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Volumn 56, Issue 20, 2013, Pages 7715-7718

Phenotypic screening as a strategic component of drug discovery programs targeting novel antiparasitic and antimycobacterial agents: An editorial

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOTHIAZOLE DERIVATIVE; AMINOPYRIDINE DERIVATIVE; ANTIMYCOBACTERIAL AGENT; ANTIPARASITIC AGENT; BENZAMIDE DERIVATIVE; IMIDAZOLOPIPERAZINE DERIVATIVE; IMIDAZOLOPYRIMIDINE DERIVATIVE; PIPERAZINE DERIVATIVE; PROTEIN N MYRISTOYLTRANSFERASE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 84886571969     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400443k     Document Type: Article
Times cited : (23)

References (26)
  • 2
    • 78650798983 scopus 로고    scopus 로고
    • Productivity shortfalls in drug discovery: Contributions from the preclinical sciences?
    • Williams, M. Productivity shortfalls in drug discovery: Contributions from the preclinical sciences? J. Pharmacol. Exp. Ther. 2011, 336, 3-8
    • (2011) J. Pharmacol. Exp. Ther. , vol.336 , pp. 3-8
    • Williams, M.1
  • 3
    • 84866739808 scopus 로고    scopus 로고
    • Drug discovery in pharmaceutical industry: Productivity challenges and trends
    • Khanna, I. Drug discovery in pharmaceutical industry: productivity challenges and trends Drug Discovery Today 2012, 17 (19/20) 1088-1102
    • (2012) Drug Discovery Today , vol.17 , Issue.19-20 , pp. 1088-1102
    • Khanna, I.1
  • 4
    • 79960100831 scopus 로고    scopus 로고
    • Reengineering translational science; The time is right
    • Collins, F. S. Reengineering translational science; the time is right Sci. Trans. Med. 2011, 3, 90cm17
    • (2011) Sci. Trans. Med. , vol.3
    • Collins, F.S.1
  • 5
    • 84861490509 scopus 로고    scopus 로고
    • Modern phenotypic drug discovery is a viable, neoclassic pharma strategy
    • Lee, J. A.; Uhlik, M. T.; Moxham, C. M.; Tomandl, D.; Sall, D. J. Modern phenotypic drug discovery is a viable, neoclassic pharma strategy J. Med. Chem. 2012, 55 (10) 4527-4538
    • (2012) J. Med. Chem. , vol.55 , Issue.10 , pp. 4527-4538
    • Lee, J.A.1    Uhlik, M.T.2    Moxham, C.M.3    Tomandl, D.4    Sall, D.J.5
  • 6
    • 41149088849 scopus 로고    scopus 로고
    • Exploiting complexity and the robustness of network architecture for drug discovery
    • Hellerstein, M. K. Exploiting complexity and the robustness of network architecture for drug discovery J. Pharmacol. Exp. Ther. 2008, 325, 1-9
    • (2008) J. Pharmacol. Exp. Ther. , vol.325 , pp. 1-9
    • Hellerstein, M.K.1
  • 8
    • 84862218504 scopus 로고    scopus 로고
    • Drug repurposing through non-hypothesis driven phenotypic screening
    • Reaume, A. G. Drug repurposing through non-hypothesis driven phenotypic screening Drug Discovery Today: Ther. Strategies 2011, 8 (3-4) 85-88
    • (2011) Drug Discovery Today: Ther. Strategies , vol.8 , Issue.34 , pp. 85-88
    • Reaume, A.G.1
  • 9
    • 84857734006 scopus 로고    scopus 로고
    • Back to the future: Lessons learned in modern target-based and whole-cell lead optimization of antimalarials
    • Chatterjee, A. K.; Yeung, B. K. S. Back to the future: lessons learned in modern target-based and whole-cell lead optimization of antimalarials Curr. Top. Med. Chem. 2012, 12, 473-483
    • (2012) Curr. Top. Med. Chem. , vol.12 , pp. 473-483
    • Chatterjee, A.K.1    Yeung, B.K.S.2
  • 11
    • 0037157590 scopus 로고    scopus 로고
    • Drug development for neglected diseases: A deficient market and a public-health policy failure
    • Trouiller, P.; Olliaro, P.; Torreele, E.; Orbinski, J.; Laing, R.; Ford, N. Drug development for neglected diseases: a deficient market and a public-health policy failure Lancet 2002, 359, 2188-2194
    • (2002) Lancet , vol.359 , pp. 2188-2194
    • Trouiller, P.1    Olliaro, P.2    Torreele, E.3    Orbinski, J.4    Laing, R.5    Ford, N.6
  • 12
    • 84870430081 scopus 로고    scopus 로고
    • Neglected tropical diseases: Diagnosis, clinical management, treatment and control
    • (PDF of the online version)
    • Utzingera, J.; Beckera, S. L.; Knoppa, S.; Blumb, J.; Neumayrb, A. L.; Keiserb, J.; Hatzb, C. F. Neglected tropical diseases: diagnosis, clinical management, treatment and control Swiss Med. Wkly. 2012, 142, w13727 (PDF of the online version, www.smw.ch)
    • (2012) Swiss Med. Wkly. , vol.142 , pp. 13727
    • Utzingera, J.1    Beckera, S.L.2    Knoppa, S.3    Blumb, J.4    Neumayrb, A.L.5    Keiserb, J.6    Hatzb, C.F.7
  • 13
    • 84856279319 scopus 로고    scopus 로고
    • The "neglected tropical diseases": Now a brand identity; Responsibilities, context and promise
    • Molyneux, D. H. The "neglected tropical diseases": now a brand identity; responsibilities, context and promise Parasites Vectors 2012, 5, 23
    • (2012) Parasites Vectors , vol.5 , pp. 23
    • Molyneux, D.H.1
  • 14
    • 84863745999 scopus 로고    scopus 로고
    • ASTMH Presidential Address. The four horsemen of the apocalypse: Tropical medicine in the fight against plague, death, famine, and war
    • Hotez, P. J. ASTMH Presidential Address. The four horsemen of the apocalypse: tropical medicine in the fight against plague, death, famine, and war Am. J. Trop. Med. Hyg. 2012, 87 (1) 3-10
    • (2012) Am. J. Trop. Med. Hyg. , vol.87 , Issue.1 , pp. 3-10
    • Hotez, P.J.1
  • 16
    • 84886542459 scopus 로고    scopus 로고
    • Drug discovery for neglected diseases: Molecular target-based and phenotypic approaches
    • DOI: 10.1021/jm400362b.
    • Gilbert, I. H. Drug discovery for neglected diseases: molecular target-based and phenotypic approaches. J. Med. Chem. 2013, DOI: 10.1021/jm400362b.
    • (2013) J. Med. Chem.
    • Gilbert, I.H.1
  • 17
    • 84886501314 scopus 로고    scopus 로고
    • Approaches to protozoan drug discovery: Phenotypic screening
    • DOI: 10.1021/jm4004279.
    • Sykes, M. L.; Avery, V. M. Approaches to protozoan drug discovery: phenotypic screening. J. Med. Chem. 2013, DOI: 10.1021/jm4004279.
    • (2013) J. Med. Chem.
    • Sykes, M.L.1    Avery, V.M.2
  • 18
    • 70549093092 scopus 로고    scopus 로고
    • Non-genetic cell-to-cell variability and the consequences for pharmacology
    • Niepel, M.; Spencer, S. L.; Sorger, P. K. Non-genetic cell-to-cell variability and the consequences for pharmacology Curr. Opin. Chem. Biol. 2009, 13 (5-6) 556-561
    • (2009) Curr. Opin. Chem. Biol. , vol.13 , Issue.56 , pp. 556-561
    • Niepel, M.1    Spencer, S.L.2    Sorger, P.K.3
  • 19
    • 71249119558 scopus 로고    scopus 로고
    • Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria
    • Cameron, J.; O'Toole, R.; Miller, C. H.; Nisa, S.; Dempsey, S. Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria Antimicrob. Agents Chemother. 2009, 5279-5283
    • (2009) Antimicrob. Agents Chemother. , pp. 5279-5283
    • Cameron, J.1    O'Toole, R.2    Miller, C.H.3    Nisa, S.4    Dempsey, S.5
  • 20
    • 77955985403 scopus 로고    scopus 로고
    • The beautiful cell: High-content screening in drug discovery
    • Bickle, M. The beautiful cell: high-content screening in drug discovery Anal. Bioanal. Chem. 2010, 398, 219-226
    • (2010) Anal. Bioanal. Chem. , vol.398 , pp. 219-226
    • Bickle, M.1
  • 21
    • 80053494971 scopus 로고    scopus 로고
    • The next opportunity in anti-malaria drug discovery: The liver stage
    • (e1002178
    • Derbyshire, E. R.; Mota, M. M.; Clardy, J. The next opportunity in anti-malaria drug discovery: the liver stage PLoS Pathog. 2011, 7 (9 e1002178
    • (2011) PLoS Pathog. , vol.7 , Issue.9
    • Derbyshire, E.R.1    Mota, M.M.2    Clardy, J.3
  • 22
    • 84886543990 scopus 로고    scopus 로고
    • Cell-based medicinal chemistry optimization of HTS hits for orally active antimalarials. Part 1: Challenges in potency and absorption, distribution, metabolism, excretion/pharmacokinetics (ADME/PK)
    • DOI: 10.1021/jm400314m.
    • Chatterjee, A. Cell-based medicinal chemistry optimization of HTS hits for orally active antimalarials. Part 1: Challenges in potency and absorption, distribution, metabolism, excretion/pharmacokinetics (ADME/PK). J. Med. Chem. 2013, DOI: 10.1021/jm400314m.
    • (2013) J. Med. Chem.
    • Chatterjee, A.1
  • 23
    • 84886541468 scopus 로고    scopus 로고
    • Cell-based medicinal chemistry optimization of HTS hits for orally active antimalarials. Part 2: Hits from SoftFocus kinase and other libraries
    • DOI: 10.1021/jm400279y.
    • Younis, Y.; Street, L. J.; Waterson, D.; Witty, M. J.; Chibale, K. Cell-based medicinal chemistry optimization of HTS hits for orally active antimalarials. Part 2: Hits from SoftFocus kinase and other libraries. J. Med. Chem. 2013, DOI: 10.1021/jm400279y.
    • (2013) J. Med. Chem.
    • Younis, Y.1    Street, L.J.2    Waterson, D.3    Witty, M.J.4    Chibale, K.5
  • 24
    • 84886495995 scopus 로고    scopus 로고
    • Development of Mycobacterium tuberculosis whole cell screening hits as potential antituberculosis agents
    • DOI: 10.1021/jm400381v.
    • Cooper, C. B. Development of Mycobacterium tuberculosis whole cell screening hits as potential antituberculosis agents. J. Med. Chem. 2013, DOI: 10.1021/jm400381v.
    • (2013) J. Med. Chem.
    • Cooper, C.B.1
  • 25
    • 84860354911 scopus 로고    scopus 로고
    • Strategies and challenges involved in the discovery of new chemical entities during early-stage tuberculosis drug discovery
    • Coxon, G. D.; Cooper, C. B.; Gillespie, S. H.; McHugh, T. D. Strategies and challenges involved in the discovery of new chemical entities during early-stage tuberculosis drug discovery J. Infect. Dis. 2012, 205 (Suppl. 2) S258-S264
    • (2012) J. Infect. Dis. , vol.205 , Issue.SUPPL. 2
    • Coxon, G.D.1    Cooper, C.B.2    Gillespie, S.H.3    McHugh, T.D.4
  • 26
    • 84886501384 scopus 로고    scopus 로고
    • Using genetic methods to define the targets of compounds with antimalarial activity
    • DOI: 10.1021/jm400325j.
    • Flannery, E. L.; Fidock, D. A.; Winzeler, E. A. Using genetic methods to define the targets of compounds with antimalarial activity. J. Med. Chem. 2013, DOI: 10.1021/jm400325j.
    • (2013) J. Med. Chem.
    • Flannery, E.L.1    Fidock, D.A.2    Winzeler, E.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.