Elevation of NT-proBNP and cardiac troponins in sepsis-related deaths: a forensic perspective

International Journal of Legal Medicine

Volumn 130, Issue 4, 2016, Pages 1035-1043

  Tettamanti, Camilla ^a   Hervet, Tania ^b   Grabherr, Silke ^b   Palmiere, Cristian ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY CENTER OF LEGAL MEDICINE   (Switzerland)

Author keywords

Autopsy; Cardiac biomarkers; Postmortem biochemistry; Sepsis

Indexed keywords

BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; CALCITONIN; PEPTIDE FRAGMENT; PRO-BRAIN NATRIURETIC PEPTIDE (1-76); TROPONIN I; TROPONIN T;

ADULT; AGED; BLOOD; CASE CONTROL STUDY; FEMALE; HUMAN; MALE; MIDDLE AGED; RETROSPECTIVE STUDY; SEPSIS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS; C-REACTIVE PROTEIN; CALCITONIN; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NATRIURETIC PEPTIDE, BRAIN; PEPTIDE FRAGMENTS; RETROSPECTIVE STUDIES; SEPSIS; TROPONIN I; TROPONIN T;

EID: 84961773507     PISSN: 09379827     EISSN: 14371596     Source Type: Journal    
DOI: 10.1007/s00414-016-1360-1     Document Type: Article

References (65)

1. Scott EC, Ho HC, Yu M, Chapital AD, Koss W, Takanishi DMJR (2008) Pre-existing cardiac disease, troponin I elevation and mortality in patients with severe sepsis and septic shock. Anaesth Intensive Care 36:51–59
2. Sheyin O, Davies O, Duan W, Perez X (2015) The prognostic significance of troponin elevation in patients with sepsis: a meta-analysis. Heart Lung 44:75–81
3. Bessière F, Khenifer S, Dubourg J, Durieu I, Lega JC (2013) Prognostic value of troponins in sepsis: a meta-analysis. Intensive Care Med 39:1181–1189
4. Tiruvoipati R, Sultana N, Lewis D (2012) Cardiac troponin I does not independently predict mortality in critically ill patients with severe sepsis. Emerg Med Australas 24:151–158
5. Bouza C, López-Cuadrado T, Saz-Parkinson Z, Amate-Blanco JM (2014) Epidemiology and recent trends of severe sepsis in Spain: a nationwide population-based analysis (2006–2011). BMC Infect Dis 14:3863
6. Kumar G, Kumar N, Taneja A, Kaleekal T, Tarima S, McGinley E, Jimenez E, Mohan A, Khan RA, Whittle J, Jacobs E, Nanchal R, Milwaukee Initiative in Critical Care Outcomes Research Group of Investigators (2011) Nationwide trends of severe sepsis in the 21st century. Chest 140:1223–1231
7. Maeder M, Fehr T, Rickli H, Ammann P (2006) Sepsis-associated myocardial dysfunction: diagnostic and prognostic impact of cardiac troponins and natriuretic peptides. Chest 129:1349–1366
8. van der Wekken LC, Alam N, Holleman F, van Exter P, Kramer MH, Nanayakkara PW (2016) Epidemiology of sepsis and its recognition by emergency medical services personnel in the Netherlands. Prehosp Emerg Care 20:90–96
9. Brueckmann M, Huhle G, Lang S, Haase KK, Bertsch T, Weiss C, Kaden JJ, Putensen C, Borggrefe M, Hoffmann U (2005) Prognostic value of plasma N-terminal pro-brain natriuretic peptide in patients with severe sepsis. Circulation 112:527–534
10. Flierl MA, Rittirsch D, Huber-Lang MS, Sarma JV, Ward PA (2008) Molecular events in the cardiomyopathy of sepsis. Mol Med 14:327–336
11. Hochstadt A, Meroz Y, Landesberg G (2011) Myocardial dysfunction in severe sepsis and septic shock: more questions than answers? J Cardiothorac Vasc Anesth 25:526–535
12. Krishnagopalan S, Kumar A, Parrillo JE, Kumar A (2002) Myocardial dysfunction in the patient with sepsis. Curr Opin Crit Care 8:376–388
13. Sevilla Berrios RA, O’Horo JC, Velagapudi V, Pulido JN (2014) Correlation of left ventricular systolic dysfunction determined by low ejection fraction and 30-day mortality in patients with severe sepsis and septic shock: a systematic review and meta-analysis. J Crit Care 29(4):495–499
14. Smith A, John M, Trout R, Davis E, Moningi S (2009) Elevated cardiac troponins in sepsis: what do they signify? W V Med J 105:29–32
15. Hussain N (2013) Elevated cardiac troponins in setting of systemic inflammatory response syndrome, sepsis and septic shock. ISRN Cardiol 2013:723435
16. Altmann DR, Korte W, Maeder MT, Fehr T, Haager P, Rickli H, Kleger G-R, Rodriguez R, Ammann P (2010) Elevated cardiac troponin I in sepsis and septic shock: no evidence for thrombus associated myocardial necrosis. PLoS One 5:e9017
17. Ammann P, Fehr T, Minder EI, Günter C, Bertel O (2001) Elevation of troponin I in sepsis and septic shock. Intensive Care Med 27:965–969
18. De Gennaro L, Brunetti ND, Cuculo A, Pellegrino PL, Izzo P, Roma F, Di Biase M (2008) Increased troponin levels in nonischemic cardiac conditions and noncardiac diseases. J Interv Cardiol 21:129–139
19. Hoffmann U, Brueckmann M, Bertsch T, Wiessner M, Liebetrau C, Lang S, Haase KK, Borggrefe M, Huhle G (2005) Increased plasma levels of NT-proANP and NT-proBNP as markers of cardiac dysfunction in septic patients. Clin Lab 51:373–379
20. Berdal JE, Stavem K, Omland T, Hall C, Smith-Erichssen N (2008) Prognostic merit of N-terminal-proBNP and N-terminal-proANP in mechanically ventilated critically ill patients. Acta Anaesthesiol Scand 52:1265–1272
21. Palmiere C, Bardy D, Mangin P, Augsburger M (2013) Value of sTREM-1, procalcitonin and CRP as laboratory parameters for postmortem diagnosis of sepsis. J Infect 67:545–555
22. Clemente G, Tuttolomondo A, Colomba D, Pecoraro R, Renda C, Della Corte V, Maida C, Simonetta I, Pinto A (2015) When sepsis affects the heart: a case report and literature review. World J Clin Case 3:743–750
23. Mehta NJ, Khan IA, Gupta V, Jani K, Gowda RM, Smith PR (2004) Cardiac troponin I predicts myocardial dysfunction and adverse outcome in septic shock. Int J Cardiol 95:13–17
24. Rudiger A, Singer M (2013) The heart in sepsis: from basic mechanisms to clinical management. Curr Vasc Pharmacol 11:187–195
25. Celes MR, Prado CM, Rossi MA (2013) Sepsis: going to the heart of the matter. Pathobiology 80:70–86
26. Rudiger A, Singer M (2007) Mechanisms of sepsis-induced cardiac dysfunction. Crit Care Med 35:1599–1608
27. Kang EW, Na HJ, Hong SM, Shin SK, Kang SW, Choi KH, Lee HY, Han DS, Han SH (2009) Prognostic value of elevated cardiac troponin I in ESRD patients with sepsis. Nephrol Dial Transplant 24:1568–1573
28. Stancoven AB, Shiue AB, Khera A, Pinkston K, Hashim IA, Wang A, de Lemos JA, Peterson GE (2011) Association of troponin T, detected with highly sensitive assay, and outcome in infective endocarditis. Am J Cardiol 108:416–420
29. Landesberg G, Jaffe AS, Gilon D, Levin PD, Goodman S, Abu-Baih A, Beeri R, Weissman C, Sprung CL, Landesberg A (2014) Troponin elevation in severe sepsis and septic shock: the role of left ventricular diastolic dysfunction and right ventricular dilatation. Crit Care Med 42:790–800
30. ver Elst KM, Spapen HD, Nguyen DN, Garbar C, Huyghens LP, Gorus FK (2000) Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock. Clin Chem 46:650–657
31. Spies C, Haude V, Fitzner R, Schröder K, Overbeck M, Runkel N, Shaffartzik W (1998) Serum cardiac troponin T as a prognostic marker in early sepsis. Chest 113:1055–1063
32. Shiue AB, Stancoven AB, Purcell JB, Pinkston K, Wang A, Khera A, de Lemos JA, Peterson GE (2010) Relation of level of B type natriuretic peptide with outcomes in patients with infective endocarditis. Am J Cardiol 106:1011–1015
33. Yucel T, Memiş D, Karamanlioglu B, Süt N, Yuksel M (2008) The prognostic value of atrial and brain natriuretic peptides, troponin I and C-reactive protein in patients with sepsis. Exp Clin Cardiol 13:183–188
34. Qian A, Zhang M, Zhao G (2015) Dynamic detection of N-terminal pro-B-type natriuretic peptide helps to predict the outcome of patients with major trauma. Eur J Trauma Emerg Surg 41:57–64
35. Tsai SH, Lin YY, Chu SJ, Hsu CW, Cheng SM (2010) Interpretation and use of natriuretic peptides in non-congestive heart failure settings. Yonsei Med J 51:151–163
36. Mani I, Garg R, Tripathi S, Pandey KN (2015) Subcellular trafficking of guanylyl cyclase/natriuretic peptide receptor-A with concurrent generation of intracellular cGMP. Biosci Rep 35:e00260
37. Panagopoulou V, Deftereos S, Kossyvakis C, Raisakis K, Giannopoulos G, Bouras G, Pyrgakis V, Cleman MW (2013) NT-proBNP: an important biomarker in cardiac disease. Curr Top Med Chem 13:82–94
38. Varpula M, Pulkki K, Karlsson S, Ruokonen E, Pettilä V, Varpula M, Pulkki K, Karlsson S, Ruokonen E, Pettilä V, FINNSEPSIS Study Group (2007) Predictive value of N-terminal pro-brain natriuretic peptide in severe sepsis and septic shock. Crit Care Med 35:1277–1283
39. Wang F, Wu Y, Tang L, Zhu W, Chen F, Xu T, Bo L, Li J, Deng X (2012) Brain natriuretic peptide for prediction of mortality in patients with sepsis: a systematic review and meta-analysis. Crit Care 16:R74
40. Baggish AL, van Kimmenade RR, Januzzi JL Jr (2008) The differential diagnosis of an elevated amino-terminal pro-B-type natriuretic peptide level. Am J Cardiol 101:43–48
41. Palmiere C, Mangin P (2012) Postmortem chemistry update part II. Int J Legal Med 126:199–215
42. Tanaka T, Hasegawa K, Fujita M, Tamaki SI, Yamazato A, Kihara Y, Nohara R, Sasayama S (1998) Marked elevation of brain natriuretic peptide levels in pericardial fluid is closely associated with left ventricular dysfunction. J Am Coll Cardiol 31:399–403
43. Zhu BL, Ishikawa T, Michiue T, Li DR, Zhao D, Tanaka S, Kamikodai Y, Tsuda K, Okazaki S, Maeda H (2007) Postmortem pericardial natriuretic peptides as markers of cardiac function in medico-legal autopsies. Int J Legal Med 121:28–35
44. Nowatzke WL, Cole TG (2003) Stability of N-terminal pro-brain natriuretic peptide after storage frozen for one year and after multiple freeze-thaw cycles. Clin Chem 49:1560–1562
45. Michaud K, Augsburger M, Donzé N, Sabatasso S, Faouzi M, Bollmann M, Mangin P (2008) Evaluation of postmortem measurement of NT-proBNP as a marker for cardiac function. Int J Legal Med 122:415–420
46. Sabatasso S, Vaucher P, Augsburger M, Donzé N, Mangin P, Michaud K (2011) Sensitivity and specificity of NT-proBNP to detect heart failure at postmortem examination. Int J Legal Med 125:849–856
47. Cina SJ, Li DJ, Chan DW, Boitnott JK, Hruban RH, Smialek JE (1998) Serum concentrations of cardiac troponin I in sudden death: a pilot study. Am J Forensic Med Pathol 19:324–328
48. Osuna E, Pérez-Cárceles MD, Alvarez MV, Noguera J, Luna A (1998) Cardiac troponin I (cTn I) and the postmortem diagnosis of myocardial infarction. Int J Legal Med 111:173–176
49. Cina SJ, Thompson WC, Fischer JR Jr, Brown DK, Titus JM, Smialek JE (1999) A study of various morphologic variables and troponin I in pericardial fluid as possible discriminators of sudden cardiac death. Am J Forensic Med Pathol 20:333–337
50. Cina SJ, Brown DK, Smialek JE, Collins KA (2001) A rapid postmortem cardiac troponin T assay. Am J Forensic Med Pathol 22:173–176
51. Ellingsen CL, Hetland Ø (2004) Serum concentrations of cardiac troponin T in sudden death. Am J Forensic Med Pathol 25:213–215
52. Pérez-Cárceles MD, Noguera J, Jiménez JL, Martínez P, Luna A, Osuna E (2004) Diagnostic efficacy of biochemical markers in diagnosis post-mortem of ischaemic heart disease. Forensic Sci Int 142:1–7
53. Martínez Díaz F, Rodríguez-Morlensín M, Pérez-Cárceles MD, Noguera J, Luna A, Osuna E (2005) Biochemical analysis and immunohistochemical determination of cardiac troponin for the postmortem diagnosis of myocardial damage. Histol Histopathol 20:475–481
54. Davies SJ, Gaze DC, Collinson PO (2005) Investigation of cardiac troponins in postmortem subjects: comparing antemortem and postmortem levels. Am J Forensic Med Pathol 26:213–215
55. Peter J, Kirchner A, Kuhlisch E, Menschikowski M, Neef B, Dressler J (2006) The relevance of the detection of troponins to the forensic diagnosis of cardiac contusions. Forensic Sci Int 160:127–133
56. Zhu BL, Ishikawa T, Michiue T, Li DR, Zhao D, Oritani S, Kamikodai Y, Tsuda K, Okazaki S, Maeda H (2006) Postmortem cardiac troponin T levels in the blood and pericardial fluid. Part 1. Analysis with special regard to traumatic causes of death. Legal Med 8:86–93
57. Zhu BL, Ishikawa T, Michiue T, Li DR, Zhao D, Kamikodai Y, Tsuda K, Okazaki S, Maeda H (2006) Postmortem cardiac troponin T levels in the blood and pericardial fluid. Part 2: analysis for application in the diagnosis of sudden cardiac death with regard to pathology. Legal Med 8:94–101
58. Khalifa AB, Najjar M, Addad F, Turki E, Mghirbi T (2006) Cardiac troponin T (cTn T) and the postmortem diagnosis of sudden death. Am J Forensic Med Pathol 27:175–177
59. Zhu BL, Ishikawa T, Michiue T, Li DR, Zhao D, Bessho Y, Kamikodai Y, Tsuda K, Okazaki S, Maeda H (2007) Postmortem cardiac troponin I and creatine kinase MB levels in the blood and pericardial fluid as markers of myocardial damage in medicolegal autopsy. Legal Med 9:241–250
60. Maeda H, Michiue T, Zhu BL, Ishikawa T, Quan L (2009) Analysis of cardiac troponins and creatine kinase MB in cerebrospinal fluid in medicolegal autopsy cases. Legal Med 11(Suppl 1):S266–S268
61. Batalis NI, Marcus BJ, Papadea CN, Collins KA (2010) The role of postmortem cardiac markers in the diagnosis of acute myocardial infarction. J Forensic Sci 55:1088–1091
62. Wang Q, Michiue T, Ishikawa T, Zhu BL, Maeda H (2011) Combined analyses of creatine kinase MB, cardiac troponin I and myoglobin in pericardial and cerebrospinal fluids to investigate myocardial and skeletal muscle injury in medicolegal autopsy cases. Legal Med 13:226–232
63. Sapouna R, Gourgiotis D, Athanaselis S, Papadodima S, Spiliopoulou C (2013) Diagnostic value of cardiac troponin I in postmortem diagnosis of myocardial infarction. Am J Forensic Med Pathol 34:139–141
64. Remmer S, Kuudeberg A, Tõnisson M, Lepik D, Väli M (2013) Cardiac troponin T in forensic autopsy cases. Forensic Sci Int 233:154–157
65. Chen JH, Inamori-Kawamoto O, Michiue T, Ikeda S, Ishikawa T, Maeda H (2015) Cardiac biomarkers in blood, and pericardial and cerebrospinal fluids of forensic autopsy cases: a reassessment with special regard to postmortem interval. Legal Med 17:343–350