DNA-PKcs and PARP1 bind to unresected stalled DNA replication forks where they recruit XRCC1 to mediate repair

Cancer Research

Volumn 76, Issue 5, 2016, Pages 1078-1088

  Ying, Songmin ^a   Chen, Zhihui ^b   Medhurst, Annette L ^c   Neal, Jessica A ^d,e   Bao, Zhengqiang ^a   Mortusewicz, Oliver ^f   McGouran, Joanna ^g   Song, Xinming ^b   Shen, Huahao ^a,h   Hamdy, Freddie C ^c   Kessler, Benedikt M ^g   Meek, Katheryn ^d,e   Helleday, Thomas ^f  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Michigan State University   (United States)

^e MICHIGAN STATE UNIVERSITY   (United States)

^f KAROLINSKA INSTITUTE   (Sweden)

^g UNIVERSITY OF OXFORD   (United Kingdom)

^h State Key Laboratory of Respiratory Diseases   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE II; DNA DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN KINASE; UNCLASSIFIED DRUG; XRCC1 PROTEIN; DNA BINDING PROTEIN; DNA DEPENDENT PROTEIN KINASE; MRE11A PROTEIN, HUMAN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUCLEAR PROTEIN; PARP1 PROTEIN, HUMAN; PRKDC PROTEIN, HUMAN; X-RAY REPAIR CROSS COMPLEMENTING PROTEIN 1;

ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER SURVIVAL; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN STABILITY; SURVIVAL RATE; CELL LINE; PHYSIOLOGY;

CASEIN KINASE II; CELL LINE; DNA REPAIR; DNA REPLICATION; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; HUMANS; NUCLEAR PROTEINS; POLY (ADP-RIBOSE) POLYMERASE-1; POLY(ADP-RIBOSE) POLYMERASES;

EID: 84961690151     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-0608     Document Type: Article

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