Elevated cardiac troponin I in sepsis and septic shock: No evidence for thrombus associated myocardial necrosis

PLoS ONE

Volumn 5, Issue 2, 2010, Pages

  Altmann, David R ^a   Korte, Wolfgang ^b   Maeder, Micha T ^c   Fehr, Thomas ^d   Haager, Philipp ^a   Rickli, Hans ^a   Kleger, Gian Reto ^e   Rodriguez, Regulo ^f   Ammann, Peter ^a  

^a Division of Cardiology   (Switzerland)

^b Institute for Clinical Chemistry and Hematology   (Switzerland)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^e Intensive Care Unit   (Switzerland)

^f Institute of Pathology   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; TROPONIN I;

ACUTE CORONARY SYNDROME; AGED; APOPTOSIS; ARTICLE; BLOOD CLOTTING TIME; BLOOD LEVEL; BLOOD SAMPLING; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); DIAGNOSTIC TEST; DISEASE ASSOCIATION; FEMALE; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE NECROSIS; HUMAN; MALE; PATHOPHYSIOLOGY; ROTATIONAL THROMBELASTOMETRY; SEPSIS; SEPTIC SHOCK; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THROMBUS; TRANSTHORACIC ECHOCARDIOGRAPHY; BLOOD; BLOOD CLOTTING TEST; HEART MUSCLE; MIDDLE AGED; NECROSIS; PATHOLOGY; THROMBOELASTOGRAPHY; THROMBOSIS;

AGED; AGED, 80 AND OVER; BLOOD COAGULATION TESTS; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM; NECROSIS; SEPSIS; SHOCK, SEPTIC; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THROMBELASTOGRAPHY; THROMBOSIS; TROPONIN I;

EID: 77949384465     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009017     Document Type: Article

References (28)

1. Ammann P, Fehr T, Minder EI, Gunter C, Bertel O (2001) Elevation of troponin I in sepsis and septic shock. Intensive Care Med 27: 965-969.
2. ver Elst KM, Spapen HD, Nguyen DN, Garbar C, Huyghens LP, et al. (2000) Cardiac troponins I and T are biological markers of left ventricular dysfunction in septic shock. Clin Chem 46: 650-657.
3. Wu AH (2001) Increased troponin in patients with sepsis and septic shock: myocardial necrosis or reversible myocardial depression? Intensive Care Med 27: 959-961.
4. Maeder M, Fehr T, Rickli H, Ammann P (2006) Sepsis-associated myocardial dysfunction: diagnostic and prognostic impact of cardiac troponins and natriuretic peptides. Chest 129: 1349-1366.
5. Ammann P, Maggiorini M, Bertel O, Haenseler E, Joller-Jemelka HI, et al. (2003) Troponin as a risk factor for mortality in critically ill patients without acute coronary syndromes. J Am Coll Cardiol 41: 2004-2009.
6. Rinder CS, Mathew JP, Rinder HM, Greg Howe J, Fontes M, et al. (2002) Platelet PlA2 polymorphism and platelet activation are associated with increased troponin I release after cardiopulmonary bypass. Anesthesiology 97: 1118-1122.
7. Bonz AW, Lengenfelder B, Strotmann J, Held S, Turschner O, et al. (2002) Effect of additional temporary glycoprotein IIb/IIIa receptor inhibition on troponin release in elective percutaneous coronary interventions after pretreatment with aspirin and clopidogrel (TOPSTAR trial). J Am Coll Cardiol 40: 662-668.
8. Cuisset T, Frere C, Quilici J, Morange PE, Nait-Saidi L, et al. (2007) High post-treatment platelet reactivity is associated with a high incidence of myonecrosis after stenting for non-ST elevation acute coronary syndromes. Thromb Haemost 97: 282-287.
9. Russwurm S, Vickers J, Meier-Hellmann A, Spangenberg P, Bredle D, et al. (2002) Platelet and leukocyte activation correlate with the severity of septic organ dysfunction. Shock 17: 263-268.
10. Furman MI, Barnard MR, Krueger LA, Fox ML, Shilale EA, et al. (2001) Circulating monocyte-platelet aggregates are an early marker of acute myocardial infarction. J Am Coll Cardiol 38: 1002-1006.
11. Ray MJ, Walters DL, Bett JN, Cameron J, Wood P, et al. (2005) Platelet-monocyte aggregates predict troponin rise after percutaneous coronary intervention and are inhibited by Abciximab. Int J Cardiol 101: 249-255.
12. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20: 864-874.
13. Le Gall JR, Lemeshow S, Saulnier F (1993) A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 270: 2957-2963.
14. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, et al. (2006) Recommendations for chamber quantification. Eur J Echocardiogr 7: 79-108.
15. Mazeika PK, Nadazdin A, Oakley CM (1992) Dobutamine stress echocardiography for detection and assessment of coronary artery disease. J Am Coll Cardiol 19: 1203-1211.
16. Luddington RJ (2005) Thrombelastography/thromboelastometry. Clin Lab Haematol 27: 81-90.
17. McCrath DJ, Cerboni E, Frumento RJ, Hirsh AL, Bennett-Guerrero E (2005) Thromboelastography maximum amplitude predicts postoperative thrombotic complications including myocardial infarction. Anesth Analg 100: 1576-1583.
18. Kaufmann CR, Dwyer KM, Crews JD, Dols SJ, Trask AL (1997) Usefulness of thrombelastography in assessment of trauma patient coagulation. J Trauma 42: 716-20; discussion 720-2.
19. Mahla E, Lang T, Vicenzi MN, Werkgartner G, Maier R, et al. (2001) Thromboelastography for monitoring prolonged hypercoagulability after major abdominal surgery. Anesth Analg 92: 572-577.
20. Coakley M, Reddy K, Mackie I, Mallett S (2006) Transfusion triggers in orthotopic liver transplantation: a comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation tests. J Cardiothorac Vasc Anesth 20: 548-553.
21. Reinhofer M, Brauer M, Franke U, Barz D, Marx G, et al. (2008) The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypass. Blood Coagul Fibrinolysis 19: 212-219.
22. Zuckerman L, Cohen E, Vagher JP, Woodward E, Caprini JA (1981) Comparison of thrombelastography with common coagulation tests. Thromb Haemost 46: 752-756.
23. Gonano C, Sitzwohl C, Meitner E, Weinstabl C, Kettner SC (2006) Four-day antithrombin therapy does not seem to attenuate hypercoagulability in patients suffering from sepsis. Crit Care 10: R160.
24. Hvitfeldt Poulsen L, Christiansen K, Sorensen B, Ingerslev J (2006) Whole blood thrombelastographic coagulation profiles using minimal tissue factor activation can display hypercoagulation in thrombosis-prone patients. Scand J Clin Lab Invest 66: 329-336.
25. Parrillo JE, Burch C, Shelhamer JH, Parker MM, Natanson C, et al. (1985) A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance. J Clin Invest 76: 1539-1553.
26. Kumar A, Thota V, Dee L, Olson J, Uretz E, et al. (1996) Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum. J Exp Med 183: 949-958.
27. Brett J, Gerlach H, Nawroth P, Steinberg S, Godman G, et al. (1989) Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins. J Exp Med 169: 1977-1991.
28. Parker MM, Shelhamer JH, Bacharach SL, Green MV, Natanson C, et al. (1984) Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 100: 483-490.