658062 scopus 로고    scopus 로고
    • New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: An open resource
    • Pena I, Pilar Manzano M, Cantizani J, et al. New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource. Sci Rep. 2015;5:8771. doi:10.1038/srep08771.
    • (2015) Sci Rep , vol.5 , pp. 8771
    • Pena, I.1    Pilar Manzano, M.2    Cantizani, J.3
  • 45
    • 84886540022 scopus 로고    scopus 로고
    • Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi
    • Keenan M, Alexander PW, Chaplin JH, et al. Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi. Future Med Chem. 2013;5(15):1733-1752. doi:10.4155/fmc.13.139.
    • (2013) Future Med Chem , vol.5 , Issue.15 , pp. 1733-1752
    • Keenan, M.1    Alexander, P.W.2    Chaplin, J.H.3
  • 46
    • 0033844976 scopus 로고    scopus 로고
    • In vitro antiproliferative effects and mechanism of action of the new triazole derivative UR-9825 against the protozoan parasite Trypanosoma (Schizotrypanum) cruzi
    • Urbina JA, Lira R, Visbal G, et al. In vitro antiproliferative effects and mechanism of action of the new triazole derivative UR-9825 against the protozoan parasite Trypanosoma (Schizotrypanum) cruzi. Antimicrob Agents Chemother. 2000;44(9):2498-2502.
    • (2000) Antimicrob Agents Chemother , vol.44 , Issue.9 , pp. 2498-2502
    • Urbina, J.A.1    Lira, R.2    Visbal, G.3
  • 47
    • 84898824975 scopus 로고    scopus 로고
    • Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: Implications for Chagas disease drug discovery and development
    • Moraes CB, Giardini MA, Kim H, et al. Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development. Sci Rep. 2014;4:4703. doi:10.1038/srep04703.
    • (2014) Sci Rep , vol.4 , pp. 4703
    • Moraes, C.B.1    Giardini, M.A.2    Kim, H.3
  • 48
    • 84908239030 scopus 로고    scopus 로고
    • Sequence variation in CYP51A from the y strain of Trypanosoma cruzi alters its sensitivity to inhibition
    • Cherkesova TS, Hargrove TY, Vanrell MC, et al. Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibition. FEBS Letters. 2014;588(21):3878-3885. doi:10.1016/j. febslet.2014.08.030.
    • (2014) FEBS Letters , vol.588 , Issue.21 , pp. 3878-3885
    • Cherkesova, T.S.1    Hargrove, T.Y.2    Vanrell, M.C.3
  • 49
    • 0031807492 scopus 로고    scopus 로고
    • Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: In vitro and in vivo studies
    • Urbina JA, Payares G, Contreras LM, et al. Antiproliferative effects and mechanism of action of SCH 56592 against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. Antimicrob Agents Chemother. 1998;42(7):1771-1777.
    • (1998) Antimicrob Agents Chemother , vol.42 , Issue.7 , pp. 1771-1777
    • Urbina, J.A.1    Payares, G.2    Contreras, L.M.3
  • 50
    • 0037220817 scopus 로고    scopus 로고
    • In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease
    • Urbina JA, Payares G, Sanoja C, et al. In vitro and in vivo activities of ravuconazole on Trypanosoma cruzi, the causative agent of Chagas disease. Int J Antimicrob Agents. 2003;21(1):27-38.
    • (2003) Int J Antimicrob Agents , vol.21 , Issue.1 , pp. 27-38
    • Urbina, J.A.1    Payares, G.2    Sanoja, C.3
  • 51
    • 77953021818 scopus 로고    scopus 로고
    • A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease
    • Olivieri BP, Molina JT, de Castro SL, et al. A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease. Int J Antimicrob Agents. 2010;36(1):79-83. doi:10.1016/j.ijantimicag.2010.03.006.
    • (2010) Int J Antimicrob Agents , vol.36 , Issue.1 , pp. 79-83
    • Olivieri, B.P.1    Molina, J.T.2    De Castro, S.L.3
  • 52
    • 84939817804 scopus 로고    scopus 로고
    • Limited ability of posaconazole to cure both acute and chronic Trypanosoma cruzi infections revealed by highly sensitive in vivo imaging
    • Francisco AF, Lewis MD, Jayawardhana S, et al. Limited ability of posaconazole to cure both acute and chronic Trypanosoma cruzi infections revealed by highly sensitive in vivo imaging. Antimicrob Agents Chemother. 2015;59(8):4653-4661. doi:10.1128/AAC.00520-15.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.8 , pp. 4653-4661
    • Francisco, A.F.1    Lewis, M.D.2    Jayawardhana, S.3
  • 53
    • 84942889762 scopus 로고    scopus 로고
    • Antitrypanosomal treatment with benznidazole is superior to posaconazole regimens in mouse models of Chagas disease
    • Khare S, Liu X, Stinson M, et al. Antitrypanosomal treatment with benznidazole is superior to posaconazole regimens in mouse models of Chagas disease. Antimicrob Agents Chemother. 2015;59 (10):6385-6394. doi:10.1128/AAC.00689-15.
    • (2015) Antimicrob Agents Chemother , vol.59 , Issue.10 , pp. 6385-6394
    • Khare, S.1    Liu, X.2    Stinson, M.3
  • 54
    • 84920081179 scopus 로고    scopus 로고
    • Chagas disease drug discovery: Toward a new era
    • Chatelain E. Chagas disease drug discovery: toward a new era. J Biomol Screen. 2015;20(1):22-35. doi:10.1177/1087057114550585.
    • (2015) J Biomol Screen , vol.20 , Issue.1 , pp. 22-35
    • Chatelain, E.1
  • 55
    • 0000416948 scopus 로고
    • Variações morfológicas observadas em diferentes amostras de Trypanosoma cruzi
    • Brener Z, Chiari E. Variações morfológicas observadas em diferentes amostras de Trypanosoma cruzi. Rev Inst Med Trop Sao Paulo. 1963;5:220-244.
    • (1963) Rev Inst Med Trop Sao Paulo , vol.5 , pp. 220-244
    • Brener, Z.1    Chiari, E.2
  • 56
    • 0023609713 scopus 로고
    • Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease
    • Filardi LS, Brener Z. Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease. Trans R Society Trop Med Hyg. 1987;81(5):755-759. DOI:10.1016/ 0035-9203(87)90020-4.
    • (1987) Trans R Society Trop Med Hyg , vol.81 , Issue.5 , pp. 755-759
    • Filardi, L.S.1    Brener, Z.2
  • 57
    • 0023804393 scopus 로고
    • Comparative studies of drug susceptibility of five strains of Trypanosoma cruzi in vivo and in vitro
    • Neal RA, Van Bueren J. Comparative studies of drug susceptibility of five strains of Trypanosoma cruzi in vivo and in vitro. Trans R Society Trop Med Hyg. 1988;82(5):709-714. doi:10.1016/0035-9203 (88)90208-8.
    • (1988) Trans R Society Trop Med Hyg , vol.82 , Issue.5 , pp. 709-714
    • Neal, R.A.1    Van Bueren, J.2
  • 58
    • 0038538181 scopus 로고    scopus 로고
    • Trypanosoma cruzi: Susceptibility to chemotherapy with benznidazole of clones isolated from the highly resistant Colombian strain
    • Camandaroba ELP, Reis EAG, Gonçalves MS, et al. Trypanosoma cruzi: susceptibility to chemotherapy with benznidazole of clones isolated from the highly resistant Colombian strain. Rev Soc Bras Med Trop. 2003;36(2):201-209.
    • (2003) Rev Soc Bras Med Trop , vol.36 , Issue.2 , pp. 201-209
    • Camandaroba, E.L.P.1    Reis, E.A.G.2    Gonçalves, M.S.3
  • 59
    • 78149233944 scopus 로고    scopus 로고
    • In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi
    • Chen YT, Brinen LS, Kerr ID, et al. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. PLoS Negl Trop Dis. 2010;4(9):e825. doi:10.1371/journal.pntd.0000825.
    • (2010) PLoS Negl Trop Dis , vol.4 , Issue.9
    • Chen, Y.T.1    Brinen, L.S.2    Kerr, I.D.3
  • 60
    • 84886501314 scopus 로고    scopus 로고
    • Approaches to protozoan drug discovery: Phenotypic screening
    • Sykes ML, Avery VM. Approaches to protozoan drug discovery: phenotypic screening. J Med Chem. 2013;56(20):7727-7740. doi:10.1021/jm4004279.
    • (2013) J Med Chem , vol.56 , Issue.20 , pp. 7727-7740
    • Sykes, M.L.1    Avery, V.M.2
  • 61
    • 84893436816 scopus 로고    scopus 로고
    • Towards a paradigm shift in the treatment of chronic Chagas disease
    • Viotti R, Alarcon de Noya B, Araujo-Jorge T, et al. Towards a paradigm shift in the treatment of chronic Chagas disease. Antimicrob Agents Chemother. 2014;58(2):635-639. doi:10.1128/AAC.01662-13.
    • (2014) Antimicrob Agents Chemother , vol.58 , Issue.2 , pp. 635-639
    • Viotti, R.1    Alarcon De Noya, B.2    Araujo-Jorge, T.3
  • 62
    • 35748983210 scopus 로고    scopus 로고
    • Target deconvolution strategies in drug discovery
    • Terstappen GC, Schlüpen C, Raggiaschi R, et al. Target deconvolution strategies in drug discovery. Nat Rev Drug Discov. 2007;6 (11):891-903. doi:10.1038/nrd2410.
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.11 , pp. 891-903
    • Terstappen, G.C.1    Schlüpen, C.2    Raggiaschi, R.3
  • 63
    • 84938767845 scopus 로고    scopus 로고
    • Utilizing chemical genomics to identify cytochrome b as a novel drug target for Chagas disease
    • Khare S, Roach SL, Barnes SW, et al. Utilizing chemical genomics to identify cytochrome b as a novel drug target for Chagas disease. PLoS Pathog. 2015;11(7):e1005058. doi:10.1371/journal. ppat.1005058.
    • (2015) PLoS Pathog , vol.11 , Issue.7
    • Khare, S.1    Roach, S.L.2    Barnes, S.W.3
  • 64
    • 69249093873 scopus 로고    scopus 로고
    • Using small molecules to dissect mechanisms of microbial pathogenesis
    • Puri AW, Bogyo M. Using small molecules to dissect mechanisms of microbial pathogenesis. ACS Chem Biol. 2009;4(8):603-616. doi:10.1021/cb9001409.
    • (2009) ACS Chem Biol , vol.4 , Issue.8 , pp. 603-616
    • Puri, A.W.1    Bogyo, M.2
  • 65
    • 79851515870 scopus 로고    scopus 로고
    • Proteomics accelerating the identification of the target molecule of bioactive small molecules
    • Wierzba K,Muroi M, Osada H. Proteomics accelerating the identification of the target molecule of bioactive small molecules. Curr Opin Chem Biol. 2011;15(1):57-65. doi:10.1016/j.cbpa.2010.10.009.
    • (2011) Curr Opin Chem Biol , vol.15 , Issue.1 , pp. 57-65
    • Wierzba Kmuroi, M.1    Osada, H.2
  • 66
    • 84874263173 scopus 로고    scopus 로고
    • Lapatinib-binding protein kinases in the African trypanosome: Identification of cellular targets for kinase-directed chemical scaffolds
    • Katiyar S, Kufareva I, Behera R, et al. Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds. PLoS ONE. 2013;8(2):e56150. doi:10.1371/journal.pone.0056150.
    • (2013) PLoS ONE , vol.8 , Issue.2
    • Katiyar, S.1    Kufareva, I.2    Behera, R.3
  • 67
    • 76049084586 scopus 로고    scopus 로고
    • Target identification using drug affinity responsive target stability (DARTS)
    • Lomenick B, Hao R, Jonai N, et al. Target identification using drug affinity responsive target stability (DARTS). PNAS. 2009;106 (51):21984-21989. doi:10.1073/pnas.0910040106.
    • (2009) PNAS , vol.106 , Issue.51 , pp. 21984-21989
    • Lomenick, B.1    Hao, R.2    Jonai, N.3
  • 68
    • 84875241586 scopus 로고    scopus 로고
    • Target deconvolution techniques in modern phenotypic profiling
    • Lee J, Bogyo M. Target deconvolution techniques in modern phenotypic profiling. Curr Opin Chem Biol. 2013;17(1):118-126. doi:10.1016/j.cbpa.2012.12.022.
    • (2013) Curr Opin Chem Biol , vol.17 , Issue.1 , pp. 118-126
    • Lee, J.1    Bogyo, M.2
  • 69
    • 79960566893 scopus 로고    scopus 로고
    • Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion
    • Hall CI, Reese ML, Weerapana E, et al. Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion. Proc Natl Acad Sci USA. 2011;108 (26):10568-10573. doi:10.1073/pnas.1105622108.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.26 , pp. 10568-10573
    • Hall, C.I.1    Reese, M.L.2    Weerapana, E.3
  • 70
    • 43749109597 scopus 로고    scopus 로고
    • Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
    • Kato N, Sakata T, Breton G, et al. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol. 2008;4(6):347-356. doi:10.1038/nchembio.87.
    • (2008) Nat Chem Biol , vol.4 , Issue.6 , pp. 347-356
    • Kato, N.1    Sakata, T.2    Breton, G.3
  • 71
    • 84856955769 scopus 로고    scopus 로고
    • High-throughput decoding of antitrypanosomal drug efficacy and resistance
    • Alsford S, Eckert S, Baker N, et al. High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature. 2012;482 (7384):232-236. doi:10.1038/nature10771.
    • (2012) Nature , vol.482 , Issue.7384 , pp. 232-236
    • Alsford, S.1    Eckert, S.2    Baker, N.3
  • 72
    • 84893808671 scopus 로고    scopus 로고
    • Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen
    • Jones NG, Thomas EB, Brown E, et al. Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen. PLoS Pathog. 2014;10(1):e1003886. doi:10.1371/journal.ppat.1003886.
    • (2014) PLoS Pathog , vol.10 , Issue.1
    • Jones, N.G.1    Thomas, E.B.2    Brown, E.3
  • 73
    • 79956326721 scopus 로고    scopus 로고
    • Visual genome-wide RNAi screening to identify human host factors required for Trypanosoma cruzi infection
    • Genovesio A, Giardini MA, Kwon Y-J, et al. Visual genome-wide RNAi screening to identify human host factors required for Trypanosoma cruzi infection. PLoS ONE. 2011;6(5):e19733. doi:10.1371/journal.pone.0019733.t001.
    • (2011) PLoS ONE , vol.6 , Issue.5
    • Genovesio, A.1    Giardini, M.A.2    Kwon, Y.-J.3
  • 74
    • 84872553101 scopus 로고    scopus 로고
    • Host metabolism regulates intracellular growth of Trypanosoma cruzi
    • Caradonna KL, Engel JC, Jacobi D, et al. Host metabolism regulates intracellular growth of Trypanosoma cruzi. Cell Host Microbe. 2013;13(1):108-117. doi:10.1016/j.chom.2012.11.011.
    • (2013) Cell Host Microbe , vol.13 , Issue.1 , pp. 108-117
    • Caradonna, K.L.1    Engel, J.C.2    Jacobi, D.3
  • 75
    • 84863012787 scopus 로고    scopus 로고
    • Functional genomics of trypanosomatids
    • Choi J, El-Sayed NM. Functional genomics of trypanosomatids. Parasite Immunol. 2012;34(2-3):72-79. doi:10.1111/j.1365- 3024.2011.01347.x.
    • (2012) Parasite Immunol , vol.34 , Issue.2-3 , pp. 72-79
    • Choi, J.1    El-Sayed, N.M.2
  • 76
    • 80052432770 scopus 로고    scopus 로고
    • The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing
    • Diaz-Gonzalez R, Kuhlmann FM, Galan-Rodriguez C, et al. The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing. PLoS Negl Trop Dis. 2011;5(8):e1297. doi:10.1371/journal. pntd.0001297.
    • (2011) PLoS Negl Trop Dis , vol.5 , Issue.8
    • Diaz-Gonzalez, R.1    Kuhlmann, F.M.2    Galan-Rodriguez, C.3


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