-
1
-
-
77649234756
-
How to improve R&D productivity: The pharmaceutical industry's grand challenge
-
Paul, S. M.; Mytelka, D. S.; Dunwiddie, C. T.; Persinger, C. C.; Munos, B. H.; Lindborg, S. R.; Schacht, A. L. How to improve R&D productivity: the pharmaceutical industry's grand challenge Nat. Rev. Drug Discovery 2010, 9, 203-214
-
(2010)
Nat. Rev. Drug Discovery
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
Mytelka, D.S.2
Dunwiddie, C.T.3
Persinger, C.C.4
Munos, B.H.5
Lindborg, S.R.6
Schacht, A.L.7
-
2
-
-
78650798983
-
Productivity shortfalls in drug discovery: Contributions from the preclinical sciences?
-
Williams, M. Productivity shortfalls in drug discovery: Contributions from the preclinical sciences? J. Pharmacol. Exp. Ther. 2011, 336, 3-8
-
(2011)
J. Pharmacol. Exp. Ther.
, vol.336
, pp. 3-8
-
-
Williams, M.1
-
3
-
-
84866739808
-
Drug discovery in pharmaceutical industry: Productivity challenges and trends
-
Khanna, I. Drug discovery in pharmaceutical industry: productivity challenges and trends Drug Discovery Today 2012, 17 (19/20) 1088-1102
-
(2012)
Drug Discovery Today
, vol.17
, Issue.19-20
, pp. 1088-1102
-
-
Khanna, I.1
-
4
-
-
79960100831
-
Reengineering translational science; The time is right
-
Collins, F. S. Reengineering translational science; the time is right Sci. Trans. Med. 2011, 3, 90cm17
-
(2011)
Sci. Trans. Med.
, vol.3
-
-
Collins, F.S.1
-
5
-
-
84861490509
-
Modern phenotypic drug discovery is a viable, neoclassic pharma strategy
-
Lee, J. A.; Uhlik, M. T.; Moxham, C. M.; Tomandl, D.; Sall, D. J. Modern phenotypic drug discovery is a viable, neoclassic pharma strategy J. Med. Chem. 2012, 55 (10) 4527-4538
-
(2012)
J. Med. Chem.
, vol.55
, Issue.10
, pp. 4527-4538
-
-
Lee, J.A.1
Uhlik, M.T.2
Moxham, C.M.3
Tomandl, D.4
Sall, D.J.5
-
6
-
-
41149088849
-
Exploiting complexity and the robustness of network architecture for drug discovery
-
Hellerstein, M. K. Exploiting complexity and the robustness of network architecture for drug discovery J. Pharmacol. Exp. Ther. 2008, 325, 1-9
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.325
, pp. 1-9
-
-
Hellerstein, M.K.1
-
8
-
-
84862218504
-
Drug repurposing through non-hypothesis driven phenotypic screening
-
Reaume, A. G. Drug repurposing through non-hypothesis driven phenotypic screening Drug Discovery Today: Ther. Strategies 2011, 8 (3-4) 85-88
-
(2011)
Drug Discovery Today: Ther. Strategies
, vol.8
, Issue.34
, pp. 85-88
-
-
Reaume, A.G.1
-
9
-
-
84857734006
-
Back to the future: Lessons learned in modern target-based and whole-cell lead optimization of antimalarials
-
Chatterjee, A. K.; Yeung, B. K. S. Back to the future: lessons learned in modern target-based and whole-cell lead optimization of antimalarials Curr. Top. Med. Chem. 2012, 12, 473-483
-
(2012)
Curr. Top. Med. Chem.
, vol.12
, pp. 473-483
-
-
Chatterjee, A.K.1
Yeung, B.K.S.2
-
10
-
-
0034771740
-
Drugs for neglected diseases: A failure of the market and a public health failure?
-
Trouiller, P.; Torreele, E.; Olliaro, P.; White, N.; Foster, S.; Wirth, D.; Pécoul, B. Drugs for neglected diseases: a failure of the market and a public health failure? Trop. Med. Int. Health 2001, 6 (11) 945-951
-
(2001)
Trop. Med. Int. Health
, vol.6
, Issue.11
, pp. 945-951
-
-
Trouiller, P.1
Torreele, E.2
Olliaro, P.3
White, N.4
Foster, S.5
Wirth, D.6
Pécoul, B.7
-
11
-
-
0037157590
-
Drug development for neglected diseases: A deficient market and a public-health policy failure
-
Trouiller, P.; Olliaro, P.; Torreele, E.; Orbinski, J.; Laing, R.; Ford, N. Drug development for neglected diseases: a deficient market and a public-health policy failure Lancet 2002, 359, 2188-2194
-
(2002)
Lancet
, vol.359
, pp. 2188-2194
-
-
Trouiller, P.1
Olliaro, P.2
Torreele, E.3
Orbinski, J.4
Laing, R.5
Ford, N.6
-
12
-
-
84870430081
-
Neglected tropical diseases: Diagnosis, clinical management, treatment and control
-
(PDF of the online version)
-
Utzingera, J.; Beckera, S. L.; Knoppa, S.; Blumb, J.; Neumayrb, A. L.; Keiserb, J.; Hatzb, C. F. Neglected tropical diseases: diagnosis, clinical management, treatment and control Swiss Med. Wkly. 2012, 142, w13727 (PDF of the online version, www.smw.ch)
-
(2012)
Swiss Med. Wkly.
, vol.142
, pp. 13727
-
-
Utzingera, J.1
Beckera, S.L.2
Knoppa, S.3
Blumb, J.4
Neumayrb, A.L.5
Keiserb, J.6
Hatzb, C.F.7
-
13
-
-
84856279319
-
The "neglected tropical diseases": Now a brand identity; Responsibilities, context and promise
-
Molyneux, D. H. The "neglected tropical diseases": now a brand identity; responsibilities, context and promise Parasites Vectors 2012, 5, 23
-
(2012)
Parasites Vectors
, vol.5
, pp. 23
-
-
Molyneux, D.H.1
-
14
-
-
84863745999
-
ASTMH Presidential Address. The four horsemen of the apocalypse: Tropical medicine in the fight against plague, death, famine, and war
-
Hotez, P. J. ASTMH Presidential Address. The four horsemen of the apocalypse: tropical medicine in the fight against plague, death, famine, and war Am. J. Trop. Med. Hyg. 2012, 87 (1) 3-10
-
(2012)
Am. J. Trop. Med. Hyg.
, vol.87
, Issue.1
, pp. 3-10
-
-
Hotez, P.J.1
-
15
-
-
84856367163
-
Global phenotypic screening for antimalarials
-
Guiguemde, W. A.; Shelat, A. A.; Garcia-Bustos, J. F.; Diagana, T. T.; Gamo, F.-J.; Guy, R. K. Global phenotypic screening for antimalarials Chem. Biol. 2012, 19, 116-129
-
(2012)
Chem. Biol.
, vol.19
, pp. 116-129
-
-
Guiguemde, W.A.1
Shelat, A.A.2
Garcia-Bustos, J.F.3
Diagana, T.T.4
Gamo, F.-J.5
Guy, R.K.6
-
16
-
-
84886542459
-
Drug discovery for neglected diseases: Molecular target-based and phenotypic approaches
-
DOI: 10.1021/jm400362b.
-
Gilbert, I. H. Drug discovery for neglected diseases: molecular target-based and phenotypic approaches. J. Med. Chem. 2013, DOI: 10.1021/jm400362b.
-
(2013)
J. Med. Chem.
-
-
Gilbert, I.H.1
-
17
-
-
84886501314
-
Approaches to protozoan drug discovery: Phenotypic screening
-
DOI: 10.1021/jm4004279.
-
Sykes, M. L.; Avery, V. M. Approaches to protozoan drug discovery: phenotypic screening. J. Med. Chem. 2013, DOI: 10.1021/jm4004279.
-
(2013)
J. Med. Chem.
-
-
Sykes, M.L.1
Avery, V.M.2
-
18
-
-
70549093092
-
Non-genetic cell-to-cell variability and the consequences for pharmacology
-
Niepel, M.; Spencer, S. L.; Sorger, P. K. Non-genetic cell-to-cell variability and the consequences for pharmacology Curr. Opin. Chem. Biol. 2009, 13 (5-6) 556-561
-
(2009)
Curr. Opin. Chem. Biol.
, vol.13
, Issue.56
, pp. 556-561
-
-
Niepel, M.1
Spencer, S.L.2
Sorger, P.K.3
-
19
-
-
71249119558
-
Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria
-
Cameron, J.; O'Toole, R.; Miller, C. H.; Nisa, S.; Dempsey, S. Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria Antimicrob. Agents Chemother. 2009, 5279-5283
-
(2009)
Antimicrob. Agents Chemother.
, pp. 5279-5283
-
-
Cameron, J.1
O'Toole, R.2
Miller, C.H.3
Nisa, S.4
Dempsey, S.5
-
20
-
-
77955985403
-
The beautiful cell: High-content screening in drug discovery
-
Bickle, M. The beautiful cell: high-content screening in drug discovery Anal. Bioanal. Chem. 2010, 398, 219-226
-
(2010)
Anal. Bioanal. Chem.
, vol.398
, pp. 219-226
-
-
Bickle, M.1
-
21
-
-
80053494971
-
The next opportunity in anti-malaria drug discovery: The liver stage
-
(e1002178
-
Derbyshire, E. R.; Mota, M. M.; Clardy, J. The next opportunity in anti-malaria drug discovery: the liver stage PLoS Pathog. 2011, 7 (9 e1002178
-
(2011)
PLoS Pathog.
, vol.7
, Issue.9
-
-
Derbyshire, E.R.1
Mota, M.M.2
Clardy, J.3
-
22
-
-
84886543990
-
Cell-based medicinal chemistry optimization of HTS hits for orally active antimalarials. Part 1: Challenges in potency and absorption, distribution, metabolism, excretion/pharmacokinetics (ADME/PK)
-
DOI: 10.1021/jm400314m.
-
Chatterjee, A. Cell-based medicinal chemistry optimization of HTS hits for orally active antimalarials. Part 1: Challenges in potency and absorption, distribution, metabolism, excretion/pharmacokinetics (ADME/PK). J. Med. Chem. 2013, DOI: 10.1021/jm400314m.
-
(2013)
J. Med. Chem.
-
-
Chatterjee, A.1
-
23
-
-
84886541468
-
Cell-based medicinal chemistry optimization of HTS hits for orally active antimalarials. Part 2: Hits from SoftFocus kinase and other libraries
-
DOI: 10.1021/jm400279y.
-
Younis, Y.; Street, L. J.; Waterson, D.; Witty, M. J.; Chibale, K. Cell-based medicinal chemistry optimization of HTS hits for orally active antimalarials. Part 2: Hits from SoftFocus kinase and other libraries. J. Med. Chem. 2013, DOI: 10.1021/jm400279y.
-
(2013)
J. Med. Chem.
-
-
Younis, Y.1
Street, L.J.2
Waterson, D.3
Witty, M.J.4
Chibale, K.5
-
24
-
-
84886495995
-
Development of Mycobacterium tuberculosis whole cell screening hits as potential antituberculosis agents
-
DOI: 10.1021/jm400381v.
-
Cooper, C. B. Development of Mycobacterium tuberculosis whole cell screening hits as potential antituberculosis agents. J. Med. Chem. 2013, DOI: 10.1021/jm400381v.
-
(2013)
J. Med. Chem.
-
-
Cooper, C.B.1
-
25
-
-
84860354911
-
Strategies and challenges involved in the discovery of new chemical entities during early-stage tuberculosis drug discovery
-
Coxon, G. D.; Cooper, C. B.; Gillespie, S. H.; McHugh, T. D. Strategies and challenges involved in the discovery of new chemical entities during early-stage tuberculosis drug discovery J. Infect. Dis. 2012, 205 (Suppl. 2) S258-S264
-
(2012)
J. Infect. Dis.
, vol.205
, Issue.SUPPL. 2
-
-
Coxon, G.D.1
Cooper, C.B.2
Gillespie, S.H.3
McHugh, T.D.4
-
26
-
-
84886501384
-
Using genetic methods to define the targets of compounds with antimalarial activity
-
DOI: 10.1021/jm400325j.
-
Flannery, E. L.; Fidock, D. A.; Winzeler, E. A. Using genetic methods to define the targets of compounds with antimalarial activity. J. Med. Chem. 2013, DOI: 10.1021/jm400325j.
-
(2013)
J. Med. Chem.
-
-
Flannery, E.L.1
Fidock, D.A.2
Winzeler, E.A.3
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