메뉴 건너뛰기




Volumn 209, Issue , 2016, Pages 167-175

Healthy aging and myocardium: A complicated process with various effects in cardiac structure and physiology

Author keywords

Age induced cardiac changes; Aged myocardium; Cardiac stem cells; Micro RNAs; Adrenergic desensitization

Indexed keywords

ION CHANNEL; MICRORNA; NEUROHORMONE; REACTIVE OXYGEN METABOLITE;

EID: 84961564518     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2016.02.039     Document Type: Review
Times cited : (61)

References (105)
  • 2
    • 13944278699 scopus 로고    scopus 로고
    • Cardiovascular disease in the elderly
    • E. Braunwald, Zipes DP, P. Libby, eighth ed. WB Saunders Philadelphia
    • J.B. Schwartz, and D.P. Zipes Cardiovascular disease in the elderly E. Braunwald, Zipes DP, P. Libby, Heart Disease eighth ed. 2007 WB Saunders Philadelphia: 1925 1949
    • (2007) Heart Disease , pp. 1925-1949
    • Schwartz, J.B.1    Zipes, D.P.2
  • 3
    • 84881656587 scopus 로고    scopus 로고
    • Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: From mechanisms to therapeutics
    • E. Marzetti, A. Csiszar, D. Dutta, G. Balagopal, R. Calvani, and C. Leeuwenburgh Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics Am. J. Physiol. Heart Circ. Physiol. 305 2013 H459 H476
    • (2013) Am. J. Physiol. Heart Circ. Physiol. , vol.305 , pp. H459-H476
    • Marzetti, E.1    Csiszar, A.2    Dutta, D.3    Balagopal, G.4    Calvani, R.5    Leeuwenburgh, C.6
  • 4
    • 60449094498 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • D. LloyJones, R. Adams, M. Carnethon, G. De Simone, T.B Ferguson, K. Flegal, and et al. Heart disease and stroke statistics - 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee Circulation 119 2009 480 486
    • (2009) Circulation , vol.119 , pp. 480-486
    • Lloyd-Jones, D.1    Adams, R.2    Carnethon, M.3    De Simone, G.4    Ferguson, T.B.5    Flegal, K.6
  • 7
    • 0023742629 scopus 로고
    • The old-age heart: Normal aging changes which can produce or mimic cardiac disease
    • B.F. Waller The old-age heart: normal aging changes which can produce or mimic cardiac disease Clin. Cardiol. 11 1988 513 517
    • (1988) Clin. Cardiol. , vol.11 , pp. 513-517
    • Waller, B.F.1
  • 9
    • 39049195123 scopus 로고    scopus 로고
    • Echocardiographically estimated left ventricular end-diastolic and right ventricular systolic pressure in normotensive healthy individuals
    • N.R. Van de Veire, J. De Backer, A.K. Ascoop, B. Middernacht, A. Velghe, and J.D. Sutter Echocardiographically estimated left ventricular end-diastolic and right ventricular systolic pressure in normotensive healthy individuals Int. J. Card. Imaging 22 2006 633 641
    • (2006) Int. J. Card. Imaging , vol.22 , pp. 633-641
    • Van De Veire, N.R.1    De Backer, J.2    Ascoop, A.K.3    Middernacht, B.4    Velghe, A.5    Sutter, J.D.6
  • 10
    • 41649103553 scopus 로고    scopus 로고
    • Right ventricular function in cardiovascular disease, part I: Anatomy, physiology, aging, and functional assessment of the right ventricle
    • F. Haddad, S.A. Hunt, D.N. Rosenthal, and D.J. Murphy Right ventricular function in cardiovascular disease, part I: anatomy, physiology, aging, and functional assessment of the right ventricle Circulation 117 2008 1436 1448
    • (2008) Circulation , vol.117 , pp. 1436-1448
    • Haddad, F.1    Hunt, S.A.2    Rosenthal, D.N.3    Murphy, D.J.4
  • 11
    • 79958778458 scopus 로고    scopus 로고
    • Sex and race differences in right ventricular structure and function: The multi-ethnic study of atherosclerosis-right ventricle study
    • S.M. Kawut, J.A. Lima, R.G. Barr, H. Chahal, A. Jain, H. Tandri, and et al. Sex and race differences in right ventricular structure and function: the multi-ethnic study of atherosclerosis-right ventricle study Circulation 123 2011 2542 2551
    • (2011) Circulation , vol.123 , pp. 2542-2551
    • Kawut, S.M.1    Lima, J.A.2    Barr, R.G.3    Chahal, H.4    Jain, A.5    Tandri, H.6
  • 12
    • 84873348239 scopus 로고    scopus 로고
    • Age-related normal structural and functional ventricular values in cardiac function assessed by magnetic resonance
    • M. Fiechter, T.A. Fuchs, C. Gebhard, J. Stehli, B. Klaeser, B.E. Stähli, and et al. Age-related normal structural and functional ventricular values in cardiac function assessed by magnetic resonance BMC Med. Imaging 13 2013 6
    • (2013) BMC Med. Imaging , vol.13 , pp. 6
    • Fiechter, M.1    Fuchs, T.A.2    Gebhard, C.3    Stehli, J.4    Klaeser, B.5    Stähli, B.E.6
  • 13
    • 0038267070 scopus 로고    scopus 로고
    • A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on valvular heart disease
    • B. Iung, G. Baron, E.G. Butchart, F. Delahaye, C. Gohlke-Bärwolf, O.W. Levang, and et al. A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on valvular heart disease Eur. Heart J. 24 2003 1231 1243
    • (2003) Eur. Heart J. , vol.24 , pp. 1231-1243
    • Iung, B.1    Baron, G.2    Butchart, E.G.3    Delahaye, F.4    Gohlke-Bärwolf, C.5    Levang, O.W.6
  • 14
    • 21044437380 scopus 로고    scopus 로고
    • Spectrum of calcific aortic valve disease: Pathogenesis, disease progression, and treatment strategies
    • R.V. Freeman, and C.M. Otto Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies Circulation 111 2005 3316 3326
    • (2005) Circulation , vol.111 , pp. 3316-3326
    • Freeman, R.V.1    Otto, C.M.2
  • 15
    • 27444441563 scopus 로고    scopus 로고
    • Aortic sclerosis: Not an innocent murmur but a marker of increased cardiovascular risk
    • A.K. Nightingale, and J.D. Horowitz Aortic sclerosis: not an innocent murmur but a marker of increased cardiovascular risk Heart 91 2005 1389 1393
    • (2005) Heart , vol.91 , pp. 1389-1393
    • Nightingale, A.K.1    Horowitz, J.D.2
  • 16
    • 35848960318 scopus 로고    scopus 로고
    • Lambl's excrescences: Review and recommendations
    • F. Aziz, and F.A. Baciewicz Jr. Lambl's excrescences: review and recommendations Tex. Heart Inst. J. 34 2007 366 368
    • (2007) Tex. Heart Inst. J. , vol.34 , pp. 366-368
    • Aziz, F.1    Baciewicz, F.A.2
  • 17
    • 0035371356 scopus 로고    scopus 로고
    • Association of coronary risk factors with progression of valvular aortic stenosis in older persons
    • D. Nassimiha, W.S. Aronow, C. Ahn, and M.E. Goldman Association of coronary risk factors with progression of valvular aortic stenosis in older persons Am. J. Cardiol. 87 2001 1313 1314
    • (2001) Am. J. Cardiol. , vol.87 , pp. 1313-1314
    • Nassimiha, D.1    Aronow, W.S.2    Ahn, C.3    Goldman, M.E.4
  • 18
    • 0018748539 scopus 로고
    • Calcification of the mitral annulus: Etiology, clinical associations, complications and therapy
    • P.K. Fulkerson, B.M. Beaver, J.C. Auseon, and H.L. Graber Calcification of the mitral annulus: etiology, clinical associations, complications and therapy Am. J. Med. 66 1979 967 977
    • (1979) Am. J. Med. , vol.66 , pp. 967-977
    • Fulkerson, P.K.1    Beaver, B.M.2    Auseon, J.C.3    Graber, H.L.4
  • 19
    • 51549101991 scopus 로고    scopus 로고
    • Impact of mitral annular calcification on cardiovascular events in a multiethnic community: The northern Manhattan study
    • S. Kohsaka, Z. Jin, T. Rundek, B. Boden-Albala, S. Homma, R.L. Sacco, and et al. Impact of mitral annular calcification on cardiovascular events in a multiethnic community: the northern Manhattan study J. Am. Coll. Cardiol. Img. 1 2008 617 623
    • (2008) J. Am. Coll. Cardiol. Img. , vol.1 , pp. 617-623
    • Kohsaka, S.1    Jin, Z.2    Rundek, T.3    Boden-Albala, B.4    Homma, S.5    Sacco, R.L.6
  • 20
    • 0037465787 scopus 로고    scopus 로고
    • Mitral annular calcification predicts cardiovascular morbidity and mortality: The Framingham heart study
    • C.S. Fox, R.S. Vasan, H. Parise, D. Levy, C.J. O'Donnell, R.B. D'Agostino, and et al. Mitral annular calcification predicts cardiovascular morbidity and mortality: the Framingham heart study Circulation 107 2003 1492 1496
    • (2003) Circulation , vol.107 , pp. 1492-1496
    • Fox, C.S.1    Vasan, R.S.2    Parise, H.3    Levy, D.4    O'Donnell, C.J.5    D'Agostino, R.B.6
  • 21
    • 33644680769 scopus 로고    scopus 로고
    • Mitral annular calcification, aortic valve sclerosis, and incident stroke in adults free of clinical cardiovascular disease: The strong heart study
    • J.R. Kizer, D.O. Wiebers, J.P. Whisnant, J.M. Galloway, T.K. Welty, E.T. Lee, and et al. Mitral annular calcification, aortic valve sclerosis, and incident stroke in adults free of clinical cardiovascular disease: the strong heart study Stroke 36 2005 2533 2537
    • (2005) Stroke , vol.36 , pp. 2533-2537
    • Kizer, J.R.1    Wiebers, D.O.2    Whisnant, J.P.3    Galloway, J.M.4    Welty, T.K.5    Lee, E.T.6
  • 22
    • 80053544011 scopus 로고    scopus 로고
    • Mitral annular calcification predicts cardiovascular morbidity and mortality in middle-aged patients with atrial fibrillation: The Belgrade atrial fibrillation study
    • T.S. Potpara, Z.M. Vasiljevic, B.D. Vujisic-Tesic, J.M. Marinkovic, M.M. Polovina, J.M. Stepanovic, and et al. Mitral annular calcification predicts cardiovascular morbidity and mortality in middle-aged patients with atrial fibrillation: the Belgrade atrial fibrillation study Chest 140 2011 902 910
    • (2011) Chest , vol.140 , pp. 902-910
    • Potpara, T.S.1    Vasiljevic, Z.M.2    Vujisic-Tesic, B.D.3    Marinkovic, J.M.4    Polovina, M.M.5    Stepanovic, J.M.6
  • 23
    • 0020534855 scopus 로고
    • Conduction disturbances related to the site and severity of mitral anular calcification: A 2-dimensional echocardiographic and electrocardiographic correlative study
    • T. Takamoto, and R.L. Popp Conduction disturbances related to the site and severity of mitral anular calcification: a 2-dimensional echocardiographic and electrocardiographic correlative study Am. J. Cardiol. 51 1983 1644 1649
    • (1983) Am. J. Cardiol. , vol.51 , pp. 1644-1649
    • Takamoto, T.1    Popp, R.L.2
  • 24
    • 33947636028 scopus 로고    scopus 로고
    • Mitral annulus calcification is associated with valvular and cardiac structural abnormalities
    • M.R. Movahed, Y. Saito, M. Ahmadi-Kashani, and R. Ebrahimi Mitral annulus calcification is associated with valvular and cardiac structural abnormalities Cardiovasc. Ultrasound 5 2007 14
    • (2007) Cardiovasc. Ultrasound , vol.5 , pp. 14
    • Movahed, M.R.1    Saito, Y.2    Ahmadi-Kashani, M.3    Ebrahimi, R.4
  • 25
    • 10644293303 scopus 로고    scopus 로고
    • Epidemiology of mitral annular calcification and its predictive value for coronary events in African Americans: The Jackson cohort of the atherosclerotic risk in communities study
    • E. Fox, D. Harkins, H. Taylor, M. McMullan, H. Han, T. Samdarshi, and et al. Epidemiology of mitral annular calcification and its predictive value for coronary events in African Americans: the Jackson cohort of the atherosclerotic risk in communities study Am. Heart J. 148 2004 979 984
    • (2004) Am. Heart J. , vol.148 , pp. 979-984
    • Fox, E.1    Harkins, D.2    Taylor, H.3    McMullan, M.4    Han, H.5    Samdarshi, T.6
  • 26
    • 29144535675 scopus 로고    scopus 로고
    • Clinical significance of calcification of the fibrous skeleton of the heart and aortosclerosis in community dwelling elderly. the cardiovascular health study (CHS)
    • E. Barasch, J.S. Gottdiener, E.K. Larsen, P.H. Chaves, A.B. Newman, and T.A. Manolio Clinical significance of calcification of the fibrous skeleton of the heart and aortosclerosis in community dwelling elderly. The cardiovascular health study (CHS) Am. Heart J. 151 2006 39 47
    • (2006) Am. Heart J. , vol.151 , pp. 39-47
    • Barasch, E.1    Gottdiener, J.S.2    Larsen, E.K.3    Chaves, P.H.4    Newman, A.B.5    Manolio, T.A.6
  • 27
    • 33947729586 scopus 로고    scopus 로고
    • Declining into failure: The age-dependent loss of the L-type calcium channel within the sinoatrial node
    • S.A. Jones, M.R. Boyett, and M.K. Lancaster Declining into failure: the age-dependent loss of the L-type calcium channel within the sinoatrial node Circulation 115 2007 1183 1190
    • (2007) Circulation , vol.115 , pp. 1183-1190
    • Jones, S.A.1    Boyett, M.R.2    Lancaster, M.K.3
  • 28
    • 64449084087 scopus 로고    scopus 로고
    • Aged atria: Electrical remodeling conducive to atrial fibrillation
    • W. Dun, and P.A. Boyden Aged atria: electrical remodeling conducive to atrial fibrillation J. Interv. Card. Electrophysiol. 25 2009 9 18
    • (2009) J. Interv. Card. Electrophysiol. , vol.25 , pp. 9-18
    • Dun, W.1    Boyden, P.A.2
  • 29
    • 33845978413 scopus 로고    scopus 로고
    • Ageing to arrhythmias: Conundrums of connections in the ageing heart
    • S.A. Jones Ageing to arrhythmias: conundrums of connections in the ageing heart J. Pharm. Pharmacol. 58 2006 1571 1576
    • (2006) J. Pharm. Pharmacol. , vol.58 , pp. 1571-1576
    • Jones, S.A.1
  • 30
    • 79956275967 scopus 로고    scopus 로고
    • Molecular mechanisms of cardiac aging
    • T.Z. Zhou, and Y. Gao Molecular mechanisms of cardiac aging J. Geriatr. Cardiol. 7 2010 184 188
    • (2010) J. Geriatr. Cardiol. , vol.7 , pp. 184-188
    • Zhou, T.Z.1    Gao, Y.2
  • 31
    • 79956330068 scopus 로고    scopus 로고
    • Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy
    • A.J. Boyle, H. Shih, J. Hwang, J. Ye, B. Lee, Y. Zhang, and et al. Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy Exp. Gerontol. 46 2011 549 559
    • (2011) Exp. Gerontol. , vol.46 , pp. 549-559
    • Boyle, A.J.1    Shih, H.2    Hwang, J.3    Ye, J.4    Lee, B.5    Zhang, Y.6
  • 33
    • 84860145209 scopus 로고    scopus 로고
    • Matricellular proteins in cardiac adaptation and disease
    • N.G. Frangogiannis Matricellular proteins in cardiac adaptation and disease Physiol. Rev. 92 2012 635 688
    • (2012) Physiol. Rev. , vol.92 , pp. 635-688
    • Frangogiannis, N.G.1
  • 34
    • 33847105538 scopus 로고    scopus 로고
    • Diastolic heart failure: Evidence of increased myocardial collagen turnover linked to diastolic dysfunction
    • R. Martos, J. Baugh, M. Ledwidge, C. O'Loughlin, C. Conlon, A. Patle, and et al. Diastolic heart failure: evidence of increased myocardial collagen turnover linked to diastolic dysfunction Circulation 115 2007 888 895
    • (2007) Circulation , vol.115 , pp. 888-895
    • Martos, R.1    Baugh, J.2    Ledwidge, M.3    O'Loughlin, C.4    Conlon, C.5    Patle, A.6
  • 36
    • 0037458070 scopus 로고    scopus 로고
    • Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part II: The aging heart in health: Links to heart disease
    • E.G. Lakatta, and D. Levy Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part II: the aging heart in health: links to heart disease Circulation 107 2003 346 354
    • (2003) Circulation , vol.107 , pp. 346-354
    • Lakatta, E.G.1    Levy, D.2
  • 37
    • 22144438713 scopus 로고    scopus 로고
    • Senile systemic amyloidosis presenting with heart failure: A comparison with light chain-associated amyloidosis
    • B. Ng, L.H. Connors, R. Davidoff, M. Skinner, and R.H. Falk Senile systemic amyloidosis presenting with heart failure: a comparison with light chain-associated amyloidosis Arch. Intern. Med. 165 2005 1425 1429
    • (2005) Arch. Intern. Med. , vol.165 , pp. 1425-1429
    • Ng, B.1    Connors, L.H.2    Davidoff, R.3    Skinner, M.4    Falk, R.H.5
  • 38
    • 41649088603 scopus 로고    scopus 로고
    • Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha-2 macroglobulin and tau: A population based study
    • M. Tanskanen, T. Peuralinna, T. Polvikoski, I.L. Notkola, R. Sulkava, J. Hardy, and et al. Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha-2 macroglobulin and tau: a population based study Ann. Med. 40 2008 232 239
    • (2008) Ann. Med. , vol.40 , pp. 232-239
    • Tanskanen, M.1    Peuralinna, T.2    Polvikoski, T.3    Notkola, I.L.4    Sulkava, R.5    Hardy, J.6
  • 39
    • 84861425967 scopus 로고    scopus 로고
    • Senile systemic amyloidosis: Are regional differences real or do they reflect different diagnostic suspicion and use of techniques?
    • R.H. Falk Senile systemic amyloidosis: are regional differences real or do they reflect different diagnostic suspicion and use of techniques? Amyloid 19 Suppl. 1 2012 68 70
    • (2012) Amyloid , vol.19 , pp. 68-70
    • Falk, R.H.1
  • 41
    • 84961643180 scopus 로고    scopus 로고
    • Senile systemic amyloidosis: A large cohort study detailing clinical features, laboratory results and survival
    • 6-10 May (Groningen, Netherlands OP 48)
    • L.H. Connors, F. Sam, G. Doros, T. Prokaeva, D.C. Seldin, and Skinner M. Senile systemic amyloidosis: a large cohort study detailing clinical features, laboratory results and survival XIIIth International Symposium on Amyloidosis 6-10 May 2012 (Groningen, Netherlands OP 48)
    • (2012) XIIIth International Symposium on Amyloidosis
    • Connors, L.H.1    Sam, F.2    Doros, G.3    Prokaeva, T.4    Seldin, D.C.5    Skinner, M.6
  • 42
    • 0037109190 scopus 로고    scopus 로고
    • Atrial amyloidosis: An arrhythmogenic substrate for persistent atrial fibrillation
    • C. Röcken, B. Peters, G. Juenemann, and et al. Atrial amyloidosis: an arrhythmogenic substrate for persistent atrial fibrillation Circulation 106 2002 2091 2097
    • (2002) Circulation , vol.106 , pp. 2091-2097
    • Röcken, C.1    Peters, B.2    Juenemann, G.3
  • 45
    • 74049135456 scopus 로고    scopus 로고
    • Effect of age on cardiac excitation-contraction coupling
    • E. Fares, and S.E. Howlett Effect of age on cardiac excitation-contraction coupling Clin. Exp. Pharmacol. Physiol. 37 2010 1 7
    • (2010) Clin. Exp. Pharmacol. Physiol. , vol.37 , pp. 1-7
    • Fares, E.1    Howlett, S.E.2
  • 47
    • 33746564095 scopus 로고    scopus 로고
    • Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity
    • N. Luong, C.R. Davies, R.J. Wessells, S.M. Graham, M.T. King, R. Veech, and et al. Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity Cell Metab. 4 2006 133 142
    • (2006) Cell Metab. , vol.4 , pp. 133-142
    • Luong, N.1    Davies, C.R.2    Wessells, R.J.3    Graham, S.M.4    King, M.T.5    Veech, R.6
  • 49
    • 50449083011 scopus 로고    scopus 로고
    • Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction
    • Q. Li, A.F. Ceylan-Isik, J. Li, and J. Ren Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction Rejuvenation Res. 11 2008 725 733
    • (2008) Rejuvenation Res. , vol.11 , pp. 725-733
    • Li, Q.1    Ceylan-Isik, A.F.2    Li, J.3    Ren, J.4
  • 51
    • 0142056143 scopus 로고    scopus 로고
    • Serum insulin like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: The Framingham heart study
    • R.S. Vasan, L.M. Sullivan, R.B. D'Agostino, R. Roubenoff, T. Harris, D.B. Sawyer, and et al. Serum insulin like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham heart study Ann. Intern. Med. 139 2003 642 648
    • (2003) Ann. Intern. Med. , vol.139 , pp. 642-648
    • Vasan, R.S.1    Sullivan, L.M.2    D'Agostino, R.B.3    Roubenoff, R.4    Harris, T.5    Sawyer, D.B.6
  • 54
    • 84893597436 scopus 로고    scopus 로고
    • β-adrenergic receptor responsiveness in aging heart and clinical implications
    • N. Ferrara, K. Komici, G. Corbi, G. Pagano, G. Furgi, C. Rengo, and et al. β-adrenergic receptor responsiveness in aging heart and clinical implications Front. Physiol. 4 2014 396
    • (2014) Front. Physiol. , vol.4 , pp. 396
    • Ferrara, N.1    Komici, K.2    Corbi, G.3    Pagano, G.4    Furgi, G.5    Rengo, C.6
  • 56
    • 0023228439 scopus 로고
    • Cardiovascular adaptations to exercise training in the elderly
    • A.A. Ehsani Cardiovascular adaptations to exercise training in the elderly Fed. Proc. 46 1987 1840 1843
    • (1987) Fed. Proc. , vol.46 , pp. 1840-1843
    • Ehsani, A.A.1
  • 57
    • 0027939626 scopus 로고
    • Influence of exercise training on myocardial-adrenergic signal transduction: Differential regulation with age
    • P.J. Scarpace, Y. Shu, and N. Tumer Influence of exercise training on myocardial-adrenergic signal transduction: differential regulation with age J. Appl. Physiol. 77 1994 737 741
    • (1994) J. Appl. Physiol. , vol.77 , pp. 737-741
    • Scarpace, P.J.1    Shu, Y.2    Tumer, N.3
  • 59
    • 34247632152 scopus 로고    scopus 로고
    • Stem cells and the regeneration of the aging cardiovascular system
    • V.L. Ballard, and J.M. Edelberg Stem cells and the regeneration of the aging cardiovascular system Circ. Res. 100 2007 1116 1127
    • (2007) Circ. Res. , vol.100 , pp. 1116-1127
    • Ballard, V.L.1    Edelberg, J.M.2
  • 60
    • 12144291084 scopus 로고    scopus 로고
    • Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression
    • D. Torella, M. Rota, D. Nurzynska, E. Musso, A. Monsen, I. Shiraishi, and et al. Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression Circ. Res. 94 2004 514 524
    • (2004) Circ. Res. , vol.94 , pp. 514-524
    • Torella, D.1    Rota, M.2    Nurzynska, D.3    Musso, E.4    Monsen, A.5    Shiraishi, I.6
  • 61
    • 84859942977 scopus 로고    scopus 로고
    • The expression of microRNA and microRNA clusters in the aging heart
    • X. Zhang, G. Azhar, and J.Y. Wei The expression of microRNA and microRNA clusters in the aging heart PLoS ONE 7 2012 e34688
    • (2012) PLoS ONE , vol.7
    • Zhang, X.1    Azhar, G.2    Wei, J.Y.3
  • 62
    • 84906791735 scopus 로고    scopus 로고
    • MicroRNAs in vascular aging and atherosclerosis
    • R. Menghini, R. Stöhr, and M. Federici MicroRNAs in vascular aging and atherosclerosis Ageing Res. Rev. 17 2014 68 78
    • (2014) Ageing Res. Rev. , vol.17 , pp. 68-78
    • Menghini, R.1    Stöhr, R.2    Federici, M.3
  • 63
    • 13944282215 scopus 로고    scopus 로고
    • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    • L.P. Lim, N.C. Lau, P. Garrett-Engele, J.M. Schelter, J. Castle, D.P. Bartel, and et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs Nature 433 2005 769 773
    • (2005) Nature , vol.433 , pp. 769-773
    • Lim, L.P.1    Lau, N.C.2    Garrett-Engele, P.3    Schelter, J.M.4    Castle, J.5    Bartel, D.P.6
  • 64
    • 79251581020 scopus 로고    scopus 로고
    • The art of microRNA research
    • E. van Rooij The art of microRNA research Circ. Res. 108 2011 219 234
    • (2011) Circ. Res. , vol.108 , pp. 219-234
    • Van Rooij, E.1
  • 65
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 66
    • 84879134613 scopus 로고    scopus 로고
    • MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart
    • V. Jazbutyte, J. Fiedler, S. Kneitz, P. Galuppo, A. Just, A. Holzmann, and et al. MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart Age (Dordr) 35 2013 747 762
    • (2013) Age (Dordr) , vol.35 , pp. 747-762
    • Jazbutyte, V.1    Fiedler, J.2    Kneitz, S.3    Galuppo, P.4    Just, A.5    Holzmann, A.6
  • 69
    • 84878592687 scopus 로고    scopus 로고
    • MiR-17-92 cluster is a novel regulatory gene of cardiac ischemic/reperfusion injury
    • M. Zhou, J. Cai, Y. Tang, Y. Tang, and Q. Zhao MiR-17-92 cluster is a novel regulatory gene of cardiac ischemic/reperfusion injury Med. Hypotheses 81 2013 108 110
    • (2013) Med. Hypotheses , vol.81 , pp. 108-110
    • Zhou, M.1    Cai, J.2    Tang, Y.3    Tang, Y.4    Zhao, Q.5
  • 70
    • 84866607741 scopus 로고    scopus 로고
    • Vascular aging: Chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease
    • M.M. Bachschmid, S. Schildknecht, R. Matsui, R. Zee, D. Haeussler, R.A. Cohen, and et al. Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease Ann. Med. 45 2013 17 36
    • (2013) Ann. Med. , vol.45 , pp. 17-36
    • Bachschmid, M.M.1    Schildknecht, S.2    Matsui, R.3    Zee, R.4    Haeussler, D.5    Cohen, R.A.6
  • 71
    • 84923365528 scopus 로고    scopus 로고
    • The role of oxidative stress and inflammation in cardiovascular aging
    • J. Wu, S. Xia, B. Kalionis, W. Wan, and T. Sun The role of oxidative stress and inflammation in cardiovascular aging Biomed. Res. Int. 2014 2014 615312
    • (2014) Biomed. Res. Int. , vol.2014 , pp. 615312
    • Wu, J.1    Xia, S.2    Kalionis, B.3    Wan, W.4    Sun, T.5
  • 73
    • 84884247290 scopus 로고    scopus 로고
    • Cardiac aging and insulin resistance: Could insulin/insulin-like growth factor (IGF) signaling be used as a therapeutic target?
    • S. Boudina Cardiac aging and insulin resistance: could insulin/insulin-like growth factor (IGF) signaling be used as a therapeutic target? Curr. Pharm. 19 2013 5684 5694
    • (2013) Curr. Pharm. , vol.19 , pp. 5684-5694
    • Boudina, S.1
  • 74
    • 78650650633 scopus 로고    scopus 로고
    • The cardiovascular continuum extended: Aging effects on the aorta and microvasculature
    • M.F. O'Rourke, M.E. Safar, and V. Dzau The cardiovascular continuum extended: aging effects on the aorta and microvasculature Vasc. Med. 15 2010 461 468
    • (2010) Vasc. Med. , vol.15 , pp. 461-468
    • O'Rourke, M.F.1    Safar, M.E.2    Dzau, V.3
  • 75
    • 38449121790 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in mammalian ageing
    • M. Terzioglu, and N.G. Larsson Mitochondrial dysfunction in mammalian ageing Novartis Found. Symp. 287 2007 197 208
    • (2007) Novartis Found. Symp. , vol.287 , pp. 197-208
    • Terzioglu, M.1    Larsson, N.G.2
  • 76
    • 38349108752 scopus 로고    scopus 로고
    • Mitochondrial dysfunction as a cause of ageing
    • A. Trifunovic, and N.G. Larsson Mitochondrial dysfunction as a cause of ageing J. Intern. Med. 263 2008 167 178
    • (2008) J. Intern. Med. , vol.263 , pp. 167-178
    • Trifunovic, A.1    Larsson, N.G.2
  • 77
    • 82955249843 scopus 로고    scopus 로고
    • Aging-associated cardiovascular changes and their relationship to heart failure
    • J.B. Strait, and E.G. Lakatta Aging-associated cardiovascular changes and their relationship to heart failure Heart Fail Clin. 8 2012 143 164
    • (2012) Heart Fail Clin. , vol.8 , pp. 143-164
    • Strait, J.B.1    Lakatta, E.G.2
  • 79
    • 0025300280 scopus 로고
    • Influence of aging on pulmonary hemodynamics in a population free of coronary artery disease
    • W.R. Davidson Jr., and E.C. Fee Influence of aging on pulmonary hemodynamics in a population free of coronary artery disease Am. J. Cardiol. 65 1990 1454 1458
    • (1990) Am. J. Cardiol. , vol.65 , pp. 1454-1458
    • Davidson, W.R.1    Fee, E.C.2
  • 80
    • 0030636010 scopus 로고    scopus 로고
    • The age of the patient should be taken into account when interpreting Doppler assessed pulmonary artery pressures
    • J.C. Dib, E. Abergel, C. Rovani, H. Raffoul, and B. Diebold The age of the patient should be taken into account when interpreting Doppler assessed pulmonary artery pressures J. Am. Soc. Echocardiogr. 10 1997 72 73
    • (1997) J. Am. Soc. Echocardiogr. , vol.10 , pp. 72-73
    • Dib, J.C.1    Abergel, E.2    Rovani, C.3    Raffoul, H.4    Diebold, B.5
  • 81
    • 84907603348 scopus 로고    scopus 로고
    • Effects of age and gender on right ventricular systolic and diastolic function using two-dimensional speckle-tracking strain
    • E.M. Chia, C.H. Hsieh, A. Boyd, P. Pham, J. Vidaic, D. Leung, and et al. Effects of age and gender on right ventricular systolic and diastolic function using two-dimensional speckle-tracking strain J. Am. Soc. Echocardiogr. 27 2014 1079 1086
    • (2014) J. Am. Soc. Echocardiogr. , vol.27 , pp. 1079-1086
    • Chia, E.M.1    Hsieh, C.H.2    Boyd, A.3    Pham, P.4    Vidaic, J.5    Leung, D.6
  • 82
    • 84884468272 scopus 로고    scopus 로고
    • Age-, body size-, and sex-specific reference values for right ventricular volumes and ejection fraction by three-dimensional echocardiography: A multicenter echocardiographic study in 507 healthy volunteers
    • F. Maffessanti, D. Muraru, R. Esposito, P. Gripari, D. Ermacora, C. Santoro, and et al. Age-, body size-, and sex-specific reference values for right ventricular volumes and ejection fraction by three-dimensional echocardiography: a multicenter echocardiographic study in 507 healthy volunteers Circ. Cardiovasc. Imaging 6 2013 700 710
    • (2013) Circ. Cardiovasc. Imaging , vol.6 , pp. 700-710
    • Maffessanti, F.1    Muraru, D.2    Esposito, R.3    Gripari, P.4    Ermacora, D.5    Santoro, C.6
  • 83
    • 0034738904 scopus 로고    scopus 로고
    • Exercise limitation in health and disease
    • N.L. Jones, and K.J. Killian Exercise limitation in health and disease N. Engl. J. Med. 343 2000 632 641
    • (2000) N. Engl. J. Med. , vol.343 , pp. 632-641
    • Jones, N.L.1    Killian, K.J.2
  • 85
    • 0026778485 scopus 로고
    • Determinants of Doppler indexes of left ventricular diastolic function in normal subjects (the Framingham heart study)
    • E.J. Benjamin, D. Levy, K.M. Anderson, P.A. Wolf, J.F. Plehn, J.C. Evans, and et al. Determinants of Doppler indexes of left ventricular diastolic function in normal subjects (the Framingham heart study) Am. J. Cardiol. 70 1992 508 515
    • (1992) Am. J. Cardiol. , vol.70 , pp. 508-515
    • Benjamin, E.J.1    Levy, D.2    Anderson, K.M.3    Wolf, P.A.4    Plehn, J.F.5    Evans, J.C.6
  • 87
    • 0026608190 scopus 로고
    • Age-associated changes in left ventricular diastolic performance during isometric exercise in normal subjects
    • C.J. Swinne, E.P. Shapiro, S.D. Lima, and J.L. Fleg Age-associated changes in left ventricular diastolic performance during isometric exercise in normal subjects Am. J. Cardiol. 69 1992 823 826
    • (1992) Am. J. Cardiol. , vol.69 , pp. 823-826
    • Swinne, C.J.1    Shapiro, E.P.2    Lima, S.D.3    Fleg, J.L.4
  • 90
    • 64449084087 scopus 로고    scopus 로고
    • Aged atria: Electrical remodeling conducive to atrial fibrillation
    • W. Dun, and P.A. Boyden Aged atria: electrical remodeling conducive to atrial fibrillation J. Interv. Card. Electrophysiol. 25 2009 9 18
    • (2009) J. Interv. Card. Electrophysiol. , vol.25 , pp. 9-18
    • Dun, W.1    Boyden, P.A.2
  • 92
    • 34247104908 scopus 로고    scopus 로고
    • New insights into pacemaker activity: Promoting understanding of sick sinus syndrome
    • H. Dobrzynski, M.R. Boyett, and R.H. Anderson New insights into pacemaker activity: promoting understanding of sick sinus syndrome Circulation 115 2007 1921 1932
    • (2007) Circulation , vol.115 , pp. 1921-1932
    • Dobrzynski, H.1    Boyett, M.R.2    Anderson, R.H.3
  • 93
    • 0028324989 scopus 로고
    • Cardiac arrhythmias on 24-hour ambulatory electrocardiography in older women and men: The cardiovascular health study
    • T.A. Manolio, C.D. Furberg, P.M. Rautaharju, D. Siscovick, A.B. Newman, N.O. Borhani, and et al. Cardiac arrhythmias on 24-hour ambulatory electrocardiography in older women and men: the cardiovascular health study J. Am. Coll. Cardiol. 23 1994 916 925
    • (1994) J. Am. Coll. Cardiol. , vol.23 , pp. 916-925
    • Manolio, T.A.1    Furberg, C.D.2    Rautaharju, P.M.3    Siscovick, D.4    Newman, A.B.5    Borhani, N.O.6
  • 94
    • 0020066862 scopus 로고
    • Cardiac arrhythmias in a healthy elderly population: Detection by 24-hour ambulatory electrocardiography
    • J.L. Fleg, and H.L. Kennedy Cardiac arrhythmias in a healthy elderly population: detection by 24-hour ambulatory electrocardiography Chest 81 1982 302 307
    • (1982) Chest , vol.81 , pp. 302-307
    • Fleg, J.L.1    Kennedy, H.L.2
  • 97
    • 0035117121 scopus 로고    scopus 로고
    • Evaluation and management of cardiac arrhythmias in the elderly
    • D.D. Tresch Evaluation and management of cardiac arrhythmias in the elderly Med. Clin. North Am. 85 2001 527 550
    • (2001) Med. Clin. North Am. , vol.85 , pp. 527-550
    • Tresch, D.D.1
  • 98
    • 0026753449 scopus 로고
    • Long-term prognosis significance of ambulatory electrocardiographic findings in apparently healthy subjects ≥ 60 years of age
    • J.L. Fleg, and H.L. Kennedy Long-term prognosis significance of ambulatory electrocardiographic findings in apparently healthy subjects ≥ 60 years of age Am. J. Cardiol. 70 1992 748 751
    • (1992) Am. J. Cardiol. , vol.70 , pp. 748-751
    • Fleg, J.L.1    Kennedy, H.L.2
  • 99
    • 0024362644 scopus 로고
    • Prevalence and long-term significance of exercise-induced frequent or repetitive ventricular ectopic beats in apparently healthy volunteers
    • M.J. Busby, E.A. Shefrin, and J.L. Fleg Prevalence and long-term significance of exercise-induced frequent or repetitive ventricular ectopic beats in apparently healthy volunteers J. Am. Coll. Cardiol. 14 1989 1659 1665
    • (1989) J. Am. Coll. Cardiol. , vol.14 , pp. 1659-1665
    • Busby, M.J.1    Shefrin, E.A.2    Fleg, J.L.3
  • 100
    • 84881356531 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of exercise-induced nonsustained ventricular tachycardia in asymptomatic volunteers: BLSA (Baltimore Longitudinal Study of Aging)
    • J.E. Marine, V. Shetty, G.V. Chow, J.G. Wright, G. Gerstenblith, S.S. Najjar, and et al. Prevalence and prognostic significance of exercise-induced nonsustained ventricular tachycardia in asymptomatic volunteers: BLSA (Baltimore Longitudinal Study of Aging) J. Am. Coll. Cardiol. 62 2013 595 600
    • (2013) J. Am. Coll. Cardiol. , vol.62 , pp. 595-600
    • Marine, J.E.1    Shetty, V.2    Chow, G.V.3    Wright, J.G.4    Gerstenblith, G.5    Najjar, S.S.6
  • 102
    • 0027417262 scopus 로고
    • Cardiovascular regulatory mechanisms in advanced age
    • E.G. Lakatta Cardiovascular regulatory mechanisms in advanced age Physiol. Rev. 73 1993 413 467
    • (1993) Physiol. Rev. , vol.73 , pp. 413-467
    • Lakatta, E.G.1
  • 104


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.