Tankyrase inhibitors stimulate the ability of tankyrases to bind axin and drive assembly of β-catenin degradation-competent axin puncta

PLoS ONE

Volumn 11, Issue 3, 2016, Pages

  Martino Echarri, Estefania ^a   Brocardo, Mariana G ^a   Mills, Kate M ^a   Henderson, Beric R ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; GLUCOSE TRANSPORTER 4; PROTEASOME; SMALL INTERFERING RNA; TANKYRASE; TANKYRASE 1; TANKYRASE 2; TANKYRASE INHIBITOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BETA CATENIN; TNKS PROTEIN, HUMAN; TNKS2 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME INACTIVATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LACRIMAL DUCT; OLIGOMERIZATION; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PUNCTA; TISSUE SCAFFOLD; ANIMAL; ANTAGONISTS AND INHIBITORS; COLORECTAL TUMOR; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; HEK293 CELL LINE; METABOLISM; MOUSE; PATHOPHYSIOLOGY; TUMOR CELL LINE; WESTERN BLOTTING; WNT SIGNALING PATHWAY;

ANIMALS; ANTINEOPLASTIC AGENTS; AXIN PROTEIN; BETA CATENIN; BLOTTING, WESTERN; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; FLUORESCENT ANTIBODY TECHNIQUE; HEK293 CELLS; HUMANS; MICE; TANKYRASES; WNT SIGNALING PATHWAY;

EID: 84961842215     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0150484     Document Type: Article

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