Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer's disease neuropathological deficits

Molecular Psychiatry

Volumn 22, Issue 3, 2017, Pages 407-416

  Shah, S A ^a   Yoon, G H ^a   Chung, S S ^b   Abid, M N ^a   Kim, T H ^a   Lee, H Y ^a   Kim, M O ^a  

^a Gyeongsang National University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN RECEPTOR 1; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NEUROPROTECTIVE AGENT; OSMOTIN; SIRTUIN 1; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; UNCLASSIFIED DRUG; ADIPONECTIN RECEPTOR; AMYLOID BETA PROTEIN; OSMOTIN PROTEIN, NICOTIANA TABACUM; PLANT PROTEIN; SECRETASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LONG TERM POTENTIATION; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECTS; GENETICS; MEMORY DISORDER; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMP-ACTIVATED PROTEIN KINASES; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; LONG-TERM POTENTIATION; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; PLANT PROTEINS; RECEPTORS, ADIPONECTIN; SIGNAL TRANSDUCTION; SIRTUIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

EID: 84961393689     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2016.23     Document Type: Article

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