Inter-domain communication of human cystathionine β-synthase: Structural basis of S-adenosyl-L-methionine activation

Journal of Biological Chemistry

Volumn 289, Issue 52, 2014, Pages 36018-36030

  McCorvie, Thomas J ^a   Kopec, Jolanta ^a   Hyung, Suk Joon ^b   Fitzpatrick, Fiona ^a   Feng, Xidong ^b   Termine, Daniel ^b   Strain Damerell, Claire ^a   Vollmar, Melanie ^a   Fleming, James ^b   Janz, Jay M ^b   Bulawa, Christine ^b   Yue, Wyatt W ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CONFORMATIONS; ELECTRIC CIRCUIT BREAKERS; ENZYMES; MAMMALS; MASS SPECTROMETRY; MUTAGENESIS;

CATALYTIC DOMAINS; CONFORMATIONAL CHANGE; CONFORMATIONAL POPULATION; ENZYME ACTIVE SITES; INTERDOMAIN COMMUNICATION; REGULATORY DOMAIN; S ADENOSYL L METHIONINES; STRUCTURAL BASIS;

X RAY CRYSTALLOGRAPHY;

CYSTATHIONINE BETA SYNTHASE; S ADENOSYLMETHIONINE; PROTEIN BINDING;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; MASS SPECTROMETRY; MOLECULAR INTERACTION; MUTAGENESIS; NONHUMAN; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; HYDROGEN BOND; PROTEIN SECONDARY STRUCTURE;

MAMMALIA;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYSTATHIONINE BETA-SYNTHASE; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; S-ADENOSYLMETHIONINE;

EID: 84919935173     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.610782     Document Type: Article

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