Recombinant Osteopontin Stabilizes Smooth Muscle Cell Phenotype via Integrin Receptor/Integrin-Linked Kinase/Rac-1 Pathway After Subarachnoid Hemorrhage in Rats

Stroke

Volumn 47, Issue 5, 2016, Pages 1319-1327

  Wu, Jiang ^a,b   Zhang, Yang ^b   Yang, Peng ^b   Enkhjargal, Budbazar ^b   Manaenko, Anatol ^b   Tang, Jiping ^b   Pearce, William J ^b   Hartman, Richard ^b   Obenaus, Andre ^b   Chen, Gang ^a   Zhang, John H ^b  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b LOMA LINDA UNIVERSITY   (United States)

Author keywords

blotting, Western; cerebral arteries; muscle; rats, Sprague Dawley; smooth, vascular; subarachnoid hemorrhage

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; ALPHA SMOOTH MUSCLE ACTIN; EOSIN; FIBRONECTIN; HEMATOXYLIN; INDIAN INK; INTEGRIN LINKED KINASE; INTEGRIN RECEPTOR; MYOSIN HEAVY CHAIN; PEPTIDE; RAC1 PROTEIN; RECOMBINANT CYTOKINE; RECOMBINANT OSTEOPONTIN; UNCLASSIFIED DRUG; INTEGRIN; INTEGRIN-LINKED KINASE; NEUROPROTECTIVE AGENT; OSTEOPONTIN; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN;

ANGIOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ARTERY; BRAIN SIZE; BRAIN WATER; CONTROLLED STUDY; CORTICAL THICKNESS (BRAIN); IMMUNOFLUORESCENCE; MALE; NONHUMAN; OUTCOME ASSESSMENT; PHENOTYPE; PRIORITY JOURNAL; RAT; SCORING SYSTEM; SMOOTH MUSCLE CELL; STAINING; SUBARACHNOID HEMORRHAGE; SWELLING; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; ANIMAL; DISEASE MODEL; DRUG EFFECTS; SPRAGUE DAWLEY RAT;

ANIMALS; CEREBRAL ARTERIES; DISEASE MODELS, ANIMAL; INTEGRINS; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEUROPROTECTIVE AGENTS; OSTEOPONTIN; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; RAC1 GTP-BINDING PROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SUBARACHNOID HEMORRHAGE;

EID: 84961391437     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.115.011552     Document Type: Article

References (40)

1. Zhang JH. Vascular neural network in subarachnoid hemorrhage. Transl Stroke Res. 2014;5:423-428. doi: 10.1007/s12975-014-0355-9.
2. Zhang JH, Badaut J, Tang J, Obenaus A, Hartman R, Pearce WJ. The vascular neural network-a new paradigm in stroke pathophysiology. Nat Rev Neurol. 2012;8:711-716. doi: 10.1038/nrneurol.2012.210.
3. Alhadidi Q, Bin Sayeed MS, Shah ZA. Cofilin as a promising therapeutic target for ischemic and hemorrhagic stroke. Transl Stroke Res. 2016;7:33-41. doi: 10.1007/s12975-015-0438-2.
4. Lee MH, Kwon BJ, Seo HJ, Yoo KE, Kim MS, Koo MA, et al. Resveratrol inhibits phenotype modulation by platelet derived growth factor-bb in rat aortic smooth muscle cells. Oxid Med Cell Longev. 2014;2014:572430. doi: 10.1155/2014/572430.
5. Yoshiyama S, Chen Z, Okagaki T, Kohama K, Nasu-Kawaharada R, Izumi T, et al. Nicotine exposure alters human vascular smooth muscle cell phenotype from a contractile to a synthetic type. Atherosclerosis. 2014;237:464-470. doi: 10.1016/j.atherosclerosis.2014.10.019.
6. Conway LW, McDonald LW. Structural changes of the intradural arteries following subarachnoid hemorrhage. J Neurosurg. 1972;37: 715-723.
7. Ohkuma H, Tsurutani H, Suzuki S. Changes of beta-actin mRNA expression in canine vasospastic basilar artery after experimental subarachnoid hemorrhage. Neurosci Lett. 2001;311:9-12.
8. Maddahi A, Povlsen GK, Edvinsson L. Regulation of enhanced cerebrovascular expression of proinflammatory mediators in experimental subarachnoid hemorrhage via the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway. J Neuroinflammation. 2012;9:274. doi: 10.1186/1742-2094-9-274.
9. Hasegawa Y, Suzuki H, Uekawa K, Kawano T, Kim-Mitsuyama S. Characteristics of cerebrovascular injury in the hyperacute phase after induced severe subarachnoid hemorrhage. Transl Stroke Res. 2015;6:458-466. doi: 10.1007/s12975-015-0423-9.
10. Edvinsson LI, Povlsen GK. Vascular plasticity in cerebrovascular disorders. J Cereb Blood Flow Metab. 2011;31:1554-1571. doi: 10.1038/jcbfm.2011.70.
11. Rensen SS, Doevendans PA, van Eys GJ. Regulation and characteristics of vascular smooth muscle cell phenotypic diversity. Neth Heart J. 2007;15:100-108.
12. Gao H, Steffen MC, Ramos KS. Osteopontin regulates α-smooth muscle actin and calponin in vascular smooth muscle cells. Cell Biol Int. 2012;36:155-161. doi: 10.1042/CBI20100240.
13. Shen D, Li J, Lepore JJ, Anderson TJ, Sinha S, Lin AY, et al. Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells. Circ Res. 2011;109:616-628. doi: 10.1161/CIRCRESAHA.110.239343.
14. Shi F, Long X, Hendershot A, Miano JM, Sottile J. Fibronectin matrix polymerization regulates smooth muscle cell phenotype through a Rac1 dependent mechanism. PLoS One. 2014;9:e94988. doi: 10.1371/journal. pone.0094988.
15. Suzuki H, Hasegawa Y, Chen W, Kanamaru K, Zhang JH. Recombinant osteopontin in cerebral vasospasm after subarachnoid hemorrhage. Ann Neurol. 2010;68:650-660. doi: 10.1002/ana.22102.
16. Suzuki H, Hasegawa Y, Kanamaru K, Zhang JH. Mechanisms of osteopontin-induced stabilization of blood-brain barrier disruption after subarachnoid hemorrhage in rats. Stroke. 2010;41:1783-1790. doi: 10.1161/STROKEAHA.110.586537.
17. Topkoru BC, Altay O, Duris K, Krafft PR, Yan J, Zhang JH. Nasal administration of recombinant osteopontin attenuates early brain injury after subarachnoid hemorrhage. Stroke. 2013;44:3189-3194. doi: 10.1161/STROKEAHA.113.001574.
18. Salahpour A, Medvedev IO, Beaulieu JM, Gainetdinov RR, Caron MG. Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animals. Biol Psychiatry. 2007;61:65-69. doi: 10.1016/j.biopsych.2006.03.020.
19. Tan AM, Stamboulian S, Chang YW, Zhao P, Hains AB, Waxman SG, et al. Neuropathic pain memory is maintained by Rac1-regulated dendritic spine remodeling after spinal cord injury. J Neurosci. 2008;28:13173-13183. doi: 10.1523/JNEUROSCI.3142-08.2008.
20. Chen Y, Zhang Y, Tang J, Liu F, Hu Q, Luo C, et al. Norrin protected blood-brain barrier via frizzled-4/β-catenin pathway after subarachnoid hemorrhage in rats. Stroke. 2015;46:529-536. doi: 10.1161/STROKEAHA.114.007265.
21. Liu F, Hu Q, Li B, Manaenko A, Chen Y, Tang J, et al. Recombinant milk fat globule-EGF factor-8 reduces oxidative stress via integrin β3/nuclear factor erythroid 2-related factor 2/heme oxygenase pathway in subarachnoid hemorrhage rats. Stroke. 2014;45:3691-3697. doi: 10.1161/STROKEAHA.114.006635.
22. Sugawara T, Ayer R, Jadhav V, Zhang JH. A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. J Neurosci Methods. 2008;167:327-334. doi: 10.1016/j. jneumeth.2007.08.004.
23. Garcia JH, Wagner S, Liu KF, Hu XJ. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke. 1995;26:627-634, discussion 635.
24. Ostrowski RP, Colohan AR, Zhang JH. Mechanisms of hyperbaric oxygen-induced neuroprotection in a rat model of subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2005;25:554-571. doi: 10.1038/sj.jcbfm.9600048.
25. Choudhri TF, Hoh BL, Solomon RA, Connolly ES Jr, Pinsky DJ. Use of a spectrophotometric hemoglobin assay to objectively quantify intracerebral hemorrhage in mice. Stroke. 1997;28:2296-2302.
26. He Z, Ostrowski RP, Sun X, Ma Q, Tang J, Zhang JH. Targeting C/EBP homologous protein with siRNA attenuates cerebral vasospasm after experimental subarachnoid hemorrhage. Exp Neurol. 2012;238:218-224. doi: 10.1016/j.expneurol.2012.08.025.
27. Liao J, Ye Z, Huang G, Xu C, Guo Q, Wang E. Delayed treatment with NSC23766 in streptozotocin-induced diabetic rats ameliorates postischemic neuronal apoptosis through suppression of mitochondrial p53 translocation. Neuropharmacology. 2014;85:508-516. doi: 10.1016/j. neuropharm.2014.06.008.
28. Shimamura N, Ohkuma H. Phenotypic transformation of smooth muscle in vasospasm after aneurysmal subarachnoid hemorrhage. Transl Stroke Res. 2014;5:357-364. doi: 10.1007/s12975-013-0310-1.
29. Ohkuma H, Suzuki S, Ogane K. Phenotypic modulation of smooth muscle cells and vascular remodeling in intraparenchymal small cerebral arteries after canine experimental subarachnoid hemorrhage. Neurosci Lett. 2003;344:193-196.
30. Edvinsson L, Larsen SS, Maddahi A, Nielsen J. Plasticity of cerebrovascular smooth muscle cells after subarachnoid hemorrhage. Transl Stroke Res. 2014;5:365-376. doi: 10.1007/s12975-014-0331-4.
31. Yamaguchi-Okada M, Nishizawa S, Koide M, Nonaka Y. Biomechanical and phenotypic changes in the vasospastic canine basilar artery after subarachnoid hemorrhage. J Appl Physiol (1985). 2005;99:2045-2052. doi: 10.1152/japplphysiol.01138.2004.
32. Song JN, An JY, Hao GS, Li DD, Sun P, Li Y, et al. Role of Akt signaling pathway in delayed cerebral vasospasm after subarachnoid hemorrhage in rats. Acta Neurochir (Wien). 2013;155:2063-2070. doi: 10.1007/s00701-013-1808-8.
33. Denhardt DT, Noda M, O'Regan AW, Pavlin D, Berman JS. Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest. 2001;107:1055-1061. doi: 10.1172/JCI12980.
34. Meller R, Stevens SL, Minami M, Cameron JA, King S, Rosenzweig H, et al. Neuroprotection by osteopontin in stroke. J Cereb Blood Flow Metab. 2005;25:217-225. doi: 10.1038/sj.jcbfm.9600022.
35. Chen W, Ma Q, Suzuki H, Hartman R, Tang J, Zhang JH. Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model. Stroke. 2011;42:764-769. doi: 10.1161/STROKEAHA.110.599118.
36. Schroeter M, Zickler P, Denhardt DT, Hartung HP, Jander S. Increased thalamic neurodegeneration following ischaemic cortical stroke in osteopontin-deficient mice. Brain. 2006;129(pt 6):1426-1437. doi: 10.1093/brain/awl094.
37. Skuli N, Monferran S, Delmas C, Favre G, Bonnet J, Toulas C, et al. Alphavbeta3/alphavbeta5 integrins-FAK-RhoB: a novel pathway for hypoxia regulation in glioblastoma. Cancer Res. 2009;69:3308-3316. doi: 10.1158/0008-5472.CAN-08-2158.
38. Spindler V, Schlegel N, Waschke J. Role of GTPases in control of microvascular permeability. Cardiovasc Res. 2010;87:243-253. doi: 10.1093/cvr/cvq086.
39. Thorne RG, Emory CR, Ala TA, Frey WH II. Quantitative analysis of the olfactory pathway for drug delivery to the brain. Brain Res. 1995;692:278-282.
40. Doyle KP, Yang T, Lessov NS, Ciesielski TM, Stevens SL, Simon RP, et al. Nasal administration of osteopontin peptide mimetics confers neuroprotection in stroke. J Cereb Blood Flow Metab. 2008;28:1235-1248. doi: 10.1038/jcbfm.2008.17.