Rescue of cystathionine β-synthase (CBS) mutants with chemical chaperones: Purification and characterization of eight CBS mutant enzymes

Journal of Biological Chemistry

Volumn 285, Issue 21, 2010, Pages 15866-15873

  Majtan, Tomas ^a,b   Liu, Lu ^c   Carpenter, John F ^c   Kraus, Jan P ^a  

^a Children's Hospital Colorado   (United States)

^b INSTITUTE OF CHEMISTRY   (Slovakia)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FUNCTIONS; CATALYTIC ACTIVITY; CHEMICAL CHAPERONE; CRUDE EXTRACT; GENETIC DISEASE; INDIRECT EFFECTS; MISFOLDED PROTEINS; MOLECULAR CHAPERONES; MUTANT ENZYMES; MUTANT PROTEINS; PROTEIN EXPRESSIONS; S ADENOSYL L METHIONINES; SIGNIFICANT IMPACTS; SPECIFIC ACTIVITY; SYNTHASES; TETRAMERS; THERMAL ACTIVATION; THERMAL STABILITY; TRIMETHYLAMINE; WILD TYPES;

CATALYSTS; DIMETHYL SULFOXIDE; ELECTRIC CIRCUIT BREAKERS; ENZYMES; ESCHERICHIA COLI; ETHANOL; PORPHYRINS; PROTEIN FOLDING; PURIFICATION; RESTORATION; THERMOGRAVIMETRIC ANALYSIS;

CONTEXT SENSITIVE GRAMMARS;

ALCOHOL; CYSTATHIONINE BETA SYNTHASE; DIMETHYL SULFOXIDE; HEME; PROTEIN DNAJ; S ADENOSYLMETHIONINE; TRIMETHYLAMINE OXIDE;

ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME PURIFICATION; ESCHERICHIA COLI; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; THERMOSTABILITY; WILD TYPE;

CYSTATHIONINE BETA-SYNTHASE; ENZYME STABILITY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HOMOCYSTINURIA; HSP40 HEAT-SHOCK PROTEINS; HUMANS; MUTATION, MISSENSE; PYRIDOXINE; RECOMBINANT PROTEINS; VITAMIN B COMPLEX;

ESCHERICHIA COLI;

EID: 77952368285     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.107722     Document Type: Article

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