메뉴 건너뛰기




Volumn 882, Issue , 2016, Pages 169-189

Intratumor heterogeneity in breast cancer

Author keywords

Breast cancer; Clonality; Evolution; Heterogeneity; Phenotype; Progression; Resistance; Selection; Therapy

Indexed keywords

HEAT SHOCK PROTEIN; TUMOR MARKER;

EID: 84961621909     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-22909-6_7     Document Type: Chapter
Times cited : (124)

References (92)
  • 1
    • 35649002422 scopus 로고    scopus 로고
    • Rudolf Carl Virchow: Medical scientist, social reformer, role model
    • Brown TM, Fee E (2006) Rudolf Carl Virchow: medical scientist, social reformer, role model. Am J Public Health 96(12):2104–2105. doi:10.2105/AJPH.2005.078436
    • (2006) Am J Public Health , vol.96 , Issue.12 , pp. 2104-2105
    • Brown, T.M.1    Fee, E.2
  • 2
    • 80053572642 scopus 로고    scopus 로고
    • The Warrens and other pioneering clinician pathologists of the Massachusetts General Hospital during its early years: An appreciation on the 200th anniversary of the hospital founding
    • Young RH, Louis DN (2011) The Warrens and other pioneering clinician pathologists of the Massachusetts General Hospital during its early years: an appreciation on the 200th anniversary of the hospital founding. Mod Pathol 24(10):1285–1294. doi:10.1038/modpathol.2011.132
    • (2011) Mod Pathol , vol.24 , Issue.10 , pp. 1285-1294
    • Young, R.H.1    Louis, D.N.2
  • 3
    • 0002487597 scopus 로고
    • A histologic classification of carcinoma of the breast
    • Foote FW Jr, Stewart FW (1946) A histologic classification of carcinoma of the breast. Surgery 19:74–99
    • (1946) Surgery , vol.19 , pp. 74-99
    • Foote, F.W.1    Stewart, F.W.2
  • 4
    • 0017704436 scopus 로고
    • Metastasis results from preexisting variant cells within a malignant tumor
    • Fidler IJ, Kripke ML (1977) Metastasis results from preexisting variant cells within a malignant tumor. Science 197(4306):893–895
    • (1977) Science , vol.197 , Issue.4306 , pp. 893-895
    • Fidler, I.J.1    Kripke, M.L.2
  • 5
    • 0018141482 scopus 로고
    • Tumor heterogeneity and the biology of cancer invasion and metastasis
    • Fidler IJ (1978) Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res 38(9):2651–2660
    • (1978) Cancer Res , vol.38 , Issue.9 , pp. 2651-2660
    • Fidler, I.J.1
  • 6
    • 0020614390 scopus 로고
    • Characterization of metastatic heterogeneity among subpopulations of a single mouse mammary tumor: Heterogeneity in phenotypic stability
    • Miller FR, Miller BE, Heppner GH (1983) Characterization of metastatic heterogeneity among subpopulations of a single mouse mammary tumor: heterogeneity in phenotypic stability. Invasion Metastasis 3(1):22–31
    • (1983) Invasion Metastasis , vol.3 , Issue.1 , pp. 22-31
    • Miller, F.R.1    Miller, B.E.2    Heppner, G.H.3
  • 7
    • 0018842017 scopus 로고
    • Oestrogen receptors and breast cancer: Current status
    • Hawkins RA, Roberts MM, Forrest AP (1980) Oestrogen receptors and breast cancer: current status. Br J Surg 67(3):153–169
    • (1980) Br J Surg , vol.67 , Issue.3 , pp. 153-169
    • Hawkins, R.A.1    Roberts, M.M.2    Forrest, A.P.3
  • 10
    • 77955236126 scopus 로고    scopus 로고
    • Clinical implementation of the intrinsic subtypes of breast cancer
    • author reply 720–711
    • Perou CM, Parker JS, Prat A, Ellis MJ, Bernard PS (2010) Clinical implementation of the intrinsic subtypes of breast cancer. Lancet Oncol 11(8):718–719; author reply 720–711. doi:10.1016/S1470-2045(10)70176-5
    • (2010) Lancet Oncol , vol.11 , Issue.8 , pp. 718-719
    • Perou, C.M.1    Parker, J.S.2    Prat, A.3    Ellis, M.J.4    Bernard, P.S.5
  • 11
    • 84875884456 scopus 로고    scopus 로고
    • Cellular heterogeneity and molecular evolution in cancer
    • Almendro V, Marusyk A, Polyak K (2013) Cellular heterogeneity and molecular evolution in cancer. Annu Rev Pathol 8:277–302. doi:10.1146/annurev-pathol-020712-163923
    • (2013) Annu Rev Pathol , vol.8 , pp. 277-302
    • Almendro, V.1    Marusyk, A.2    Polyak, K.3
  • 12
    • 84860214990 scopus 로고    scopus 로고
    • Intra-tumour heterogeneity: A looking glass for cancer?
    • Marusyk A, Almendro V, Polyak K (2012) Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer 12(5):323–334. doi:10.1038/nrc3261
    • (2012) Nat Rev Cancer , vol.12 , Issue.5 , pp. 323-334
    • Marusyk, A.1    Almendro, V.2    Polyak, K.3
  • 13
    • 0026520375 scopus 로고
    • Genetic heterogeneity in breast cancer
    • Wolman SR, Heppner GH (1992) Genetic heterogeneity in breast cancer. J Natl Cancer Inst 84(7):469–470
    • (1992) J Natl Cancer Inst , vol.84 , Issue.7 , pp. 469-470
    • Wolman, S.R.1    Heppner, G.H.2
  • 15
    • 33646204788 scopus 로고    scopus 로고
    • Clonal interference and the periodic selection of new beneficial mutations in Escherichia coli
    • de Visser JA, Rozen DE (2006) Clonal interference and the periodic selection of new beneficial mutations in Escherichia coli. Genetics 172(4):2093–2100. doi:10.1534/genetics.105.052373
    • (2006) Genetics , vol.172 , Issue.4 , pp. 2093-2100
    • De Visser, J.A.1    Rozen, D.E.2
  • 16
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC (1976) The clonal evolution of tumor cell populations. Science 194(4260):23–28
    • (1976) Science , vol.194 , Issue.4260 , pp. 23-28
    • Nowell, P.C.1
  • 17
    • 84908032167 scopus 로고    scopus 로고
    • Noncell-autonomous driving of tumour growth supports sub-clonal heterogeneity
    • Marusyk A, Tabassum DP, Altrock PM, Almendro V, Michor F, Polyak K (2014) Noncell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Nature 514(7520):54–58. doi:10.1038/nature13556
    • (2014) Nature , vol.514 , Issue.7520 , pp. 54-58
    • Marusyk, A.1    Tabassum, D.P.2    Altrock, P.M.3    Almendro, V.4    Michor, F.5    Polyak, K.6
  • 18
    • 79953283356 scopus 로고    scopus 로고
    • Genetic interactions in cancer progression and treatment
    • Ashworth A, Lord CJ, Reis-Filho JS (2011) Genetic interactions in cancer progression and treatment. Cell 145(1):30–38. doi:10.1016/j.cell.2011.03.020
    • (2011) Cell , vol.145 , Issue.1 , pp. 30-38
    • Ashworth, A.1    Lord, C.J.2    Reis-Filho, J.S.3
  • 19
    • 78149452881 scopus 로고    scopus 로고
    • Protein homeostasis and the phenotypic manifestation of genetic diversity: Principles and mechanisms
    • Jarosz DF, Taipale M, Lindquist S (2010) Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms. Annu Rev Genet 44:189–216. doi:10.1146/annurev.genet.40.110405.090412
    • (2010) Annu Rev Genet , vol.44 , pp. 189-216
    • Jarosz, D.F.1    Taipale, M.2    Lindquist, S.3
  • 20
    • 84922322678 scopus 로고    scopus 로고
    • Dysregulation of the epigenome in human breast cancer: Contributions of gene-specific DNA hypermethylation to breast cancer pathobiology and targeting the breast cancer methylome for improved therapy
    • Sandhu R, Roll JD, Rivenbark AG, Coleman WB (2014) Dysregulation of the epigenome in human breast cancer: contributions of gene-specific DNA hypermethylation to breast cancer pathobiology and targeting the breast cancer methylome for improved therapy. Am J Pathol. doi:10.1016/j.ajpath.2014.12.003
    • (2014) Am J Pathol
    • Sandhu, R.1    Roll, J.D.2    Rivenbark, A.G.3    Coleman, W.B.4
  • 21
    • 31344466008 scopus 로고    scopus 로고
    • DNA methylation and gene silencing in cancer
    • Baylin SB (2005) DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol 2(Suppl 1):S4–S11. doi:10.1038/ncponc0354
    • (2005) Nat Clin Pract Oncol , vol.2 , pp. SS4-S11
    • Baylin, S.B.1
  • 22
    • 31544435739 scopus 로고    scopus 로고
    • Breast cancer DNA methylation profiles in cancer cells and tumor stroma: Association with HER-2/neu status in primary breast cancer
    • Fiegl H, Millinger S, Goebel G, Muller-Holzner E, Marth C, Laird PW, Widschwendter M (2006) Breast cancer DNA methylation profiles in cancer cells and tumor stroma: association with HER-2/neu status in primary breast cancer. Cancer Res 66(1):29–33. doi:10.1158/0008-5472.CAN-05-2508
    • (2006) Cancer Res , vol.66 , Issue.1 , pp. 29-33
    • Fiegl, H.1    Millinger, S.2    Goebel, G.3    Muller-Holzner, E.4    Marth, C.5    Laird, P.W.6    Widschwendter, M.7
  • 23
    • 55749101607 scopus 로고    scopus 로고
    • Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors
    • Sunami E, Shinozaki M, Sim MS, Nguyen SL, Vu AT, Giuliano AE, Hoon DS (2008) Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors. Breast Cancer Res 10(3):R46. doi:10.1186/bcr2098
    • (2008) Breast Cancer Res , vol.10 , Issue.3
    • Sunami, E.1    Shinozaki, M.2    Sim, M.S.3    Nguyen, S.L.4    Vu, A.T.5    Giuliano, A.E.6    Hoon, D.S.7
  • 24
    • 2542629617 scopus 로고    scopus 로고
    • Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen
    • Widschwendter M, Siegmund KD, Muller HM, Fiegl H, Marth C, Muller-Holzner E, Jones PA, Laird PW (2004) Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer Res 64(11):3807–3813. doi:10.1158/0008-5472.CAN-03-3852
    • (2004) Cancer Res , vol.64 , Issue.11 , pp. 3807-3813
    • Widschwendter, M.1    Siegmund, K.D.2    Muller, H.M.3    Fiegl, H.4    Marth, C.5    Muller-Holzner, E.6    Jones, P.A.7    Laird, P.W.8
  • 26
    • 0036170908 scopus 로고    scopus 로고
    • Quantitative assessment of promoter hypermethylation during breast cancer development
    • Lehmann U, Langer F, Feist H, Glockner S, Hasemeier B, Kreipe H (2002) Quantitative assessment of promoter hypermethylation during breast cancer development. Am J Pathol 160(2):605–612. doi:10.1016/S0002-9440(10)64880-8
    • (2002) Am J Pathol , vol.160 , Issue.2 , pp. 605-612
    • Lehmann, U.1    Langer, F.2    Feist, H.3    Glockner, S.4    Hasemeier, B.5    Kreipe, H.6
  • 27
    • 34648846673 scopus 로고    scopus 로고
    • Quantification of CpG island methylation in progressive breast lesions from normal to invasive carcinoma
    • Pasquali L, Bedeir A, Ringquist S, Styche A, Bhargava R, Trucco G (2007) Quantification of CpG island methylation in progressive breast lesions from normal to invasive carcinoma. Cancer Lett 257(1):136–144. doi:10.1016/j.canlet.2007.07.010
    • (2007) Cancer Lett , vol.257 , Issue.1 , pp. 136-144
    • Pasquali, L.1    Bedeir, A.2    Ringquist, S.3    Styche, A.4    Bhargava, R.5    Trucco, G.6
  • 28
    • 58149380742 scopus 로고    scopus 로고
    • Stem cell concepts renew cancer research
    • Dick JE (2008) Stem cell concepts renew cancer research. Blood 112(13):4793–4807. doi:10.1182/blood-2008-08-077941
    • (2008) Blood , vol.112 , Issue.13 , pp. 4793-4807
    • Dick, J.E.1
  • 29
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3(7):730–737
    • (1997) Nat Med , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 31
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises, promises and challenges
    • Clevers H (2011) The cancer stem cell: premises, promises and challenges. Nat Med 17(3):313–319. doi:10.1038/nm.2304
    • (2011) Nat Med , vol.17 , Issue.3 , pp. 313-319
    • Clevers, H.1
  • 33
    • 4644343922 scopus 로고    scopus 로고
    • Bacterial persistence as a phenotypic switch
    • Balaban NQ, Merrin J, Chait R, Kowalik L, Leibler S (2004) Bacterial persistence as a phenotypic switch. Science 305(5690):1622–1625. doi:10.1126/science.1099390
    • (2004) Science , vol.305 , Issue.5690 , pp. 1622-1625
    • Balaban, N.Q.1    Merrin, J.2    Chait, R.3    Kowalik, L.4    Leibler, S.5
  • 34
    • 77249114260 scopus 로고    scopus 로고
    • Variability in gene expression underlies incomplete penetrance
    • Raj A, Rifkin SA, Andersen E, van Oudenaarden A (2010) Variability in gene expression underlies incomplete penetrance. Nature 463(7283):913–918. doi:10.1038/nature08781
    • (2010) Nature , vol.463 , Issue.7283 , pp. 913-918
    • Raj, A.1    Rifkin, S.A.2    Andersen, E.3    Van Oudenaarden, A.4
  • 36
    • 66249136447 scopus 로고    scopus 로고
    • Non-genetic origins of cellto-cell variability in TRAIL-induced apoptosis
    • Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK (2009) Non-genetic origins of cellto-cell variability in TRAIL-induced apoptosis. Nature 459(7245):428–432. doi:10.1038/nature08012
    • (2009) Nature , vol.459 , Issue.7245 , pp. 428-432
    • Spencer, S.L.1    Gaudet, S.2    Albeck, J.G.3    Burke, J.M.4    Sorger, P.K.5
  • 37
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
    • Fillmore CM, Kuperwasser C (2008) Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 10(2):R25. doi:10.1186/bcr1982
    • (2008) Breast Cancer Res , vol.10 , Issue.2
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 38
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. (2012) Comprehensive molecular portraits of human breast tumours. Nature 490(7418):61–70. doi:10.1038/nature11412
    • (2012) Nature , vol.490 , Issue.7418 , pp. 61-70
  • 39
    • 84918583047 scopus 로고    scopus 로고
    • Genomedriven integrated classification of breast cancer validated in over 7, 500 samples
    • Ali HR, Rueda OM, Chin SF, Curtis C, Dunning MJ, Aparicio SA, Caldas C (2014) Genomedriven integrated classification of breast cancer validated in over 7, 500 samples. Genome Biol 15(8):431. doi:10.1186/s13059-014-0431-1
    • (2014) Genome Biol , vol.15 , Issue.8 , pp. 431
    • Ali, H.R.1    Rueda, O.M.2    Chin, S.F.3    Curtis, C.4    Dunning, M.J.5    Aparicio, S.A.6    Caldas, C.7
  • 41
    • 84874354257 scopus 로고    scopus 로고
    • The implications of clonal genome evolution for cancer medicine
    • Aparicio S, Caldas C (2013) The implications of clonal genome evolution for cancer medicine. N Engl J Med 368(9):842–851. doi:10.1056/NEJMra1204892
    • (2013) N Engl J Med , vol.368 , Issue.9 , pp. 842-851
    • Aparicio, S.1    Caldas, C.2
  • 49
    • 84903289930 scopus 로고    scopus 로고
    • Reliable single cell array CGH for clinical samples
    • Czyz ZT, Hoffmann M, Schlimok G, Polzer B, Klein CA (2014) Reliable single cell array CGH for clinical samples. PloS One 9(1):e85907. doi:10.1371/journal.pone.0085907
    • (2014) Plos One , vol.9 , Issue.1
    • Czyz, Z.T.1    Hoffmann, M.2    Schlimok, G.3    Polzer, B.4    Klein, C.A.5
  • 51
    • 84886379960 scopus 로고    scopus 로고
    • Going with the flow: From circulating tumor cells to DNA
    • Bidard FC, Weigelt B, Reis-Filho JS (2013) Going with the flow: from circulating tumor cells to DNA. Sci Transl Med 5(207):207 ps214. doi:10.1126/scitranslmed.3006305
    • (2013) Sci Transl Med , vol.5 , Issue.207 , pp. 207
    • Bidard, F.C.1    Weigelt, B.2    Reis-Filho, J.S.3
  • 52
    • 39149134332 scopus 로고    scopus 로고
    • Protocols for the in situ PCR-amplification and detection of mRNA and DNA sequences
    • Bagasra O (2007) Protocols for the in situ PCR-amplification and detection of mRNA and DNA sequences. Nat Protoc 2(11):2782–2795. doi:10.1038/nprot.2007.395
    • (2007) Nat Protoc , vol.2 , Issue.11 , pp. 2782-2795
    • Bagasra, O.1
  • 53
    • 77952243279 scopus 로고    scopus 로고
    • In situ detection and genotyping of individual mRNA molecules
    • Larsson C, Grundberg I, Soderberg O, Nilsson M (2010) In situ detection and genotyping of individual mRNA molecules. Nat Methods 7(5):395–397. doi:10.1038/nmeth.1448
    • (2010) Nat Methods , vol.7 , Issue.5 , pp. 395-397
    • Larsson, C.1    Grundberg, I.2    Soderberg, O.3    Nilsson, M.4
  • 54
    • 84873340340 scopus 로고    scopus 로고
    • In situ detection of individual mRNA molecules and protein complexes or post-translational modifications using padlock probes combined with the in situ proximity ligation assay
    • Weibrecht I, Lundin E, Kiflemariam S, Mignardi M, Grundberg I, Larsson C, Koos B, Nilsson M, Soderberg O (2013) In situ detection of individual mRNA molecules and protein complexes or post-translational modifications using padlock probes combined with the in situ proximity ligation assay. Nat Protoc 8(2):355–372. doi:10.1038/nprot.2013.006
    • (2013) Nat Protoc , vol.8 , Issue.2 , pp. 355-372
    • Weibrecht, I.1    Lundin, E.2    Kiflemariam, S.3    Mignardi, M.4    Grundberg, I.5    Larsson, C.6    Koos, B.7    Nilsson, M.8    Soderberg, O.9
  • 58
    • 76649128993 scopus 로고    scopus 로고
    • Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype
    • Park SY, Gonen M, Kim HJ, Michor F, Polyak K (2010) Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. J Clin Invest 120(2):636–644. doi:10.1172/JCI40724
    • (2010) J Clin Invest , vol.120 , Issue.2 , pp. 636-644
    • Park, S.Y.1    Gonen, M.2    Kim, H.J.3    Michor, F.4    Polyak, K.5
  • 61
    • 34547675728 scopus 로고    scopus 로고
    • Detection of gene point mutation in paraffin sections using in situ loop-mediated isothermal amplification
    • Ikeda S, Takabe K, Inagaki M, Funakoshi N, Suzuki K (2007) Detection of gene point mutation in paraffin sections using in situ loop-mediated isothermal amplification. Pathol Int 57(9):594–599. doi:10.1111/j.1440–1827.2007.02144.x
    • (2007) Pathol Int , vol.57 , Issue.9 , pp. 594-599
    • Ikeda, S.1    Takabe, K.2    Inagaki, M.3    Funakoshi, N.4    Suzuki, K.5
  • 62
    • 0033653953 scopus 로고    scopus 로고
    • In situ detection of specific p53 mutations in cultured cells using the amplification refractory mutation system polymerase chain reaction
    • Low EO, Gibbins JR, Walker DM (2000) In situ detection of specific p53 mutations in cultured cells using the amplification refractory mutation system polymerase chain reaction. Diagn Mol Pathol 9(4):210–220
    • (2000) Diagn Mol Pathol , vol.9 , Issue.4 , pp. 210-220
    • Low, E.O.1    Gibbins, J.R.2    Walker, D.M.3
  • 63
    • 0033655524 scopus 로고    scopus 로고
    • Whole mount in situ hybridization to study gene expression during mouse development
    • Lowe LA, Kuehn MR (2000) Whole mount in situ hybridization to study gene expression during mouse development. Methods Mol Biol 137:125–137. doi:10.1385/1-59259-066-7:125
    • (2000) Methods Mol Biol , vol.137 , pp. 125-137
    • Lowe, L.A.1    Kuehn, M.R.2
  • 64
    • 84895541878 scopus 로고    scopus 로고
    • Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT
    • Jungmann R, Avendano MS, Woehrstein JB, Dai M, Shih WM, Yin P (2014) Multiplexed 3D cellular super-resolution imaging with DNA-PAINT and Exchange-PAINT. Nat Methods 11(3):313–318. doi:10.1038/nmeth.2835
    • (2014) Nat Methods , vol.11 , Issue.3 , pp. 313-318
    • Jungmann, R.1    Avendano, M.S.2    Woehrstein, J.B.3    Dai, M.4    Shih, W.M.5    Yin, P.6
  • 67
    • 82655171622 scopus 로고    scopus 로고
    • Frequency of HER2 heterogeneity by fluorescence in situ hybridization according to CAP expert panel recommendations: Time for a new look at how to report heterogeneity
    • Allison KH, Dintzis SM, Schmidt RA (2011) Frequency of HER2 heterogeneity by fluorescence in situ hybridization according to CAP expert panel recommendations: time for a new look at how to report heterogeneity. Am J Clin Pathol 136(6):864–871. doi:10.1309/AJCPXTZSKBRIP07W
    • (2011) Am J Clin Pathol , vol.136 , Issue.6 , pp. 864-871
    • Allison, K.H.1    Dintzis, S.M.2    Schmidt, R.A.3
  • 68
    • 84863470138 scopus 로고    scopus 로고
    • Intratumoral heterogeneity of HER2 gene amplification in breast cancer: Its clinicopathological significance
    • Seol H, Lee HJ, Choi Y, Lee HE, Kim YJ, Kim JH, Kang E, Kim SW, Park SY (2012) Intratumoral heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance. Mod Pathol 25(7):938–948. doi:10.1038/modpathol.2012.36
    • (2012) Mod Pathol , vol.25 , Issue.7 , pp. 938-948
    • Seol, H.1    Lee, H.J.2    Choi, Y.3    Lee, H.E.4    Kim, Y.J.5    Kim, J.H.6    Kang, E.7    Kim, S.W.8    Park, S.Y.9
  • 71
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • nrc2627[pii]10.1038/nrc2627
    • Klein CA (2009) Parallel progression of primary tumours and metastases. Nat Rev Cancer 9(4):302–312. doi:nrc2627[pii]10.1038/nrc2627
    • (2009) Nat Rev Cancer , vol.9 , Issue.4 , pp. 302-312
    • Klein, C.A.1
  • 73
    • 0013891262 scopus 로고
    • The growth rate of human tumours
    • Steel GG, Lamerton LF (1966) The growth rate of human tumours. Br J Cancer 20(1):74–86
    • (1966) Br J Cancer , vol.20 , Issue.1 , pp. 74-86
    • Steel, G.G.1    Lamerton, L.F.2
  • 79
    • 84904335201 scopus 로고    scopus 로고
    • Metastatic breast cancer: Mechanisms and opportunities for cytology
    • Martins D, Beca F, Schmitt F (2014) Metastatic breast cancer: mechanisms and opportunities for cytology. Cytopathology 25(4):225–230. doi:10.1111/cyt.12158
    • (2014) Cytopathology , vol.25 , Issue.4 , pp. 225-230
    • Martins, D.1    Beca, F.2    Schmitt, F.3
  • 80
    • 84904278509 scopus 로고    scopus 로고
    • Growing indication for FNA to study and analyze tumor heterogeneity at metastatic sites
    • Beca F, Schmitt F (2014) Growing indication for FNA to study and analyze tumor heterogeneity at metastatic sites. Cancer Cytopathol 122(7):504–511. doi:10.1002/cncy.21395
    • (2014) Cancer Cytopathol , vol.122 , Issue.7 , pp. 504-511
    • Beca, F.1    Schmitt, F.2
  • 85
    • 0017705147 scopus 로고
    • Tumor size, sensitivity to therapy, and design of treatment schedules
    • Norton L, Simon R (1977) Tumor size, sensitivity to therapy, and design of treatment schedules. Cancer Treat Rep 61(7):1307–1317
    • (1977) Cancer Treat Rep , vol.61 , Issue.7 , pp. 1307-1317
    • Norton, L.1    Simon, R.2
  • 86
    • 0022600727 scopus 로고
    • The Norton-Simon hypothesis revisited
    • Norton L, Simon R (1986) The Norton-Simon hypothesis revisited. Cancer Treat Rep 70(1):163–169
    • (1986) Cancer Treat Rep , vol.70 , Issue.1 , pp. 163-169
    • Norton, L.1    Simon, R.2
  • 87
    • 84907248796 scopus 로고    scopus 로고
    • Tumor heterogeneity: The lernaean hydra of oncology?
    • Janiszewska M, Beca F, Polyak K (2014) Tumor heterogeneity: the lernaean hydra of oncology? Oncology 28(9):781–782
    • (2014) Oncology , vol.28 , Issue.9 , pp. 781-782
    • Janiszewska, M.1    Beca, F.2    Polyak, K.3
  • 88
    • 84855457952 scopus 로고    scopus 로고
    • Hsp90 molecular chaperone inhibitors: Are we there yet?
    • Neckers L, Workman P (2012) Hsp90 molecular chaperone inhibitors: are we there yet? Clin Cancer Res 18(1):64–76. doi:10.1158/1078-0432.CCR-11-1000
    • (2012) Clin Cancer Res , vol.18 , Issue.1 , pp. 64-76
    • Neckers, L.1    Workman, P.2
  • 89
    • 78650644709 scopus 로고    scopus 로고
    • Hsp90 and environmental stress transform the adaptive value of natural genetic variation
    • Jarosz DF, Lindquist S (2010) Hsp90 and environmental stress transform the adaptive value of natural genetic variation. Science 330(6012):1820–1824. doi:10.1126/science.1195487
    • (2010) Science , vol.330 , Issue.6012 , pp. 1820-1824
    • Jarosz, D.F.1    Lindquist, S.2
  • 92
    • 84860652628 scopus 로고    scopus 로고
    • Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance
    • Wilting RH, Dannenberg JH (2012) Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance. Drug Resist Updat 15(1–2):21–38. doi:10.1016/j.drup.2012.01.008
    • (2012) Drug Resist Updat , vol.15 , Issue.12 , pp. 21-38
    • Wilting, R.H.1    Dannenberg, J.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.