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Volumn 20, Issue 8, 2014, Pages 1104-1111

Treatment with a Rho Kinase Inhibitor Improves Survival from Graft-Versus-Host Disease in Mice after MHC-Haploidentical Hematopoietic Cell Transplantation

Author keywords

Allogeneic; Fasudil; GVHD; Haploidentical; Intestinal tract; Rho kinase

Indexed keywords

FASUDIL; GAMMA INTERFERON; THYMOCYTE ANTIBODY; RHO KINASE;

EID: 84903955937     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2014.04.029     Document Type: Article
Times cited : (13)

References (70)
  • 1
    • 0034193057 scopus 로고    scopus 로고
    • The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation
    • Hill G.R., Ferrara J.L. The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood 2000, 95:2754-2759.
    • (2000) Blood , vol.95 , pp. 2754-2759
    • Hill, G.R.1    Ferrara, J.L.2
  • 2
    • 84880458648 scopus 로고    scopus 로고
    • Acritical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease
    • Chen X., Dodge J., Komorowski R., Drobyski W.R. Acritical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease. Blood 2013, 121:3970-3980.
    • (2013) Blood , vol.121 , pp. 3970-3980
    • Chen, X.1    Dodge, J.2    Komorowski, R.3    Drobyski, W.R.4
  • 3
    • 0037248411 scopus 로고    scopus 로고
    • Intestinal graft-versus-host disease: mechanisms and management
    • Takatsuka H., Iwasaki T., Okamoto T., Kakishita E. Intestinal graft-versus-host disease: mechanisms and management. Drugs 2003, 63:1-15.
    • (2003) Drugs , vol.63 , pp. 1-15
    • Takatsuka, H.1    Iwasaki, T.2    Okamoto, T.3    Kakishita, E.4
  • 4
    • 84862824212 scopus 로고    scopus 로고
    • Graft-versus-tumor effect according to type of graft-versus-host disease defined by National Institutes of Health consensus criteria and associated outcomes
    • Cho B.S., Lee S.E., Song H.H., et al. Graft-versus-tumor effect according to type of graft-versus-host disease defined by National Institutes of Health consensus criteria and associated outcomes. Biol Blood Marrow Transplant 2012, 18:1136-1143.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 1136-1143
    • Cho, B.S.1    Lee, S.E.2    Song, H.H.3
  • 5
    • 84863680262 scopus 로고    scopus 로고
    • Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease
    • Reshef R., Luger S.M., Hexner E.O., et al. Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease. NEngl J Med 2012, 367:135-145.
    • (2012) NEngl J Med , vol.367 , pp. 135-145
    • Reshef, R.1    Luger, S.M.2    Hexner, E.O.3
  • 6
    • 84862177965 scopus 로고    scopus 로고
    • Effect of acute and chronic GVHD on relapse and survival after reduced-intensity conditioning allogeneic transplantation for myeloma
    • Ringdén O., Shrestha S., da Silva G.T., et al. Effect of acute and chronic GVHD on relapse and survival after reduced-intensity conditioning allogeneic transplantation for myeloma. Bone Marrow Transplant 2012, 47:831-837.
    • (2012) Bone Marrow Transplant , vol.47 , pp. 831-837
    • Ringdén, O.1    Shrestha, S.2    da Silva, G.T.3
  • 7
    • 0037100551 scopus 로고    scopus 로고
    • Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse
    • Lee S.J., Klein J.P., Barrett A.J., et al. Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse. Blood 2002, 100:406-414.
    • (2002) Blood , vol.100 , pp. 406-414
    • Lee, S.J.1    Klein, J.P.2    Barrett, A.J.3
  • 8
    • 84869092299 scopus 로고    scopus 로고
    • Chronic GVHD is associated with lower relapse risk irrespective of stem cell source among patients receiving transplantation from unrelated donors
    • Signori A., Crocchiolo R., Oneto R., et al. Chronic GVHD is associated with lower relapse risk irrespective of stem cell source among patients receiving transplantation from unrelated donors. Bone Marrow Transplant 2012, 47:1474-1478.
    • (2012) Bone Marrow Transplant , vol.47 , pp. 1474-1478
    • Signori, A.1    Crocchiolo, R.2    Oneto, R.3
  • 9
    • 0035026686 scopus 로고    scopus 로고
    • Infusion of select leukemia-reactive TCR Vbeta+ T cells provides graft-versus-leukemia responses with minimization of graft-versus-host disease following murine hematopoietic stem cell transplantation
    • Patterson A.E., Korngold R. Infusion of select leukemia-reactive TCR Vbeta+ T cells provides graft-versus-leukemia responses with minimization of graft-versus-host disease following murine hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2001, 7:187-196.
    • (2001) Biol Blood Marrow Transplant , vol.7 , pp. 187-196
    • Patterson, A.E.1    Korngold, R.2
  • 10
    • 84871839866 scopus 로고    scopus 로고
    • Unraveling graft-versus-host disease and graft-versus-leukemia responses using TCR Vβ spectratype analysis in a murine bone marrow transplantation model
    • Fanning S.L., Zilberberg J., Stein J., et al. Unraveling graft-versus-host disease and graft-versus-leukemia responses using TCR Vβ spectratype analysis in a murine bone marrow transplantation model. JImmunol 2013, 190:447-457.
    • (2013) JImmunol , vol.190 , pp. 447-457
    • Fanning, S.L.1    Zilberberg, J.2    Stein, J.3
  • 11
    • 33847189975 scopus 로고    scopus 로고
    • Increased frequencies of CD4(+)CD25(high) T(regs) correlate with disease relapse after allogeneic stem cell transplantation for chronic myeloid leukemia
    • Nadal E., Garin M., Kaeda J., et al. Increased frequencies of CD4(+)CD25(high) T(regs) correlate with disease relapse after allogeneic stem cell transplantation for chronic myeloid leukemia. Leukemia 2007, 21:472-479.
    • (2007) Leukemia , vol.21 , pp. 472-479
    • Nadal, E.1    Garin, M.2    Kaeda, J.3
  • 12
    • 10744230688 scopus 로고    scopus 로고
    • LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease
    • Petrovic A., Alpdogan O., Willis L.M., et al. LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease. Blood 2004, 103:1542-1547.
    • (2004) Blood , vol.103 , pp. 1542-1547
    • Petrovic, A.1    Alpdogan, O.2    Willis, L.M.3
  • 13
    • 84887761550 scopus 로고    scopus 로고
    • Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice
    • Haarberg K.M., Li J., Heinrichs J., et al. Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice. Blood 2013, 122:2500-2511.
    • (2013) Blood , vol.122 , pp. 2500-2511
    • Haarberg, K.M.1    Li, J.2    Heinrichs, J.3
  • 14
    • 77953689269 scopus 로고    scopus 로고
    • Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth
    • Penack O., Henke E., Suh D., et al. Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth. JNatl Cancer Inst 2010, 102:894-908.
    • (2010) JNatl Cancer Inst , vol.102 , pp. 894-908
    • Penack, O.1    Henke, E.2    Suh, D.3
  • 15
    • 79956106246 scopus 로고    scopus 로고
    • The importance of neovascularization and its inhibition for allogeneic hematopoietic stem cell transplantation
    • Penack O., Socié G., van den Brink M.R. The importance of neovascularization and its inhibition for allogeneic hematopoietic stem cell transplantation. Blood 2011, 117:4181-4189.
    • (2011) Blood , vol.117 , pp. 4181-4189
    • Penack, O.1    Socié, G.2    van den Brink, M.R.3
  • 16
    • 84861603110 scopus 로고    scopus 로고
    • Shift of graft-versus-host-disease target organ tropism by dietary vitamin A
    • Koenecke C., Prinz I., Bubke A., et al. Shift of graft-versus-host-disease target organ tropism by dietary vitamin A. PLoS One 2012, 7:e38252.
    • (2012) PLoS One , vol.7
    • Koenecke, C.1    Prinz, I.2    Bubke, A.3
  • 17
    • 75749115630 scopus 로고    scopus 로고
    • Chemokine receptor CCR5 mediates alloimmune responses in graft-versus-host disease
    • Palmer L.A., Sale G.E., Balogun J.I., et al. Chemokine receptor CCR5 mediates alloimmune responses in graft-versus-host disease. Biol Blood Marrow Transplant 2010, 16:311-319.
    • (2010) Biol Blood Marrow Transplant , vol.16 , pp. 311-319
    • Palmer, L.A.1    Sale, G.E.2    Balogun, J.I.3
  • 18
    • 0032740991 scopus 로고    scopus 로고
    • Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease
    • Murai M., Yoneyama H., Harada A., et al. Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease. JClin Invest 1999, 104:49-57.
    • (1999) JClin Invest , vol.104 , pp. 49-57
    • Murai, M.1    Yoneyama, H.2    Harada, A.3
  • 19
    • 84859921644 scopus 로고    scopus 로고
    • Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice
    • Stirzaker R.A., Biswas P.S., Gupta S., et al. Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice. Lupus 2012, 21:656-661.
    • (2012) Lupus , vol.21 , pp. 656-661
    • Stirzaker, R.A.1    Biswas, P.S.2    Gupta, S.3
  • 20
    • 1042304317 scopus 로고    scopus 로고
    • Enhancement of migration and invasion of hepatoma cells via a rho GTPase signaling pathway
    • Wang D.S., Dou K.F., Li K.Z., Song Z.S. Enhancement of migration and invasion of hepatoma cells via a rho GTPase signaling pathway. World J Gastroenterol 2004, 10:299-302.
    • (2004) World J Gastroenterol , vol.10 , pp. 299-302
    • Wang, D.S.1    Dou, K.F.2    Li, K.Z.3    Song, Z.S.4
  • 21
    • 35348997467 scopus 로고    scopus 로고
    • ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging
    • Vishnubhotla R., Sun S., Huq J., et al. ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging. Lab Invest 2007, 87:1149-1158.
    • (2007) Lab Invest , vol.87 , pp. 1149-1158
    • Vishnubhotla, R.1    Sun, S.2    Huq, J.3
  • 22
    • 0037817325 scopus 로고    scopus 로고
    • Significant association of rho/ROCK pathway with invasion and metastasis of bladder cancer
    • Kamai T., Tsujii T., Arai K., et al. Significant association of rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res 2003, 9:2632-2641.
    • (2003) Clin Cancer Res , vol.9 , pp. 2632-2641
    • Kamai, T.1    Tsujii, T.2    Arai, K.3
  • 23
    • 0036305635 scopus 로고    scopus 로고
    • ROCK and Dia have opposing effects on adherens junctions downstream of rho
    • Sahai E., Marshall C.J. ROCK and Dia have opposing effects on adherens junctions downstream of rho. Nat Cell Biol 2002, 4:408-415.
    • (2002) Nat Cell Biol , vol.4 , pp. 408-415
    • Sahai, E.1    Marshall, C.J.2
  • 24
    • 10844230332 scopus 로고    scopus 로고
    • Conditional ROCK activation invivo induces tumor cell dissemination and angiogenesis
    • Croft D.R., Sahai E., Mavria G., et al. Conditional ROCK activation invivo induces tumor cell dissemination and angiogenesis. Cancer Res 2004, 64:8994-9001.
    • (2004) Cancer Res , vol.64 , pp. 8994-9001
    • Croft, D.R.1    Sahai, E.2    Mavria, G.3
  • 25
    • 0034708373 scopus 로고    scopus 로고
    • Rho-kinase inhibitor retards migration and invivo dissemination of human prostate cancer cells
    • Somlyo A.V., Bradshaw D., Ramos S., et al. Rho-kinase inhibitor retards migration and invivo dissemination of human prostate cancer cells. Biochem Biophys Res Commun 2000, 269:652-659.
    • (2000) Biochem Biophys Res Commun , vol.269 , pp. 652-659
    • Somlyo, A.V.1    Bradshaw, D.2    Ramos, S.3
  • 26
    • 33749538874 scopus 로고    scopus 로고
    • The rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models
    • Ying H., Biroc S.L., Li W.W., et al. The rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models. Mol Cancer Ther 2006, 5:2158-2164.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2158-2164
    • Ying, H.1    Biroc, S.L.2    Li, W.W.3
  • 27
    • 0032812619 scopus 로고    scopus 로고
    • Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells
    • Bourguignon L.Y., Zhu H., Shao L., et al. Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells. Cell Motil Cytoskeleton 1999, 43:269-287.
    • (1999) Cell Motil Cytoskeleton , vol.43 , pp. 269-287
    • Bourguignon, L.Y.1    Zhu, H.2    Shao, L.3
  • 28
    • 0037166942 scopus 로고    scopus 로고
    • Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes
    • Barreiro O., Yanez-Mo M., Serrador J.M., et al. Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. JCell Biol 2002, 157:1233-1245.
    • (2002) JCell Biol , vol.157 , pp. 1233-1245
    • Barreiro, O.1    Yanez-Mo, M.2    Serrador, J.M.3
  • 29
    • 45849130862 scopus 로고    scopus 로고
    • Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study
    • discussion 247-248
    • Suzuki Y., Shibuya M., Satoh S., et al. Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study. Neurol Med Chir (Tokyo) 2008, 48:241-247. discussion 247-248.
    • (2008) Neurol Med Chir (Tokyo) , vol.48 , pp. 241-247
    • Suzuki, Y.1    Shibuya, M.2    Satoh, S.3
  • 30
    • 80054934973 scopus 로고    scopus 로고
    • Fasudil Aneurysmal Subarachnoid Hemorrhage Study Group. Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine
    • Zhao J., Zhou D., Guo J., et al. Fasudil Aneurysmal Subarachnoid Hemorrhage Study Group. Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine. Neurol Med Chir (Tokyo) 2011, 51:679-683.
    • (2011) Neurol Med Chir (Tokyo) , vol.51 , pp. 679-683
    • Zhao, J.1    Zhou, D.2    Guo, J.3
  • 31
    • 79955485553 scopus 로고    scopus 로고
    • CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice
    • Nguyen H.T., Dalmasso G., Torkvist L., et al. CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice. JClin Invest 2011, 121:1733-1747.
    • (2011) JClin Invest , vol.121 , pp. 1733-1747
    • Nguyen, H.T.1    Dalmasso, G.2    Torkvist, L.3
  • 32
    • 84867816187 scopus 로고    scopus 로고
    • Blockade of chemotaxis in graft-versus-host disease
    • author reply 1667-1668
    • Davies J.K., Gribben J.G. Blockade of chemotaxis in graft-versus-host disease. NEngl J Med 2012, 367:1667. author reply 1667-1668.
    • (2012) NEngl J Med , vol.367 , pp. 1667
    • Davies, J.K.1    Gribben, J.G.2
  • 33
    • 84903995104 scopus 로고    scopus 로고
    • A novel CD4+CD146+CCR5+ T-cell population is a biomarker of intestinal graft-versus-host disease. Presented at the 39th annual meeting of the European Group for Bloodand Marrow Transplantation
    • April 10, 2013, London, UK, abstract0390.
    • Gomez A, Hammer S, Braun T, etal. A novel CD4+CD146+CCR5+ T-cell population is a biomarker of intestinal graft-versus-host disease. Presented at the 39th annual meeting of the European Group for Bloodand Marrow Transplantation, April 10, 2013, London, UK, abstract0390.
    • Gomez, A.1    Hammer, S.2    Braun, T.3
  • 34
    • 33847613527 scopus 로고    scopus 로고
    • Expression of CCR5 in graft-versus-host disease (GVHD) of the skin: immunohistochemical staining of 38 cases
    • Morita N.I., Matsumura Y., Morita K., Miyachi Y. Expression of CCR5 in graft-versus-host disease (GVHD) of the skin: immunohistochemical staining of 38 cases. JDermatol 2007, 34:254-257.
    • (2007) JDermatol , vol.34 , pp. 254-257
    • Morita, N.I.1    Matsumura, Y.2    Morita, K.3    Miyachi, Y.4
  • 35
    • 33846536952 scopus 로고    scopus 로고
    • Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus
    • Li Y., Harada T., Juang Y.T., et al. Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus. JImmunol 2007, 178:1938-1947.
    • (2007) JImmunol , vol.178 , pp. 1938-1947
    • Li, Y.1    Harada, T.2    Juang, Y.T.3
  • 36
    • 0041384357 scopus 로고    scopus 로고
    • LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment
    • Smith A., Bracke M., Leitinger B., et al. LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment. JCell Sci 2003, 116(Pt 15):3123-3133.
    • (2003) JCell Sci , vol.116 , Issue.PT 15 , pp. 3123-3133
    • Smith, A.1    Bracke, M.2    Leitinger, B.3
  • 37
    • 43049136576 scopus 로고    scopus 로고
    • ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury
    • Noma K., Rikitake Y., Oyama N., et al. ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury. JClin Invest 2008, 118:1632-1644.
    • (2008) JClin Invest , vol.118 , pp. 1632-1644
    • Noma, K.1    Rikitake, Y.2    Oyama, N.3
  • 38
    • 7244247060 scopus 로고    scopus 로고
    • Roles of p-ERM and rho-ROCK signaling in lymphocyte polarity and uropod formation
    • Lee J.H., Katakai T., Hara T., et al. Roles of p-ERM and rho-ROCK signaling in lymphocyte polarity and uropod formation. JCell Biol 2004, 167:327-337.
    • (2004) JCell Biol , vol.167 , pp. 327-337
    • Lee, J.H.1    Katakai, T.2    Hara, T.3
  • 39
    • 79960300426 scopus 로고    scopus 로고
    • Rho kinase inhibitor fasudil suppresses migration and invasion through down-regulating the expression of VEGF in lung cancer cell line A549
    • Zhu F., Zhang Z., Wu G., et al. Rho kinase inhibitor fasudil suppresses migration and invasion through down-regulating the expression of VEGF in lung cancer cell line A549. Med Oncol 2011, 28:565-571.
    • (2011) Med Oncol , vol.28 , pp. 565-571
    • Zhu, F.1    Zhang, Z.2    Wu, G.3
  • 40
    • 43049085527 scopus 로고    scopus 로고
    • Rapid leukocyte migration by integrin-independent flowing and squeezing
    • Lämmermann T., Bader B.L., Monkley S.J., et al. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature 2008, 453:51-55.
    • (2008) Nature , vol.453 , pp. 51-55
    • Lämmermann, T.1    Bader, B.L.2    Monkley, S.J.3
  • 41
    • 0038743116 scopus 로고    scopus 로고
    • Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes
    • Bardi G., Niggli V., Loetscher P. Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes. FEBS Lett 2003, 542:79-83.
    • (2003) FEBS Lett , vol.542 , pp. 79-83
    • Bardi, G.1    Niggli, V.2    Loetscher, P.3
  • 43
    • 33745861998 scopus 로고    scopus 로고
    • Involvement of rho/ROCK signalling in small cell lung cancer migration through human brain microvascular endothelial cells
    • Li B., Zhao W.D., Tan Z.M., et al. Involvement of rho/ROCK signalling in small cell lung cancer migration through human brain microvascular endothelial cells. FEBS Lett 2006, 580:4252-4260.
    • (2006) FEBS Lett , vol.580 , pp. 4252-4260
    • Li, B.1    Zhao, W.D.2    Tan, Z.M.3
  • 44
    • 0042744676 scopus 로고    scopus 로고
    • CAMs and rho small GTPases: gatekeepers for leukocyte transendothelial migration. Focus on "VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration"
    • Alevriadou B.R. CAMs and rho small GTPases: gatekeepers for leukocyte transendothelial migration. Focus on "VCAM-1-mediated Rac signaling controls endothelial cell-cell contacts and leukocyte transmigration". Am J Physiol Cell Physiol 2003, 285:C250-C252.
    • (2003) Am J Physiol Cell Physiol , vol.285
    • Alevriadou, B.R.1
  • 45
    • 0037416129 scopus 로고    scopus 로고
    • Identification of a tight junction-associated guanine nucleotide exchange factor that activates rho and regulates paracellular permeability
    • Benais-Pont G., Punn A., Flores-Maldonado C., et al. Identification of a tight junction-associated guanine nucleotide exchange factor that activates rho and regulates paracellular permeability. JCell Biol 2003, 160:729-740.
    • (2003) JCell Biol , vol.160 , pp. 729-740
    • Benais-Pont, G.1    Punn, A.2    Flores-Maldonado, C.3
  • 46
    • 33845659817 scopus 로고    scopus 로고
    • Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease
    • Nohria A., Grunert M.E., Rikitake Y., et al. Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease. Circ Res 2006, 99:1426-1432.
    • (2006) Circ Res , vol.99 , pp. 1426-1432
    • Nohria, A.1    Grunert, M.E.2    Rikitake, Y.3
  • 47
    • 33745094734 scopus 로고    scopus 로고
    • Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE)
    • Persidsky Y., Heilman D., Haorah J., et al. Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood 2006, 107:4770-4780.
    • (2006) Blood , vol.107 , pp. 4770-4780
    • Persidsky, Y.1    Heilman, D.2    Haorah, J.3
  • 48
    • 39549112926 scopus 로고    scopus 로고
    • Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells
    • Yamamoto M., Ramirez S.H., Sato S., et al. Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am J Pathol 2008, 172:521-533.
    • (2008) Am J Pathol , vol.172 , pp. 521-533
    • Yamamoto, M.1    Ramirez, S.H.2    Sato, S.3
  • 49
    • 2942678702 scopus 로고    scopus 로고
    • RhoA/rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction
    • Bivalacqua T.J., Champion H.C., Usta M.F., et al. RhoA/rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction. Proc Natl Acad Sci USA 2004, 101:9121-9126.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9121-9126
    • Bivalacqua, T.J.1    Champion, H.C.2    Usta, M.F.3
  • 50
    • 0036892061 scopus 로고    scopus 로고
    • 3Rho GTPase/rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells
    • Ming X.F., Viswambharan H., Barandier C., et al. 3Rho GTPase/rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol 2002, 22:8467-8477.
    • (2002) Mol Cell Biol , vol.22 , pp. 8467-8477
    • Ming, X.F.1    Viswambharan, H.2    Barandier, C.3
  • 51
    • 57249108205 scopus 로고    scopus 로고
    • Rho-kinase inhibitors decrease TGF-beta-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts
    • Kuno M., Takai S., Matsushima-Nishiwaki R., et al. Rho-kinase inhibitors decrease TGF-beta-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts. Biochem Pharmacol 2009, 77:196-203.
    • (2009) Biochem Pharmacol , vol.77 , pp. 196-203
    • Kuno, M.1    Takai, S.2    Matsushima-Nishiwaki, R.3
  • 52
    • 49849096424 scopus 로고    scopus 로고
    • Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells
    • Takata K., Morishige K., Takahashi T., et al. Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells. Mol Cancer Ther 2008, 7:1551-1561.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1551-1561
    • Takata, K.1    Morishige, K.2    Takahashi, T.3
  • 53
    • 41549109771 scopus 로고    scopus 로고
    • Antiangiogenic properties of fasudil, a potent rho-Kinase inhibitor
    • Hata Y., Miura M., Nakao S., et al. Antiangiogenic properties of fasudil, a potent rho-Kinase inhibitor. Jpn J Ophthalmol 2008, 52:16-23.
    • (2008) Jpn J Ophthalmol , vol.52 , pp. 16-23
    • Hata, Y.1    Miura, M.2    Nakao, S.3
  • 54
    • 80053187979 scopus 로고    scopus 로고
    • Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis
    • Washida N., Wakino S., Tonozuka Y., et al. Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis. Nephrol Dial Transplant 2011, 26:2770-2779.
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 2770-2779
    • Washida, N.1    Wakino, S.2    Tonozuka, Y.3
  • 55
    • 79952087218 scopus 로고    scopus 로고
    • HA1077, a rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways
    • Nakabayashi H., Shimizu K. HA1077, a rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways. Cancer Sci 2011, 102:393-399.
    • (2011) Cancer Sci , vol.102 , pp. 393-399
    • Nakabayashi, H.1    Shimizu, K.2
  • 56
    • 84867381718 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    • Clambey E.T., McNamee E.N., Westrich J.A., et al. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci USA 2012, 109:E2784-E2793.
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Clambey, E.T.1    McNamee, E.N.2    Westrich, J.A.3
  • 57
    • 84878292368 scopus 로고    scopus 로고
    • Intratumor hypoxia promotes immune tolerance by inducing regulatory T cells via TGF-β1 in gastric cancer
    • Deng B., Zhu J.M., Wang Y., et al. Intratumor hypoxia promotes immune tolerance by inducing regulatory T cells via TGF-β1 in gastric cancer. PLoS One 2013, 8:e63777.
    • (2013) PLoS One , vol.8
    • Deng, B.1    Zhu, J.M.2    Wang, Y.3
  • 58
    • 61849173436 scopus 로고    scopus 로고
    • CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure
    • Fiegl M., Samudio I., Clise-Dwyer K., et al. CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure. Blood 2009, 113:1504-1512.
    • (2009) Blood , vol.113 , pp. 1504-1512
    • Fiegl, M.1    Samudio, I.2    Clise-Dwyer, K.3
  • 59
    • 84860390598 scopus 로고    scopus 로고
    • Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers
    • Yan M., Jene N., Byrne D., et al. Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers. Breast Cancer Res 2011, 13:R47.
    • (2011) Breast Cancer Res , vol.13
    • Yan, M.1    Jene, N.2    Byrne, D.3
  • 60
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    • Facciabene A., Peng X., Hagemann I.S., et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 2011, 475:226-230.
    • (2011) Nature , vol.475 , pp. 226-230
    • Facciabene, A.1    Peng, X.2    Hagemann, I.S.3
  • 61
    • 85047685683 scopus 로고    scopus 로고
    • Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
    • Synnestvedt K., Furuta G.T., Comerford K.M., et al. Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. JClin Invest 2002, 110:993-1002.
    • (2002) JClin Invest , vol.110 , pp. 993-1002
    • Synnestvedt, K.1    Furuta, G.T.2    Comerford, K.M.3
  • 62
    • 59449096105 scopus 로고    scopus 로고
    • Central role of Sp1-regulated CD39 in hypoxia/ischemia protection
    • Eltzschig H.K., Köhler D., Eckle T., et al. Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. Blood 2009, 113:224-232.
    • (2009) Blood , vol.113 , pp. 224-232
    • Eltzschig, H.K.1    Köhler, D.2    Eckle, T.3
  • 63
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo C.A., Condamine T., Lu L., et al. HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. JExp Med 2010, 207:2439-2453.
    • (2010) JExp Med , vol.207 , pp. 2439-2453
    • Corzo, C.A.1    Condamine, T.2    Lu, L.3
  • 64
    • 77957564570 scopus 로고    scopus 로고
    • Extracellular adenosine triphosphate and adenosine in cancer
    • Stagg J., Smyth M.J. Extracellular adenosine triphosphate and adenosine in cancer. Oncogene 2010, 29:5346-5358.
    • (2010) Oncogene , vol.29 , pp. 5346-5358
    • Stagg, J.1    Smyth, M.J.2
  • 65
    • 84860388676 scopus 로고    scopus 로고
    • CD73: a potent suppressor of antitumor immune responses
    • Beavis P.A., Stagg J., Darcy P.K., Smyth M.J. CD73: a potent suppressor of antitumor immune responses. Trends Immunol 2012, 33:231-237.
    • (2012) Trends Immunol , vol.33 , pp. 231-237
    • Beavis, P.A.1    Stagg, J.2    Darcy, P.K.3    Smyth, M.J.4
  • 66
    • 77950231071 scopus 로고    scopus 로고
    • CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression
    • Jin D., Fan J., Wang L., et al. CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression. Cancer Res 2010, 70:2245-2255.
    • (2010) Cancer Res , vol.70 , pp. 2245-2255
    • Jin, D.1    Fan, J.2    Wang, L.3
  • 67
    • 84888385324 scopus 로고    scopus 로고
    • Immunity, inflammation and cancer: a leading role for adenosine
    • Antonioli L., Blandizzi C., Pacher P., Haskó G. Immunity, inflammation and cancer: a leading role for adenosine. Nat Rev Cancer 2013, 13:842-857.
    • (2013) Nat Rev Cancer , vol.13 , pp. 842-857
    • Antonioli, L.1    Blandizzi, C.2    Pacher, P.3    Haskó, G.4
  • 69
    • 80053252088 scopus 로고    scopus 로고
    • Mechanisms of ATP-mediated vasodilation in humans: modest role for nitric oxide and vasodilating prostaglandins
    • Crecelius A.R., Kirby B.S., Richards J.C., et al. Mechanisms of ATP-mediated vasodilation in humans: modest role for nitric oxide and vasodilating prostaglandins. Am J Physiol Heart Circ Physiol 2011, 301:H1302-H1310.
    • (2011) Am J Physiol Heart Circ Physiol , vol.301
    • Crecelius, A.R.1    Kirby, B.S.2    Richards, J.C.3
  • 70
    • 84860779616 scopus 로고    scopus 로고
    • Inhibition of allogenic T-cell cytotoxicity by hepatic stellate cell via CD4[U+207A] CD25[U+207A] Foxp3[U+207A] regulatory T cells invitro
    • Wu T.J., Wang Y.C., Wu T.H., et al. Inhibition of allogenic T-cell cytotoxicity by hepatic stellate cell via CD4[U+207A] CD25[U+207A] Foxp3[U+207A] regulatory T cells invitro. Transplant Proc 2012, 44:1055-1059.
    • (2012) Transplant Proc , vol.44 , pp. 1055-1059
    • Wu, T.J.1    Wang, Y.C.2    Wu, T.H.3


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