Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): Complex regulation of CBS activity and stability by SAM

Biochemical Journal

Volumn 449, Issue 1, 2013, Pages 109-121

  Pey, Angel L ^a   Majtan, Tomas ^b,c   Sanchez Ruiz, Jose M ^a   Kraus, Jan P ^b  

^a UNIVERSITY OF GRANADA   (Spain)

^b University of Colorado Denver and Children s Hospital Colorado   (United States)

^c INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

Cystathionine synthase (CBS); Enzyme activation; Homocystinuria; Ligand binding sites; Protein kinetic stability

Indexed keywords

CYSTATHIONINE BETA SYNTHASE; S ADENOSYLMETHIONINE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CALORIMETRY; CATALYSIS; DENATURATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME STABILITY; HUMAN; IN VIVO STUDY; LIGAND BINDING; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; STOICHIOMETRY;

BINDING SITES; CYSTATHIONINE BETA-SYNTHASE; ENZYME ACTIVATION; HOMOCYSTINURIA; HUMANS; PROTEIN BINDING; PROTEIN STABILITY; S-ADENOSYLMETHIONINE;

EID: 84870860045     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20120731     Document Type: Article

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