Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine: Potential approach to pharmacological chaperone therapy for homocystinuria

Biochimie

Volumn 126, Issue , 2016, Pages 6-13

  Majtan, Tomas ^a   Pey, Angel L ^b   Kraus, Jan P ^a  

^a Children's Hospital Colorado   (United States)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

Calorimetry; Cystathionine beta synthase; Homocystinuria; Kinetic stability; Pharmacological chaperone; S adenosylmethionine

Indexed keywords

CYSTATHIONINE BETA SYNTHASE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SINEFUNGIN;

ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; CYSTATHIONINE BETA SYNTHASE DEFICIENT HOMOCYSTINURIA; DRUG PROTEIN BINDING; DRUG SPECIFICITY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME REGULATION; ENZYME STABILITY; ENZYME SUBSTRATE COMPLEX; HOMOCYSTINURIA; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HUMAN; KINETICS; METABOLISM;

CYSTATHIONINE BETA-SYNTHASE; ENZYME STABILITY; HOMOCYSTINURIA; HUMANS; KINETICS; S-ADENOSYLMETHIONINE;

EID: 84961841666     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2016.01.009     Document Type: Article

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