Effect of age on cardiac excitation-contraction coupling

Clinical and Experimental Pharmacology and Physiology

Volumn 37, Issue 1, 2010, Pages 1-7

  Fares, Elias ^a   Howlett, Susan E ^a,b  

^a DALHOUSIE UNIVERSITY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Aged; Calcium release; Calcium transients; Contraction; Senescence

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALSEQUESTRIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; MYOSIN; PHOSPHOLAMBAN; RYANODINE RECEPTOR; RYANODINE RECEPTOR 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN;

AGING; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; EXCITATION CONTRACTION COUPLING; EXERCISE; HEART CONTRACTION; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILE FORCE; HEART PACING; HEART VENTRICLE; HUMAN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REVIEW;

AGING; ANIMALS; CALCIUM; EXCITATION CONTRACTION COUPLING; HUMANS; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC;

EID: 74049135456     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2009.05276.x     Document Type: Review

References (75)

1. Lakatta EG, Levy D. Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part II. The aging heart in health: Links to heart disease. Circulation 2003 107 : 346 354. (Pubitemid 36135235)
2. Olivetti G, Melissari M, Capasso JM, Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ. Res. 1991 68 : 1560 1568.
3. Bernhard D, Laufer G. The aging cardiomyocyte: A mini-review. Gerontology 2008 54 : 24 31.
4. Fleg JL, O'Connor F, Gerstenblith G et al. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J. Appl. Physiol. 1995 78 : 890 900.
5. Najjar SS, Schulman SP, Gerstenblith G et al. Age and gender affect ventricular-vascular coupling during aerobic exercise. J. Am. Coll. Cardiol. 2004 44 : 611 617.
6. Ruan Q, Nagueh SF. Effect of age on left ventricular systolic function in humans: A study of systolic isovolumic acceleration rate. Exp. Physiol. 2005 90 : 527 534.
7. Lakatta EG, Sollott SJ. Perspectives on mammalian cardiovascular aging: Humans to molecules. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2002 132 : 699 721.
8. Grundy EMD. The Epidemiology of aging. In : Tallis R, Fillit H (eds). Brocklehurst's Textbook of Geriatric Medicine and Gerontology, 6th edn. Churchill Livingstone, London. 2003 4 20.
9. Turturro A, Witt WW, Lewis S, Hass BS, Lipman RD, Hart RW. Growth curves and survival characteristics of the animals used in the biomarkers of aging program. J. Gerontol. Biol. Sci. 1999 54 (11 B492 501.
10. Hacker TA, McKiernan SH, Douglas PS, Wanagat J, Aiken JM. Age-related changes in cardiac structure and function in Fischer 344, x Brown Norway hybrid rats. Am. J. Physiol. Heart Circ. Physiol. 2006 290 : H304 11.
11. Fraticelli A, Josephson R, Danziger R, Lakatta E, Spurgeon H. Morphological and contractile characteristics of rat cardiac myocytes from maturation to senescence. Am. J. Physiol. 1989 257 : H259 65.
12. Walker KE, Lakatta EG, Houser SR. Age associated changes in membrane currents in rat ventricular myocytes. Cardiovasc. Res. 1993 27 : 1968 1977.
13. Xiao RP, Spurgeon HA, O'Connor F, Lakatta EG. Age-associated changes in β-adrenergic modulation on rat cardiac excitation-contraction coupling. J. Clin. Invest. 1994 94 : 2051 2059.
14. Lim CC, Apstein CS, Colucci WS, Liao R. Impaired cell shortening and relengthening with increased pacing frequency are intrinsic to the senescent mouse cardiomyocyte. J. Mol. Cell. Cardiol. 2000 32 : 2075 2082.
15. 2+ currents in rat ventricular myocytes. Am. J. Physiol. Heart Circ. Physiol. 2000 279 : H889 900.
16. Dibb KM, Rueckschloss U, Eisner DA, Isenberg G, Trafford AW. Mechanisms underlying enhanced cardiac excitation contraction coupling observed in the senescent sheep myocardium. J. Mol. Cell. Cardiol. 2004 37 : 1171 1181.
17. Kajstura J, Cheng W, Sarangarajan R et al. Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats. Am. J. Physiol. 1996 271 : H1215 28.
18. Assayag P, Charlemagne D, Marty I et al. Effects of sustained low-flow ischemia on myocardial function and calcium-regulating proteins in adult and senescent rat hearts. Cardiovasc. Res. 1998 38 : 169 180.
19. Lakatta EG, Gerstenblith G, Angell CS, Shock NW, Weisfeldt ML. Diminished inotropic response of aged myocardium to catecholamines. Circ. Res. 1975 36 : 262 269.
20. Froehlich JP, Lakatta EG, Beard E, Spurgeon HA, Weisfeldt ML, Gerstenblith G. Studies of sarcoplasmic reticulum function and contraction duration in young adult and aged rat myocardium. J. Mol. Cell. Cardiol. 1978 10 : 427 438.
21. Capasso JM, Malhotra A, Remily RM, Scheuer J, Sonnenblick EH. Effects of age on mechanical and electrical performance of rat myocardium. Am. J. Physiol. 1983 245 : H72 81.
22. Wei JY, Spurgeon HA, Lakatta EG. Excitation-contraction in rat myocardium: Alterations with adult aging. Am. J. Physiol. 1984 246 : H784 91.
23. Orchard CH, Lakatta EG. Intracellular calcium transients and developed tension in rat heart muscle. A mechanism for the negative interval-strength relationship. J. Gen. Physiol. 1985 86 : 637 651.
24. Anversa P, Capasso JM, Puntillo E, Sonnenblick EH, Olivetti G. Morphometric analysis of the infarcted heart. Pathol. Res. Pract. 1989 185 : 544 550.
25. Rozenberg S, Tavernier B, Riou B et al. Severe impairment of ventricular compliance accounts for advanced age-associated hemodynamic dysfunction in rats. Exp. Gerontol. 2006 41 : 289 295.
26. Hano O, Bogdanov KY, Sakai M, Danziger RG, Spurgeon HA, Lakatta EG. Reduced threshold for myocardial cell calcium intolerance in the rat heart with aging. Am. J. Physiol. 1995 269 : H1607 12.
27. 2+-ATPase. Circulation 2000 101 : 790 796.
28. Lieber SC, Qiu H, Chen L et al. Cardiac dysfunction in aging conscious rats: Altered cardiac cytoskeletal proteins as a potential mechanism. Am. J. Physiol. Heart Circ. Physiol. 2008 295 : H860 6.
29. Bers DM. Calcium cycling and signaling in cardiac myocytes. Annu. Rev. Physiol. 2008 70 : 23 49.
30. Bers DM. Cardiac excitation-contraction coupling. Nature 2002 415 : 198 205.
31. Meissner G. Molecular regulation of cardiac ryanodine receptor ion channel. Cell Calcium 2004 35 : 621 628.
32. Fabiato A. Rapid ionic modifications during the aequorin-detected calcium transient in a skinned canine cardiac Purkinje cell. J. Gen. Physiol. 1985 85 : 189 246.
33. Fabiato A. Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell. J. Gen. Physiol. 1985 85 : 291 320. (Pubitemid 15130973)
34. Fabiato A. Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell. J. Gen. Physiol. 1985 85 : 247 290.
35. Shutt RH, Howlett SE. Hypothermia increases the gain of excitation-contraction coupling in guinea pig ventricular myocytes. Am. J. Physiol. Cell Physiol. 2008 295 : C692 700.
36. 2+ current trigger. J. Physiol. 2004 556 : 463 480.
37. Sjaastad I, Wasserstrom JA, Sejersted OM. Heart failure: a challenge to our current concepts of excitation-contraction coupling. J. Physiol. 2003 546 : 33 47.
38. 2+ current amplitude and open channel probability. Circ. Res. 2007 101 : 590 597.
39. 2+ ATPase pump expression and its relevance to cardiac muscle physiology and pathology. Cardiovasc. Res. 2008 77 : 265 273.
40. 2+ exchange in the regulation of cardiac excitation-contraction coupling. Cardiovasc. Res. 2005 67 : 198 207. (Pubitemid 40943612)
41. Eisner DA, Sipido KR. Sodium calcium exchange in the heart: Necessity or luxury? Circ. Res. 2004 95 : 549 551.
42. Cheng H, Lederer WJ, Cannell MB. Calcium sparks: Elementary events underlying excitation-contraction coupling in heart muscle. Science 1993 262 : 740 744.
43. 2+ in voltage-clamped rat heart cells: Visualization with confocal microscopy. J. Physiol. 1994 480 : 21 9.
44. 2+ sparks and local control theories for cardiac excitation-contraction coupling. Circ. Res. 1996 78 : 166 171.
45. Inoue M, Bridge JH. Variability in couplon size in rabbit ventricular myocytes. Biophys. J. 2005 89 : 3102 3110.
46. Bootman MD, Higazi DR, Coombes S, Roderick HL. Calcium signalling during excitation-contraction coupling in mammalian atrial myocytes. J. Cell Sci. 2006 119 : 3915 3925.
47. Scriven DR, Klimek A, Lee KL, Moore ED. The molecular architecture of calcium microdomains in rat cardiomyocytes. Ann. NY Acad. Sci. 2002 976 : 488 499.
48. 2+ channels and ryanodine receptors in heart cells. Nature 2001 410 : 592 596.
49. i transient. J. Mol. Cell. Cardiol. 2002 34 : 941 950.
50. Ferrier GR, Smith RH, Howlett SE. Calcium sparks in mouse ventricular myocytes at physiological temperature. Am. J. Physiol. Heart Circ. Physiol. 2003 285 : H1495 505.
51. 2+ spark frequency in ventricular myocytes. Am. J. Physiol. 1997 272 : H657 68.
52. Bers DM. Excitation-Contraction Coupling and Cardiac Contractile Force, 2nd edn. Kluwer Academic Publishers, Dordrecht. 2001.
53. 2+ signaling in intact myocardium. J. Pharmacol. Sci. 2006 100 : 525 537.
54. Capasso JM, Fitzpatrick D, Anversa P. Cellular mechanisms of ventricular failure: Myocyte kinetics and geometry with age. Am. J. Physiol. 1992 262 : H1770 81.
55. Farrell SR, Howlett SE. The effects of isoproterenol on abnormal electrical and contractile activity and diastolic calcium are attenuated in myocytes from aged Fischer 344 rats. Mech. Ageing Dev. 2007 128 : 566 573.
56. 2+ transients of cardiomyocytes from senescent mice peak late and decay slowly. Cell Calcium 2003 34 : 271 280.
57. Farrell SR, Howlett SE. The age-related decrease in catecholamine sensitivity is mediated by β-adrenergic receptors linked to a decrease in adenylate cyclase activity in ventricular myocytes from male Fischer 344 rats. Mech. Ageing Dev. 2008 129 : 735 744.
58. 2-adrenergic responses without changes in inhibitory G proteins or receptor kinases. J. Clin. Invest. 1998 101 : 1273 1282.
59. Raitt MH, Tamblyn C, Allen JM, Abrass IB. β-Adrenergic receptor downregulation and recovery in heart and lung in the Fischer 344 rat: Effects of aging and correlation with mRNA levels. J. Gerontol. 1995 50 : B213 7.
60. Scarpase PJ. Decreased β-adrenergic responsiveness during senescence. Fed. Proc. 1986 45 : 51 4.
61. Abrass IB, Davis JL, Scarpace PJ. Isoproterenol responsiveness and myocardial β-adrenergic receptors in young and old rats. J. Gerontol. 1982 37 : 156 160.
62. Buttrick P, Malhotra A, Factor S, Greenen D, Leinwand L, Scheuer J. Effect of aging and hypertension on myosin biochemistry and gene expression in the rat heart. Circ. Res. 1991 68 : 645 652.
63. 2+-ATPase and calsequestrin genes in rat heart during ontogenic development and aging. Circ. Res. 1991 69 : 1380 1388.
64. Lim CC, Liao R, Varma N, Apstein CS. Impaired lusitropy-frequency in the aging mouse. Role of Ca2+-handling proteins and effects of isoproterenol. Am. J. Physiol. 1999 277 : H2083 90.
65. 2+ cycling proteins and their phosphorylation in rat myocardium. Am. J. Physiol. 1998 275 : H2087 94.
66. Rodriguez P, Kranias EG. Phospholamban. A key determinant of cardiac function and dysfunction. Arch. Mal. Coeur Vaiss. 2005 98 : 1239 1243.
67. 2+ exchange in the aging myocardium. Age 1988 11 : 1 6.
68. 2+ exchange in rat papillary muscle. J. Gerontol. A Biol. Sci. Med. Sci. 1996 51 : M251 9.
69. 2+ exchange. J. Appl. Physiol. 2003 95 : 1994 2003.
70. Nicholl PA, Howlett SE. Sarcoplasmic reticulum calcium release channels in ventricles of older adult hamsters. Can. J. Aging 2006 25 : 107 113.
71. Györke S, Carnes C. Dysregulated sarcoplasmic reticulum calcium release: Potential pharmacological target in cardiac disease. Pharmacol. Ther. 2008 119 : 340 354.
72. Howlett SE, Grandy SA, Ferrier GR. Calcium spark properties in ventricular myocytes are altered in aged mice. Am. J. Physiol. Heart Circ. Physiol. 2006 290 : H1566 74.
73. 2+ sparks and gating properties of ryanodine receptors in aging cardiomyocytes. Cell Calcium 2005 37 : 583 591.
74. Howlett SE, Nicholl PA. Density of 1,4-dihydropyridine receptors decreases in the hearts of aging hamsters. J. Mol. Cell. Cardiol. 1992 24 : 885 894.
75. Grandy SA, Howlett SE. Cardiac excitation-contraction coupling is altered in myocytes from aged male mice but not in cells from aged female mice. Am. J. Physiol. Heart Circ. Physiol. 2006 291 : H2362 70.