Single-dose rosuvastatin ameliorates lung ischemia-reperfusion injury via upregulation of endothelial nitric oxide synthase and inhibition of macrophage infiltration in rats with pulmonary hypertension

Journal of Thoracic and Cardiovascular Surgery

Volumn 149, Issue 3, 2015, Pages 902-909

  Matsuo, Satoshi ^a   Adachi, Osamu ^a   Kawamoto, Shunsuke ^a   Fukushige, Shinichi ^a   Horii, Akira ^a   Saiki, Yoshikatsu ^a   Saiki, Yuriko ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORDANE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MEVALONOLACTONE; MONOCROTALINE; ROSUVASTATIN; ANTIINFLAMMATORY AGENT; CD68 PROTEIN, RAT; DIFFERENTIATION ANTIGEN; FLUOROBENZENE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEUKOCYTE ANTIGEN; MEVALONIC ACID; NOS3 PROTEIN, RAT; OXYGEN; PYRIMIDINE DERIVATIVE; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL OXYGEN TENSION; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DRUG MECHANISM; IMMUNOHISTOCHEMISTRY; LUNG FUNCTION; LUNG INJURY; LUNG ISCHEMIA REPERFUSION INJURY; LUNG WEIGHT; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY ARTERY OCCLUSION; PULMONARY HYPERTENSION; RAT; REPERFUSION INJURY; SINGLE DRUG DOSE; UPREGULATION; VASCULAR REMODELING; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; HYPERTENSION, PULMONARY; IMMUNOLOGY; LUNG; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PULMONARY EDEMA; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; FLUOROBENZENES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERTENSION, PULMONARY; LUNG; LUNG INJURY; MACROPHAGES; MALE; MEVALONIC ACID; MONOCROTALINE; NITRIC OXIDE SYNTHASE TYPE III; OXYGEN; PHOSPHORYLATION; PULMONARY EDEMA; PYRIMIDINES; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; ROSUVASTATIN CALCIUM; SULFONAMIDES; UP-REGULATION;

EID: 84961290120     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2014.10.030     Document Type: Article

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