Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages

PLoS ONE

Volumn 11, Issue 2, 2016, Pages

  Tallam, Aravind ^a,c   Perumal, Thaneer M ^a,d   Antony, Paul M ^a   Jäger, Christian ^a   Fritz, Joëlle V ^a   Vallar, Laurent ^b   Balling, Rudi ^a   Del Sol, Antonio ^a   Michelucci, Alessandro ^a,b  

^a UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^b LUXEMBOURG INSTITUTE OF HEALTH   (Luxembourg)

^c INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^d SAGE BIONETWORKS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACONITIC ACID; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; CELL PROTEIN; CIS ACONITIC ACID DECARBOXYLASE; GAMMA INTERFERON; IMMUNORESPONSIVE GENE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; ISOCITRATE LYASE; ITACONIC ACID; PROTEIN FOS; REACTIVE OXYGEN METABOLITE; STAT1 PROTEIN; STAT4 PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR JUNB; TRANSCRIPTION FACTOR RUNX1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; IRF1 PROTEIN, HUMAN; IRG1 PROTEIN, HUMAN; LIPOPOLYSACCHARIDE; PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CITRIC ACID CYCLE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE REGULATORY NETWORK; GENE SILENCING; GENETIC ALGORITHM; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMMUNOCOMPETENT CELL; IMMUNOFLUORESCENCE; IRG1 GENE; MACROPHAGE; MASS FRAGMENTOGRAPHY; MICROARRAY ANALYSIS; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; RNA EXTRACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; VIRUS REPLICATION; WESTERN BLOTTING; ANIMAL; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; IMMUNOLOGY; MALE; METABOLISM; MONONUCLEAR CELL; PHYSIOLOGY; PROTEIN TRANSPORT; RAW 264.7 CELL LINE;

ANIMALS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE REGULATORY NETWORKS; HUMANS; INTERFERON REGULATORY FACTOR-1; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MITOCHONDRIA; PROTEIN TRANSPORT; PROTEINS; RAW 264.7 CELLS; TRANSCRIPTION, GENETIC;

EID: 84961771217     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0149050     Document Type: Article

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