Postmortem cardiac troponin I and creatine kinase MB levels in the blood and pericardial fluid as markers of myocardial damage in medicolegal autopsy

Legal Medicine

Volumn 9, Issue 5, 2007, Pages 241-250

  Zhu, Bao Li ^a,b   Ishikawa, Takaki ^a,b   Michiue, Tomomi ^a,b   Li, Dong Ri ^a,b   Zhao, Dong ^a   Bessho, Yasumori ^a   Kamikodai, Yasunobu ^a   Tsuda, Kohei ^a   Okazaki, Shuji ^a   Maeda, Hitoshi ^a,b  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Osaka Medical Examiner's Office   (Japan)

Author keywords

Blood; Cardiac troponin I; Creatine kinase MB; Forensic pathology; Pericardial fluid; Postmortem biochemistry

Indexed keywords

CREATINE KINASE MB; MOLECULAR MARKER; TROPONIN I;

ACUTE HEART INFARCTION; ADOLESCENT; ADULT; AGED; ARTICLE; ASPHYXIA; AUTOPSY; BLOOD LEVEL; CADAVER; CARBON MONOXIDE INTOXICATION; CAUSE OF DEATH; CEREBROVASCULAR DISEASE; CONGESTIVE CARDIOMYOPATHY; DROWNING; FEMALE; HEART MUSCLE INJURY; HUMAN; HUMAN TISSUE; HYPERTHERMIA; MALE; PERICARDIAL EFFUSION; TIME OF DEATH;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AMPHETAMINE-RELATED DISORDERS; ASPHYXIA; BIOLOGICAL MARKERS; CARBON MONOXIDE POISONING; CENTRAL NERVOUS SYSTEM STIMULANTS; CEREBRAL HEMORRHAGE; CREATINE KINASE, MB FORM; DROWNING; FEMALE; FEVER; FORENSIC PATHOLOGY; HUMANS; MALE; METHAMPHETAMINE; MIDDLE AGED; MYOCARDIAL INFARCTION; MYOCARDIUM; PERICARDIUM; POSTMORTEM CHANGES; RECURRENCE; ROC CURVE; SENSITIVITY AND SPECIFICITY; SUBARACHNOID HEMORRHAGE; TROPONIN I;

EID: 34447619703     PISSN: 13446223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.legalmed.2007.01.010     Document Type: Article

References (25)

1. Dressler J., Felscher D., Koch R., and Muller E. Troponin T in legal medicine. Lancet 352 (1998) 38
2. Osuna E., Perez-Carceles M.D., Alvarez M.V., Noguera J., and Luna A. Cardiac troponin I (cTn I) and the postmortem diagnosis of myocardial infarction. Int J Legal Med 111 (1998) 173-176
3. Cina S.J., Brown D.K., Smialek J.E., and Collins K.A. A rapid postmortem cardiac troponin T assay: laboratory evidence of sudden cardiac death. Am J Forensic Med Pathol 22 (2001) 173-176
4. Cina S.J., Li D.J., Chan D.W., Boitnott J.K., Hruban R.H., and Smialek J.E. Serum concentrations of cardiac troponin I in sudden death: a pilot study. Am J Forensic Med Pathol 19 (1998) 324-328
5. Cina S.J., Thompson W.C., Fischer Jr. J.R., Brown D.K., Titus J.M., and Smialek J.E. A study of various morphologic variables and troponin I in pericardial fluid as possible discriminators of sudden cardiac death. Am J Forensic Med Pathol 20 (1999) 333-337
6. Perez-Carceles M.D., Noguera J., Jimenez J.L., Martinez P., Luna A., and Osuna E. Diagnostic efficacy of biochemical markers in diagnosis postmortem of ischemic heart disease. Forensic Sci Int 142 (2004) 1-7
7. Ellingsen C.L., and Hetland O. Serum concentrations of cardiac troponin T in sudden death. Am J Forensic Med Pathol 25 (2004) 213-215
8. Zhu B.L., Ishikawa T., Michiue T., Li D.R., Zhao D., Oritani S., et al. Postmortem cardiac troponin T levels in the blood and pericardial fluid. Part 1: analysis with special regard to traumatic causes of death. Legal Med 8 (2006) 86-93
9. Zhu B.L., Ishikawa T., Michiue T., Li D.R., Zhao D., Kamikodai Y., et al. Postmortem cardiac troponin T levels in the blood and pericardial fluid Part 2: analysis for application in the diagnosis of sudden cardiac death with regard to pathology. Legal Med 8 (2006) 94-101
10. Altinier S., Mion M., Cappelletti A., Zaninotto M., and Plebani M. Rapid measurement of cardiac markers on Stratus CS. Clin Chim 46 (2000) 991-993
11. Beneteau-Burnat B., Baudin B., and Vaubourdolle M. Evaluation of Stratus CS stat fluorimetric analyzer for measurement of cardiac markers troponini I (cTnI), creatine kinase MB (CK-MB), and myoglobin. J Clin Lab Anal 15 (2001) 314-318
12. Ishikawa Y., Komiyama K., Masuda S., Murakami M., Akasaka Y., Ito K., et al. Expression of type V secretory phospholipase A2 in myocardial remodeling after infarction. Histopathology 47 (2005) 257-267
13. Baum H., Braun S., Gerhardt W., Gilson G., Hafner G., Muller-Bardorff M., et al. Multicenter evalution of a second-generation assay for cardiac troponin T. Clin Chem 43 (1997) 1877-1884
14. Maeda H., Fukita K., Oritani S., Nagai K., and Zhu B.L. Evaluation of postmortem oxymetry in fire victims. Forensic Sci Int 81 (1996) 201-209
15. Maeda H., Fukita K., Oritani S., Ishida K., and Zhu B.L. Evaluation of postmortem oxymetry with reference to the causes death. Forensic Sci Int 87 (1997) 201-210
16. Zweig M.H., and Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39 (1993) 561-577
17. Beck J.R., and Shultz E.K. The use of relative operating characteristic (ROC) curves in test performance evaluation. Arch Pathol Lab Med 110 (1986) 13-20
18. McLaurin M.D., Apple F.S., Voss E.M., Herzoq C.A., and Sharkey S.W. Cardiac troponin I, cardiac troponin T, and creatine kinase MB in dialysis patients without ischemic heart disease: evidence of cardiac troponin T expression in skeletal muscle. Clin Chim 43 (1997) 976-982
19. del Rey J.M., Madrid A.H., Valino J.M., Rubi J., Mercader J., Moro C., et al. Cardiac troponin I and minor cardiac damage: biochemical markers in a clinical model of myocardial lesions. Clin Chim 44 (1998) 2270-2276
20. Apple F.S. Tissue specificity of cardiac troponin I, cardiac troponin T and creatine kinase-MB. Clin Chim Acta 184 (1999) 151-159
21. Seino Y., Tomita Y., Hoshino K., Setsuta K., Takano T., and Hayakawa H. Pathophysiological analysis of serum troponin T release kinetics in evolving ischemic myocardial injury. Jpn Circ J 60 (1996) 265-276
22. Fuster V., Badimon L., Badimon J.J., and Chesebro J.H. The pathogenesis of coronary artery disease and the acute coronary syndromes (Part 1). N Engl J Med 326 (1992) 242-250
23. Fuster V., Badimon L., Badimon J.J., and Chesebro J.H. The pathogenesis of coronary artery disease and the acute coronary syndromes (Part 2). N Engl J Med 326 (1992) 310-318
24. Ray K.K., Sheridan P.J., Bolton J., Clayton T.C., Veitch A., Manivarmane R., et al. Management and outcomes of acute coronary syndrome with minimal myocardial necrosis: analysis of a large prospective registry from a non-interventional center. Int J Clin Parct 60 (2006) 383-390
25. Wu A.H., and Ford L. Release of cardiac troponin in acute coronary syndromes: ischemia or necrosis?. Clin Chim Acta 284 (1999) 161-174